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Hantavirus
''Orthohantavirus'' is a genus of viruses that includes all hantaviruses (family ''Hantaviridae'') that cause disease in humans. Orthohantaviruses, hereafter referred to as hantaviruses, are naturally found primarily in rodents. In general, each hantavirus is carried by one rodent species and each rodent that carries a hantavirus carries one hantavirus species. Hantaviruses in their natural reservoirs usually cause an asymptomatic, persistent infection. In humans, however, hantaviruses cause two diseases: hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). HFRS is mainly caused by hantaviruses in Africa, Asia, and Europe, called Old World hantaviruses, and HPS is usually caused by hantaviruses in the Americas, called New World hantaviruses. Hantaviruses are transmitted mainly through aerosols and droplets that contain rodent excretions, as well as through contaminated food, bites, and scratches. Environmental factors such as rainfall, temperature, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hemorrhagic Fever With Renal Syndrome
Hantavirus hemorrhagic fever with renal syndrome (HFRS) is a hemorrhagic fever caused by hantaviruses. Symptoms usually occur 12–16 days after exposure to the virus and come in five distinct phases: febrile, hypotensive, low urine production (oliguric), high urine production (diuretic), and recovery. Early symptoms include headache, lower back pain, nausea, vomiting, diarrhea, bloody stool, the appearance of spots on the skin, bleeding in the respiratory tract, and renal symptoms such as kidney swelling, excess protein in urine, and blood in urine. During the hypotensive phase, blood pressure lowers due to microvascular leakage. Renal failure then causes the diuretic phase, before recovering and increasing urine production as disease progression improves. The severity of symptoms varies depending on which virus causes HFRS and ranges from a mild illness to severe. The case fatality rate likewise varies by virus, at less than 1% up to 15%. HFRS is caused mainly by four viruses in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hantavirus Pulmonary Syndrome
Hantavirus pulmonary syndrome (HPS), also called hantavirus cardiopulmonary syndrome (HCPS), is a severe respiratory disease caused by hantaviruses. The main features of illness are microvascular leakage and acute respiratory distress syndrome. Symptoms occur anywhere from one to eight weeks after exposure to the virus and come in three distinct phases. First, there is an early phase with flu-like symptoms such as fever, muscle aches, headache, and shortness of breath, as well as low platelet count. Second, there is cardiopulmonary phase during which people experience elevated or irregular heart rate, cardiogenic shock, and pulmonary capillary leakage, which can lead to respiratory failure, low blood pressure, and buildup of fluid in the lungs and chest cavity. The final phase is recovery, which typically takes months, but difficulties with breathing can persist for up to two years. The disease has a case fatality rate of 30 to 60 percent. Death usually occurs suddenly during the c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1993 Four Corners Hantavirus Outbreak
The 1993 Four Corners hantavirus outbreak was an outbreak of Orthohantavirus, hantavirus disease in the United States in the Four Corners region of Arizona, Colorado, and New Mexico. Hantaviruses that cause disease in humans are native to rodents and, before the outbreak, were mainly found in Asia and Europe. Previously, however, they were only known to cause hemorrhagic fever with renal syndrome. The outbreak in the Four Corners region led to the discovery of hantaviruses from the Western Hemisphere that could cause disease and revealed the existence of a second disease caused by hantaviruses: hantavirus pulmonary syndrome (HPS). Thirty-three HPS cases were confirmed in the Four Corners states in 1993, Nationwide, 48 cases were confirmed, 27 of which (56%) resulted in death. The earliest confirmed cases of HPS in 1993 occurred in March, but the outbreak was not discovered until May when a young Navajo couple died within days of each other due to sudden respiratory failure. Inv ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sin Nombre Virus
Sin Nombre virus (SNV) is the most common cause of hantavirus pulmonary syndrome (HPS) in North America. Sin Nombre virus is transmitted mainly by the western deer mouse (''Peromyscus sonoriensis''). In its natural reservoir, SNV causes an asymptomatic, persistent infection and is spread through excretions, fighting, and grooming. Humans can become infected by inhaling aerosols that contain rodent saliva, urine, or feces, as well as through bites and scratches. In humans, infection leads to HPS, an illness characterized by an early phase of mild and moderate symptoms such as fever, headache, and fatigue, followed by sudden respiratory failure. The case fatality rate from infection is 30 to 50 percent. The genome of SNV is about 12.3 kilobases (kb) in length and segmented into three negative-sense, single-stranded RNA (-ssRNA) strands. The small strand encodes the viral nucleoprotein, the medium strand encodes the viral spike protein, which attaches to cell receptors for entry i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Puumala Virus
Puumala virus (PUUV) is the main cause of hemorrhagic fever with renal syndrome (HFRS) in Europe and Russia. Puumala virus is transmitted by the bank vole (''Clethrionomys glareolus''). In its natural reservoir, PUUV causes a persistent infection with few symptoms and is spread through excretions, fighting, and grooming. Humans can become infected by inhaling aerosols that contain rodent saliva, urine, or feces, as well as through bites and scratches. In humans, infection is usually asymptomatic but can lead to a mild form of HFRS often called nephropathia epidemica (NE). Symptoms include fever and headache, impaired vision, as well as the appearance of spots on the skin and renal symptoms such as kidney swelling, excess protein in urine, blood in urine, decreased urine production, and kidney failure. The case fatality rate from infection is less than 1%. The genome of PUUV is about 12 kilobases (kb) in length and segmented into three negative-sense, single-stranded RNA (-ssRNA) ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hantaan Virus
Hantaan virus (HTNV) is the main cause of hemorrhagic fever with renal syndrome (HFRS) in East Asia. Hantaan virus is transmitted by the striped field mouse (''Apodemus agrarius'') In its natural reservoir, HTNV causes a persistent, asymptomatic infection and is spread through excretions, fighting, and grooming. Humans can become infected by inhaling aerosols that contain rodent saliva, urine, or feces, as well as through bites and scratches. In humans, infection causes such as fever and headache, as well as the appearance of spots on the skin, hepatitis, and renal symptoms such as kidney swelling, excess protein in urine, blood in urine, decreased urine production, and kidney failure. Rarely, HTNV infection affects the pituitary gland and can cause empty sella syndrome. The case fatality rate from infection is up to 6.3%. The genome of HTNV is about 11.9 kilobases (kb) in length and segmented into three negative-sense, single-stranded RNA (-ssRNA) strands. The small strand enco ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Seoul Virus
Seoul virus (SEOV) is one of the main causes of hemorrhagic fever with renal syndrome (HFRS). Seoul virus is transmitted by the brown rat (''Rattus norvegicus'') and the black rat (''Rattus rattus''). In its natural reservoirs, SEOV causes an asymptomatic, persistent infection and is spread through excretions, fighting, and grooming. Humans can become infected by inhaling aerosols that contain rodent saliva, urine, or feces, as well as through bites and scratches. In humans, infection leads to HFRS, an illness characterized by general symptoms such as fever and headache, as well as the appearance of spots on the skin and renal symptoms such as kidney swelling, excess protein in urine, blood in urine, decreased urine production, and kidney failure. The case fatality rate from infection is 1–2%. The genome of SEOV is about 12 kilobases (kb) in length and segmented into three negative-sense, single-stranded RNA (-ssRNA) strands. The small strand encodes the viral nucleoprotein, t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dobrava-Belgrade Virus
Dobrava-Belgrade virus (DOBV) is the main cause of hemorrhagic fever with renal syndrome (HFRS) in southern Europe. In its natural reservoirs, DOBV causes a persistent, asymptomatic infection and is spread through excretions, fighting, and grooming. Humans can become infected by inhaling aerosols that contain rodent saliva, urine, or feces, as well as through bites and scratches. In humans, infection causes such as fever and headache, as well as the appearance of spots on the skin and renal symptoms such as kidney swelling, excess protein in urine, blood in urine, decreased urine production, and kidney failure. Acute respiratory distress syndrome occurs in about 10% of cases. DOBV has four genotypes: Dobrava virus, Sochi virus, Kurkino virus, and Saaremaa virus. These genotypes are native to different rodent species and vary in how severe of illness they cause. Dobrava virus is carried by the yellow-necked mouse (''Apodemus flavicollis'') and has moderate-to-severe symptoms with ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Negative-strand RNA Virus
Negative-strand RNA viruses (−ssRNA viruses) are a group of related viruses that have Sense (molecular biology), negative-sense, single-stranded genomes made of ribonucleic acid (RNA). They have genomes that act as complementary strands from which messenger RNA (mRNA) is synthesized by the viral enzyme RNA-dependent RNA polymerase (RdRp). During replication of the viral genome, RdRp synthesizes a positive-sense antigenome that it uses as a template to create genomic negative-sense RNA. Negative-strand RNA viruses also share a number of other characteristics: most contain a viral envelope that surrounds the capsid, which encases the viral genome, −ssRNA virus genomes are usually linear, and it is common for their genome to be segmented. Negative-strand RNA viruses constitute the phylum ''Negarnaviricota'', in the kingdom ''Orthornavirae'' and realm ''Riboviria''. They are descended from a common ancestor that was a Double-stranded RNA viruses, double-stranded RNA (dsRNA) virus ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Natural Reservoir
In Infection, infectious disease ecology and epidemiology, a natural reservoir, also known as a disease reservoir or a reservoir of infection, is the population of organisms or the specific environment in which an infectious pathogen naturally lives and reproduces, or upon which the pathogen primarily depends for its survival. A reservoir is usually a living Host (biology), host of a certain species, such as an animal or a plant, inside of which a pathogen survives, often (though not always) without causing disease for the reservoir itself. By some definitions a reservoir may also be an environment external to an organism, such as a volume of contaminated air or water. Because of the enormous variety of infectious microorganisms capable of causing disease, precise definitions for what constitutes a natural reservoir are numerous, various, and often conflicting. The reservoir concept applies only for pathogens capable of infecting more than one host population and only with respect ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hantaviridae
''Hantaviridae'' is a family of viruses in the order ''Bunyavirales''. It is named for the Hantan River area in South Korea South Korea, officially the Republic of Korea (ROK), is a country in East Asia. It constitutes the southern half of the Korea, Korean Peninsula and borders North Korea along the Korean Demilitarized Zone, with the Yellow Sea to the west and t ... where an early outbreak of one of its species was observed. Taxonomy The family contains the following subfamilies and genera (-''virinae'' denotes subfamily and -''virus'' denotes genus): * '' Actantavirinae'' ** '' Actinovirus'' ** '' Percilovirus'' * '' Agantavirinae'' ** '' Agnathovirus'' * '' Mammantavirinae'' ** '' Loanvirus'' ** '' Mobatvirus'' ** '' Orthohantavirus'' ** '' Thottimvirus'' * '' Repantavirinae'' ** '' Reptillovirus'' References {{Taxonbar, from=Q29001075 Virus families Bunyavirales ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rodent
Rodents (from Latin , 'to gnaw') are mammals of the Order (biology), order Rodentia ( ), which are characterized by a single pair of continuously growing incisors in each of the upper and Mandible, lower jaws. About 40% of all mammal species are rodents. They are native to all major land masses except for Antarctica, and several oceanic islands, though they have subsequently been introduced to most of these land masses by human activity. Rodents are extremely diverse in their ecology and lifestyles and can be found in almost every terrestrial habitat, including human-made environments. Species can be arboreal, fossorial (burrowing), saltatorial/ricochetal (leaping on their hind legs), or semiaquatic. However, all rodents share several morphological features, including having only a single upper and lower pair of ever-growing incisors. Well-known rodents include Mouse, mice, rats, squirrels, prairie dogs, porcupines, beavers, Cavia, guinea pigs, and hamsters. Once included wi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
