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Kerion or kerion celsi is an acute inflammatory process which is the result of the host's response to a fungal
ringworm Dermatophytosis, also known as tinea and ringworm, is a mycosis, fungal infection of the skin (a dermatomycosis), that may affect skin, hair, and nails. Typically it results in a red, itchy, scaly, circular rash. Hair loss may occur in the a ...
infection of the
hair follicle The hair follicle is an organ found in mammalian skin. It resides in the dermal layer of the skin and is made up of 20 different cell types, each with distinct functions. The hair follicle regulates hair growth via a complex interaction betwee ...
s of the
scalp The scalp is the area of the head where head hair grows. It is made up of skin, layers of connective and fibrous tissues, and the membrane of the skull. Anatomically, the scalp is part of the epicranium, a collection of structures covering th ...
(occasionally the
beard A beard is the hair that grows on the jaw, chin, upper lip, lower lip, cheeks, and neck of humans and some non-human animals. In humans, beards are most commonly seen on pubescent or adult males, though women have been observed with beards ...
) that can be accompanied by secondary bacterial infection(s). It usually appears as raised, spongy lesions, and typically occurs in children. This honeycomb is a painful inflammatory reaction with deep suppurative lesions on the scalp. Follicles may be seen discharging pus. There may be sinus formation and rarely mycetoma-like grains are produced. It is usually caused by dermatophytes (fungal infections of the skin affecting humans and animals) such as '' Trichophyton verrucosum'', '' T. mentagrophytes'', and ''
Microsporum canis ''Microsporum canis'' is a pathogenic, asexual fungus in the phylum Ascomycota that infects the upper, dead layers of skin on domesticated cats, and occasionally dogs and humans. The species has a worldwide distribution. Taxonomy and evolution ...
''. Treatment with oral griseofulvin common.


Symptoms and signs

There may be loss of hair as hair will come out easily. Sometimes, there is growth of organisms. Lymph and fever symptoms may be present. This condition can be mistaken for a case of impetigo.


Diagnosis

The basis for the diagnosis of kerion is clinical finding, positive microscopic examinations (such as positive KOH preparation, Lactophenol cotton blue wet mount, Chicago sky blue stained (CSB) slide, Calcofluor white stained slide, Periodic acid–Schiff stained slide, and Gomori’s methenamine silver stained slide), mycological culture and modern molecular tests (such as PCR-reverse line blot test, real-time PCR test, multiplex PCR test, PCR-ELISA test, and MALDI-TOF test) of clinical specimens. Wood's lamp (blacklight) examination will reveal a bright green to yellow-green fluorescence of hairs infected by ''Trichophyton mentagrophytes var. Mentagrophytes'', in kerion infection caused by ''Trichophyton verrucosum'' Invaded hairs show an ectothrix infection and fluorescence under Wood's ultra-violet light has been noted in cattle but not in humans.


Differential Diagnosis

Kerion has been called a great mimicker. It can be easily confused with bacterial scalp abscess and various other conditions. In a recent report, a previously well 9-year-old boy presented to the outpatients’ clinic with a tender, swollen occipital scalp lesion progressing over one month’s duration. He was initially misdiagnosed as having a
bacterial infection Pathogenic bacteria are bacteria that can cause disease. This article focuses on the bacteria that are pathogenic to humans. Most species of bacteria are harmless and many are beneficial but others can cause infectious diseases. The number of t ...
, and was given a 2 weeks’ course of oral cephalexin. No improvement was noticed after the course. It was only after the scalp scrapings were examined, that the child was found to be having a local infection with the fungus '' Trichophyton tonsurans'', which had resulted in kerion. Antifungal therapy was then started, which resulted in complete cure.


Treatment

Unlike most other manifestations of Tinea dermatophyte infections, Kerion is not sufficiently treated with topical antifungals and requires systemic therapy. Typical therapy consists of oral antifungals, such as griseofulvin or terbinafine, for a sustained duration of at least 6 to 8 weeks depending on severity. Successful treatment of kerion often requires empiric bacterial antibiotics given the high prevalence of secondary bacterial infection.


See also

* Favus *
List of cutaneous conditions Many skin conditions affect the human integumentary system—the organ system covering the entire surface of the Human body, body and composed of Human skin, skin, hair, Nail (anatomy), nails, and related muscle and glands. The major function o ...


References


External links

* {{Mycoses Mycosis-related cutaneous conditions