FGI-106 is a broad-spectrum

antiviral drug Antiviral drugs are a class of medication used for treating viral infections. Most antivirals target specific viruses, while a broad-spectrum antiviral is effective against a wide range of viruses. Antiviral drugs are a class of antimicrobials ...

developed as a potential treatment for enveloped RNA viruses, in particular

viral hemorrhagic fever Viral hemorrhagic fevers (VHFs) are a diverse group of diseases. "Viral" means a health problem caused by infection from a virus, " hemorrhagic" means to bleed, and "fever" means an unusually high body temperature. Bleeding and fever are comm ...

s from the bunyavirus,

flavivirus ''Flavivirus'', renamed ''Orthoflavivirus'' in 2023, is a genus of positive-strand RNA viruses in the family ''Flaviviridae''. The genus includes the West Nile virus, dengue virus, tick-borne encephalitis virus, yellow fever virus, Zika viru ...

and

filovirus ''Filoviridae'' () is a family of single-stranded negative-sense RNA viruses in the order ''Mononegavirales''. Two members of the family that are commonly known are Ebola virus and Marburg virus. Both viruses, and some of their lesser known rela ...

families. It acts as an inhibitor which blocks viral entry into host cells. In animal tests FGI-106 shows both prophylactic and curative action against a range of deadly viruses for which few existing treatments are available, including the bunyaviruses

hantavirus ''Orthohantavirus'' is a genus of viruses that includes all hantaviruses (family ''Hantaviridae'') that cause disease in humans. Orthohantaviruses, hereafter referred to as hantaviruses, are naturally found primarily in rodents. In general, each ...

Rift Valley fever virus In geology, a rift is a linear zone where the lithosphere is being pulled apart and is an example of extensional tectonics. Typical rift features are a central linear downfaulted depression, called a graben, or more commonly a half-graben w ...

and Crimean-Congo hemorrhagic fever virus, the flavivirus

dengue virus Dengue virus (DENV) is the cause of dengue fever. It is a mosquito-borne, single positive-stranded RNA virus of the family ''Flaviviridae''; genus '' Flavivirus''. Four serotypes of the virus have been found, and a reported fifth has yet to be ...

, and the filoviruses

Ebola virus ''Orthoebolavirus zairense'' or Zaire ebolavirus, more commonly known as Ebola virus (; EBOV), is one of six known species within the genus ''Ebolavirus''. Four of the six known ebolaviruses, including EBOV, cause a severe and often fatal vira ...

and

Marburg virus Marburg virus (MARV) is a hemorrhagic fever virus of the '' Filoviridae'' family of viruses and a member of the species '' Marburg marburgvirus'', genus '' Marburgvirus''. It causes Marburg virus disease in primates, a form of viral hemorrhag ...

References

Anti–RNA virus drugs Antiviral drugs Ebola Experimental antiviral drugs Nitrogen heterocycles Heterocyclic compounds with 4 rings Dimethylamino compounds {{antiinfective-drug-stub

See also

References