In molecular biology the FYVE zinc finger domain is named after the four cysteine-rich

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respon ...

s: Fab 1 (yeast orthologue of PIKfyve), YOTB, Vac 1 (vesicle transport protein), and EEA1, in which it has been found. FYVE domains bind phosphatidylinositol 3-phosphate, in a way dependent on its metal ion coordination and basic amino acids. The FYVE domain inserts into cell membranes in a pH-dependent manner. The FYVE domain has been connected to vacuolar protein sorting and

endosome Endosomes are a collection of intracellular sorting organelles in eukaryotic cells. They are parts of endocytic membrane transport pathway originating from the trans Golgi network. Molecules or ligands internalized from the plasma membrane c ...

function.

Structure

The FYVE domain is composed of two small beta hairpins (or zinc knuckles) followed by an alpha helix. The FYVE finger binds two

zinc Zinc is a chemical element with the symbol Zn and atomic number 30. Zinc is a slightly brittle metal at room temperature and has a shiny-greyish appearance when oxidation is removed. It is the first element in group 12 (IIB) of the periodic t ...

ions. The FYVE finger has eight potential zinc coordinating cysteine positions and is characterized by having basic amino acids around the cysteines. Many members of this family also include two histidines in a sequence motif: The FYVE finger is structurally similar to the RING domain and the PHD finger.

Examples

The following is a list of human proteins containing this domain: *

ANKFY1 Ankyrin repeat and FYVE domain-containing protein 1 is a protein that in humans is encoded by the ''ANKFY1'' gene. Function This gene encodes a cytoplasmic protein that contains a coiled-coil structure and a BTB/POZ domain at its N-terminus, ...

, EEA1,

FGD1 FYVE, RhoGEF and PH domain-containing protein 1 (FGD1) also known as faciogenital dysplasia 1 protein (FGDY), zinc finger FYVE domain-containing protein 3 (ZFYVE3), or Rho/Rac guanine nucleotide exchange factor FGD1 (Rho/Rac GEF) is a protein th ...

, FGD2, FGD3, FGD4, FGD5, FGD6, FYCO1, HGS, MTMR3, MTMR4, PIKFYVE, PLEKHF1,

PLEKHF2 Pleckstrin homology domain-containing family F member 2 is a protein that in humans is encoded by the ''PLEKHF2'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredi ...

RUFY1 RUN and FYVE domain-containing protein 1 is a protein that in humans is encoded by the ''RUFY1'' gene. It is named after the RUN and FYVE domains it contains. Interactions RUFY1 has been shown to interact Advocates for Informed Choice, ...

RUFY2 RUN and FYVE domain containing 2 (RUFY2) is a protein that in humans is encoded by the ''RUFY2'' gene. The RUFY2 gene is named for two of its domains, the RUN domain and FYVE domains. RUFY2 is a member of the RUFY family of proteins that include ...

, WDF3, WDFY1, WDFY2, WDFY3, ZFYVE1, ZFYVE16,

ZFYVE19 Zinc finger FYVE domain-containing protein 19 is a protein that in humans is encoded by the ''ZFYVE19'' gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." mea ...

, ZFYVE20, ZFYVE21,

ZFYVE26 Zinc finger, FYVE domain containing 26 is a protein that in humans is encoded by the ZFYVE26 gene. Function This gene encodes a protein which contains a FYVE zinc finger binding domain. The presence of this domain is thought to target these pr ...

ZFYVE27 Zinc finger, FYVE domain containing 27 is a protein that in humans is encoded by the ZFYVE27 gene. Function This gene encodes a protein with several Transmembrane domains, a Rab11-binding domain and a lipid-binding FYVE finger domain. The enco ...

, ZFYVE28, ZFYVE9

Structure

Examples

References

Further reading