Jeffrey Harold Siewerdsen (born 1969) is an

American American(s) may refer to: * American, something of, from, or related to the United States of America, commonly known as the "United States" or "America" ** Americans, citizens and nationals of the United States of America ** American ancestry, p ...

physicist A physicist is a scientist who specializes in the field of physics, which encompasses the interactions of matter and energy at all length and time scales in the physical universe. Physicists generally are interested in the root or ultimate cau ...

and

biomedical engineer Biomedicine (also referred to as Western medicine, mainstream medicine or conventional medicine)

who is a Professor of Imaging Physics at The University of Texas MD Anderson Cancer Center as well as

Biomedical Engineering Biomedical engineering (BME) or medical engineering is the application of engineering principles and design concepts to medicine and biology for healthcare applications (e.g., diagnostic or therapeutic purposes). BME also integrates the logica ...

, Computer Science, Radiology, and Neurosurgery at

Johns Hopkins University The Johns Hopkins University (often abbreviated as Johns Hopkins, Hopkins, or JHU) is a private university, private research university in Baltimore, Maryland, United States. Founded in 1876 based on the European research institution model, J ...

.He is among the original inventors of cone-beam CT-guided

radiotherapy Radiation therapy or radiotherapy (RT, RTx, or XRT) is a treatment using ionizing radiation, generally provided as part of cancer therapy to either kill or control the growth of malignant cells. It is normally delivered by a linear particle ...

as well as weight-bearing cone-beam CT for musculoskeletal radiology and orthopedic surgery. His work also includes the early development of flat-panel detectors on mobile C-arms for intraoperative cone-beam CT in

image-guided surgery Image-guided surgery (IGS) is any surgical procedure where the surgeon uses tracked surgical instruments in conjunction with preoperative or intraoperative images in order to directly or indirectly guide the procedure. Image guided surgery systems u ...

. He developed early models for the signal and noise performance of flat-panel detectors and later extended such analysis to dual-energy imaging and 3D imaging performance in cone-beam CT. He founded the ISTAR Lab (Imaging for Surgery, Therapy, and Radiology) in the Department of Biomedical Engineering, the Carnegie Center for Surgical Innovation at Johns Hopkins Hospital, and the Surgical Data Science Program at the Institute for Data Science in Oncology at The University of Texas MD Anderson Cancer Center.

Biography and scientific work

Jeffrey Siewerdsen did his undergraduate studies at the

University of Minnesota The University of Minnesota Twin Cities (historically known as University of Minnesota) is a public university, public Land-grant university, land-grant research university in the Minneapolis–Saint Paul, Twin Cities of Minneapolis and Saint ...

in Minneapolis, MN, where he received his

Bachelor of Arts A Bachelor of Arts (abbreviated B.A., BA, A.B. or AB; from the Latin ', ', or ') is the holder of a bachelor's degree awarded for an undergraduate program in the liberal arts, or, in some cases, other disciplines. A Bachelor of Arts deg ...

degree in Physics and Astrophysics with a minor in Japanese in 1992. His undergraduate research experience included construction and testing of particle detectors for the

Soudan 2 Soudan 2 was a particle detector located in the Soudan Mine in Northern Minnesota, United States, that operated from 1989 to 2001. It was a 960-ton iron tracking calorimeter whose primary purpose was to search for proton decay, although its data ...

proton decay project. Siewerdsen began graduate studies at the

University of Michigan The University of Michigan (U-M, U of M, or Michigan) is a public university, public research university in Ann Arbor, Michigan, United States. Founded in 1817, it is the oldest institution of higher education in the state. The University of Mi ...

in Ann Arbor, MI, in 1992, working initially in high-energy physics ( D0 experiment) under supervision of Professor Homer Neal and earning his

Master of Science A Master of Science (; abbreviated MS, M.S., MSc, M.Sc., SM, S.M., ScM or Sc.M.) is a master's degree. In contrast to the Master of Arts degree, the Master of Science degree is typically granted for studies in sciences, engineering and medici ...

degree in Physics in 1994. Siewerdsen's doctoral research involved early development of

amorphous silicon Amorphous silicon (a-Si) is the non-crystalline form of silicon used for solar cells and thin-film transistors in LCDs. Used as semiconductor material for a-Si solar cells, or thin-film silicon solar cells, it is deposited in thin films onto ...

Flat panel detector Flat-panel detectors are a class of solid-state x-ray digital radiography devices similar in principle to the image sensors used in digital photography and video. They are used in both projectional radiography and as an alternative to x-ray ima ...

for medical x-ray imaging under the supervision of Professor Larry E. Antonuk. Siewerdsen's work focused on the development of early

flat-panel detector Flat-panel detectors are a class of solid-state x-ray digital radiography devices similar in principle to the image sensors used in digital photography and video. They are used in both projectional radiography and as an alternative to x-ray ima ...

systems for diagnostic

radiography Radiography is an imaging technology, imaging technique using X-rays, gamma rays, or similar ionizing radiation and non-ionizing radiation to view the internal form of an object. Applications of radiography include medical ("diagnostic" radiog ...

fluoroscopy Fluoroscopy (), informally referred to as "fluoro", is an imaging technique that uses X-rays to obtain real-time moving images of the interior of an object. In its primary application of medical imaging, a fluoroscope () allows a surgeon to see t ...

, and

mammography Mammography (also called mastography; DICOM modality: MG) is the process of using low-energy X-rays (usually around 30 kVp) to examine the human breast for diagnosis and screening. The goal of mammography is the early detection of breast cance ...

as well as megavoltage portal imaging for guidance of

radiation therapy Radiation therapy or radiotherapy (RT, RTx, or XRT) is a therapy, treatment using ionizing radiation, generally provided as part of treatment of cancer, cancer therapy to either kill or control the growth of malignancy, malignant cell (biology), ...

. His doctoral dissertation established mathematical models for the signal-to-noise properties (specifically, the

modulation transfer function The optical transfer function (OTF) of an optical system such as a camera, microscope, human eye, or image projector, projector is a scale-dependent description of their imaging contrast. Its magnitude is the image contrast of the Sine and cosine ...

, noise-power spectrum, and detective quantum efficiency) of flat-panel x-ray detectors. His Ph.D. thesis was awarded the Kent M. Terwilliger Prize for Best Doctoral Dissertation in Physics, 1998. Siewerdsen conducted post-graduate research beginning in 1998 as a research scientist at

William Beaumont Hospital Corewell Health William Beaumont University Hospital is a nationally ranked, 1131 bed non-profit, acute care teaching hospital located in Royal Oak, Michigan, providing tertiary care and healthcare services to the Royal Oak region and Metro Detr ...

in Royal Oak, MI, with Dr. David Jaffray and Dr. John Wong on the topic of

cone beam computed tomography Cone beam computed tomography (or CBCT, also referred to as C-arm CT, cone beam volume CT, flat panel CT or Digital Volume Tomography (DVT)) is a medical imaging technique consisting of X-ray computed tomography where the X-rays are divergent, ...

(CBCT) for image-guided radiation therapy (IGRT). The Beaumont team produced the first IGRT system for CBCT, beginning with laboratory studies to investigate image quality characteristics, and translating to clinical studies for guidance of prostate cancer therapy. Siewerdsen joined the

Ontario Cancer Institute The Ontario Cancer Institute (OCI) is the research division of Princess Margaret Cancer Centre, affiliated to the University Health Network of the University of Toronto Faculty of Medicine. As Canada's first dedicated cancer hospital, it opened off ...

and

University of Toronto The University of Toronto (UToronto or U of T) is a public university, public research university whose main campus is located on the grounds that surround Queen's Park (Toronto), Queen's Park in Toronto, Ontario, Canada. It was founded by ...

Department of Medical Biophysics as a scientist and assistant professor, respectively, in 2002, and subsequently as senior scientist and associate professor in 2007. Research in his laboratory focused on

, new imaging methods such as dual-energy imaging, and

image registration Image registration is the process of transforming different sets of data into one coordinate system. Data may be multiple photographs, data from different sensors, times, depths, or viewpoints. It is used in computer vision, medical imaging, mil ...

. His work involved the development of early systems for

(CBCT) with a

on mobile C-arms for

and translated the first such systems to clinical studies in image-guided

Otolaryngology–Head and Neck Surgery ''Otolaryngology–Head and Neck Surgery'' is a monthly peer-reviewed medical journal that covers the field of otolaryngology, especially surgery of the head and neck. The journal's editor-in-chief is Cecelia Schmalbach (Temple University). It wa ...

with Dr. Jonathan Irish. He also collaborated closely with Dr. Kristy Brock on deformable image registration using the Demons algorithm and with Dr. Narinder Paul on development of dual-energy

chest radiography A chest radiograph, chest X-ray (CXR), or chest film is a projection radiograph of the chest used to diagnose conditions affecting the chest, its contents, and nearby structures. Chest radiographs are the most common film taken in medicine. Li ...

systems for detection of early stage

lung cancer Lung cancer, also known as lung carcinoma, is a malignant tumor that begins in the lung. Lung cancer is caused by genetic damage to the DNA of cells in the airways, often caused by cigarette smoking or inhaling damaging chemicals. Damaged ...

. His research also extended cascaded systems models for x-ray imaging performance to describe 3D imaging performance in CBCT and helped to establish mathematical methods for imaging system optimization according to the imaging task. Siewerdsen joined Johns Hopkins Biomedical Engineering as an associate professor in 2009 and subsequently as a professor in 2012, with cross-appointment in

Computer Science Computer science is the study of computation, information, and automation. Computer science spans Theoretical computer science, theoretical disciplines (such as algorithms, theory of computation, and information theory) to Applied science, ...

Radiology Radiology ( ) is the medical specialty that uses medical imaging to diagnose diseases and guide treatment within the bodies of humans and other animals. It began with radiography (which is why its name has a root referring to radiation), but tod ...

, and

Neurosurgery Neurosurgery or neurological surgery, known in common parlance as brain surgery, is the specialty (medicine), medical specialty that focuses on the surgical treatment or rehabilitation of disorders which affect any portion of the nervous system ...

. He founded th
I-STAR Lab
(Imaging for Surgery, Therapy, and Radiology) as a collaborative research endeavor bridging biomedical engineering with clinical collaborators at Johns Hopkins Hospital. In 2015, he established th
Carnegie Center for Surgical Innovation
in the Johns Hopkins School of Medicine. He was also a John C. Malone Professor in Computer Science and Member of the Malone Center for Engineering in Healthcare. Research in Siewerdsen's laboratory includes: mathematical modeling /

imaging science Imaging is the representation or reproduction of an object's form; especially a visual representation (i.e., the formation of an image). Imaging technology is the application of materials and methods to create, preserve, or duplicate images. ...

of digital x-ray, dual-energy imaging,

(CBCT), and computed tomography (CT) systems;

; multi-modality medical

; new imaging systems for musculoskeletal radiology and

orthopedic surgery Orthopedic surgery or orthopedics ( alternative spelling orthopaedics) is the branch of surgery concerned with conditions involving the musculoskeletal system. Orthopedic surgeons use both surgical and nonsurgical means to treat musculoskeletal ...

; and clinical research collaborations in

robot-assisted surgery Robot-assisted surgery or robotic surgery are any types of surgical procedures that are performed using robotic systems. Robotically assisted surgery was developed to try to overcome the limitations of pre-existing minimally-invasive surgical ...

and

data science Data science is an interdisciplinary academic field that uses statistics, scientific computing, scientific methods, processing, scientific visualization, algorithms and systems to extract or extrapolate knowledge from potentially noisy, stru ...

related to

medical imaging Medical imaging is the technique and process of imaging the interior of a body for clinical analysis and medical intervention, as well as visual representation of the function of some organs or tissues (physiology). Medical imaging seeks to revea ...

. In 2022, Siewerdsen joined The University of Texas MD Anderson Cancer as a Professor Imaging Physics, Radiation Physics, and Neurosurgery, where he directs the Surgical Data Science Program in the Institute for Data Science in Oncology. Notable scientific contributions from Siewerdsen's work include: *

Cone beam computed tomography Cone beam computed tomography (or CBCT, also referred to as C-arm CT, cone beam volume CT, flat panel CT or Digital Volume Tomography (DVT)) is a medical imaging technique consisting of X-ray computed tomography where the X-rays are divergent, ...

(CBCT) systems on mobile C-arms for

. *

(CBCT) systems for imaging of the weight-bearing foot, ankle, and knee with high spatial resolution and low radiation dose. *

(CBCT) systems for image-guided radiation therapy (IGRT). *

(CBCT) systems for high-quality, low-dose imaging of

intracranial hemorrhage Intracranial hemorrhage (ICH) refers to any form of Hemorrhage, bleeding Internal bleeding, within the Human skull, skull. It can result from trauma, vascular abnormalities, hypertension, or other medical conditions. ICH is broadly categorized ...

. * Influence of x-ray

Compton scattering Compton scattering (or the Compton effect) is the quantum theory of high frequency photons scattering following an interaction with a charged particle, usually an electron. Specifically, when the photon hits electrons, it releases loosely bound e ...

(CBCT). * Image registration methods for minimally invasive spine surgery. * Image registration methods for

. * Mathematical models of 3D imaging performance in

(CBCT). * Mathematical models of

spectral ''Spectral'' is a 2016 Hungarian-American military science fiction action film co-written and directed by Nic Mathieu. Written with Ian Fried & George Nolfi, the film stars James Badge Dale as DARPA research scientist Mark Clyne, with Max Marti ...

and

phase-contrast __NOTOC__ Phase-contrast microscopy (PCM) is an optical microscopy technique that converts phase shifts in light passing through a transparent specimen to brightness changes in the image. Phase shifts themselves are invisible, but become visible ...

imaging performance for

photon counting Photon counting is a technique in which individual photons are counted using a single-photon detector (SPD). A single-photon detector emits a pulse of signal for each detected photon. The counting efficiency is determined by the quantum efficienc ...

x-ray detectors. * Mathematical models of 2D imaging performance for flat-panel detectors. * Software tools for x-ray spectrum modeling (spektr).

References

External links

Laboratory for Imaging in Surgery, Therapy, and Radiology.

Carnegie Center for Surgical Innovation.

AAPM Lecture: C-arm Computed Tomography.
{{DEFAULTSORT:Siewerdsen, Jeffrey 1969 births Living people American biomedical engineers Johns Hopkins University faculty University of Minnesota College of Science and Engineering alumni University of Michigan alumni Academic staff of the University of Toronto