Jeffrey Harold Siewerdsen (born 1969) is an

American American(s) may refer to: * American, something of, from, or related to the United States of America, commonly known as the "United States" or "America" ** Americans, citizens and nationals of the United States of America ** American ancestry, pe ...

physicist A physicist is a scientist who specializes in the field of physics, which encompasses the interactions of matter and energy at all length and time scales in the physical universe. Physicists generally are interested in the root or ultimate caus ...

and biomedical engineer who is a Professor of

Biomedical Engineering Biomedical engineering (BME) or medical engineering is the application of engineering principles and design concepts to medicine and biology for healthcare purposes (e.g., diagnostic or therapeutic). BME is also traditionally logical sciences ...

, Computer Science, Radiology, and Neurosurgery at

Johns Hopkins University Johns Hopkins University (Johns Hopkins, Hopkins, or JHU) is a private university, private research university in Baltimore, Maryland. Founded in 1876, Johns Hopkins is the oldest research university in the United States and in the western hem ...

. He is Co-Director of the Carnegie Center for Surgical Innovation at Johns Hopkins School of Medicine and is a member of the Malone Center for Engineering in Healthcare. He is among the original inventors of cone-beam CT-guided

radiotherapy Radiation therapy or radiotherapy, often abbreviated RT, RTx, or XRT, is a therapy using ionizing radiation, generally provided as part of cancer treatment to control or kill malignant cells and normally delivered by a linear accelerator. Radia ...

as well as weight-bearing cone-beam CT for musculoskeletal radiology and orthopedic surgery. His work also includes the early development of flat-panel detectors on mobile C-arms for intraoperative cone-beam CT in image-guided surgery. He developed early models for the signal and noise performance of flat-panel detectors and later extended such analysis to dual-energy imaging and 3D imaging performance in cone-beam CT. His core laboratory at Johns Hopkins University is the ISTAR Lab (Imaging for Surgery, Therapy, and Radiology) in the Department of Biomedical Engineering at the Johns Hopkins Hospital.

Biography and scientific work

Jeffrey Siewerdsen did his undergraduate studies at the

University of Minnesota The University of Minnesota, formally the University of Minnesota, Twin Cities, (UMN Twin Cities, the U of M, or Minnesota) is a public university, public Land-grant university, land-grant research university in the Minneapolis–Saint Paul, Tw ...

in Minneapolis, MN, where he received his

Bachelor of Arts Bachelor of arts (BA or AB; from the Latin ', ', or ') is a bachelor's degree awarded for an undergraduate program in the arts, or, in some cases, other disciplines. A Bachelor of Arts degree course is generally completed in three or four years ...

degree in Physics and Astrophysics with a minor in Japanese in 1992. His undergraduate research experience included construction and testing of particle detectors for the

Soudan 2 Soudan 2 was a particle detector located in the Soudan Mine in Northern Minnesota, United States, that operated from 1989 to 2001. It was a 960-ton iron tracking calorimeter whose primary purpose was to search for proton decay, although its data ...

proton decay project. Siewerdsen began graduate studies at the

University of Michigan , mottoeng = "Arts, Knowledge, Truth" , former_names = Catholepistemiad, or University of Michigania (1817–1821) , budget = $10.3 billion (2021) , endowment = $17 billion (2021)As o ...

in Ann Arbor, MI, in 1992, working initially in high-energy physics (

D0 experiment D, or d, is the fourth letter in the Latin alphabet, used in the modern English alphabet, the alphabets of other western European languages and others worldwide. Its name in English is ''dee'' (pronounced ), plural ''dees''. History The ...

) under supervision of Professor

Homer Neal Homer Alfred Neal (June 13, 1942 – May 23, 2018) was an American particle physicist and a distinguished professor at the University of Michigan. Neal was President of the American Physical Society in 2016. He was also a board member of Ford Mo ...

and earning his

Master of Science A Master of Science ( la, Magisterii Scientiae; abbreviated MS, M.S., MSc, M.Sc., SM, S.M., ScM or Sc.M.) is a master's degree in the field of science awarded by universities in many countries or a person holding such a degree. In contrast to ...

degree in Physics in 1994. Siewerdsen's doctoral research involved early development of amorphous silicon

Flat panel detector Flat-panel detectors are a class of solid-state x-ray digital radiography devices similar in principle to the image sensors used in digital photography and video. They are used in both projectional radiography and as an alternative to x-ray image ...

for medical x-ray imaging under the supervision of Professor Larry E. Antonuk. Siewerdsen's work focused on the development of early

flat-panel detector Flat-panel detectors are a class of solid-state x-ray digital radiography devices similar in principle to the image sensors used in digital photography and video. They are used in both projectional radiography and as an alternative to x-ray imag ...

systems for diagnostic

radiography Radiography is an imaging technique using X-rays, gamma rays, or similar ionizing radiation and non-ionizing radiation to view the internal form of an object. Applications of radiography include medical radiography ("diagnostic" and "therapeut ...

, fluoroscopy, and

mammography Mammography (also called mastography) is the process of using low-energy X-rays (usually around 30 kVp) to examine the human breast for diagnosis and screening. The goal of mammography is the early detection of breast cancer, typically through d ...

as well as megavoltage portal imaging for guidance of

radiation therapy Radiation therapy or radiotherapy, often abbreviated RT, RTx, or XRT, is a therapy using ionizing radiation, generally provided as part of cancer treatment to control or kill malignant cells and normally delivered by a linear accelerator. Radia ...

. His doctoral dissertation established mathematical models for the signal-to-noise properties (specifically, the

modulation transfer function The optical transfer function (OTF) of an optical system such as a camera, microscope, human eye, or image projector, projector specifies how different spatial frequencies are captured or transmitted. It is used by optical engineers to describe h ...

, noise-power spectrum, and detective quantum efficiency) of flat-panel x-ray detectors. His Ph.D. thesis was awarded the Kent M. Terwilliger Prize for Best Doctoral Dissertation in Physics, 1998. Siewerdsen conducted post-graduate research beginning in 1998 as a Research Scientist at

William Beaumont Hospital Beaumont Hospital, Royal Oak (BHRO) is a nationally ranked, 1131 bed non-profit, acute care teaching hospital located in Royal Oak, Michigan, providing tertiary care and healthcare services to the Royal Oak region and Metro Detroit. Beaumont Hospi ...

in Royal Oak, MI, with Dr.

David Jaffray David A. Jaffray is a Canadian medical physicist and Senior Scientist in the Division of Biophysics and Bioimaging at the Ontario Cancer Institute. He is also a professor and Vice Chair in the University of Toronto's Department of Radiation Oncol ...

and Dr. John Wong on the topic of

cone beam computed tomography Cone beam computed tomography (or CBCT, also referred to as C-arm CT, cone beam volume CT, flat panel CT or Digital Volume Tomography (DVT)) is a medical imaging technique consisting of X-ray computed tomography where the X-rays are divergent, fo ...

(CBCT) for

image-guided radiation therapy Image-guided radiation therapy is the process of frequent imaging, during a course of radiation treatment, used to direct the treatment, position the patient, and compare to the pre-therapy imaging from the treatment plan. Immediately prior to, o ...

(IGRT). The Beaumont team produced the first IGRT system for CBCT, beginning with laboratory studies to investigate image quality characteristics, and translating to clinical studies for guidance of prostate cancer therapy. Siewerdsen joined the Ontario Cancer Institute and

University of Toronto The University of Toronto (UToronto or U of T) is a public research university in Toronto, Ontario, Canada, located on the grounds that surround Queen's Park. It was founded by royal charter in 1827 as King's College, the first institution ...

Department of Medical Biophysics as a Scientist and Assistant Professor, respectively, in 2002, and subsequently as Senior Scientist and Associate Professor in 2007. Research in his laboratory focused on image-guided surgery, new imaging methods such as dual-energy imaging, and image registration. His work involved the development of early systems for

(CBCT) with a

on mobile C-arms for image-guided surgery and translated the first such systems to clinical studies in image-guided

Otolaryngology–Head and Neck Surgery ''Otolaryngology–Head and Neck Surgery'' is a monthly peer-reviewed medical journal that covers the field of otolaryngology, especially surgery of the head and neck. The journal's editor-in-chief is Cecelia Schmalbach (Temple University). It ...

with Dr. Jonathan Irish. He also collaborated closely with Dr. Kristy Brock on deformable image registration using the Demons algorithm and with Dr. Narinder Paul on development of dual-energy

chest radiography A chest radiograph, called a chest X-ray (CXR), or chest film, is a projection radiograph of the chest used to diagnose conditions affecting the chest, its contents, and nearby structures. Chest radiographs are the most common film taken in med ...

systems for detection of early stage

lung cancer Lung cancer, also known as lung carcinoma (since about 98–99% of all lung cancers are carcinomas), is a malignant lung tumor characterized by uncontrolled cell growth in tissue (biology), tissues of the lung. Lung carcinomas derive from tran ...

. His research also extended cascaded systems models for x-ray imaging performance to describe 3D imaging performance in CBCT and helped to establish mathematical methods for imaging system optimization according to the imaging task. Siewerdsen joined Johns Hopkins Biomedical Engineering as an Associate Professor in 2009 and subsequently as a Professor in 2012, with cross-appointment in

Computer Science Computer science is the study of computation, automation, and information. Computer science spans theoretical disciplines (such as algorithms, theory of computation, information theory, and automation) to Applied science, practical discipli ...

Radiology Radiology ( ) is the medical discipline that uses medical imaging to diagnose diseases and guide their treatment, within the bodies of humans and other animals. It began with radiography (which is why its name has a root referring to radiat ...

, and

Neurosurgery Neurosurgery or neurological surgery, known in common parlance as brain surgery, is the medical specialty concerned with the surgical treatment of disorders which affect any portion of the nervous system including the brain, spinal cord and peri ...

. He founded th
I-STAR Lab
(Imaging for Surgery, Therapy, and Radiology) as a collaborative research endeavor bridging biomedical engineering with clinical collaborators at Johns Hopkins Hospital. In 2015, he established th
Carnegie Center for Surgical Innovation
in the Johns Hopkins School of Medicine. He is also a

John C. Malone John Carl Malone (born March 7, 1941) is an American billionaire businessman, landowner and philanthropist. He was chief executive officer (CEO) of Tele-Communications Inc. (TCI), a cable and media giant, for twenty-four years from 1973 to 1996. ...

Professor in Computer Science and Member of the Malone Center for Engineering in Healthcare. Research in Siewerdsen's laboratory includes: mathematical modeling / imaging science of digital x-ray, dual-energy imaging,

(CBCT), and computed tomography (CT) systems; image-guided surgery; multi-modality medical image registration; new imaging systems for musculoskeletal radiology and

orthopedic surgery Orthopedic surgery or orthopedics ( alternatively spelt orthopaedics), is the branch of surgery concerned with conditions involving the musculoskeletal system. Orthopedic surgeons use both surgical and nonsurgical means to treat musculoskeletal ...

; and clinical research collaborations in

robot-assisted surgery Robotic surgery are types of surgical procedures that are done using robotic systems. Robotically assisted surgery was developed to try to overcome the limitations of pre-existing minimally-invasive surgical procedures and to enhance the capabil ...

and

data science Data science is an interdisciplinary field that uses scientific methods, processes, algorithms and systems to extract or extrapolate knowledge and insights from noisy, structured and unstructured data, and apply knowledge from data across a br ...

related to

medical imaging Medical imaging is the technique and process of imaging the interior of a body for clinical analysis and medical intervention, as well as visual representation of the function of some organs or tissues (physiology). Medical imaging seeks to rev ...

. Notable scientific contributions from Siewerdsen's work include: *

Cone beam computed tomography Cone beam computed tomography (or CBCT, also referred to as C-arm CT, cone beam volume CT, flat panel CT or Digital Volume Tomography (DVT)) is a medical imaging technique consisting of X-ray computed tomography where the X-rays are divergent, fo ...

(CBCT) systems on mobile C-arms for image-guided surgery. *

(CBCT) systems for imaging of the weight-bearing foot, ankle, and knee with high spatial resolution and low radiation dose. *

(CBCT) systems for

(IGRT). *

(CBCT) systems for high-quality, low-dose imaging of

intracranial hemorrhage Intracranial hemorrhage (ICH), also known as intracranial bleed, is bleeding within the skull. Subtypes are intracerebral bleeds ( intraventricular bleeds and intraparenchymal bleeds), subarachnoid bleeds, epidural bleeds, and subdural bleeds. ...

. * Influence of x-ray Compton scattering in

(CBCT). * Image registration methods for

minimally invasive spine surgery Minimally invasive spine surgery, also known as MISS, has no specific meaning or definition. It implies a lack of severe surgical invasion. The older style of open-spine surgery for a relatively small disc problem used to require a 5-6 inch incisio ...

. * Image registration methods for

. * Mathematical models of 3D imaging performance in

(CBCT). * Mathematical models of

spectral ''Spectral'' is a 2016 3D military science fiction, supernatural horror fantasy and action-adventure thriller war film directed by Nic Mathieu. Written by himself, Ian Fried, and George Nolfi from a story by Fried and Mathieu. The film stars J ...

and

phase-contrast __NOTOC__ Phase-contrast microscopy (PCM) is an optical microscopy technique that converts phase shifts in light passing through a transparent specimen to brightness changes in the image. Phase shifts themselves are invisible, but become visible ...

imaging performance for photon counting x-ray detectors. * Mathematical models of 2D imaging performance for flat-panel detectors. * Software tools for x-ray spectrum modeling (spektr).

References

External links

Laboratory for Imaging in Surgery, Therapy, and Radiology.

Carnegie Center for Surgical Innovation.

AAPM Lecture: C-arm Computed Tomography.
{{DEFAULTSORT:Siewerdsen, Jeffrey 1969 births Living people American biomedical engineers Johns Hopkins University faculty University of Minnesota College of Science and Engineering alumni University of Michigan alumni Academic staff of the University of Toronto