Myotubularin
domain represents a region within eukaryotic myotubularin-related proteins that is sometimes found with the
GRAM domain. Myotubularin is a dual-specific lipid
phosphatase
In biochemistry, a phosphatase is an enzyme that uses water to cleave a phosphoric acid Ester, monoester into a phosphate ion and an Alcohol (chemistry), alcohol. Because a phosphatase enzyme catalysis, catalyzes the hydrolysis of its Substrate ...
that dephosphorylates
phosphatidylinositol 3-phosphate and
phosphatidylinositol (3,5)-bi-phosphate.
Mutations in gene encoding myotubularin-related proteins have been associated with disease.
Human proteins containing this domain
MTM1
Myotubularin is a protein that in humans is encoded by the ''MTM1'' gene.
This gene is a member of a gene family that encodes lipid phosphatases. Myotubularin is required for muscle cell differentiation and mutations in this gene have been ident ...
;
MTMR1;
MTMR2;
MTMR3;
MTMR4;
MTMR6;
MTMR7;
MTMR8;
MTMR9;
MTMR10;
MTMR11;
MTMR12;
MTMR14;
SBF1;
SBF2;
References
External links
* - Myotubularin phosphatase domain in
PROSITE
{{Protein tyrosine phosphatases
Protein domains
Peripheral membrane proteins