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RUFY2
RUN and FYVE domain containing 2 (RUFY2) is a protein that in humans is encoded by the ''RUFY2'' gene. The RUFY2 gene is named for two of its domains, the RUN domain and FYVE domains. RUFY2 is a member of the RUFY family of proteins that include RUFY1, RUFY2, RUFY3, and RUFY4. RUFY2 protein has a dynamic role in endosomal membrane trafficking. Gene The human ''RUFY2'' gene is located on the long (q) arm of chromosome 10 (human), chromosome 10 at region 21 band 3, from base pair 70,100,864 to base pair 70,167,051 on the reverse strand (Build GRCh37/hg19(map) The gene produces a 2,080 base pair mRNA. There are 18 predicted exons in the human gene with 13 alternative transcripts. Gene neighborhood 8,180 base pairs upstream of RUFY2 is the protein-coding gene for phenazine biosynthesis-like protein domain containing (PBLD). While 6,770 base pairs downstream from RUFY2 is a DNA2 conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
FYVE Domain
In molecular biology the FYVE zinc finger domain is named after the four cysteine-rich proteins: Fab 1 (yeast orthologue of PIKfyve), YOTB, Vac 1 (vesicle transport protein), and EEA1, in which it has been found. FYVE domains bind phosphatidylinositol 3-phosphate, in a way dependent on its metal ion coordination and basic amino acids. The FYVE domain inserts into cell membranes in a pH-dependent manner. The FYVE domain has been connected to vacuolar protein sorting and endosome function. Structure The FYVE domain is composed of two small beta hairpins (or zinc knuckles) followed by an alpha helix. The FYVE finger binds two zinc ions. The FYVE finger has eight potential zinc coordinating cysteine positions and is characterized by having basic amino acids around the cysteines. Many members of this family also include two histidines in a sequence motif: The FYVE finger is structurally similar to the RING domain and the PHD finger The PHD finger was discovered in 1993 as a Cys ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
RUN Domain
The RUN domain is an evolutionary conserved protein–protein binding protein domain. They often interact with GTPases and could play a role in multiple Ras-like GTPase signalling pathways. This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signaling pathways. The domain comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases. Examples Human genes encoding proteins containing this domain include: * LOC440456; * PLEKHM1; PLEKHM2; * RAB6IP1; RPIB9; RPIP8; RUFY1; RUFY2 RUN and FYVE domain containing 2 (RUFY2) is a protein that in humans is encoded by the ''RUFY2'' gene. The RUFY2 gene is named for two of its domains, the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
FYVE Domains
In molecular biology the FYVE zinc finger domain is named after the four cysteine-rich proteins: Fab 1 (yeast orthologue of PIKfyve), YOTB, Vac 1 (vesicle transport protein), and EEA1, in which it has been found. FYVE domains bind phosphatidylinositol 3-phosphate, in a way dependent on its metal ion coordination and basic amino acids. The FYVE domain inserts into cell membranes in a pH-dependent manner. The FYVE domain has been connected to vacuolar protein sorting and endosome function. Structure The FYVE domain is composed of two small beta hairpins (or zinc knuckles) followed by an alpha helix. The FYVE finger binds two zinc ions. The FYVE finger has eight potential zinc coordinating cysteine positions and is characterized by having basic amino acids around the cysteines. Many members of this family also include two histidines in a sequence motif: The FYVE finger is structurally similar to the RING domain and the PHD finger. Examples The following is a list of human prote ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SH3 Domain
The SRC Homology 3 Domain (or SH3 domain) is a small protein domain of about 60 amino acid residues. Initially, SH3 was described as a conserved sequence in the viral adaptor protein v-Crk. This domain is also present in the molecules of phospholipase and several cytoplasmic tyrosine kinases such as Abl and Src. It has also been identified in several other protein families such as: PI3 Kinase, Ras GTPase-activating protein, CDC24 and cdc25. SH3 domains are found in proteins of signaling pathways regulating the cytoskeleton, the Ras protein, and the Src kinase and many others. The SH3 proteins interact with adaptor proteins and tyrosine kinases. Interacting with tyrosine kinases, SH3 proteins usually bind far away from the active site. Approximately 300 SH3 domains are found in proteins encoded in the human genome. In addition to that, the SH3 domain was responsible for controlling protein-protein interactions in the signal transduction pathways and regulating the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paralogs
Sequence homology is the biological homology between DNA, RNA, or protein sequences, defined in terms of shared ancestry in the evolutionary history of life. Two segments of DNA can have shared ancestry because of three phenomena: either a speciation event (orthologs), or a duplication event (paralogs), or else a horizontal (or lateral) gene transfer event (xenologs). Homology among DNA, RNA, or proteins is typically inferred from their nucleotide or amino acid sequence similarity. Significant similarity is strong evidence that two sequences are related by evolutionary changes from a common ancestral sequence. Alignments of multiple sequences are used to indicate which regions of each sequence are homologous. Identity, similarity, and conservation The term "percent homology" is often used to mean "sequence similarity”, that is the percentage of identical residues (''percent identity''), or the percentage of residues conserved with similar physicochemical properties (''p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nucleic Acids Research
''Nucleic Acids Research'' is an open-access peer-reviewed scientific journal published since 1974 by the Oxford University Press. The journal covers research on nucleic acids, such as DNA and RNA, and related work. According to the ''Journal Citation Reports'', the journal's 2021 impact factor is 19.160. The journal publishes two yearly special issues; the first issue of each year is dedicated to biological databases, published in January since 1993, and the other is devoted to papers describing web-based software resources of value to the biological community (web server A web server is computer software and underlying Computer hardware, hardware that accepts requests via Hypertext Transfer Protocol, HTTP (the network protocol created to distribute web content) or its secure variant HTTPS. A user agent, co ...s), published in July since 2003. Journal Rankings Presented below is a summary of current bibliometric rankings for Nucleic Acids Research based on leading eval ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nicolas Hulo
Nicolas or Nicolás may refer to: People Given name * Nicolas (given name) Mononym * Nicolas (footballer, born 1999), Brazilian footballer * Nicolas (footballer, born 2000), Brazilian footballer Surname Nicolas * Dafydd Nicolas (c.1705–1774), Welsh poet * Jean Nicolas (1913–1978), French international football player * Nicholas Harris Nicolas (1799–1848), English antiquary * Paul Nicolas (1899–1959), French international football player * Robert Nicolas (1595–1667), English politician Nicolás * Adolfo Nicolás (1936–2020), Superior General of the Society of Jesus * Eduardo Nicolás (born 1972), Spanish former professional tennis player Other uses * Nicolas (wine retailer), a French chain of wine retailers * ''Le Petit Nicolas'', a series of children's books by René Goscinny See also * San Nicolás (other) * Nicholas (other) * Nicola (other) * Nikola Nikola () is a given name which, like Nicholas, is a version of the Greek '' Nikolaos ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Amos Bairoch
Amos Bairoch (born 22 November 1957) is a Swiss bioinformatician and Professor of Bioinformatics at the Department of Human Protein Sciences of the University of Geneva where he leads the CALIPHO group at the Swiss Institute of Bioinformatics, Swiss Institute of Bioinformatics (SIB) combining bioinformatics, curation, and experimental efforts to functionally characterize human proteins. His father was the economic historian Paul Bairoch. Education His first project as a PhD student was the development of PC/Gene, an MS-DOS–based software package for the analysis of protein and nucleotide sequences. PC/Gene was commercialized, first by a Swiss company (Genofit) then by Intelligenetics in the US which was later bought by Oxford Molecular. Research His main work is in the field of protein sequence analysis and more particularly in the development of databases and software tools for this purpose. His most important contribution is the input of human knowledge by careful manual a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Elisabeth Gasteiger
Elisabeth Gasteiger is a Swiss bioinformatician known for her work in developing and managing tools for protein analysis. Her efforts have been instrumental in advancing proteomics research, particularly through her contributions to the ExPASy (Expert Protein Analysis System), a bioinformatics resource platform. She currently holds the position of Senior User Experience and Support Manager at the Swiss Institute of Bioinformatics (SIB). Career Gasteiger's work at the Swiss Institute of Bioinformatics (SIB) has been instrumental in the development and enhancement of key bioinformatics resources, including the UniProt database, an integrated platform that combines protein sequence data from Swiss-Prot, TrEMBL, and PIR, as well as the ExPASy platform, which provides a suite of tools to support protein sequence analysis and related research. She has played a pivotal role in the development and enhancement of the ExPASy (Expert Protein Analysis System) platform, coordinating soft ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Petra S
Petra (; "Rock"), originally known to its inhabitants as Raqmu (Nabataean: or , *''Raqēmō''), is an ancient city and archaeological site in southern Jordan. Famous for its rock-cut architecture and water conduit systems, Petra is also called the "Rose City" because of the colour of the sandstone from which it is carved. The city is one of the New 7 Wonders of the World and a UNESCO World Heritage Site. The area around Petra has been inhabited from as early as 7000 BC, and was settled by the Nabataeans, a nomadic Arab people, in the 4th century BC. Petra would later become the capital city of the Nabataean Kingdom in the second century BC. The Nabataeans invested in Petra's proximity to the incense trade routes by establishing it as a major regional trading hub, which gained them considerable revenue. Unlike their enemies, the Nabataeans were accustomed to living in the barren deserts and thus were able to defend their kingdom. They were particularly skillful in agricultu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Virginie Bulliard
''Virginie'' is a French-language Canadian television series that aired Monday through Thursday on Radio-Canada (the French-language CBC television network). It debuted in 1996. The show examined the public and private lives of teachers, students, and families at the fictional Sainte-Jeanne-d'Arc high school. It frequently dealt with controversial social topics, such as teen drug use, ethnic prejudice, divorce, and other subjects touching on contemporary Quebec life. "Virginie" was a '' téléroman''-style drama that often used "cliffhangers" in the storylines. It aired 120 episodes per year of 30 minutes each. The series was produced and largely written by Fabienne Larouche. Virginie ended in December 2010 after 15 years on air; the last episode aired on December 15, 2010. The final episode drew more than 807,000 viewers in Quebec, or about 200,000 more than its average viewership for a typical episode. The program maintained a high level of popularity throughout its televisio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alexandre Gattiker , a Portuguese hypocoristic of the name "Alexandre"
{{Disambig ...
Alexandre may refer to: * Alexandre (given name) * Alexandre (surname) * Alexandre (film) See also * Alexander * Alexandra (other) * Xano (other) Xano is the name of: * Xano, a Portuguese hypocoristic of the name " Alexandre (other)" * Idálio Alexandre Ferreira (born 1983), Portuguese footballer known as "Xano", currently playing for Sligo Rovers {{hndis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
