Formiminoglutamic acid (FIGLU;
conjugate base, formiminoglutamate) is an intermediate in the
catabolism
Catabolism () is the set of metabolic pathways that breaks down molecules into smaller units that are either oxidized to release energy or used in other anabolic reactions. Catabolism breaks down large molecules (such as polysaccharides, lipids, ...
of
L-histidine
Histidine (symbol His or H) is an essential amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated –NH3+ form under biological conditions), a carboxylic acid group (which is in the d ...
to
L-glutamic acid. It thus is also a
biomarker for
intracellular levels of
folate. The FIGLU test is used to identify
vitamin B₁₂ deficiency,
folate deficiency, and
liver failure or
liver disease. It is elevated with folate trapping, where it is accompanied by decreased
methylmalonic acid, increased folate and a decrease in
homocysteine.
See also
*
Formiminotransferase cyclodeaminase
*
Glutamate-1-semialdehyde
*
Glutamic acid
Glutamic acid (symbol Glu or E; the ionic form is known as glutamate) is an α-amino acid that is used by almost all living beings in the biosynthesis of proteins. It is a non-essential nutrient for humans, meaning that the human body can synt ...
*
Imidazol-4-one-5-propionic acid
Imidazol-4-one-5-propionic acid is an intermediate in the metabolism of histidine. It is a colorless compound that is sensitive to light in air. The compound features an imidazolone ring.
Occurrence
It arises via the action of urocanase on ur ...
References
{{biochem-stub
Dicarboxylic acids
Amidines
Amino acid derivatives