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Prosulfocarb
Prosulfocarb is a pre-emergent herbicide used agriculturally in Australia, the EU, Japan, New Zealand, (since 2020), Morocco and Iran, for control of annual ryegrass and toad rush in wheat and barley crops. It was introduced to the EU in 1988 and is rapidly growing in use, with sales increasing by over 500% in France since 2008. Prosulfocarb is a thiocarbamate, and is absorbed by the roots of germinating seedlings to inhibit growth in the meristem by inhibiting fat synthesis, of resistance HRAC Group J, (Aus), K3/N, (Global), 15. (numeric) Applying prosulfocarb repeatedly builds weed resistance but undoes trifluralin (Group 3) resistance, as they have opposing mechanisms: prosulfocarb is resisted by decreasing pesticide metabolism; trifluralin is resisted by increasing metabolism. Application To target annual ryegrass, 2.5L/ha (of 800 g/L emulsifiable concentrate) is prepared and sprayed before sowing. It can be applied to barley post-emergence, but if applied wrongly may ...
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Trifluralin
Trifluralin is a common pre-emergent selective herbicide, a dinitroaniline. With about used in the United States in 2001, and in 2012, it is one of the most widely used herbicides. Trifluralin is also used in Australia, New Zealand, Brazil and previously in the EU. Introduced in 1964, Trifluralin was the first organofluorine compound used as an agrochemical. Trifluralin is generally applied to the soil to control annual grass and broadleaf weed species. It inhibits root development by interrupting mitosis and controls weeds as they germinate. Trifluralin moves very little inside the plant, remaining in the roots. Discovery Selective herbicides were unavailable in the 1950s to protect soybean and cotton ( 2,4-DNP could have been used but had to be exactingly applied lest it destroy the crops), so Lilly Research Laboratories screened ~2000 compounds from 1958 to 1980 blindly looking for a result. Trifluralin was initially thought a failure, yet the plots stayed free of w ...
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Herbicide Resistance Classification
The Herbicide Resistance Action Committee (HRAC) classifies herbicides by their mode of action (MoA) to provide a uniform way for farmers and growers to identify the agents they use and better manage pesticide resistance around the world. It is run by CropLife International in conjunction with the Weed Science Society of America (WSSA). Resistance overview A weed that develops resistance to one herbicide typically has resistance to other herbicides with the same mode of action (MoA), so herbicides with different MoAs, or different resistance groups, are needed. Preventative weed resistance management rotates herbicide types to prevent selective breeding of resistance to the same mode of action. By rotating MoAs, successive generations gain no advantage from any resistant mutations of the last generation. ''Cross-resistant'' and ''multiply resistant'' weeds resist multiple MoAs, and are particularly difficult to control. There is limited evidence of resistance undoing other resis ...
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Thiocarbamate
In organic chemistry, thiocarbamates (thiourethanes) are a family of organosulfur compounds. As the prefix ''thio-'' suggests, they are sulfur analogues of carbamates. There are two isomeric forms of thiocarbamates: ''O''-thiocarbamates, (esters), and ''S''-thiocarbamates, (thioesters). Synthesis Thiocarbamates can be synthesised by the reaction of water or alcohols upon thiocyanates (Riemschneider thiocarbamate synthesis): :RSCN + H2O → RSC(=O)NH2 :RSCN + R'OH → RSC(=O)NR'H Similar reactions are seen between alcohols and thiocarbamoyl chlorides such as dimethylthiocarbamoyl chloride; as well as between thiols and cyanates. The herbicide Cycloate is produced in this way: : Other related thiocarbamate herbicides include vernolate and triallate (. Salts of thiocarbamate arise by the reaction of amines with carbonyl sulfide: : Reactions In the Newman-Kwart rearrangement ''O''-thiocarbamates can isomerise to ''S''-thiocarbamates. This reaction, which generally require ...
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Herbicide
Herbicides (, ), also commonly known as weed killers, are substances used to control undesired plants, also known as weeds.EPA. February 201Pesticides Industry. Sales and Usage 2006 and 2007: Market Estimates. Summary in press releasMain page for EPA reports on pesticide use ihere Selective herbicides control specific weed species while leaving the desired crop relatively unharmed, while non-selective herbicides (sometimes called "total weed killers") kill plants indiscriminately. The combined effects of herbicides, nitrogen fertilizer, and improved cultivars has increased yields (per acre) of major crops by three to six times from 1900 to 2000. In the United States in 2012, about 91% of all herbicide usage, was determined by weight applied, in agriculture. In 2012, world pesticide expenditures totaled nearly US$24.7 billion; herbicides were about 44% of those sales and constituted the biggest portion, followed by insecticides, fungicides, and fumigants. Herbicide is also used ...
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Solvent Naphtha
White spirit (AU, UK and Ireland)Primarily in the United Kingdom and Australia. In New Zealand "white spirit" can also refer to Coleman fuel (white gas). or mineral spirits (US, Canada), also known as mineral turpentine (AU/NZ/ZA), turpentine substitute, and petroleum spirits, is a petroleum-derived clear liquid used as a common organic solvent in painting. There are also terms for specific kinds of white spirit, including Stoddard solvent and solvent naphtha (petroleum). White spirit is often used as a paint thinner, or as a component thereof, though paint thinner is a broader category of solvent. Odorless mineral spirits (OMS) have been refined to remove the more toxic Aromaticity, aromatic compounds, and are recommended for applications such as oil painting. A mixture of Aliphatic compound, aliphatic, open-chain or alicyclic C7 to C12 hydrocarbons, white spirit is insoluble in water and is used as an Liquid–liquid extraction, extraction solvent, as a cleaning solvent, as a d ...
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Liver
The liver is a major metabolic organ (anatomy), organ exclusively found in vertebrates, which performs many essential biological Function (biology), functions such as detoxification of the organism, and the Protein biosynthesis, synthesis of various proteins and various other Biochemistry, biochemicals necessary for digestion and growth. In humans, it is located in the quadrants and regions of abdomen, right upper quadrant of the abdomen, below the thoracic diaphragm, diaphragm and mostly shielded by the lower right rib cage. Its other metabolic roles include carbohydrate metabolism, the production of a number of hormones, conversion and storage of nutrients such as glucose and glycogen, and the decomposition of red blood cells. Anatomical and medical terminology often use the prefix List of medical roots, suffixes and prefixes#H, ''hepat-'' from ἡπατο-, from the Greek language, Greek word for liver, such as hepatology, and hepatitis The liver is also an accessory digestive ...
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Kidneys
In humans, the kidneys are two reddish-brown bean-shaped blood-filtering organs that are a multilobar, multipapillary form of mammalian kidneys, usually without signs of external lobulation. They are located on the left and right in the retroperitoneal space, and in adult humans are about in length. They receive blood from the paired renal arteries; blood exits into the paired renal veins. Each kidney is attached to a ureter, a tube that carries excreted urine to the bladder. The kidney participates in the control of the volume of various body fluids, fluid osmolality, acid-base balance, various electrolyte concentrations, and removal of toxins. Filtration occurs in the glomerulus: one-fifth of the blood volume that enters the kidneys is filtered. Examples of substances reabsorbed are solute-free water, sodium, bicarbonate, glucose, and amino acids. Examples of substances secreted are hydrogen, ammonium, potassium and uric acid. The nephron is the structural and functi ...
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Carcinogen
A carcinogen () is any agent that promotes the development of cancer. Carcinogens can include synthetic chemicals, naturally occurring substances, physical agents such as ionizing and non-ionizing radiation, and biologic agents such as viruses and bacteria. Most carcinogens act by creating mutations in DNA that disrupt a cell's normal processes for regulating growth, leading to uncontrolled cellular proliferation. This occurs when the cell's DNA repair processes fail to identify DNA damage allowing the defect to be passed down to daughter cells. The damage accumulates over time. This is typically a multi-step process during which the regulatory mechanisms within the cell are gradually dismantled allowing for unchecked cellular division. The specific mechanisms for carcinogenic activity is unique to each agent and cell type. Carcinogens can be broadly categorized, however, as activation-dependent and activation-independent which relate to the agent's ability to engage dir ...
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Genotoxicity
Genotoxicity is the chemical property, property of chemical agents that damage the genetic information within a cell causing mutations, which may lead to cancer. While genotoxicity is often confused with mutagenicity, all mutagens are genotoxic, but some genotoxic substances are not mutagenic. The alteration can have direct or indirect effects on the DNA: the induction of mutations, mistimed event activation, and direct DNA damage leading to mutations. The permanent, heritable changes can affect either somatic cells of the organism or germ cells to be passed on to future generations. Cells prevent expression of the genotoxic mutation by either DNA repair or apoptosis; however, the damage may not always be fixed leading to mutagenesis. To bioassay, assay for genotoxic molecules, researchers assay for DNA damage in cells exposed to the toxic substrates. This DNA damage can be in the form of single- and double-strand breaks, loss of excision repair, cross-linking, alkali-labile sites, ...
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Teratogenic
Teratology is the study of abnormalities of physiological development in organisms during their life span. It is a sub-discipline in medical genetics which focuses on the classification of congenital abnormalities in dysmorphology caused by teratogens and also in pharmacology and toxicology. Teratogens are substances that may cause non-heritable birth defects via a toxic effect on an embryo or fetus. Defects include malformations, disruptions, deformations, and dysplasia that may cause stunted growth, delayed mental development, or other congenital disorders that lack structural malformations. These defects can be recognized prior to or at birth as well as later during early childhood. The related term developmental toxicity includes all manifestations of abnormal development that are caused by environmental insult. The extent to which teratogens will impact an embryo is dependent on several factors, such as how long the embryo has been exposed, the stage of development t ...
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Rats
Rats are various medium-sized, long-tailed rodents. Species of rats are found throughout the order Rodentia, but stereotypical rats are found in the genus ''Rattus''. Other rat genera include ''Neotoma'' (pack rats), '' Bandicota'' (bandicoot rats) and ''Dipodomys'' (kangaroo rats). Rats are typically distinguished from mice by their size. Usually the common name of a large muroid rodent will include the word "rat", while a smaller muroid's name will include "mouse". The common terms ''rat'' and ''mouse'' are not taxonomically specific. There are 56 known species of rats in the world. Species and description The best-known rat species are the black rat (''Rattus rattus'') and the brown rat (''Rattus norvegicus''). This group, generally known as the Old World rats or true rats, originated in Asia. Rats are bigger than most Old World mice, which are their relatives, but seldom weigh over in the wild. The term ''rat'' is also used in the names of other small mammals that ar ...
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Halflife
Half-life is a mathematical and scientific description of exponential or gradual decay. Half-life, half life or halflife may also refer to: Film * ''Half-Life'' (film), a 2008 independent film by Jennifer Phang * '' Half Life: A Parable for the Nuclear Age'', a 1985 Australian documentary film Literature * ''Half Life'' (Jackson novel), a 2006 novel by Shelley Jackson * ''Half-Life'' (Krach novel), a 2004 novel by Aaron Krach * ''Halflife'' (Michalowski novel), a 2004 novel by Mark Michalowski * '' Rozpad połowiczny'' (), a 1988 award-winning dystopia novel by Edmund Wnuk-Lipiński Music * ''Half Life'' (3 album) (2001) * ''Halflife'' (EP), an EP by Lacuna Coil and the title track *'' Half-Life E.P.'', an EP by Local H * "Half Life", a song by 10 Years from '' The Autumn Effect'' * "Half Life", a song by Come from '' Near-Life Experience'' * "Half Life", a song by Imogen Heap from her album ''Ellipse'' * "Half Life", a song by Prototype from the album ''Trinity'' * "H ...
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