Mineralocorticoid Ester
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corticosteroid ester Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones. Two main classes of corticosteroids, glucocorticoids and mineralocorticoids, are involved ...
s, including
ester In chemistry, an ester is a compound derived from an acid (either organic or inorganic) in which the hydrogen atom (H) of at least one acidic hydroxyl group () of that acid is replaced by an organyl group (R). These compounds contain a distin ...
s of
steroid A steroid is an organic compound with four fused compound, fused rings (designated A, B, C, and D) arranged in a specific molecular configuration. Steroids have two principal biological functions: as important components of cell membranes t ...
al
glucocorticoid Glucocorticoids (or, less commonly, glucocorticosteroids) are a class of corticosteroids, which are a class of steroid hormones. Glucocorticoids are corticosteroids that bind to the glucocorticoid receptor that is present in almost every vertebra ...
s and
mineralocorticoid Mineralocorticoids are a class of corticosteroids, which in turn are a class of steroid hormones. Mineralocorticoids are produced in the adrenal cortex and influence salt and water balances (electrolyte balance and fluid balance). The primary ...
s.


Esters of natural corticosteroids


Desoxycortone esters

*
Desoxycortone acetate Desoxycorticosterone acetate (also known as DOCA and 11-deoxycorticosterone 21-acetate and sold under the brand names Percorten Acetate and Decosterone, among others) is a mineralocorticoid medication and a mineralocorticoid ester. It is formula ...
(deoxycortone acetate; desoxycorticosterone acetate) * Desoxycortone cypionate (deoxycortone cypionate; desoxycorticosterone cypionate) * Desoxycortone enanthate (deoxycortone enanthate; deoxycorticosterone enanthate) * Desoxycortone glucoside (deoxycortone glucoside; deoxycorticosterone glucoside) * Desoxycortone pivalate (deoxycortone pivalate; deoxycorticosterone pivalate)


Hydrocortisone esters

* Benzodrocortisone (hydrocortisone 17-benzoate) * Hydrocortamate (hydrocortisone 21-(diethylamino)acetate) * Hydrocortisone aceponate (hydrocortisone 21-acetate 17α-propionate) * Hydrocortisone acetate * Hydrocortisone bendazac *
Hydrocortisone buteprate Hydrocortisone buteprate, also known as hydrocortisone probutate and as hydrocortisone butyrate propionate, is a topical steroid, topical corticosteroid. It is an ester of hydrocortisone (cortisol) with butyric acid and propionic acid. Referen ...
(hydrocortisone 17α-butyrate 21-propionate) *
Hydrocortisone butyrate Hydrocortisone butyrate is a corticosteroid that comes in one of the following forms: * ''Hydrocortisone-17-butyrate'' — * ''Hydrocortisone-21-butyrate'' — It is a group IV corticosteroid under US classification. See also * Cortisol Ex ...
(hydrocortisone 17α-butyrate) * Hydrocortisone 21-butyrate *
Hydrocortisone cypionate Hydrocortisone cypionate, sold under the brand name Cortef, is a synthetic glucocorticoid corticosteroid and a corticosteroid ester Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well ...
(hydrocortisone cyclopentanepropionate) * Hydrocortisone phosphate *
Hydrocortisone succinate Hydrocortisone hemisuccinate (), also known as hydrocortisone hydrogen succinate () or simply hydrocortisone succinate and sold under the brand name Solu-Cortel among many others, is a synthetic glucocorticoid corticosteroid and a corticosteroid ...
(hydrocortisone hemisuccinate) * Hydrocortisone tebutate * Hydrocortisone valerate *
Hydrocortisone xanthogenic acid Hydrocortisone is the name for the hormone cortisol when supplied as a medication. It is a corticosteroid and works as an anti-inflammatory and by immunosuppressant, immune suppression. Uses include conditions such as adrenocortical insufficie ...


Esters of other natural corticosteroids

* 11-Dehydrocorticosterone acetate * Cortifen (cortodoxone chlorphenacyl ester) *
Cortisone acetate Cortisone acetate (brand names Adreson, Cortison, Cortisone, Cortisone Acetate, Cortone, Cortistab, Cortisyl, others) is a synthetic glucocorticoid corticosteroid and corticosteroid ester which is marketed (under prescription) in many countries ...
* Corticosterone acetate * Corticosterone benzoate * Cortodoxone acetate


Esters of synthetic corticosteroids


Beclometasone esters

*
Beclometasone dipropionate Beclometasone or beclomethasone, also known as beclomethasone dipropionate, and sold under the brand name Qvar among others, is a steroid medication. It is available as an inhaler, cream, pills, and nasal spray. The inhaled form is used in th ...
(beclomethasone dipropionate) * Beclometasone salicylate * Beclometasone valeroacetate


Betamethasone esters

* Betamethasone acetate * Betamethasone acibutate (betamethasone 21-acetate 17α-isobutyrate) * Betamethasone adamantoate * Betamethasone benzoate *
Betamethasone dipropionate Betamethasone dipropionate is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties. It is applied as a topical cream, ointment, lotion or gel (Diprolene) to treat itching and other skin conditions such as eczema. Minor ...
*
Betamethasone divalerate Betamethasone is a steroid medication. It is used for a number of diseases including rheumatic disorder Rheumatism or rheumatic disorders are conditions causing chronic, often intermittent pain affecting the joints or connective tissue. R ...
* Betamethasone phosphate (betamethasone phosphate) * Betamethasone succinate *
Betamethasone valerate Betamethasone valerate is a synthetic glucocorticoid ester. It is the 17-valerate ester of betamethasone Betamethasone is a corticosteroid, steroid medication. It is used for a number of diseases including rheumatic disorders such as rheum ...
*
Betamethasone valeroacetate Betamethasone is a steroid medication. It is used for a number of diseases including rheumatic disorders such as rheumatoid arthritis and systemic lupus erythematosus, skin diseases such as dermatitis and psoriasis, allergic conditions such as ...
(betamethasone 21-acetate 17α-valerate) * Cortobenzolone (betamethasone salicylate)


Clocortolone esters

* Clocortolone acetate * Clocortolone caproate * Clocortolone pivalate


Dexamethasone esters

* Dexamethasone acefurate * Dexamethasone acetate (flumeprednisolone) * Dexamethasone cipecilate *
Dexamethasone diethylaminoacetate Dexamethasone is a fluorinated Glucocorticoid#Pharmacology, glucocorticoid medication used to treat rheumatology, rheumatic problems, a number of skin diseases, severe allergies, asthma, chronic obstructive pulmonary disease (COPD), croup, ce ...
* Dexamethasone dipropionate * Dexamethasone isonicotinate * Dexamethasone linoleate * Dexamethasone metasulphobenzoate * Dexamethasone palmitate * Dexamethasone phosphate * Dexamethasone pivalate * Dexamethasone succinate * Dexamethasone sulfate * Dexamethasone tebutate (dexamethasone ''tert''-butylacetate) * Dexamethasone troxundate * Dexamethasone valerate


Fluocinolone acetonide esters

* Ciprocinonide (fluocinolone acetonide cyclopropylcarboxylate) *
Fluocinonide Fluocinonide is a potent glucocorticoid used topically as an anti-inflammatory agent for the treatment of skin disorders such as eczema and seborrhoeic dermatitis. It relieves itching, redness, dryness, crusting, scaling, inflammation ...
(fluocinolone acetonide 21-acetate) * Procinonide (fluocinolone acetonide propionate)


Fluocortolone esters

*
Fluocortin Fluocortin is a corticosteroid. It is similar to fluocortolone, but with one more carbonyl group In organic chemistry, a carbonyl group is a functional group with the formula , composed of a carbon atom double-bonded to an oxygen atom, and i ...
(fluocortolone-21-carboxylate) * Fluocortin butyl (fluocortolone-21-carboxylate 21-butylate) * Fluocortolone caproate *
Fluocortolone pivalate Fluocortolone is a glucocorticoid used in the treatment of several conditions, including hemorrhoids. It is similar to fluocortin, but with one less carbonyl group. See also * Corticosteroids Corticosteroids are a class of steroid hormones ...


Fluprednisolone esters

* Fluprednisolone acetate *
Fluprednisolone succinate Fluprednisolone is a pregnane. It is a corticosteroid Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones. Two main classes of corticoste ...
(fluprednisolone hemisuccinate) *
Fluprednisolone valerate Fluprednisolone is a pregnane. It is a corticosteroid Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones. Two main classes of corticoste ...


Methylprednisolone esters

*
Methylprednisolone aceponate Methylprednisolone aceponate, or methylprednisolone acetate propionate, sold under the brand names Advantan and Avancort, is a glucocorticoid and a corticosteroid ester—specifically the C17α propionate and C21 acetate diester of methylprednis ...
*
Methylprednisolone acetate Methylprednisolone acetate, sold under the brand names Depo-Medrol among others, is a synthetic glucocorticoid corticosteroid and a corticosteroid ester—specifically the C21 acetate ester of methylprednisolone—which is used in clinical and v ...
* Methylprednisolone cyclopentylpropionate *
Methylprednisolone phosphate Methylprednisolone (Depo-Medrol, Medrol, Solu-Medrol) is a synthetic glucocorticoid, primarily prescribed for its anti-inflammatory and immunosuppressive effects. It is either used at low doses for chronic illnesses or used at high doses durin ...
*
Methylprednisolone succinate Methylprednisolone succinate, sold under the brand name Solu-Medrol among others, is a synthetic glucocorticoid corticosteroid and a corticosteroid ester—specifically the C21 succinate ester of methylprednisolone—which is used by intraveno ...
(methylprednisolone hemisuccinate) *
Methylprednisolone suleptanate Methylprednisolone suleptanate, sold under the brand names Medrosol and Promedrol, is a synthetic glucocorticoid corticosteroid and a corticosteroid ester—specifically, the C21 suleptanate 21-(8-(methyl-(2-sulfoethyl)amino)-1,8-dioxooctanoate) ...


Prednisolone esters

*
Prednazate Prednazate, a combination of prednisolone hemisuccinate with perphenazine, is a synthetic compound, synthetic glucocorticoid corticosteroid as well as typical antipsychotic and sedative/tranquilizer. It was a component of Sixty Six-20, a combinat ...
( prednisolone succinate and
perphenazine Perphenazine is a typical antipsychotic drug. Chemically, it is classified as a piperazinyl phenothiazine. Originally marketed in the United States as Trilafon, it has been in clinical use for decades. Perphenazine is roughly ten times as pote ...
compound) *
Prednazoline Prednazoline, a compound of prednisolone phosphate with fenoxazoline, is a synthetic compound, synthetic corticosteroid as well as vasoconstrictor and alpha-adrenergic receptor, α-adrenergic sympathomimetic. See also * Prednazate * Prednimustin ...
( prednisolone phosphate and fenoxazoline compound) *
Prednicarbate Prednicarbate is a relatively new topical corticosteroid drug. It is similar in potency to hydrocortisone. Corticosteroids have always been an important part of the pharmacological arsenal of dermatology Dermatology is the branch of medicin ...
(prednisolone 17-(ethyl carbonate) 21-propionate) *
Prednimustine Prednimustine, sold under the brand names Mostarina and Sterecyst, is a medication which is used in chemotherapy in the treatment of leukemias and lymphomas. It is the ester formed from two other drugs, prednisolone and chlorambucil. Rarely, it ...
(prednisolone
chlorambucil Chlorambucil, sold under the brand name Leukeran among others, is a chemotherapy medication used to treat chronic lymphocytic leukemia (CLL), Hodgkin lymphoma, and non-Hodgkin lymphoma. For CLL it is a preferred treatment. It is given by mouth ...
ester) * Prednisolamate (prednisolone diethylaminoacetate) *
Prednisolone acetate Prednisolone acetate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. It is the 21-acetate ester of prednisolone. Safety Prednisolone acetate is acutely toxic with an LD50 of >240 mg/kg for a rat and 3500 mg ...
* Prednisolone hexanoate * Prednisolone metasulphobenzoate (prednisolone 21-(3-sulfobenzoate)) * Prednisolone palmitate * Prednisolone phosphate * Prednisolone piperidinoacetate * Prednisolone pivalate * Prednisolone steaglate (prednisolone stearoyl-glycolate) * Prednisolone stearoylglycolate * Prednisolone succinate (prednisolone hemisuccinate) * Prednisolone sulfate * Prednisolone tebutate (prednisolone ''tert''-butylacetate) * Prednisolone tetrahydrophthalate * Prednisolone valerate *
Prednisolone valeroacetate Prednisolone is a corticosteroid, a steroid hormone used to treat certain types of allergies, inflammatory conditions, autoimmune disorders, and cancers, electrolyte imbalances and skin conditions. Some of these conditions include adrenocor ...


Prednisone esters

*
Prednisone acetate Prednisone is a glucocorticoid medication mostly used to suppress the immune system and decrease inflammation in conditions such as asthma, COPD, and rheumatologic diseases. It is also used to treat high blood calcium due to cancer and adre ...
* Prednisone palmitate * Prednisone succinate


Tixocortol esters

*
Butixocort Butixocort, also known as tixocortol butyrate, is a synthetic glucocorticoid corticosteroid Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these h ...
(tixocortol butyrate) *
Butixocort propionate Butixocort, also known as tixocortol butyrate, is a synthetic glucocorticoid corticosteroid Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these h ...
(tixocortol butyrate propionate) * Tixocortol pivalate


Triamcinolone acetonide esters

* Flupamesone (triamcinolone acetonide metembonate) * Triamcinolone acetonide phosphate *
Triamcinolone acetonide succinate Triamcinolone is a glucocorticoid used to treat certain skin diseases, allergies, and rheumatic disorders among others. It is also used to prevent worsening of asthma and chronic obstructive pulmonary disease (COPD). It can be taken in various ...
(triamcinolone acetonide hemisuccinate) *
Triamcinolone benetonide Triamcinolone benetonide (brand names Alcorten, Benecorten, Tibicorten; also known as triamcinolone acetonide 21-(benzoyl-β-aminoisobutyrate) or TBI) is a synthetic glucocorticoid corticosteroid Corticosteroids are a class of steroid hormones ...
(triamcinolone acetonide 21-(benzoyl-β-aminoisobutyrate)) *
Triamcinolone furetonide Triamcinolone furetonide (developmental code name HE-192; also known as triamcinolone acetonide 21-(2-benzofurancarboxylate)) is a synthetic glucocorticoid corticosteroid Corticosteroids are a class of steroid hormones that are produced in the ...
(triamcinolone acetonide 21-(2-benzofurancarboxylate)) * Triamcinolone hexacetonide (triamcinolone acetonide 21-(''tert''-butylacetate))


Esters of other synthetic corticosteroids

* Δ7-Prednisolone 21-acetate * Alclometasone dipropionate *
Amcinonide Amcinonide (trade name Cyclocort) is a topical glucocorticoid used to treat itching, redness and swelling associated with several dermatologic conditions such as atopic dermatitis and allergic contact dermatitis. Amcinonide can also be classifie ...
(triamcinolone acetate cyclopentanonide) * Chloroprednisone acetate * Ciclometasone (a corticosteroid 21- -[(acetylamino)methylyclohexyl">acetylamino)methyl.html" ;"title="-[(acetylamino)methyl">-[(acetylamino)methylyclohexylarboxylate ester) * Clobetasol propionate * Clobetasone butyrate * Cloprednol acetate * Cormetasone acetate * Cortivazol (a corticosteroid 21-acetate ester) * Cloticasone propionate * Deflazacort (a corticosteroid 21-acetate ester) *
Deprodone propionate Deprodone, also known as desolone, is a synthetic glucocorticoid corticosteroid Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones. Two ...
* Desonide phosphate * Desonide pivalate * Dichlorisone acetate * Dichlorisone diacetate * Diflorasone diacetate *
Diflucortolone pivalate Diflucortolone (INN), or difluocortolone, is a corticosteroid Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones. Two main classes of cor ...
*
Diflucortolone valerate Diflucortolone valerate (also Nerisone cream/ointment/fatty ointment, Neriderm ointment, Japanese ) is a corticosteroid rated Class 3 "potent" (100–150 times) in the New Zealand topical steroid system. It is a white to creamy white crystalline p ...
* Difluprednate (difluoroprednisolone butyrate acetate) * Dimesone acetate * Drocinonide phosphate * Etiprednol dicloacetate * Fluazacort (a corticosteroid 21-acetate ester) *
Fludrocortisone acetate Fludrocortisone, sold under the brand name Florinef among others, is a corticosteroid used to treat congenital adrenal hyperplasia, postural hypotension, and adrenal insufficiency. In adrenal insufficiency, it is generally taken together with ...
*
Flumetasone acetate Flumetasone, also known as flumethasone, is a corticosteroid for topical use. It has anti- inflammatory, antipruritic, and vasoconstrictive properties, and it is approved for human and animal use for a variety of medical conditions. It was pat ...
*
Flumetasone pivalate Flumetasone pivalate is a synthetic glucocorticoid corticosteroid Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones. Two main classes o ...
* Flunisolide acetate *
Fluorometholone acetate Fluorometholone acetate, also known as oxylone acetate and sold under the brand names Flarex, Florate, and Omnitrol, is a synthetic glucocorticoid corticosteroid and a corticosteroid ester, as well as a progestogen and progestogen ester. It is t ...
* Fluperolone acetate *
Fluprednidene acetate Fluprednidene acetate (trade name Decoderm among others) is a moderately potent glucocorticoid used in form of a cream to treat skin inflammations such as atopic dermatitis and contact dermatitis. Contraindications Similar to other corticoids, ...
*
Fluticasone furoate Fluticasone furoate, sold under the brand name Flonase Sensimist among others, is a corticosteroid for the treatment of non-allergic and allergic rhinitis administered by a nasal spray. It is also available as an inhaled corticosteroid to help ...
*
Fluticasone propionate Fluticasone propionate, sold under the brand names Flovent and Flonase among others, is a glucocorticoid steroid medication. When inhaled it is used for the long term management of asthma and chronic obstructive pulmonary disease (COPD). In t ...
* Formocortal (a corticosteroid 21-acetate ester) * Halopredone acetate (halopredone diacetate) * Icometasone enbutate * Isoflupredone acetate * Locicortolone dicibate *
Loteprednol etabonate Loteprednol (formulated as the ester loteprednol etabonate) is a topical corticosteroid used to treat inflammations of the eye. It is marketed by Bausch and Lomb as Lotemax and Loterex. It was patented in 1980 and approved for medical use in 1 ...
* Meclorisone dibutyrate *
Meprednisone acetate Meprednisone is a glucocorticoid. It is a methylated derivative of prednisone. See also * Glucocorticoid * Corticosteroid Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the ...
* Meprednisone succinate (meprednisone hemisuccinate) *
Mometasone furoate Mometasone, also known as mometasone furoate, is a steroid (specifically, a glucocorticoid) medication used to treat certain skin conditions, hay fever, and asthma. Specifically it is used to prevent rather than treat asthma attacks. It can be ...
* Nicocortonide (a corticosteroid 21-isonicotinate ester) *
Nicocortonide acetate Nicocortonide is a synthetic glucocorticoid corticosteroid Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones. Two main classes of corti ...
* Paramethasone acetate *
Paramethasone phosphate Paramethasone is a fluorinated glucocorticoid with anti-inflammatory and immunosuppressant properties.ToxnetParamethasone References Further reading

* * * Glucocorticoids Organofluorides {{systemic-hormonal-drug-stub ...
*
Prebediolone acetate Prebediolone acetate (brand names Acetoxanon, Acetoxanone, Acetoxy-Prenolon, Artisone, Artivis, Pregnartrone, Sterosone), also known as 21-hydroxypregnenolone 21-acetate or 21-acetoxypregnenolone (A.O.P.), as well as 3β,21-dihydroxypregn-5-en-20 ...
* Prednylidene diethylaminoacetate * Rofleponide palmitate * Ticabesone propionate * Timobesone acetate *
Triamcinolone aminobenzal benzamidoisobutyrate Triamcinolone aminobenzal benzamidoisobutyrate (TBI-PAB; brand name Taucorten) is a synthetic glucocorticoid corticosteroid Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the ...
*
Triamcinolone diacetate Triamcinolone diacetate is a synthetic compound, synthetic glucocorticoid corticosteroid and a corticosteroid ester. References

Corticosteroid esters Glucocorticoids Acetate esters {{steroid-stub ...
* Ulobetasol propionate (halobetasol propionate)


See also

*
Steroid ester A steroid ester is an ester of a steroid. They include androgen esters, estrogen esters, progestogen esters, and corticosteroid esters. Steroid esters may be naturally occurring/endogenous like DHEA sulfate or synthetic like estradiol valerate. ...
* List of corticosteroid cyclic ketals *
List of corticosteroids This is a list of corticosteroids (glucocorticoids and mineralocorticoids) or derivative (chemistry), derivatives of cortisol (hydrocortisone). Most esters of these corticosteroids are not included in this list; for esters, see corticosteroid est ...
* List of steroid esters


References

{{Mineralocorticoid receptor modulators Corticosteroids Steroid esters Glucocorticoids Prodrugs