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Relapse
In internal medicine, relapse or recidivism is a recurrence of a past (typically medical) condition. For example, multiple sclerosis and malaria often exhibit peaks of activity and sometimes very long periods of dormancy, followed by relapse or recrudescence. In psychiatry, relapse or reinstatement of drug-seeking behavior, is the recurrence of pathological drug use, self harm or other symptoms after a period of recovery. Relapse is often observed in individuals who have developed a drug addiction or a form of drug dependence, as well as those who have a mental disorder. Risk factors Dopamine D2 receptor availability The availability of the dopamine receptor D2 plays a role in self-administration and the reinforcing effects of cocaine and other stimulants. The D2 receptor availability has an inverse relationship to the vulnerability of reinforcing effects of the drug. With the D2 receptors becoming limited, the user becomes more susceptible to the reinforcing effects of coc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Multiple Sclerosis
Multiple sclerosis (MS) is an autoimmune disease resulting in damage to myelinthe insulating covers of nerve cellsin the brain and spinal cord. As a demyelinating disease, MS disrupts the nervous system's ability to Action potential, transmit signals, resulting in a range of signs and symptoms, including physical, cognitive disability, mental, and sometimes psychiatric problems. Symptoms include double vision, vision loss, eye pain, muscle weakness, and loss of Sensation (psychology), sensation or coordination. MS takes several forms, with new symptoms either occurring in isolated attacks (relapsing forms) or building up over time (progressive forms). In relapsing forms of MS, symptoms may disappear completely between attacks, although some permanent neurological problems often remain, especially as the disease advances. In progressive forms of MS, bodily function slowly deteriorates once symptoms manifest and will steadily worsen if left untreated. While its cause is unclear, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Malaria
Malaria is a Mosquito-borne disease, mosquito-borne infectious disease that affects vertebrates and ''Anopheles'' mosquitoes. Human malaria causes Signs and symptoms, symptoms that typically include fever, Fatigue (medical), fatigue, vomiting, and headaches. In severe cases, it can cause jaundice, Epileptic seizure, seizures, coma, or death. Symptoms usually begin 10 to 15 days after being bitten by an infected ''Anopheles'' mosquito. If not properly treated, people may have recurrences of the disease months later. In those who have recently survived an infection, reinfection usually causes milder symptoms. This partial Immunity (medical), resistance disappears over months to years if the person has no continuing exposure to malaria. The mosquitoes themselves are harmed by malaria, causing reduced lifespans in those infected by it. Malaria is caused by protozoa, single-celled microorganisms of the genus ''Plasmodium''. It is spread exclusively through bites of infected female ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Recrudescence
Recrudescence is the recurrence of an undesirable condition. In medicine, it is usually defined as the recurrence of symptoms after a period of remission or quiescence, in which sense it can sometimes be synonymous with relapse. In a narrower sense, it can also be such a recurrence with higher severity than before the remission. "Relapse" conventionally has a specific (albeit somewhat illogical) meaning when used in relation to malaria (see below). Malaria In malaria, recurrence can take place due to ''recrudescence''; or ''relapse''; or ''re-infection'' (via mosquito transmission). ''Relapse'' means that a recurrence has been precipitated by a dormant stage in the liver called a "hypnozoite". Thus, ''relapse'' is applied only for those plasmodial species that have hypnozoites in the life cycle, such as ''Plasmodium vivax'' and '' P. ovale''. On the other hand, ''recrudescence'' means that circulating, multiplying parasites are detected after having persisted in the bloodstream ( ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drug Addiction
Addiction is a neuropsychological disorder characterized by a persistent and intense urge to use a drug or engage in a behavior that produces natural reward, despite substantial harm and other negative consequences. Repetitive drug use can alter brain function in synapses similar to natural rewards like food or falling in love in ways that perpetuate craving and weakens self-control for people with pre-existing vulnerabilities. This phenomenon – drugs reshaping brain function – has led to an understanding of addiction as a brain disorder with a complex variety of psychosocial as well as neurobiological factors that are implicated in the development of addiction. While mice given cocaine showed the compulsive and involuntary nature of addiction, for humans this is more complex, related to behavior or personality traits. Classic signs of addiction include compulsive engagement in rewarding stimuli, ''preoccupation'' with substances or behavior, and continued use de ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Social Hierarchy
Social stratification refers to a society's categorization of its people into groups based on socioeconomic factors like wealth, income, race, education, ethnicity, gender, occupation, social status, or derived power (social and political). It is a hierarchy within groups that ascribe them to different levels of privileges. As such, stratification is the relative social position of persons within a social group, category, geographic region, or social unit. In modern Western societies, social stratification is defined in terms of three social classes: an upper class, a middle class, and a lower class; in turn, each class can be subdivided into an upper-stratum, a middle-stratum, and a lower stratum. Moreover, a social stratum can be formed upon the bases of kinship, clan, tribe, or caste, or all four. The categorization of people by social stratum occurs most clearly in complex state-based, polycentric, or feudal societies, the latter being based upon socio-economic re ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Social Interaction
A social relation is the fundamental unit of analysis within the social sciences, and describes any voluntary or involuntary interpersonal relationship between two or more conspecifics within and/or between groups. The group can be a language or kinship group, a social institution or organization, an economic class, a nation, or gender. Social relations are derived from human behavioral ecology, and, as an aggregate, form a coherent social structure whose constituent parts are best understood relative to each other and to the social ecosystem as a whole. History Early inquiries into the nature of social relations featured in the work of sociologists such as Max Weber in his theory of social action, where social relationships composed of both positive (affiliative) and negative (agonistic) interactions represented opposing effects. Categorizing social interactions enables observational and other social research, such as Gemeinschaft and Gesellschaft (), collective conscio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Animal Studies
Animal studies is a recently recognised field in which animals are studied in a variety of cross-disciplinary ways. Scholars who engage in animal studies may be formally trained in a number of diverse fields, including art history, anthropology, biology, film studies, geography, history, psychology, literary studies, museology, philosophy, communication, and sociology. They engage with questions about notions of "animality," "animalization," or "becoming animal," to understand human-made representations of and cultural ideas about "the animal" and what it is to be human by employing various theoretical perspectives. Using these perspectives, those who engage in animal studies seek to understand both human-animal relations now and in the past as defined by our knowledge of them. Because the field is still developing, scholars and others have some freedom to define their own criteria about what issues may structure the field. History Animal studies became popular in the 1970s as a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dominance Hierarchy
In the zoological field of ethology, a dominance hierarchy (formerly and colloquially called a pecking order) is a type of social hierarchy that arises when members of animal social animal, social groups interact, creating a ranking system. Different types of interactions can result in dominance depending on the species, including Ritualized aggression, ritualized displays of aggression or direct physical violence. In social living groups, members are likely to compete for access to limited resources and mating opportunities. Rather than fighting each time they meet, individuals of the same sex establish a relative rank, with higher-ranking individuals often gaining more access to resources and mates. Based on repetitive interactions, a social order is created that is subject to change each time a dominant animal is challenged by a subordinate one. Definitions Dominance is an individual's preferential access to resources over another based on coercive capacity based on streng ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Internal Medicine
Internal medicine, also known as general medicine in Commonwealth nations, is a medical specialty for medical doctors focused on the prevention, diagnosis, and treatment of diseases in adults. Its namesake stems from "treatment of diseases of the internal organs". Medical practitioners of internal medicine are referred to as internists, or physicians in Commonwealth nations. Internists possess specialized skills in managing patients with undifferentiated or multi-system disease processes. They provide care to both hospitalized (inpatient) and ambulatory (outpatient) patients and often contribute significantly to teaching and research. Internists are qualified physicians who have undergone postgraduate training in internal medicine, and should not be confused with " interns", a term commonly used for a medical doctor who has obtained a medical degree but does not yet have a license to practice medicine unsupervised. In the United States and Commonwealth nations, there is often ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Reinforce
In behavioral psychology, reinforcement refers to consequences that increase the likelihood of an organism's future behavior, typically in the presence of a particular '' antecedent stimulus''. For example, a rat can be trained to push a lever to receive food whenever a light is turned on; in this example, the light is the antecedent stimulus, the lever pushing is the ''operant behavior'', and the food is the ''reinforcer''. Likewise, a student that receives attention and praise when answering a teacher's question will be more likely to answer future questions in class; the teacher's question is the antecedent, the student's response is the behavior, and the praise and attention are the reinforcements. Punishment is the inverse to reinforcement, referring to any behavior that decreases the likelihood that a response will occur. In operant conditioning terms, punishment does not need to involve any type of pain, fear, or physical actions; even a brief spoken expression of disappr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pharmacokinetics
Pharmacokinetics (from Ancient Greek ''pharmakon'' "drug" and ''kinetikos'' "moving, putting in motion"; see chemical kinetics), sometimes abbreviated as PK, is a branch of pharmacology dedicated to describing how the body affects a specific substance after administration. The substances of interest include any chemical xenobiotic such as pharmaceutical drugs, pesticides, food additives, cosmetics, etc. It attempts to analyze chemical metabolism and to discover the fate of a chemical from the moment that it is administered up to the point at which it is completely eliminated from the body. Pharmacokinetics is based on mathematical modeling that places great emphasis on the relationship between drug plasma concentration and the time elapsed since the drug's administration. Pharmacokinetics is the study of how an organism affects the drug, whereas pharmacodynamics (PD) is the study of how the drug affects the organism. Both together influence dosing, benefit, and adverse effe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
