Ernst Boris Chain
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Sir Ernst Boris Chain (19 June 1906 – 12 August 1979) was a German-born British biochemist and co-recipient of the
Nobel Prize in Physiology or Medicine The Nobel Prize in Physiology or Medicine () is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, acco ...
for his work on
penicillin Penicillins (P, PCN or PEN) are a group of beta-lactam antibiotic, β-lactam antibiotics originally obtained from ''Penicillium'' Mold (fungus), moulds, principally ''Penicillium chrysogenum, P. chrysogenum'' and ''Penicillium rubens, P. ru ...
.


Life and career

Chain was born in Berlin, the son of Margarete () and Michael Chain, a chemist and industrialist dealing in chemical products. His family was of both
Sephardic Sephardic Jews, also known as Sephardi Jews or Sephardim, and rarely as Iberian Peninsular Jews, are a Jewish diaspora population associated with the historic Jewish communities of the Iberian Peninsula (Spain and Portugal) and their descendant ...
and
Ashkenazi Jewish Ashkenazi Jews ( ; also known as Ashkenazic Jews or Ashkenazim) form a distinct subgroup of the Jewish diaspora, that Ethnogenesis, emerged in the Holy Roman Empire around the end of the first millennium Common era, CE. They traditionally spe ...
descent. His father emigrated from Russia to study chemistry abroad and his mother was from Berlin. In 1930, he received his degree in
chemistry Chemistry is the scientific study of the properties and behavior of matter. It is a physical science within the natural sciences that studies the chemical elements that make up matter and chemical compound, compounds made of atoms, molecules a ...
from Friedrich Wilhelm University. His father descends from Zerahiah ben Shealtiel Ḥen who was a prominent figure among the Catalonian Jewry and whose ancestors were leading Jewish figures in Babylonia. He was a lifelong friend of Professor
Albert Neuberger Albert Neuberger (15 April 1908 – 14 August 1996) was a British Professor of Chemical Pathology, St Mary's Hospital, 1955–1973, and later emeritus professor. Education in Germany Born in Hassfurt, northern Bavaria, the first of the thre ...
, whom he met in Berlin in the 1930s. After the
Nazis Nazism (), formally named National Socialism (NS; , ), is the far-right politics, far-right Totalitarianism, totalitarian socio-political ideology and practices associated with Adolf Hitler and the Nazi Party (NSDAP) in Germany. During H ...
came to power, Chain understood that, being Jewish, he would no longer be safe in Germany. He left Germany and moved to England, arriving on 2 April 1933 with £10 in his pocket. Geneticist and physiologist J. B. S. Haldane helped him obtain a position at
University College Hospital University College Hospital (UCH) is a teaching hospital in the Fitzrovia area of the London Borough of Camden, England. The hospital, which was founded as the North London Hospital in 1834, is closely associated with University College Lo ...
, London. After a couple of months he was accepted as a PhD student at
Fitzwilliam College, Cambridge Fitzwilliam College is a constituent college of the University of Cambridge, England. The college has origins from 1869, with the foundation of the Non-Collegiate Students Board, a venture intended to offer academically excellent students of all ...
, where he began working on
phospholipid Phospholipids are a class of lipids whose molecule has a hydrophilic "head" containing a phosphate group and two hydrophobic "tails" derived from fatty acids, joined by an alcohol residue (usually a glycerol molecule). Marine phospholipids typ ...
s under the direction of Sir
Frederick Gowland Hopkins Sir Frederick Gowland Hopkins (20 June 1861 – 16 May 1947) was an English biochemist who was awarded the Nobel Prize in Physiology or Medicine in 1929, with Christiaan Eijkman, for the discovery of vitamins. He also discovered the amino ...
. In 1935, he accepted a job at
Oxford University The University of Oxford is a collegiate research university in Oxford, England. There is evidence of teaching as early as 1096, making it the oldest university in the English-speaking world and the second-oldest continuously operating u ...
as a lecturer in
pathology Pathology is the study of disease. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in the context of modern medical treatme ...
. During this time he worked on a range of research topics, including
snake venom Snake venom is a highly toxic saliva containing zootoxins that facilitates in the immobilization and digestion of prey. This also provides defense against threats. Snake venom is usually injected by unique fangs during a Snakebite, bite, though ...
s,
tumour A neoplasm () is a type of abnormal and excessive growth of tissue (biology), tissue. The process that occurs to form or produce a neoplasm is called neoplasia. The growth of a neoplasm is uncoordinated with that of the normal surrounding tiss ...
metabolism,
lysozyme Lysozyme (, muramidase, ''N''-acetylmuramide glycanhydrolase; systematic name peptidoglycan ''N''-acetylmuramoylhydrolase) is an antimicrobial enzyme produced by animals that forms part of the innate immune system. It is a glycoside hydrolase ...
s, and
biochemistry Biochemistry, or biological chemistry, is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology, a ...
techniques. Chain was naturalised as a
British subject The term "British subject" has several different meanings depending on the time period. Before 1949, it referred to almost all subjects of the British Empire (including the United Kingdom, Dominions, and colonies, but excluding protectorates ...
in April 1939. In 1939, he joined
Howard Florey Howard Walter Florey, Baron Florey, (; 24 September 1898 – 21 February 1968) was an Australian pharmacologist and pathologist who shared the Nobel Prize in Physiology or Medicine in 1945 with Ernst Chain and Sir Alexander Fleming for his ro ...
to investigate natural antibacterial agents produced by
microorganism A microorganism, or microbe, is an organism of microscopic scale, microscopic size, which may exist in its unicellular organism, single-celled form or as a Colony (biology)#Microbial colonies, colony of cells. The possible existence of unseen ...
s. This led him and Florey to revisit the work of
Alexander Fleming Sir Alexander Fleming (6 August 1881 – 11 March 1955) was a Scottish physician and microbiologist, best known for discovering the world's first broadly effective antibiotic substance, which he named penicillin. His discovery in 1928 of wha ...
, who had described
penicillin Penicillins (P, PCN or PEN) are a group of beta-lactam antibiotic, β-lactam antibiotics originally obtained from ''Penicillium'' Mold (fungus), moulds, principally ''Penicillium chrysogenum, P. chrysogenum'' and ''Penicillium rubens, P. ru ...
nine years earlier. Chain and Florey went on to discover penicillin's therapeutic action and its chemical composition. Chain and Florey discovered how to isolate and concentrate the germ-killing agent in penicillin. For this research, Chain, Florey, and Fleming received the Nobel Prize in 1945. Along with
Edward Abraham Sir Edward Penley Abraham, (10 June 1913 – 8 May 1999) was an English biochemist instrumental in the development of the first antibiotics penicillin and cephalosporin. Early life and education Abraham was born on 10 June 1913 at 47 South V ...
he was also involved in theorising the beta-lactam structure of penicillin in 1942, which was confirmed by
X-ray crystallography X-ray crystallography is the experimental science of determining the atomic and molecular structure of a crystal, in which the crystalline structure causes a beam of incident X-rays to Diffraction, diffract in specific directions. By measuring th ...
done by
Dorothy Hodgkin Dorothy Mary Crowfoot Hodgkin (née Crowfoot; 12 May 1910 – 29 July 1994) was a Nobel Prize-winning English chemist who advanced the technique of X-ray crystallography to determine the structure of biomolecules, which became essential for ...
in 1945. Towards the end of World War II, Chain learned his mother and sister had been killed by the Nazis. After World War II, Chain moved to Rome, to work at the Istituto Superiore di Sanità (Superior Institute of Health). He returned to Britain in 1964 as the founder and head of the biochemistry department at
Imperial College London Imperial College London, also known as Imperial, is a Public university, public research university in London, England. Its history began with Prince Albert of Saxe-Coburg and Gotha, Prince Albert, husband of Queen Victoria, who envisioned a Al ...
, where he stayed until his retirement, specialising in fermentation technologies. On 17 March 1948 Chain was appointed a
Fellow of the Royal Society Fellowship of the Royal Society (FRS, ForMemRS and HonFRS) is an award granted by the Fellows of the Royal Society of London to individuals who have made a "substantial contribution to the improvement of natural science, natural knowledge, incl ...
. In spite of his successful scientific career and widespread recognition from his Nobel Prize, Chain was for some time barred from entry to the United States under the
McCarran Internal Security Act The Internal Security Act of 1950, (Public Law 81-831), also known as the Subversive Activities Control Act of 1950, the McCarran Act after its principal sponsor Sen. Pat McCarran (D-Nevada), or the Concentration Camp Law, is a United States f ...
of 1950, being declined a visa on two occasions in 1951. In 1948, he married Anne Beloff, sister of Renee Beloff, Max Beloff, John Beloff and Nora Beloff, and a biochemist of significant standing herself. In his later life, his Jewish identity became increasingly important to him. Chain was an ardent Zionist and he became a member of the board of governors of the
Weizmann Institute of Science The Weizmann Institute of Science ( ''Machon Weizmann LeMada'') is a Public university, public research university in Rehovot, Israel, established in 1934, fourteen years before the State of Israel was founded. Unlike other List of Israeli uni ...
at
Rehovot Rehovot (, / ) is a city in the Central District (Israel), Central District of Israel, about south of Tel Aviv. In it had a population of . Etymology Israel Belkind, founder of the Bilu (movement), Bilu movement, proposed the name "Rehovot ...
in 1954, and later a member of the executive council. He raised his children securely within the Jewish faith, arranging much extracurricular tuition for them. His views were expressed most clearly in his speech 'Why I am a Jew' given at the World Jewish Congress Conference of Intellectuals in 1965. Chain was appointed
Knight Bachelor The title of Knight Bachelor is the basic rank granted to a man who has been knighted by the monarch but not inducted as a member of one of the organised Order of chivalry, orders of chivalry; it is a part of the Orders, decorations, and medals ...
in the 1969 Birthday Honours. Chain died in 1979 at the Mayo General Hospital in
Castlebar Castlebar () is the county town of County Mayo, Ireland. Developing around a 13th-century castle of the de Barry family, from which the town got its name, the town now acts as a social and economic focal point for the surrounding hinterland. Wi ...
, Ireland. The
Imperial College London Imperial College London, also known as Imperial, is a Public university, public research university in London, England. Its history began with Prince Albert of Saxe-Coburg and Gotha, Prince Albert, husband of Queen Victoria, who envisioned a Al ...
biochemistry building is named after him, as is a road in
Castlebar Castlebar () is the county town of County Mayo, Ireland. Developing around a 13th-century castle of the de Barry family, from which the town got its name, the town now acts as a social and economic focal point for the surrounding hinterland. Wi ...
.


See also

* List of Jewish Nobel laureates


References


Bibliography

*


External links

* including the Nobel Lecture, 20 March 1946 ''The Chemical Structure of the Penicillins'' * * {{DEFAULTSORT:Chain, Ernst Boris 1906 births 1979 deaths Nobel laureates in Physiology or Medicine British Nobel laureates Academics of Imperial College London Fellows of Fitzwilliam College, Cambridge 20th-century German chemists Jewish chemists Jewish creationists Jewish emigrants from Nazi Germany to the United Kingdom Jewish Nobel laureates Knights Bachelor People of Sephardic-Jewish descent Fellows of the Royal Society Members of the French Academy of Sciences Naturalised citizens of the United Kingdom British people of Russian-Jewish descent Beloff family Recipients of the Order of the Rising Sun, 2nd class British expatriates in Italy Physicians of the Charité Jewish British scientists Fellows of the Royal Society of Arts