Cynthia Jane Kenyon (born February 21, 1954) is an American

molecular biologist Molecular biology is a branch of biology that seeks to understand the molecule, molecular basis of biological activity in and between Cell (biology), cells, including biomolecule, biomolecular synthesis, modification, mechanisms, and interactio ...

and

biogerontologist Biogerontology is the sub-field of gerontology concerned with the biological aging process, its evolutionary origins, and potential means to intervene in the process. The term "biogerontology" was coined by S. Rattan, and came in regular use wi ...

known for her genetic dissection of

aging Ageing (or aging in American English) is the process of becoming Old age, older until death. The term refers mainly to humans, many other animals, and fungi; whereas for example, bacteria, perennial plants and some simple animals are potentiall ...

in a widely used

model organism A model organism is a non-human species that is extensively studied to understand particular biological phenomena, with the expectation that discoveries made in the model organism will provide insight into the workings of other organisms. Mo ...

, the roundworm ''

Caenorhabditis elegans ''Caenorhabditis elegans'' () is a free-living transparent nematode about 1 mm in length that lives in temperate soil environments. It is the type species of its genus. The name is a Hybrid word, blend of the Greek ''caeno-'' (recent), ''r ...

''. She is the vice president of aging research at Calico Research Labs, and emeritus professor of biochemistry and biophysics at the

University of California, San Francisco The University of California, San Francisco (UCSF) is a Public university, public Land-grant university, land-grant research university in San Francisco, California, United States. It is part of the University of California system and is dedic ...

(

UCSF The University of California, San Francisco (UCSF) is a public land-grant research university in San Francisco, California, United States. It is part of the University of California system and is dedicated entirely to health science and life ...

Career

Cynthia Kenyon graduated valedictorian in chemistry and biochemistry from the

University of Georgia The University of Georgia (UGA or Georgia) is a Public university, public Land-grant university, land-grant research university with its main campus in Athens, Georgia, United States. Chartered in 1785, it is the oldest public university in th ...

in 1976. She received her Ph.D. in 1981 from

MIT The Massachusetts Institute of Technology (MIT) is a private research university in Cambridge, Massachusetts, United States. Established in 1861, MIT has played a significant role in the development of many areas of modern technology and sc ...

where, in Graham Walker's laboratory, she looked for genes on the basis of their activity profiles, discovering that

DNA Deoxyribonucleic acid (; DNA) is a polymer composed of two polynucleotide chains that coil around each other to form a double helix. The polymer carries genetic instructions for the development, functioning, growth and reproduction of al ...

-damaging agents activate a battery of

DNA repair DNA repair is a collection of processes by which a cell (biology), cell identifies and corrects damage to the DNA molecules that encode its genome. A weakened capacity for DNA repair is a risk factor for the development of cancer. DNA is cons ...

genes in

E. coli ''Escherichia coli'' ( )Wells, J. C. (2000) Longman Pronunciation Dictionary. Harlow ngland Pearson Education Ltd. is a gram-negative, facultative anaerobic, rod-shaped, coliform bacterium of the genus ''Escherichia'' that is commonly foun ...

. She then did postdoctoral studies with Nobel laureate

Sydney Brenner Sydney Brenner (13 January 1927 – 5 April 2019) was a South African biologist. In 2002, he shared the Nobel Prize in Physiology or Medicine with H. Robert Horvitz and Sir John E. Sulston. Brenner made significant contributions to wo ...

at the

MRC Laboratory of Molecular Biology The Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) is a research institute in Cambridge, England, involved in the revolution in molecular biology which occurred in the 1950–60s. Since then it has remained a major medical r ...

Cambridge Cambridge ( ) is a List of cities in the United Kingdom, city and non-metropolitan district in the county of Cambridgeshire, England. It is the county town of Cambridgeshire and is located on the River Cam, north of London. As of the 2021 Unit ...

, England, studying the development of ''C. elegans.'' Since 1986 she has been at the UCSF, where she was the

Herbert Boyer Herbert Wayne "Herb" Boyer (born July 10, 1936) is an American biotechnologist, researcher and entrepreneur in biotechnology. Along with Stanley N. Cohen and Paul Berg, he discovered recombinant DNA, a method to coax bacteria into producing for ...

Distinguished Professor of

Biochemistry Biochemistry, or biological chemistry, is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology, a ...

and

Biophysics Biophysics is an interdisciplinary science that applies approaches and methods traditionally used in physics to study biological phenomena. Biophysics covers all scales of biological organization, from molecular to organismic and populations ...

and is now an

American Cancer Society The American Cancer Society (ACS) is a nationwide non-profit organization dedicated to eliminating cancer. The ACS publishes the journals ''Cancer'', '' CA: A Cancer Journal for Clinicians'' and '' Cancer Cytopathology''. History The society w ...

Professor. In 1999, she co founded-

Elixir Pharmaceuticals An elixir is a sweet liquid used for medical purposes, to be taken orally and intended to cure one's illness. When used as a pharmaceutical preparation, an elixir contains at least one active ingredient designed to be taken orally. Etymolog ...

with

Leonard Guarente Leonard Pershing Guarente (born 1952) is an American biologist best known for his research on life span extension in the budding yeast ''Saccharomyces cerevisiae'', roundworms (''Caenorhabditis elegans''), and mice. He is a Novartis Professor o ...

to try to discover and develop drugs that would slow down the process that makes people age. In April 2014, Kenyon was named Vice President of Aging Research at

Calico Calico (; in British usage since 1505) is a heavy plain-woven textile made from unbleached, and often not fully processed, cotton. It may also contain unseparated husk parts. The fabric is far coarser than muslin, but less coarse and thick than ...

, a new company focused on health, well-being, and longevity. Prior to that, she served as a part-time advisor beginning in November 2013. Kenyon remains affiliated with UCSF as an emeritus professor. Her early work led to the discovery that

Hox gene Hox genes, a subset of homeobox, homeobox genes, are a gene cluster, group of related genes that Evolutionary developmental biology, specify regions of the body plan of an embryo along the craniocaudal axis, head-tail axis of animals. Hox protein ...

s, which were known to pattern the body segments of the fruit fly (''Drosophila'') also pattern the body of ''C. elegans''. These findings demonstrated that Hox genes were not simply involved in segmentation, as thought, but instead were part of a much more ancient and fundamental

metazoan Animals are multicellular, eukaryotic organisms in the biological kingdom Animalia (). With few exceptions, animals consume organic material, breathe oxygen, have myocytes and are able to move, can reproduce sexually, and grow from a ho ...

patterning system. Michael Klass discovered that lifespan of ''C. elegans'' could be altered by mutations, but Klass believed that the effect was due to reduced food consumption (

caloric restriction Calorie restriction (CR, also known as caloric restriction or energy restriction) is a dietary regimen that reduces the energy intake from foods and beverages without incurring malnutrition. The possible effect of calorie restriction on body we ...

). Thomas Johnson later showed that the 65%

life extension Life extension is the concept of extending the human lifespan, either modestly through improvements in medicine or dramatically by increasing the maximum lifespan beyond its generally-settled biological limit of around 125 years. Several resea ...

effect was due to the mutation itself rather than due to caloric restriction. In 1993, Kenyon's discovery that a single-gene mutation (

Daf-2 The DAF-2 gene encodes for the insulin-like growth factor 1 (IGF-1) receptor in the worm ''Caenorhabditis elegans''. DAF-2 is part of the first metabolic pathway discovered to regulate the rate of aging. DAF-2 is also known to regulate reproducti ...

) could double the lifespan of ''C. elegans'' and that this could be reversed by a second mutation in

daf-16 DAF-16 is the sole Homology (biology)#Orthology, ortholog of the FOX proteins, FOXO family of transcription factors in the nematode ''Caenorhabditis elegans''. It is responsible for activating genes involved in longevity, lipogenesis, heat shock ...

m, sparked an intensive study of the molecular biology of aging, including work by

and David Sinclair. Kenyon's findings have led to the discovery that an evolutionarily conserved hormone signaling system influences aging in other organisms, perhaps also including mammals.

Awards and honors

* 1997 Member,

American Academy of Arts and Sciences The American Academy of Arts and Sciences (The Academy) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and other ...

* 2000

King Faisal Prize The King Faisal Prize (, formerly King Faisal International Prize), is an annual award sponsored by King Faisal Foundation presented to "dedicated men and women whose contributions make a positive difference". The foundation awards prizes in fiv ...

for Medicine * 2003 Member,

United States National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nati ...

* 2003 President,

Genetics Society of America The Genetics Society of America (GSA) is a scholarly membership society of more than 5,500 genetics researchers and educators, established in 1931. The Society was formed from the reorganization of the Joint Genetics Sections of the American Soc ...

* 2004

Association of American Medical Colleges Association may refer to: *Club (organization), an association of two or more people united by a common interest or goal *Trade association, an organization founded and funded by businesses that operate in a specific industry * Voluntary associati ...

Award for Distinguished Research * 2005 Ilse & Helmut Wachter Award for Exceptional Scientific Achievement * 2006 La Fondation IPSEN Prize in Longevity * 2008

AARP AARP, formerly the American Association of Retired Persons, is an interest group in the United States focusing on issues affecting those 50 and older. The organization, which is headquartered in Washington, D.C., said it had more than 38 ...

Inspire Award * 2011

Dan David Prize The Dan David Prize is an international group of awards that recognize and support outstanding contributions to the study of history and other disciplines that shed light on the human past. Nine prizes of $300,000 are awarded each year to outstand ...

for the Future – Aging: Facing the Challenge * 2021

Dickson Prize The Dickson Prize in Medicine and the Dickson Prize in Science were both established in 1969 by Joseph Z. Dickson and Agnes Fischer Dickson. Dickson Prize in Medicine The Dickson Prize in Medicine is awarded annually by the University of Pittsbur ...

in Medicine.

Personal diet

Kenyon's research prompted her to make personal dietary changes. In 2000, when she discovered that putting sugar on the worms' food shortened their lifespans, she stopped eating high

glycemic index The glycemic (glycaemic) index (GI; ) is a number from 0 to 100 assigned to a food, with pure glucose arbitrarily given the value of 100, which represents the relative rise in the blood glucose level two hours after consuming that food. The GI of ...

carbohydrates and started eating a

low-carbohydrate diet Low-carbohydrate diets restrict carbohydrate consumption relative to the average diet (nutrition), diet. Foods high in carbohydrates (e.g., sugar, bread, pasta) are limited, and replaced with foods containing a higher percentage of fat and pro ...

. She briefly experimented with a

calorie restriction Calorie restriction (CR, also known as caloric restriction or energy restriction) is a dietary regimen that reduces the energy intake from foods and beverages without incurring malnutrition. The possible effect of calorie restriction on body w ...

diet for two days, but couldn't stand the constant hunger.

Bibliography

* Old World: Project Syndicate's Special Supplement on Aging * The Harvey Lectures 2004-2005

References

External links