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Edward Abraham
Sir Edward Penley Abraham, (10 June 1913 – 8 May 1999) was an English biochemist instrumental in the development of the first antibiotics penicillin and cephalosporin. Early life and education Abraham was born on 10 June 1913 at 47 South View Road, Shirley, Southampton. From 1924 Abraham attended King Edward VI School, Southampton, before achieving a First in Chemistry at The Queen's College, Oxford. Abraham completed his DPhil at the University of Oxford under the supervision of Sir Robert Robinson, during which he was the first to crystallise lysozyme, an enzyme discovered by Sir Alexander Fleming and shown to have antibacterial properties, and was later the first enzyme to have its structure solved using X-ray crystallography, by Lord David Phillips. Research In 1938 Abraham won a Rockefeller Foundation travel fellowship and spent a year in Stockholm at the Biokemiska Institut. He then moved back to Oxford and became part of a research team led by Sir Howard ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Shirley, Southampton
Shirley is a broad district and a former village on the western side of Southampton, in the ceremonial county of Hampshire, England. Shirley's main roles are retailing and residential. It is the most important suburban shopping area in the west of the city. Housing is a mixture of council houses in the centre of the district surrounded by private housing, with larger suburban houses concentrated in Upper Shirley. Shirley is separated from Highfield, Hampshire, Highfield by Southampton Common, a large green public space. History The Lower Palaeolithic is represented at Shirley, a small number of Acheulian hand-axes and associated implements have been found. Other finds include an adze, adze head from the Neolithic. The place-name Shirley commonly means "bright clearing", from the Old English language, Old English English orthography, very similarly pronounced ''scir'' (bright) and ''leah'' (cleared land in a wood). Shirley is recorded as a manor with a mill in the Domesday Boo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Doctor Of Philosophy
A Doctor of Philosophy (PhD, DPhil; or ) is a terminal degree that usually denotes the highest level of academic achievement in a given discipline and is awarded following a course of Postgraduate education, graduate study and original research. The name of the degree is most often abbreviated PhD (or, at times, as Ph.D. in North American English, North America), pronounced as three separate letters ( ). The University of Oxford uses the alternative abbreviation "DPhil". PhDs are awarded for programs across the whole breadth of academic fields. Since it is an earned research degree, those studying for a PhD are required to produce original research that expands the boundaries of knowledge, normally in the form of a Thesis, dissertation, and, in some cases, defend their work before a panel of other experts in the field. In many fields, the completion of a PhD is typically required for employment as a university professor, researcher, or scientist. Definition In the context o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lincoln College, Oxford
Lincoln College (formally, The College of the Blessed Mary and All Saints, Lincoln) is a Colleges of the University of Oxford, constituent college of the University of Oxford, in the United Kingdom. Lincoln was founded in 1427 by Richard Fleming (bishop), Richard Fleming, the then Bishop of Lincoln, who obtained a charter for the college from King Henry VI. The college is situated on Turl Street in central Oxford and has three quadrangle (architecture), quadrangles. The first quadrangle dates from the 15th century, with the second Chapel quadrangle added in the early 17th century and The Grove added in the 19th century. The college library is located in the converted 18th-century All Saints' Church, Oxford, All Saints' Church which became part of the college in 1971. Its sister college is Downing College, Cambridge. Mensa International, Mensa, the oldest high-IQ society in the world, was founded at the college in 1946. The Rector (academic), Rector of the college is former pres ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dorothy Hodgkin
Dorothy Mary Crowfoot Hodgkin (née Crowfoot; 12 May 1910 – 29 July 1994) was a Nobel Prize-winning English chemist who advanced the technique of X-ray crystallography to determine the structure of biomolecules, which became essential for structural biology. Among her most influential discoveries are the confirmation of the structure of penicillin as previously surmised by Edward Abraham and Ernst Boris Chain; and mapping the structure of vitamin B12, vitamin B12, for which in 1964 she became the third woman to win the Nobel Prize in Chemistry. Hodgkin also elucidated the structure of insulin in 1969 after 35 years of work. Hodgkin used the name "Dorothy Crowfoot" until twelve years after marrying Thomas Lionel Hodgkin, when she began using "Dorothy Crowfoot Hodgkin". Hodgkin is referred to as "Dorothy Hodgkin" by the Royal Society (when referring to its sponsorship of the Dorothy Hodgkin fellowship), and by Somerville College. The National Archives (United Kingdom), The ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ernst Boris Chain
Sir Ernst Boris Chain (19 June 1906 – 12 August 1979) was a German-born British biochemist and co-recipient of the Nobel Prize in Physiology or Medicine for his work on penicillin. Life and career Chain was born in Berlin, the son of Margarete () and Michael Chain, a chemist and industrialist dealing in chemical products. His family was of both Sephardic and Ashkenazi Jewish descent. His father emigrated from Russia to study chemistry abroad and his mother was from Berlin. In 1930, he received his degree in chemistry from Friedrich Wilhelm University. His father descends from Zerahiah ben Shealtiel Ḥen who was a prominent figure among the Catalonian Jewry and whose ancestors were leading Jewish figures in Babylonia. He was a lifelong friend of Professor Albert Neuberger, whom he met in Berlin in the 1930s. After the Nazis came to power, Chain understood that, being Jewish, he would no longer be safe in Germany. He left Germany and moved to England, arriving on 2 Apri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Penicillinase
Beta-lactamases (β-lactamases) are enzymes () produced by bacteria that provide multi-resistance to beta-lactam antibiotics such as penicillins, cephalosporins, cephamycins, monobactams and carbapenems ( ertapenem), although carbapenems are relatively resistant to beta-lactamase. Beta-lactamase provides antibiotic resistance by breaking the antibiotics' structure. These antibiotics all have a common element in their molecular structure: a four-atom ring known as a beta-lactam (β-lactam) ring. Through hydrolysis, the enzyme lactamase breaks the β-lactam ring open, deactivating the molecule's antibacterial properties. Beta-lactamases produced by gram-negative bacteria are usually secreted, especially when antibiotics are present in the environment. Structure The structure of a ''Streptomyces'' serine β-lactamase (SBLs) is given by . The alpha-beta fold () resembles that of a DD-transpeptidase, from which the enzyme is thought to have evolved. β-lactam antibioti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chemical Structure
A chemical structure of a molecule is a spatial arrangement of its atoms and their chemical bonds. Its determination includes a chemist's specifying the molecular geometry and, when feasible and necessary, the electronic structure of the target molecule or other solid. Molecular geometry refers to the spatial arrangement of atoms in a molecule and the chemical bonds that hold the atoms together and can be represented using structural formulae and by molecular models; complete electronic structure descriptions include specifying the occupation of a molecule's molecular orbitals. Structure determination can be applied to a range of targets from very simple molecules (e.g., diatomic oxygen or nitrogen) to very complex ones (e.g., such as protein or DNA). Background Theories of chemical structure were first developed by August Kekulé, Archibald Scott Couper, and Aleksandr Butlerov, among others, from about 1858. These theories were first to state that chemical compounds are not a ran ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sir William Dunn School Of Pathology
The Sir William Dunn School of Pathology is a department within the University of Oxford. Its research programme includes the cellular and molecular biology of pathogens, the immune response, cancer and cardiovascular disease. It teaches undergraduate and graduate courses in the medical sciences. The school is named for Sir William Dunn, 1st Baronet, of Lakenheath, whose will provided the initial funding. It is located towards the east end of South Parks Road, to the north of the city centre. __TOC__ History The first course of Pathology teaching in the University of Oxford was given in 1894 by Professor John Burdon Sanderson, Professor of Physiology, (Regius Professor of Medicine from 1895 to 1905), and Dr James Ritchie, who, in 1897, was appointed as the first University Lecturer in Pathology. The first Department of Pathology was opened in 1901 and functioned until 1927 when it was handed over to Pharmacology on completion of the new purpose-built Sir William Dunn School ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Howard Florey
Howard Walter Florey, Baron Florey, (; 24 September 1898 – 21 February 1968) was an Australian pharmacologist and pathologist who shared the Nobel Prize in Physiology or Medicine in 1945 with Ernst Chain and Sir Alexander Fleming for his role in the development of penicillin. Although Fleming received most of the credit for the discovery of penicillin, it was Florey and his team at the University of Oxford who made it into a useful and effective drug, ten years after Fleming had abandoned its development. They developed techniques for growing, purifying and manufacturing the drug, tested it for toxicity and efficacy on animals, and carried out the first clinical trials. In 1941, they used it to treat a police constable from Oxford. He started to recover, but subsequently died because Florey was unable, at that time, to make enough penicillin. Later trials in Britain, the United States and North Africa were highly successful. A graduate of the University of Adelaide, Florey ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stockholm
Stockholm (; ) is the Capital city, capital and List of urban areas in Sweden by population, most populous city of Sweden, as well as the List of urban areas in the Nordic countries, largest urban area in the Nordic countries. Approximately 1 million people live in the Stockholm Municipality, municipality, with 1.6 million in the Stockholm urban area, urban area, and 2.5 million in the Metropolitan Stockholm, metropolitan area. The city stretches across fourteen islands where Mälaren, Lake Mälaren flows into the Baltic Sea. Outside the city to the east, and along the coast, is the island chain of the Stockholm archipelago. The area has been settled since the Stone Age, in the 6th millennium BC, and was founded as a city in 1252 by Swedish statesman Birger Jarl. The city serves as the county seat of Stockholm County. Stockholm is the cultural, media, political, and economic centre of Sweden. The Stockholm region alone accounts for over a third of the country's Gros ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rockefeller Foundation
The Rockefeller Foundation is an American private foundation and philanthropic medical research and arts funding organization based at 420 Fifth Avenue, New York City. The foundation was created by Standard Oil magnate John D. Rockefeller ("Senior") and son " Junior", and their primary business advisor, Frederick Taylor Gates, on May 14, 1913, when its charter was granted by New York. It is the second-oldest major philanthropic institution in America (after the Carnegie Corporation) and ranks as the 30th largest foundation globally by endowment, with assets of over $6.3 billion in 2022. The Rockefeller Foundation is legally independent from other Rockefeller entities, including the Rockefeller University and Rockefeller Center, and operates under the oversight of its own independent board of trustees, with its own resources and distinct mission. Since its inception, the foundation has donated billions of dollars to various causes, becoming the largest philanthropic enter ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
