MSPI is an irreversible
acetylcholinesterase inhibitor
Acetylcholinesterase inhibitors (AChEIs) also often called cholinesterase inhibitors, inhibit the enzyme acetylcholinesterase from breaking down the neurotransmitter acetylcholine into choline and acetate, thereby increasing both the level an ...
. MSPI reacts with the
acetylcholinesterase
Acetylcholinesterase (HUGO Gene Nomenclature Committee, HGNC symbol ACHE; EC 3.1.1.7; systematic name acetylcholine acetylhydrolase), also known as AChE, AChase or acetylhydrolase, is the primary cholinesterase in the body. It is an enzyme th ...
to form an aged enzyme adduct that can't be reactivated by
cholinesterase reactivators.
See also
*
EA-2192
*
Guanitoxin
References
Acetylcholinesterase inhibitors
Imidazolium compounds
Methyl esters
Phosphoramidothioates
Zwitterions
Nerve agents
{{Neurotoxin-stub