HRAC Classification
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The Herbicide Resistance Action Committee (HRAC) classifies
herbicide Herbicides (, ), also commonly known as weed killers, are substances used to control undesired plants, also known as weeds.EPA. February 201Pesticides Industry. Sales and Usage 2006 and 2007: Market Estimates. Summary in press releasMain page f ...
s by their
mode of action In pharmacology and biochemistry, mode of action (MoA) describes a functional or anatomical change, resulting from the exposure of a living organism to a substance. In comparison, a mechanism of action (MOA) describes such changes at the molecul ...
(MoA) to provide a uniform way for farmers and growers to identify the agents they use and better manage pesticide resistance around the world. It is run by CropLife International in conjunction with the Weed Science Society of America (WSSA).


Resistance overview

A weed that develops resistance to one herbicide typically has resistance to other herbicides with the same mode of action (MoA), so herbicides with different MoAs, or different resistance groups, are needed. Preventative weed resistance management rotates herbicide types to prevent selective breeding of resistance to the same mode of action. By rotating MoAs, successive generations gain no advantage from any resistant mutations of the last generation. ''Cross-resistant'' and ''multiply resistant'' weeds resist multiple MoAs, and are particularly difficult to control. There is limited evidence of resistance undoing other resistances. For example, prosulfocarb and trifluralin: their inverse mechanisms of resistance contradict, and so by evolving to one the weed loses resistance to the other, at least by metabolic resistance. Prosulfocarb requires a weed to metabolise it very slowly to survive; trifluralin on the other hand must be metabolised quickly before it can deal damage to the weed. Resistance first became problematic in the 1970s and 1980s, and herbicide resistant weeds have developed against 23 of 26 known herbicide sites of action, and over 163 different herbicides. Herbicide development has slowed down significantly, with no new mechanisms being discovered from circa 2000 to 2020.


Naming types

The HRAC give a letter based class to each active constituent herbicide. The Australian HRAC code is separately assigned, though is often the same as the global code. In 2021, alternative numeric classes were added, to make codes globally more consistent. This set of classification changes also added or moved a few herbicides that had been misclassified, and reduced regional concerns that using the
English alphabet Modern English is written with a Latin-script alphabet consisting of 26 Letter (alphabet), letters, with each having both uppercase and lowercase forms. The word ''alphabet'' is a Compound (linguistics), compound of ''alpha'' and ''beta'', t ...
could be an impediment for international growers. Herbicides that act through multiple modes have multiple classifications, corresponding to each MoA. For example, Quinmerac is classified as Group 4/29 (O/L) because it is both an Auxin mimic (Group 4 or O) and inhibits cellulose synthesis (Group 29 or L).


Groups


See also

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Insecticide Resistance Action Committee The Insecticide Resistance Action Committee (IRAC) was formed in 1984 and works as a specialist technical group of the industry association CropLife to be able to provide a coordinated industry response to prevent or delay the development of insec ...


References

{{Herbicides Herbicides