Sir Rudolph Albert Peters MC MID FRS H

FRSE Fellowship of the Royal Society of Edinburgh (FRSE) is an award granted to individuals that the Royal Society of Edinburgh, Scotland's national academy of science and letters, judged to be "eminently distinguished in their subject". This so ...

FRCP LLD (13 April 1889 – 29 January 1982) was a British biochemist. He led the research team at Oxford who developed British Anti-Lewisite (BAL), an antidote for the chemical warfare agent

lewisite Lewisite (L) (A-243) is an organoarsenic compound. It was once manufactured in the U.S., Japan, Germany and the Soviet Union for use as a Chemical warfare, chemical weapon, acting as a vesicant (blister agent) and lung irritant. Although the substa ...

. His efforts investigating the mechanism of arsenic war gases were deemed crucial in maintaining battlefield effectiveness.

Life

He was born in Kensington in

London London is the capital and List of urban areas in the United Kingdom, largest city of England and the United Kingdom, with a population of just under 9 million. It stands on the River Thames in south-east England at the head of a estuary dow ...

the son of Dr Albert E. D. R. Peters (1863-1945), a physician, and his wife, Agnes Malvina Watts (1867-1950). He was educated at

Wellington College, Berkshire Wellington College is a public school (English independent day and boarding school) in the village of Crowthorne, Berkshire, England. Wellington is a registered charity and currently educates roughly 1,200 pupils, between the ages of 13 and ...

, then studied Medicine at King's College London and

Gonville and Caius College, Cambridge Gonville and Caius College, often referred to simply as Caius ( ), is a constituent college of the University of Cambridge in Cambridge, England. Founded in 1348, it is the fourth-oldest of the University of Cambridge's 31 colleges and one of ...

. In the

First World War World War I (28 July 1914 11 November 1918), often abbreviated as WWI, was one of the deadliest global conflicts in history. Belligerents included much of Europe, the Russian Empire, the United States, and the Ottoman Empire, with fig ...

he served in the

Royal Army Medical Corps The Royal Army Medical Corps (RAMC) is a specialist corps in the British Army which provides medical services to all Army personnel and their families, in war and in peace. The RAMC, the Royal Army Veterinary Corps, the Royal Army Dental Corps ...

as Medical Officer to the 60th Rifles. From 1917 he was attached to the chemical warfare section at

Porton Down Porton Down is a science park in Wiltshire, England, just northeast of the village of Porton, near Salisbury. It is home to two British government facilities: a site of the Ministry of Defence's Defence Science and Technology Laboratory (Dstl) ...

. After the war he returned to

Cambridge University , mottoeng = Literal: From here, light and sacred draughts. Non literal: From this place, we gain enlightenment and precious knowledge. , established = , other_name = The Chancellor, Masters and Schola ...

lecturing in Biochemistry. In 1923 he was created Professor of Biochemistry at

Oxford University Oxford () is a city in England. It is the county town and only city of Oxfordshire. In 2020, its population was estimated at 151,584. It is north-west of London, south-east of Birmingham and north-east of Bristol. The city is home to the ...

. After the

Second World War World War II or the Second World War, often abbreviated as WWII or WW2, was a world war that lasted from 1939 to 1945. It involved the World War II by country, vast majority of the world's countries—including all of the great power ...

, he researched

pyruvate Pyruvic acid (CH3COCOOH) is the simplest of the alpha-keto acids, with a carboxylic acid and a ketone functional group. Pyruvate, the conjugate base, CH3COCOO−, is an intermediate in several metabolic pathways throughout the cell. Pyruvic aci ...

metabolism, focussing particularly on the toxicity of

fluoroacetate Fluoroacetate may refer to: * Fluoroacetic acid * Sodium fluoroacetate Sodium fluoroacetate is an organofluorine chemical compound with the formula FCH2CO2Na. This colourless salt has a taste similar to that of sodium chloride and is used as a ...

. The fact that fluoroacetate in itself is far less toxic than its metabolite fluorocitrate led him to coin the term " lethal synthesis" which was the title of his

Croonian Lecture The Croonian Medal and Lecture is a prestigious award, a medal, and lecture given at the invitation of the Royal Society and the Royal College of Physicians. Among the papers of William Croone at his death in 1684, was a plan to endow a single ...

of 1951. Peters retired from academia in 1954 to establish, at age 65, a new department of biochemistry at the Agricultural Research Council Animal Physiology Unit at Babraham; he retired five years later. He was elected FRS in 1935. In 1940, he received the

Cameron Prize for Therapeutics of the University of Edinburgh The Cameron Prize for Therapeutics of the University of Edinburgh is awarded by the College of Medicine and Veterinary Medicine to a person who has made any highly important and valuable addition to Practical Therapeutics in the previous five ye ...

. He was knighted by Queen

Elizabeth II Elizabeth II (Elizabeth Alexandra Mary; 21 April 1926 – 8 September 2022) was Queen of the United Kingdom and other Commonwealth realms from 6 February 1952 until her death in 2022. She was queen regnant of 32 sovereign states during ...

in 1952 and elected an Honorary Fellow of the

Royal Society of Edinburgh The Royal Society of Edinburgh is Scotland's national academy of science and letters. It is a registered charity that operates on a wholly independent and non-partisan basis and provides public benefit throughout Scotland. It was established i ...

in 1957. He died in Cambridge on 29 January 1982, and was cremated there on 4 February. Some of Sir Rudolph's papers are held at the

Bodleian Library The Bodleian Library () is the main research library of the University of Oxford, and is one of the oldest libraries in Europe. It derives its name from its founder, Sir Thomas Bodley. With over 13 million printed items, it is the sec ...

Family

Peters married Frances Williamina Vérel at the Queen's Park Free Church, Glasgow, on 7 November 1917. Frances was the daughter of Francis William Vérel, a photographic chemist, and had been at school in

Westgate-on-Sea Westgate-on-Sea is a seaside town and civil parish on the north-east coast of Kent, England. It is within the Thanet local government district and borders the larger seaside resort of Margate. Its two sandy beaches have remained a popular touris ...

with Peters's sister, Gwendoline. They had two sons: Rudolph V (1918-2013), and Francis Raymond, born in 1922.

Life

Family

References

Further reading