This list contains a list of EC numbers for the fourth group, EC 4, lyases, placed in numerical order as determined by the Nomenclature Committee of the

International Union of Biochemistry and Molecular Biology The International Union of Biochemistry and Molecular Biology (IUBMB) is an international non-governmental organisation concerned with biochemistry and molecular biology. Formed in 1955 as the International Union of Biochemistry (IUB), the union ...

. All official information is tabulated at the website of the committee. The database is developed and maintained by Andrew McDonald.

EC 4.1: Carbon-Carbon Lyases

EC 4.1.1: Carboxy-lyases

* :

pyruvate decarboxylase Pyruvate decarboxylase is an enzyme () that catalyses the decarboxylation of pyruvic acid to acetaldehyde. It is also called 2-oxo-acid carboxylase, alpha-ketoacid carboxylase, and pyruvic decarboxylase. In anaerobic conditions, this enzyme pa ...

* : oxalate decarboxylase * EC 4.1.1.3: Now recognized to be two enzymes xaloacetate decarboxylase (Na⁺ extruding)and (oxaloacetate decarboxylase). * : acetoacetate decarboxylase * : acetolactate decarboxylase * : ''cis''-aconitate decarboxylase * : benzoylformate decarboxylase * : oxalyl-CoA decarboxylase * :

malonyl-CoA decarboxylase Malonyl-CoA decarboxylase (), (which can also be called MCD and malonyl-CoA carboxyl-lyase) is found in bacteria and humans and has important roles in regulating fatty acid metabolism and food intake, and it is an attractive target for drug discove ...

* EC 4.1.1.10: Now included with , aspartate 4-decarboxylase * : aspartate 1-decarboxylase * : aspartate 4-decarboxylase * EC 4.1.1.13: deleted * : valine decarboxylase * :

glutamate decarboxylase Glutamate decarboxylase or glutamic acid decarboxylase (GAD) is an enzyme that catalyzes the Decarboxylation#Decarboxylation of amino acids, decarboxylation of glutamate to gamma-aminobutyric acid (GABA) and carbon dioxide (). GAD uses pyridoxal ...

* : hydroxyglutamate decarboxylase * :

ornithine decarboxylase The enzyme ornithine decarboxylase (, ODC) catalyzes the decarboxylation of ornithine (a product of the urea cycle) to form putrescine. This reaction is the committed step in polyamine synthesis. In humans, this protein has 461 amino acids ...

* : lysine decarboxylase * : arginine decarboxylase * : diaminopimelate decarboxylase * : phosphoribosylaminoimidazole carboxylase * :

histidine decarboxylase The enzyme histidine decarboxylase (, HDC) is transcribed on chromosome 15, region q21.1-21.2, and Catalysis, catalyzes the decarboxylation of histidine to form histamine. In mammals, histamine is an important biogenic amine with regulatory roles ...

* : orotidine-5′-phosphate decarboxylase * : aminobenzoate decarboxylase * : tyrosine decarboxylase * EC 4.1.1.26: Now included with aromatic-L-amino-acid decarboxylase * EC 4.1.1.27: Now included with aromatic-L-amino-acid decarboxylase * : aromatic-L-amino-acid decarboxylase * : sulfoalanine decarboxylase * : pantothenoylcysteine decarboxylase * : phospho''enol''pyruvate carboxylase * : phospho''enol''pyruvate carboxykinase (GTP) * :

diphosphomevalonate decarboxylase Diphosphomevalonate decarboxylase (), most commonly referred to in scientific literature as mevalonate diphosphate decarboxylase, is an enzyme that catalysis, catalyzes the chemical reaction :ATP + (R)-5-diphosphomevalonate \rightleftharpoons A ...

EC 4.1.2: Aldehyde-lyases

* EC 4.1.2.1: Now included with 4-hydroxy-2-oxoglutarate aldolase * : ketotetrose-phosphate aldolase * EC 4.1.2.3: deleted, was pentosealdolase. * : deoxyribose-phosphate aldolase * : L-threonine aldolase * EC 4.1.2.6: Deleted, reaction is due to , glycine hydroxymethyltransferase * EC 4.1.2.7: Now included with fructose-bisphosphate aldolase * : indole-3-glycerol-phosphate lyase * : phosphoketolase * : (''R'')-mandelonitrile lyase * : hydroxymandelonitrile lyase * : 2-dehydropantoate aldolase * :

fructose-bisphosphate aldolase Fructose-bisphosphate aldolase (), often just aldolase, is an enzyme catalyzing a reversible reaction that splits the aldol, fructose 1,6-bisphosphate, into the triose phosphates dihydroxyacetone phosphate (DHAP) and glyceraldehyde 3-phosp ...

* : 2-dehydro-3-deoxy-phosphogluconate aldolase * EC 4.1.2.15: Now , 3-deoxy-7-phosphoheptulonate synthase * EC 4.1.2.16: Now , 3-deoxy-8-phosphooctulonate synthase * : L-fuculose-phosphate aldolase * : 2-dehydro-3-deoxy-L-pentonate aldolase * : rhamnulose-1-phosphate aldolase * : 2-dehydro-3-deoxyglucarate aldolase * : 2-dehydro-3-deoxy-6-phosphogalactonate aldolase * : fructose-6-phosphate phosphoketolase * : 3-deoxy-D-''manno''-octulosonate aldolase * : dimethylaniline-''N''-oxide aldolase * : dihydroneopterin aldolase * : phenylserine aldolase * : sphinganine-1-phosphate aldolase * : 2-dehydro-3-deoxy-D-pentonate aldolase * : 5-dehydro-2-deoxyphosphogluconate aldolase * EC 4.1.2.30: Now }, 17α-hydroxyprogesterone deacetylase * EC 4.1.2.31: Now included with 4-hydroxy-2-oxoglutarate aldolase * : trimethylamine-oxide aldolase * : fucosterol-epoxide lyase * : 4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase * : propioin synthase * : lactate aldolase * EC 4.1.2.37: Now covered by liphatic (''R'')-hydroxynitrile lyaseand ''S'')-hydroxynitrile ketone-lyase (cyanide forming)* : benzoin aldolase * EC 4.1.2.39: Deleted, identical to , hydroxynitrilase * : tagatose-bisphosphate aldolase * EC 4.1.2.41: Now included with , feruloyl-CoA hydratase/lyase * : D-threonine aldolase * : 3-hexulose-6-phosphate synthase * : benzoyl-CoA-dihydrodiol lyase * : ''trans-o''-hydroxybenzylidenepyruvate hydratase-aldolase * : aliphatic (''R'')-hydroxynitrile lyase * : (''S'')-hydroxynitrile lyase * : low-specificity L-threonine aldolase * : L-''allo''-threonine aldolase * : 6-carboxytetrahydropterin synthase * * : 6-carboxytetrahydropterin synthase * * * : 2-dehydro-3-deoxy-D-gluconate aldolase * * * : 4-hydroxy-2-oxoheptanedioate aldolase * * * : 2-keto-3-deoxy-L-rhamnonate aldolase * * * : L-''threo''-3-deoxy-hexylosonate aldolase * * * : 2-dehydro-3-deoxy-phosphogluconate/2-dehydro-3-deoxy-6-phosphogalactonate aldolase * * * : 2-amino-4,5-dihydroxy-6-oxo-7-(phosphooxy)heptanoate synthase * * * : sulfofructosephosphate aldolase * * * : 2-dehydro-3,6-dideoxy-6-sulfogluconate aldolase * * * : dihydroneopterin phosphate aldolase * * * : dihydroneopterin triphosphate aldolase * * * : feruloyl-CoA hydratase/lyase * * * : 5-deoxyribulose 1-phosphate aldolase * * * : 2-hydroxyacyl-CoA lyase * : *No Wikipedia article

EC 4.1.3: Oxo-Acid-Lyases

* :

isocitrate lyase Isocitrate lyase (), or ICL, is an enzyme in the glyoxylate cycle that catalyzes the cleavage of isocitrate to succinate and glyoxylate. Together with malate synthase, it bypasses the two decarboxylation steps of the tricarboxylic acid cycle ...

* EC 4.1.3.2: Now , malate synthase * : ''N''-acetylneuraminate lyase * : hydroxymethylglutaryl-CoA lyase * EC 4.1.3.5: Now , hydroxymethylglutaryl-CoA synthase * : citrate (''pro''-3''S'')-lyase * EC 4.1.3.7: Now , citrate (''Si'')-synthase * EC 4.1.3.8: Now , ATP citrate synthase * EC 4.1.3.9: Now , 2-hydroxyglutarate synthase * EC 4.1.3.10: Now , 3-ethylmalate synthase * EC 4.1.3.11: Now , 3-propylmalate synthase * EC 4.1.3.12: Now , 2-isopropylmalate synthase * : oxalomalate lyase * : L-''erythro''-3-hydroxyaspartate aldolase * EC 4.1.3.15: Now , 2-hydroxy-3-oxoadipate synthase * : 4-hydroxy-2-oxoglutarate aldolase * : 4-hydroxy-4-methyl-2-oxoglutarate aldolase * EC 4.1.3.18: Now , acetolactate synthase * EC 4.1.3.19: Now * EC 4.1.3.20: Now * EC 4.1.3.21: Now * : citramalate lyase * EC 4.1.3.23: Now , decylcitrate synthase * : malyl-CoA lyase * : (''S'')-citramalyl-CoA lyase * : 3-hydroxy-3-isohexenylglutaryl-CoA lyase * : anthranilate synthase * EC 4.1.3.28: Now , citrate (''Re'')-synthase * EC 4.1.3.29: Now , decylhomocitrate synthase * : methylisocitrate lyase * EC 4.1.3.31: Now , 2-methylcitrate synthase * : 2,3-dimethylmalate lyase * : Now * : citryl-CoA lyase * : (1-hydroxycyclohexan-1-yl)acetyl-CoA lyase * : naphthoate synthase * EC 4.1.3.37: Now , 1-deoxy-D-xylulose 5-phosphate synthase * : aminodeoxychorismate lyase * : 4-hydroxy-2-oxovalerate aldolase * :

chorismate lyase The enzyme chorismate lyase () catalysis, catalyzes the first step in ubiquinone biosynthesis, the removal of pyruvate from chorismate, to yield 4-hydroxybenzoate in ''Escherichia coli'' and other Gram-negative bacteria. It belongs to the family of ...

* : 3-hydroxy-D-aspartate aldolase * : (4''S'')-4-hydroxy-2-oxoglutarate aldolase * * : 4-hydroxy-2-oxohexanoate aldolase * * : tRNA 4-demethylwyosine synthase (AdoMet-dependent) * * : 3-hydroxybenzoate synthase * * : (''R'')-citramalyl-CoA lyase * : *No Wikipedia article

EC 4.1.99: Other Carbon-Carbon Lyases

* :

tryptophanase The enzyme tryptophanase () catalyzes the chemical reaction :L-tryptophan + H2O \rightleftharpoons indole + pyruvate + NH3 This enzyme belongs to the family of lyases, specifically in the "catch-all" class of carbon-carbon lyases. The system ...

* : tyrosine phenol-lyase * : deoxyribodipyrimidine photo-lyase * EC 4.1.99.4: Now , 1-aminocyclopropane-1-carboxylate deaminase * EC 4.1.99.5: octadecanal decarbonylase * EC 4.1.99.6: Now , trichodiene synthase * EC 4.1.99.7: Now , aristolochene synthase * EC 4.1.99.8: Now , pinene synthase * EC 4.1.99.9: Now , myrcene synthase * EC 4.1.99.10: Now , (4''S'')-limonene synthase * : benzylsuccinate synthase * : 3,4-dihydroxy-2-butanone-4-phosphate synthase * : (6-4)DNA photolyase * : spore photoproduct lyase * EC 4.1.99.15: The activity is covered by , spore photoproduct lyase * :

geosmin synthase Geosmin synthase or germacradienol-geosmin synthase designates a class of bifunctional enzymes () that catalyze the conversion of farnesyl diphosphate (FPP) to geosmin, a volatile organic compound, volatile organic compound known for its earthy ...

* : phosphomethylpyrimidine synthase * EC 4.1.99.18: Now known to be catalysed by the combined effect of , GTP 3,8-cyclase, and , cyclic pyranopterin monophosphate synthase * : 2-iminoacetate synthase * : 3-amino-4-hydroxybenzoate synthase * * : Now (5-formylfuran-3-yl)methyl phosphate synthase. * : GTP 3′,8-cyclase * * : 5-hydroxybenzimidazole synthase * * : L-tyrosine isonitrile synthase * * : L-tryptophan isonitrile synthase * * : 3-amino-5- 4-hydroxyphenyl)methyl4,4-dimethylpyrrolidin-2-one * : *No Wikipedia article

EC 4.2: Carbon-Oxygen Lyases

EC 4.2.1: Hydro-lyases

* :

carbonic anhydrase The carbonic anhydrases (or carbonate dehydratases) () form a family of enzymes that catalyst, catalyze the interconversion between carbon dioxide and water and the Dissociation (chemistry), dissociated ions of carbonic acid (i.e. bicarbonate a ...

* : fumarate hydratase * : aconitate hydratase * EC 4.2.1.4: Now known to be a partial reaction catalysed by , aconitate hydratase * : arabinonate dehydratase * : galactonate dehydratase * : altronate dehydratase * : mannonate dehydratase * : dihydroxy-acid dehydratase * : 3-dehydroquinate dehydratase * : phosphopyruvate hydratase (enolase) * : phosphogluconate dehydratase * EC 4.2.1.13: Now , L-serine ammonia-lyase * EC 4.2.1.14: Now , D-serine ammonia-lyase * EC 4.2.1.15: Identical with cystathionine γ-lyase * EC 4.2.1.16: Now , threonine ammonia-lyase * : enoyl-CoA hydratase * : methylglutaconyl-CoA hydratase * : imidazoleglycerol-phosphate dehydratase * : tryptophan synthase * EC 4.2.1.21: Now cystathionine β-synthase * : cystathionine β-synthase * EC 4.2.1.23: deleted, the reaction was due to a side-reaction of cystathionine β-synthase * : porphobilinogen synthase * : L-arabinonate dehydratase * EC 4.2.1.26: identical to , glucosaminate ammonia-lyase * : acetylenecarboxylate hydratase * : propanediol dehydratase * EC 4.2.1.29: Now , indoleacetaldoxime dehydratase * : glycerol dehydratase * : maleate hydratase * : L(+)-tartrate dehydratase * :

3-isopropylmalate dehydratase 3-Isopropylmalate dehydratase () is an aconitase homologue, which catalyses the isomerisation of isopropylmalate, 2-isopropylmalate to 3-isopropylmalate, via Dehydration reaction, dehydration, in the biosynthesis of leucine. References Extern ...

* : (''S'')-2-methylmalate dehydratase * : (''R'')-2-methylmalate dehydratase * : homoaconitate hydratase * EC 4.2.1.37: Now , ''trans''-epoxysuccinate hydrolase * EC 4.2.1.38: Now , ''erythro''-3-hydroxyaspartate ammonia-lyase * : gluconate dehydratase * : glucarate dehydratase * : 5-dehydro-4-deoxyglucarate dehydratase * : galactarate dehydratase * : 2-dehydro-3-deoxy-L-arabinonate dehydratase * : ''myo''-inosose-2 dehydratase * : CDP-glucose 4,6-dehydratase * : dTDP-glucose 4,6-dehydratase * : GDP-mannose 4,6-dehydratase * : D-glutamate cyclase * : urocanate hydratase * : pyrazolylalanine synthase * : prephenate dehydratase * EC 4.2.1.52: Now , 4-hydroxy-2,3,4,5-tetrahydrodipicolinate synthase. * : oleate hydratase * : lactoyl-CoA dehydratase * : 3-hydroxybutyryl-CoA dehydratase * : itaconyl-CoA hydratase * : isohexenylglutaconyl-CoA hydratase * EC 4.2.1.58: The reaction described is covered by * : 3-hydroxyacyl- cyl-carrier-proteindehydratase * EC 4.2.1.60: 3-hydroxydecanoyl-(acyl-carrier-protein) dehydratase * EC 4.2.1.61: The reaction described is covered by . * : 5α-hydroxysteroid dehydratase * EC 4.2.1.63: Now known to comprise two enzymes, microsomal epoxide hydrolase () and soluble epoxide hydrolase () * EC 4.2.1.64: Now known to comprise two enzymes, microsomal epoxide hydrolase () and soluble epoxide hydrolase () * : 3-cyanoalanine hydratase * : cyanide hydratase * : D-fuconate dehydratase * : L-fuconate dehydratase * : cyanamide hydratase * : pseudouridylate synthase * EC 4.2.1.71: identical to , acetylenecarboxylate hydratase * EC 4.2.1.72: Now , acetylenedicarboxylate decarboxylase * : protoaphin-aglucone dehydratase (cyclizing) * : long-chain-enoyl-CoA hydratase * : uroporphyrinogen-III synthase * : UDP-glucose 4,6-dehydratase * : ''trans''-L-3-hydroxyproline dehydratase * : (''S'')-norcoclaurine synthase * : 2-methylcitrate dehydratase * : 2-oxopent-4-enoate hydratase * : D(-)-tartrate dehydratase * : xylonate dehydratase * : 4-oxalmesaconate hydratase * : nitrile hydratase * : dimethylmaleate hydratase * EC 4.2.1.86: identical to , 16α-hydroxyprogesterone dehydratase * : octopamine dehydratase * : synephrine dehydratase * EC 4.2.1.89: The activity has now been shown to be due to , L-carnitine CoA-transferase and , crotonobetainyl-CoA hydratase * : L-rhamnonate dehydratase * : arogenate dehydratase * : hydroperoxide dehydratase * : ATP-dependent NAD(P)H-hydrate dehydratase * : scytalone dehydratase * : kievitone hydratase * : 4a-hydroxytetrahydrobiopterin dehydratase * : phaseollidin hydratase * : 16α-hydroxyprogesterone dehydratase * : 2-methylisocitrate dehydratase * : cyclohexa-1,5-dienecarbonyl-CoA hydratase * EC 4.2.1.101: Now included with , feruloyl-CoA hydratase/lyase * EC 4.2.1.102: Now , cyclohexa-1,5-dienecarbonyl-CoA hydratase * : cyclohexyl-isocyanide hydratase * : cyanase * : 2-hydroxyisoflavanone dehydratase * : bile-acid 7α-dehydratase * : 3α,7α,12α-trihydroxy-5β-cholest-24-enoyl-CoA hydratase * : ectoine synthase * : methylthioribulose 1-phosphate dehydratase * : aldos-2-ulose dehydratase * : 1,5-anhydro-D-fructose dehydratase * : acetylene hydratase * : ''o''-succinylbenzoate synthase * : methanogen homoaconitase * : UDP-''N''-acetylglucosamine 4,6-dehydratase (configuration-inverting) * : 3-hydroxypropionyl-CoA dehydratase * : 2-methylcitrate dehydratase (2-methyl-''trans''-aconitate forming) * : 3-dehydroshikimate dehydratase * : enoyl-CoA hydratase 2 * : 4-hydroxybutanoyl-CoA dehydratase * : colneleate synthase * : tryptophan synthase (indole-salvaging) * : tetrahymanol synthase * : arabidiol synthase * : dammarenediol II synthase * : ''N''-acetylmuramic acid 6-phosphate etherase * : linalool dehydratase * : lupan-3β,20-diol synthase * : squalene—hopanol cyclase * : D-lactate dehydratase * : carotenoid 1,2-hydratase * : 2-hydroxyhexa-2,4-dienoate hydratase * : copal-8-ol diphosphate hydratase * : very-long-chain (3''R'')-3-hydroxyacyl-CoA dehydratase * : UDP-''N''-acetylglucosamine 4,6-dehydratase (configuration-retaining) * : ADP-dependent NAD(P)H-hydrate dehydratase * : sporulenol synthase * : (+)-Caryolan-1-ol synthase * : pterocarpan synthase * * : gluconate/galactonate dehydratase * * : 2-dehydro-3-deoxyD-arabinonate dehydratase * * : 5′-oxoaverantin cyclase * * : versicolorin B synthase * * : 3-amino-5-hydroxybenzoate synthase * * : capreomycidine synthase * * : L-galactonate dehydratase * * : 5,6,7,8-tetrahydromethanopterin hydro-lyase * * : 2-methylfumaryl-CoA hydratase * * : crotonobetainyl-CoA hydratase * * : short-chain-enoyl-CoA hydratase * * : chorismate dehydratase * * : hydroperoxy icosatetraenoate dehydratase * * : 3-methylfumaryl-CoA hydratase * * : tetracenomycin F2 cyclase * * : (methylthio)acryloyl-CoA hydratase * * : L-talarate dehydratase * * : (''R'')-2-hydroxyisocaproyl-CoA dehydratase * * : galactarate dehydratase (D-threo-forming) * * : dTDP-4-dehydro-6-deoxy-α-glucopyranose 2,3-dehydratase * * : 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3''H'')-one isomerase/dehydratase * * : bisanhydrobacterioruberin hydratase * * : 6-deoxy-6-sulfo-D-gluconate dehydratase * * : 2-oxo-hept-4-ene-1,7-dioate hydratase * * : dTDP-4-dehydro-2,6-dideoxy-D-glucose 3-dehydratase * * : chlorophyllide ''a'' 3¹-hydratase * * : phosphinomethylmalate isomerase * * : (''R'')-2-hydroxyglutaryl-CoA dehydratase * * : GDP-4-dehydro-6-deoxy-α-D-mannose 3-dehydratase * * : 3-vinyl bacteriochlorophyllide ''d'' 3¹-hydratase * * : 2-(ω-methylthio)alkylmalate dehydratase * * : ''cis''-L-3-hydroxyproline dehydratase * * : ''trans''-4-hydroxy-L-proline dehydratase * * : ''ent''-8α-hydroxylabd-13-en-15-yl diphosphate synthase * * : peregrinol diphosphate synthase * * : (''R'')-3-(aryl)lactoyl-CoA dehydratase * * : L-lyxonate dehydratase * * : (2''S'')-3-sulfopropanediol dehydratase * : *No Wikipedia article

EC 4.2.2: Acting on Polysaccharides

* : hyaluronate lyase * :

pectate lyase Pectate lyase () is an enzyme involved in the maceration and soft rotting of plant tissue. Pectate lyase is responsible for the eliminative cleavage of pectate, yielding oligosaccharides with 4-deoxy-α-D-mann-4-enuronosyl groups at their non-re ...

* : mannuronate-specific alginate lyase * EC 4.2.2.4: Now known to comprise two enzymes: , chondroitin-sulfate-ABC endolyase and , chondroitin-sulfate-ABC exolyase * : chondroitin AC lyase * : oligogalacturonide lyase * : heparin lyase * : heparin-sulfate lyase * : pectate disaccharide-lyase * :

pectin lyase Pectin lyase is a polysaccharide enzyme with a complex structure that is present in plant cell walls. It has a significant role in pectin degradation and different biotechnological and industrial applications. It can be found in many different or ...

* : guluronate-specific alginate lyase * : xanthan lyase * : exo-(1→4)-α-D-glucan lyase * : glucuronan lyase * : anhydrosialidase * : levan fructotransferase (DFA-IV-forming) * : inulin fructotransferase (DFA-I-forming) * : inulin fructotransferase (DFA-III-forming) * : chondroitin B lyase * : chondroitin-sulfate-ABC endolyase * : chondroitin-sulfate-ABC exolyase * : pectate trisaccharide-lyase * : rhamnogalacturonan endolyase * : rhamnogalacturonan exolyase * : gellan lyase * : oligo-alginate lyase * * : pectin monosaccharide-lyase * : *No Wikipedia article

EC 4.2.3: Acting on phosphates

* : threonine synthase * : ethanolamine-phosphate phospho-lyase * :

methylglyoxal synthase The enzyme methylglyoxal synthase () catalysis, catalyzes the chemical reaction :glycerone phosphate \rightleftharpoons 2-oxopropanalCommonly known as methylglyoxal + phosphate Attempts to observe Reversible reaction, reversibility of this react ...

* : 3-dehydroquinate synthase * : chorismate synthase * : trichodiene synthase * : pentalenene synthase * : casbene synthase * : aristolochene synthase * : (–)-''endo''-fenchol synthase * : sabinene-hydrate synthase * : 6-pyruvoyltetrahydropterin synthase * : (+)-δ-cadinene synthase * EC 4.2.3.14: Now covered by , (–)-α-pinene synthase, and , (–)-β-pinene synthase * : myrcene synthase * : (4''S'')-limonene synthase * : taxadiene synthase * : abietadiene synthase * : ''ent''-kaurene synthase * : (''R'')-limonene synthase * : vetispiradiene synthase * : germacradienol synthase * : germacrene-A synthase * : amorpha-4,11-diene synthase * : ''S''-linalool synthase * : ''R''-linalool synthase * :

isoprene synthase The enzyme isoprene synthase (EC 4.2.3.27) catalysis, catalyzes the chemical reaction : prenyl pyrophosphate \rightleftharpoons isoprene + diphosphate This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on ...

EC 4.2.99: Other Carbon-Oxygen Lyases

* EC 4.2.99.1: Now , hyaluronate lyase * EC 4.2.99.2: Now , threonine synthase * EC 4.2.99.3: Now , pectate lyase * EC 4.2.99.4: Now , poly(β-D-mannuronate) lyase * EC 4.2.99.5: deleted * EC 4.2.99.6: Now included with (chondroitin ABC lyase) and (chondroitin AC lyase) * EC 4.2.99.7: Now , ethanolamine-phosphate phospho-lyase * EC 4.2.99.8: Now , cysteine synthase * EC 4.2.99.9: Now , cystathionine γ-synthase * EC 4.2.99.10: Now , ''O''-acetylhomoserine aminocarboxypropyltransferase * EC 4.2.99.11: Now , methylglyoxal synthase * : carboxymethyloxysuccinate lyase * EC 4.2.99.13: Now , zeatin 9-aminocarboxyethyltransferase * EC 4.2.99.14: Now , β-pyrazolylalanine synthase * EC 4.2.99.15: Now , L-mimosine synthase * EC 4.2.99.16: Now , uracilylalanine synthase * EC 4.2.99.17: Listed as , β-pyrazolylalanine synthase * : DNA-(apurinic or apyrimidinic site) lyase * EC 4.2.99.19: Now , 2-hydroxypropyl-CoM lyase * : 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase * : isochorismate lyase * : tuliposide A-converting enzyme * * : tuliposide B-converting enzyme * * : thebaine synthase * : *No Wikipedia article

EC 4.3: Carbon-Nitrogen Lyases

EC 4.3.1: Ammonia-Lyases

* :

aspartate ammonia-lyase Aspartic acid (symbol Asp or D; the ionic form is known as aspartate), is an α-amino acid that is used in the biosynthesis of proteins. The L-isomer of aspartic acid is one of the 22 proteinogenic amino acids, i.e., the building blocks of protein ...

* : methylaspartate ammonia-lyase * :

histidine ammonia-lyase Histidine ammonia-lyase (, histidase, histidinase) is an enzyme that in humans is encoded by the ''HAL'' gene. It converts histidine into ammonia and urocanic acid. Its systematic name is L-histidine ammonia-lyase (urocanate-forming). Function ...

* : formiminotetrahydrofolate cyclodeaminase * EC 4.3.1.5: Now divided into (tyrosine ammonia-lyase), (phenylalanine ammonia-lyase) and (phenylalanine/tyrosine ammonia-lyase) * : β-alanyl-CoA ammonia-lyase * : ethanolamine ammonia-lyase * EC 4.3.1.8: Now , hydroxymethylbilane synthase * : glucosaminate ammonia-lyase * : serine-sulfate ammonia-lyase * EC 4.3.1.11: Deleted: inadequately characterized * : ornithine cyclodeaminase * : carbamoyl-serine ammonia-lyase * : 3-aminobutyryl-CoA ammonia-lyase * : diaminopropionate ammonia-lyase * : ''threo''-3-hydroxy-L-aspartate ammonia-lyase * : L-serine ammonia-lyase * : D-serine ammonia-lyase * : threonine ammonia-lyase * : ''erythro''-3-hydroxy-L-aspartate ammonia-lyase * EC 4.3.1.21: identical to , glucosaminate ammonia-lyase * : 3,4-dihydroxyphenylalanine reductive deaminase * : tyrosine ammonia-lyase * :

phenylalanine ammonia-lyase The enzyme phenylalanine ammonia lyase (EC 4.3.1.24) catalysis, catalyzes the conversion of L-phenylalanine to ammonia and cinnamic acid, ''trans''-cinnamic acid.: :L-phenylalanine = ''trans''-cinnamate + NH3 Phenylalanine ammonia lyase (PAL) i ...

* : phenylalanine/tyrosine ammonia-lyase * EC 4.3.1.26: Now , dichlorochromopyrrolate synthase * : ''threo''-3-hydroxy-D-aspartate ammonia-lyase * : L-lysine cyclodeaminase * : D-glucosaminate-6-phosphate ammonia-lyase * * : dTDP-4-amino-4,6-dideoxy-D-glucose ammonia-lyase * * : L-tryptophan ammonia lyase * * : 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase * : *No Wikipedia article

EC 4.3.2: Amidine-Lyases

* : argininosuccinate lyase * : adenylosuccinate lyase * : ureidoglycolate lyase * : purine imidazole-ring cyclase * : peptidylamidoglycolate lyase * : γ-L-glutamyl-butirosin B γ-glutamyl cyclotransferase * : glutathione-specific γ-glutamylcyclotransferase * * : γ-glutamylamine cyclotransferase * * : γ-glutamylcyclotransferase * * : imidazole glycerol-phosphate synthase * : *No Wikipedia article

EC 4.3.3: Amine-Lyases

* : 3-ketovalidoxylamine C-N-lyase * :

strictosidine synthase Strictosidine synthase (EC 4.3.3.2) is an enzyme in alkaloid biosynthesis that catalyses the condensation of tryptamine with secologanin to form strictosidine in a formal Pictet–Spengler reaction: :3-α(''S'')-strictosidine + H2O = tryptamine ...

* : deacetylisoipecoside synthase * : deacetylipecoside synthase * : 4′-demethylrebeccamycin synthase * : pyridoxal 5′-phosphate synthase (glutamine hydrolysing) * : 4-hydroxy-tetrahydrodipicolinate synthase

EC 4.3.99: Other Carbon-Nitrogen Lyases

* EC 4.3.99.1: Now , cyanate hydratase * EC 4.3.99.2: Now , carboxybiotin decarboxylase * : 7-carboxy-7-deazaguanine synthase * : choline trimethylamine-lyase * : *No Wikipedia article

EC 4.4: Carbon-Sulfur Lyases

EC 4.4.1: Carbon-sulfur lyases (only sub-subclass identified to date)

* : cystathionine γ-lyase * : homocysteine desulfhydrase * : dimethylpropiothetin dethiomethylase * : alliin lyase * : lactoylglutathione lyase * EC 4.4.1.6: Now included in , cysteine-''S''-conjugate β-lyase * EC 4.4.1.7: Now included with glutathione transferase * EC 4.4.1.8: Now included in , cysteine-''S''-conjugate β-lyase * : L-3-cyanoalanine synthase * : cysteine lyase * : methionine γ-lyase * EC 4.4.1.12: deleted: activity due to , sulfoacetaldehyde acetyltransferase * : cysteine-''S''-conjugate β-lyase * : 1-aminocyclopropane-1-carboxylate synthase * : D-cysteine desulfhydrase * : selenocysteine lyase * : holocytochrome-''c'' synthase * EC 4.4.1.18: Now , prenylcysteine oxidase * : phosphosulfolactate synthase * : leukotriene-C₄ synthase * : ''S''-ribosylhomocysteine lyase * : ''S''-(hydroxymethyl)glutathione synthase * : 2-hydroxypropyl-CoM lyase * : (2''R'')-sulfolactate sulfo-lyase * : L-cysteate sulfo-lyase * : olivetolic acid cyclase * EC 4.4.1.27: Now , carbon disulfide hydrolase : *No Wikipedia article

EC 4.5: Carbon-Halide Lyases

EC 4.5.1: Carbon-halide lyases (only sub-subclass identified to date)

* : DDT-dehydrochlorinase * : 3-chloro-D-alanine dehydrochlorinase * : dichloromethane dehalogenase * : L-2-amino-4-chloropent-4-enoate dehydrochlorinase * : ''S''-carboxymethylcysteine synthase

EC 4.6: Phosphorus-Oxygen Lyases

EC 4.6.1: Phosphorus-oxygen lyases (only sub-subclass identified to date)

* :

adenylate cyclase Adenylate cyclase (EC 4.6.1.1, also commonly known as adenyl cyclase and adenylyl cyclase, abbreviated AC) is an enzyme with systematic name ATP diphosphate-lyase (cyclizing; 3′,5′-cyclic-AMP-forming). It catalyzes the following reaction: :A ...

* : guanylate cyclase * EC 4.6.1.3: Now , 3-dehydroquinate synthase * EC 4.6.1.4: Now , chorismate synthase * EC 4.6.1.5: Now , pentalenene synthase * : cytidylate cyclase * EC 4.6.1.7: Now , casbene synthase * EC 4.6.1.8: Now , (-)-''endo''-fenchol synthase * EC 4.6.1.9: Now Now , sabinene-hydrate synthase * EC 4.6.1.10: Now , 6-pyruvoyltetrahydropterin synthase * EC 4.6.1.11: Now , (+)-δ-cadinene synthase * : 2-''C''-methyl-D-erythritol 2,4-cyclodiphosphate synthase * : phosphatidylinositol diacylglycerol-lyase * : glycosylphosphatidylinositol diacylglycerol-lyase * : FAD-AMP lyase (cyclizing) * : tRNA-intron lyase * : cyclic pyranopterin monophosphate synthase * * : pancreatic ribonuclease * * : ribonuclease T₂ * * : ribonuclease U₂ * * : ''Enterobacter'' ribonuclease * * : ''Bacillus subtilis'' ribonuclease * * : ribotoxin * * : ribonuclease T₁ * * : bacteriophage T₄ restriction endoribonuclease RegB * : *No Wikipedia article

EC 4.7: Carbon-phosphorus lyases

EC 4.7.1: Carbon-phosphorus lyases (only sub-subclass identified to date)

* α-D ribose 1-methylphosphonate 5-phosphate C-P-lyase * : *No Wikipedia article

EC 4.8: Nitrogen-oxygen lyases

EC 4.8.1: Hydro-lyases

* : L-piperazate synthase * * : aliphatic aldoxime dehydratase * * : indoleacetaldoxime dehydratase * * : phenylacetaldoxime dehydratase * : *No Wikipedia article

EC 4.98: ATP-independent chelatases

EC 4.98.1: Forming coordination complexes

* : protoporphyrin ferrochelatase

EC 4.99: Other Lyases

EC 4.99.1: Sole sub-subclass for lyases that do not belong in the other subclasses

* : Now EC 4.98.1.1 * : alkylmercury lyase * : sirohydrochlorin cobaltochelatase * : sirohydrochlorin ferrochelatase * EC 4.99.1.5: Now , aliphatic aldoxime dehydratase * EC 4.99.1.6: Now , indoleacetaldoxime dehydratase * EC 4.99.1.7: Now , phenylacetaldoxime dehydratase * : heme ligase * : coproporphyrin ferrochelatase * * : magnesium dechelatase * * : sirohydrochlorin nickelchelatase * * : pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel chelatase * : *No Wikipedia article

References

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