Maria Leptin
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Maria Leptin (born 15 September 1954) is a German developmental biologist and immunologist, and the current president of the
European Research Council The European Research Council (ERC) is a public body for funding of scientific and technological research conducted within the European Union (EU). Established by the European Commission in 2007, the ERC is composed of an independent Scientific ...
. She was the director of the
European Molecular Biology Organization The European Molecular Biology Organization (EMBO) is a professional, non-profit organization of more than 2,100 life scientists. Its goal is to promote research in life science and enable international exchange between scientists. It co-funds cour ...
from 2010 to 2021.


Education

Leptin studied
mathematics Mathematics is a field of study that discovers and organizes methods, Mathematical theory, theories and theorems that are developed and Mathematical proof, proved for the needs of empirical sciences and mathematics itself. There are many ar ...
and
biology Biology is the scientific study of life and living organisms. It is a broad natural science that encompasses a wide range of fields and unifying principles that explain the structure, function, growth, History of life, origin, evolution, and ...
at the
University of Bonn The University of Bonn, officially the Rhenish Friedrich Wilhelm University of Bonn (), is a public research university in Bonn, North Rhine-Westphalia, Germany. It was founded in its present form as the () on 18 October 1818 by Frederick Willi ...
and the
Heidelberg University Heidelberg University, officially the Ruprecht Karl University of Heidelberg (; ), is a public research university in Heidelberg, Baden-Württemberg, Germany. Founded in 1386 on instruction of Pope Urban VI, Heidelberg is Germany's oldest unive ...
. Initially planning to become a teacher, she decided to pursue a
PhD A Doctor of Philosophy (PhD, DPhil; or ) is a terminal degree that usually denotes the highest level of academic achievement in a given discipline and is awarded following a course of graduate study and original research. The name of the deg ...
in 1979 at the Basel Institute for Immunology after a practical taught by researchers from the institute. She was supervised by Fritz Melchers and studied
B-cell B cells, also known as B lymphocytes, are a type of the lymphocyte subtype. They function in the humoral immunity component of the adaptive immune system. B cells produce antibody molecules which may be either secreted or inserted into the plasm ...
activation and maturation into
plasma cells Plasma cells, also called plasma B cells or effector B cells, are white blood cells that originate in the lymphoid organs as B cells and secrete large quantities of proteins called antibodies in response to being presented specific substances c ...
as part of the
immune response An immune response is a physiological reaction which occurs within an organism in the context of inflammation for the purpose of defending against exogenous factors. These include a wide variety of different toxins, viruses, intra- and extracellula ...
to
infections An infection is the invasion of tissue (biology), tissues by pathogens, their multiplication, and the reaction of host (biology), host tissues to the infectious agent and the toxins they produce. An infectious disease, also known as a transmis ...
. She completed her PhD in 1983.


Career

After her
PhD A Doctor of Philosophy (PhD, DPhil; or ) is a terminal degree that usually denotes the highest level of academic achievement in a given discipline and is awarded following a course of graduate study and original research. The name of the deg ...
, in 1984, Leptin joined Michael Wilcox's group at the
MRC Laboratory of Molecular Biology The Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) is a research institute in Cambridge, England, involved in the revolution in molecular biology which occurred in the 1950–60s. Since then it has remained a major medical r ...
(LMB) in
Cambridge Cambridge ( ) is a List of cities in the United Kingdom, city and non-metropolitan district in the county of Cambridgeshire, England. It is the county town of Cambridgeshire and is located on the River Cam, north of London. As of the 2021 Unit ...
as a postdoctoral fellow. It is here that she became involved in
developmental biology Developmental biology is the study of the process by which animals and plants grow and develop. Developmental biology also encompasses the biology of Regeneration (biology), regeneration, asexual reproduction, metamorphosis, and the growth and di ...
, studying the role of position-specific
integrins Integrins are transmembrane receptors that help cell–cell and cell– extracellular matrix (ECM) adhesion. Upon ligand binding, integrins activate signal transduction pathways that mediate cellular signals such as regulation of the cell cycle, ...
in the
embryonic development In developmental biology, animal embryonic development, also known as animal embryogenesis, is the developmental stage of an animal embryo. Embryonic development starts with the fertilization of an egg cell (ovum) by a sperm, sperm cell (spermat ...
of ''
Drosophila ''Drosophila'' (), from Ancient Greek δρόσος (''drósos''), meaning "dew", and φίλος (''phílos''), meaning "loving", is a genus of fly, belonging to the family Drosophilidae, whose members are often called "small fruit flies" or p ...
''. In 1988, she became a staff scientist at LMB. Leptin's years at LMB raised her interest in cell shape, early cell movement and
gastrulation Gastrulation is the stage in the early embryonic development of most animals, during which the blastula (a single-layered hollow sphere of cells), or in mammals, the blastocyst, is reorganized into a two-layered or three-layered embryo known as ...
, the last of which she began researching in 1989 during her brief stay at Patrick O'Farrell's group at the
University of California, San Francisco The University of California, San Francisco (UCSF) is a Public university, public Land-grant university, land-grant research university in San Francisco, California, United States. It is part of the University of California system and is dedic ...
as a guest scientist. Afterwards she moved to the Max Planck Institute for Developmental Biology in
Tübingen Tübingen (; ) is a traditional college town, university city in central Baden-Württemberg, Germany. It is situated south of the state capital, Stuttgart, and developed on both sides of the Neckar and Ammer (Neckar), Ammer rivers. about one in ...
,
Germany Germany, officially the Federal Republic of Germany, is a country in Central Europe. It lies between the Baltic Sea and the North Sea to the north and the Alps to the south. Its sixteen States of Germany, constituent states have a total popu ...
, leading a research group focused on gastrulation until 1994 when she became a
professor Professor (commonly abbreviated as Prof.) is an Academy, academic rank at university, universities and other tertiary education, post-secondary education and research institutions in most countries. Literally, ''professor'' derives from Latin ...
at the
University of Cologne The University of Cologne () is a university in Cologne, Germany. It was established in 1388. It closed in 1798 before being re-established in 1919. It is now one of the largest universities in Germany with around 45,187 students. The Universit ...
, Institute of Genetics, a position she is still holding. She is also leading a research group at Cologne, which initially continued her study on gastrulation, but later shifted to the development of the ''Drosophila''
respiratory system The respiratory system (also respiratory apparatus, ventilatory system) is a biological system consisting of specific organs and structures used for gas exchange in animals and plants. The anatomy and physiology that make this happen varies grea ...
. Eventually, Leptin started using
zebrafish The zebrafish (''Danio rerio'') is a species of freshwater ray-finned fish belonging to the family Danionidae of the order Cypriniformes. Native to South Asia, it is a popular aquarium fish, frequently sold under the trade name zebra danio (an ...
as a
model organism A model organism is a non-human species that is extensively studied to understand particular biological phenomena, with the expectation that discoveries made in the model organism will provide insight into the workings of other organisms. Mo ...
to study the innate immune response. Subsequently, she had two more experiences as a
visiting professor In academia, a visiting scholar, visiting scientist, visiting researcher, visiting fellow, visiting lecturer, or visiting professor is a scholar from an institution who visits a host university to teach, lecture, or perform research on a topic fo ...
, the first at the
École Normale Supérieure École or Ecole may refer to: * an elementary school in the French educational stages normally followed by Secondary education in France, secondary education establishments (collège and lycée) * École (river), a tributary of the Seine flowing i ...
in
Paris Paris () is the Capital city, capital and List of communes in France with over 20,000 inhabitants, largest city of France. With an estimated population of 2,048,472 residents in January 2025 in an area of more than , Paris is the List of ci ...
in 2001 and the second as visiting scientist at the
Wellcome Sanger Institute The Wellcome Sanger Institute, previously known as The Sanger Centre and Wellcome Trust Sanger Institute, is a non-profit organisation, non-profit British genomics and genetics research institute, primarily funded by the Wellcome Trust. It is l ...
in UK between 2004 and 2005. In 2009, Leptin was appointed the director of the
European Molecular Biology Organization The European Molecular Biology Organization (EMBO) is a professional, non-profit organization of more than 2,100 life scientists. Its goal is to promote research in life science and enable international exchange between scientists. It co-funds cour ...
, a role she took up in January 2010. She also set up a research group at the
European Molecular Biology Laboratory The European Molecular Biology Laboratory (EMBL) is an intergovernmental organization dedicated to molecular biology research and is supported by 29 member states, two prospect member states, and one associate member state. EMBL was created in ...
in
Heidelberg Heidelberg (; ; ) is the List of cities in Baden-Württemberg by population, fifth-largest city in the States of Germany, German state of Baden-Württemberg, and with a population of about 163,000, of which roughly a quarter consists of studen ...
, which studies the factors determining cell shape in ''Drosophila'' and the ''in vivo'' imaging of innate immune response in zebrafish. Leptin had a stay at the
University of Oxford The University of Oxford is a collegiate university, collegiate research university in Oxford, England. There is evidence of teaching as early as 1096, making it the oldest university in the English-speaking world and the List of oldest un ...
in 2018, where she was a visiting professor of Cell and Developmental Biology. In June 2021, Leptin was appointed as the next president of the
European Research Council The European Research Council (ERC) is a public body for funding of scientific and technological research conducted within the European Union (EU). Established by the European Commission in 2007, the ERC is composed of an independent Scientific ...
, starting from 1 October 2021. It was announced in September, however, that she would delay taking up the new role to 1 November. Other than academic appointments, Leptin was the president of the German Society for Developmental Biology from 1996 to 1997, a member of the advisory board of the German Genetics Society from 2008 to 2012, the president of the Initiative for Science in Europe from 2012 to 2017. She was also a member of the board of trustees of the
Max Delbrück Center for Molecular Medicine in the Helmholtz Association The Max Delbrück Center for Molecular Medicine in the Helmholtz Association (Max Delbrück Center) in Berlin is one of the 18 institutions that make up the Helmholtz Association. It combines basic molecular biology research with clinical research ...
from 2004 to 2009 and of the
Babraham Institute The Babraham Institute is a life sciences research institution focussing on healthy ageing. The Babraham Institute is based on the Babraham Research Campus, partly occupying a former manor house, but also laboratory and science facility buil ...
between 2006 and 2009. She served on the editorial board of ''
Developmental Biology Developmental biology is the study of the process by which animals and plants grow and develop. Developmental biology also encompasses the biology of Regeneration (biology), regeneration, asexual reproduction, metamorphosis, and the growth and di ...
'' from 1996 to 2001 and ''
Developmental Cell ''Developmental Cell'' is a peer-reviewed scientific journal of cell and developmental biology. The journal was established in 2001, and is edited by Julie Sollier. It published by Cell Press, an imprint of Elsevier, and its articles becomes op ...
'' since 2001, as well as a co-editor of '' Mechanisms of Development'' and ''Gene Expression Patterns'' between 2002 and 2009. She is currently sitting on the Scientific Advisory Board of the Max Planck Institute of Molecular Cell Biology and Genetics, of the Mechanobiology Institute,
National University of Singapore The National University of Singapore (NUS) is a national university, national Public university, public research university in Singapore. It was officially established in 1980 by the merging of the University of Singapore and Nanyang University ...
, and of the Institute of Molecular Biotechnology, as well as on the University Council of the University of Cologne. She is also one of the directors of the Christiane Nüsslein-Volhard Foundation.


Honours and awards

* Member of the
European Molecular Biology Organisation The European Molecular Biology Organization (EMBO) is a professional, non-profit organization of more than 2,100 life scientists. Its goal is to promote research in life science and enable international exchange between scientists. It co-funds cour ...
(1996) * Member of
Academia Europaea The Academia Europaea is a pan-European Academy of humanities, letters, law, and sciences. The Academia was founded in 1988 as a functioning Europe-wide Academy that encompasses all fields of scholarly inquiry. It acts as co-ordinator of Europe ...
(1998) * Corresponding Member of the North Rhine-Westphalian Academy of Sciences, Humanities and the Arts (2010) * Member of the
German National Academy of Sciences Leopoldina The German National Academy of Sciences Leopoldina (), in short Leopoldina, is the national academy of Germany, and is located in Halle (Saale). Founded on 1 January 1652, based on academic models in Italy, it was originally named the ''Academi ...
(2016) * Honorary Fellow of the
Academy of Medical Sciences The Academy of Medical Sciences is an organisation established in the UK in 1998. It is one of the four UK National Academy, National Academies, the others being the British Academy, the Royal Academy of Engineering and the Royal Society. Its ...
(2017) *
Foreign Member of the Royal Society Fellowship of the Royal Society (FRS, ForMemRS and HonFRS) is an award granted by the Fellows of the Royal Society of London to individuals who have made a "substantial contribution to the improvement of natural science, natural knowledge, incl ...
(2022)


References

{{DEFAULTSORT:Leptin, Maria Living people 21st-century German biologists German women biologists Women immunologists 20th-century German women scientists 21st-century German women scientists Members of the European Molecular Biology Organization Members of the German National Academy of Sciences Leopoldina Foreign members of the Royal Society Academic staff of the University of Cologne Heidelberg University alumni University of Bonn alumni 1954 births