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Babraham Institute
The Babraham Institute is a life sciences research institution focussing on healthy ageing. The Babraham Institute is based on the Babraham Research Campus, partly occupying a former manor house, but also laboratory and science facility buildings on the campus, surrounded by an extensive parkland estate, just south of Cambridge, England. It is an independent and charitable organization which is involved in biomedical research, including healthy aging and molecular biology. The director is Dr Simon Cook who also leads the Institute's signalling research programme. The Babraham Institute is a member of EU-LIFE, an alliance of leading life sciences research centres in Europe. It is also a partner organisation of the University of Cambridge History The institute is located on the historic Babraham Hall Estate (now called the Babraham Research Campus), situated six miles south-east of Cambridge University, near the Gog Magog Hills. It is close to where the ancient Roman Via De ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Babraham
Babraham is a village and civil parishes in England, civil parish in the South Cambridgeshire district of Cambridgeshire, England, about south-east of Cambridge on the A1307 road. Babraham is home to the Babraham Institute which undertakes research into Cell biology, cell and molecular biology. History The parish of Babraham covers an area of and is roughly rectangular in shape. Its straight northern boundary is formed by the ancient Wool Street, separating it from Fulbourn, and its eastern border follows the Icknield Way (now the A11 road (England), A11), separating it from Little Abington. The remaining boundaries with Stapleford, Cambridgeshire, Stapleford, Sawston and Pampisford are formed by field boundaries and a small section of the River Granta, on which the village lies. The course of the River Granta through the parish has been changed on numerous occasions; a watermill was listed as valueless in the 14th century when the river had changed course, and additional wat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Icknield Way
The Icknield Way is an ancient trackway in southern and eastern England that runs from Norfolk to Wiltshire. It follows the chalk escarpment that includes the Berkshire Downs and Chiltern Hills. Background It is generally said to be, within Great Britain, one of the oldest roads the route of which can still be traced, being one of the few long-distance trackways to have existed before the Romans occupied the country. However, this has been disputed, and the evidence for its being a prehistoric route has been questioned. The name is Celto-British in derivation, and may be named after the Iceni tribe. They may have established this route to permit trade with other parts of the country from their base in East Anglia. It has also been suggested that the road has older prehistoric origins. The name is also said to have been initially used for the part to the west and south (i.e. south of the River Thames) but now refers usually to the track or traces north of the Thames. From ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Inositol Trisphosphate
Inositol trisphosphate or inositol 1,4,5-trisphosphate abbreviated InsP3 or Ins3P or IP3 is an inositol phosphate signaling molecule. It is made by hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2), a phospholipid that is located in the plasma membrane, by phospholipase C (PLC). Together with diacylglycerol (DAG), IP3 is a second messenger molecule used in signal transduction in biological cells. While DAG stays inside the membrane, IP3 is soluble and diffuses through the cell, where it binds to its receptor, which is a calcium channel located in the endoplasmic reticulum. When IP3 binds its receptor, calcium is released into the cytosol, thereby activating various calcium regulated intracellular signals. Properties Chemical formula and molecular weight IP3 is an organic molecule with a molecular mass of 420.10 g/mol. Its empirical formula is C6H15O15P3. It is composed of an inositol ring with three phosphate groups bound at the 1, 4, and 5 carbon positions, and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alec Bangham
Alec Douglas Bangham FRS (10 November 1921 Manchester – 9 March 2010 Great Shelford) was a British biophysicist who first studied blood clotting mechanisms but became well known for his research on liposomes and his invention of clinically useful artificial lung surfactants. Life Bangham was the son of Donald Bangham, and Edith Kerby. He studied at the Downs School, and then Bryanston School, and proceeded to earn an MB MS in medicine from University College London. He was appointed to Addenbrooke's Hospital, where he served as a pathologist, in the Royal Army Medical Corps, becoming a captain in 1948. Bangham worked at the Babraham Institute in Cambridge from 1952 to 1982. He is best known for his research on liposomes. Family He was married to Rosalind; they had four children and eleven grandchildren. His brother was Derek Bangham. Awards *1965 doctorate of medicine from London University *1977 Fellow of the Royal Society *1981 Fellow of University College London ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Liposomes
A liposome is a small artificial vesicle, spherical in shape, having at least one lipid bilayer. Due to their hydrophobicity and/or hydrophilicity, biocompatibility, particle size and many other properties, liposomes can be used as drug delivery vehicles for administration of pharmaceutical drugs and nutrients, such as lipid nanoparticles in mRNA vaccines, and DNA vaccines. Liposomes can be prepared by disrupting biological membranes (such as by sonication). Liposomes are most often composed of phospholipids, especially phosphatidylcholine, and cholesterol, but may also include other lipids, such as those found in egg and phosphatidylethanolamine, as long as they are compatible with lipid bilayer structure. A liposome design may employ surface ligands for attaching to desired cells or tissues. Based on vesicle structure, there are seven main categories for liposomes: multilamellar large (MLV), oligolamellar (OLV), small unilamellar (SUV), medium-sized unilamellar (MUV), larg ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epigenetics
In biology, epigenetics is the study of changes in gene expression that happen without changes to the DNA sequence. The Greek prefix ''epi-'' (ἐπι- "over, outside of, around") in ''epigenetics'' implies features that are "on top of" or "in addition to" the traditional (DNA sequence based) genetic mechanism of inheritance. Epigenetics usually involves a change that is not erased by cell division, and affects the regulation of gene expression. Such effects on cellular and physiological traits may result from environmental factors, or be part of normal development. The term also refers to the mechanism of changes: functionally relevant alterations to the genome that do not involve mutation of the nucleotide sequence. Examples of mechanisms that produce such changes are DNA methylation and histone modification, each of which alters how genes are expressed without altering the underlying DNA sequence. Further, non-coding RNA sequences have been shown to play a key role in the r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Signalling Pathways
Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events. Proteins responsible for detecting stimuli are generally termed receptors, although in some cases the term sensor is used. The changes elicited by ligand binding (or signal sensing) in a receptor give rise to a biochemical cascade, which is a chain of biochemical events known as a signaling pathway. When signaling pathways interact with one another they form networks, which allow cellular responses to be coordinated, often by combinatorial signaling events. At the molecular level, such responses include changes in the transcription or translation of genes, and post-translational and conformational changes in proteins, as well as changes in their location. These molecular events are the basic mechanisms controlling cell growth, proliferation, metabolism and many other processes. In multicellular organisms, signal transduction pathways regulat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Agricultural And Food Research Council
The Agricultural and Food Research Council (AFRC) was a British Research Council responsible for funding and managing scientific and technological developments in farming and horticulture. History The AFRC was formed in 1983 from its predecessor, the Agricultural Research Council (ARC). It was replaced by the Biotechnology and Biological Sciences Research Council Biotechnology and Biological Sciences Research Council (BBSRC), part of UK Research and Innovation, is a non-departmental public body (NDPB), and is the largest UK public funder of non-medical bioscience. It predominantly funds science, scient ... (BBSRC) as a result of government reorganisation in 1994. At that time, Sir William Henderson who was secretary to the AFRC claimed that "agriculture was a success story" hence the AFRC could be closed and a new vision for research was envisaged in the creation of the BBSRC. With this shift in emphasis, there also followed the closure of several educational and research o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Roslin, Midlothian
Roslin (formerly spelt Rosslyn or Roslyn) is a village in Midlothian, Scotland, 11 kilometres (7 mi) to the south of the capital city Edinburgh. It stands on high ground, near the northwest bank of the river River Esk, Lothian, North Esk. The name The name Roslin (recorded in 1138 as ''Roskelyn'') appears to derive from Scottish Gaelic. The second element is clearly ''linne'' usually meaning a pond or a lake, but here probably means a waterfall and refers to the nearby Linn of Roslin. The first element is more obscure, but may derive from ''riasg'' meaning a peat moor. The theory that it is a corruption of ''Rose line'', a supposed medieval meridian passing through Paris and Rosslyn Chapel, is fanciful. Roslin is believed to be the source of the name for the Roslyn, New York, Village of Roslyn, on Long Island, in the United States, U.S. New York (state), State of New York; its location reminded officials of the hills in Roslin. Roslindale, Massachusetts is also named afte ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rex Malcolm Chaplin Dawson
Rex Malcolm Chaplin Dawson FRS (1924–2021) was a British biochemist whose research was primarily dedicated to the study of phospholipids. His career was based at the Babraham Institute, Cambridge, starting in 1955, in the newly formed biochemistry department. He served as honorary publications secretary for The Biochemical Society (1973–1980), and was elected Fellow of the Royal Society in 1981. Biography Rex Malcom Chaplin Dawson was born on 3 June 1924 in Stoke Golding, Leicestershire, the second son of James Dawson, newspaperman, and Ethel Mary (née Chaplin), teacher of music, English and art. When he was 11 the family moved to nearby Hinckley, where Dawson attended the local Grammar School. There, "he gained a sudden early fascination with science" after reading Wonders of Chemistry. He gained a scholarship to University College London (UCL) and was awarded first class honours for his degree in applied and theoretical physics in 1945. He then moved to Cardiff to join ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oxford University
The University of Oxford is a collegiate research university in Oxford, England. There is evidence of teaching as early as 1096, making it the oldest university in the English-speaking world and the second-oldest continuously operating university globally. It expanded rapidly from 1167, when Henry II prohibited English students from attending the University of Paris. When disputes erupted between students and the Oxford townspeople, some Oxford academics fled northeast to Cambridge, where they established the University of Cambridge in 1209. The two English ancient universities share many common features and are jointly referred to as ''Oxbridge''. The University of Oxford comprises 43 constituent colleges, consisting of 36 semi-autonomous colleges, four permanent private halls and three societies (colleges that are departments of the university, without their own royal charter). and a range of academic departments that are organised into four divisions. Each college ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rudolph Peters
Sir Rudolph Albert Peters MC MID FRS HFRSE FRCP LLD (13 April 1889 – 29 January 1982) was a British biochemist. He led the research team at Oxford who developed British Anti-Lewisite (BAL), an antidote for the chemical warfare agent lewisite. His efforts investigating the mechanism of arsenic war gases were deemed crucial in maintaining battlefield effectiveness. Life He was born in Kensington in London the son of Dr Albert E. D. R. Peters (1863–1945), a physician, and his wife, Agnes Malvina Watts (1867–1950). He was educated at Wellington College, Berkshire, then studied medicine at King's College London and Gonville and Caius College, Cambridge. In the First World War he served in the Royal Army Medical Corps as Medical Officer to the 60th Rifles. From 1917 he was attached to the chemical warfare section at Porton Down. After the war he returned to Cambridge University lecturing in biochemistry. In 1923 he was created professor of biochemistry at Oxford University. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
