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Leonard Guarente
Leonard Pershing Guarente (born 1952) is an American biologist best known for his research on life span extension in the budding yeast ''Saccharomyces cerevisiae'', roundworms (''Caenorhabditis elegans''), and mice. He is a Novartis Professor of Biology at the Massachusetts Institute of Technology. Early life and education Leonard Guarente was born and raised in Revere, Massachusetts and was the first person in his family to attend college, when he started his undergraduate work at MIT in 1970. He earned his Ph.D. at MIT, studying under Jon Beckwith and Mark Ptashne. He did a post doc at Harvard. Science MIT hired Guarente and he opened his own lab in 1981; he earned tenure there in 1986. For the first nine years, his lab studied gene regulation in yeast. In 1991 his lab started to study genes involved in aging. In 1993, Cynthia Kenyon's lab at UCSF discovered that a single-gene mutation in ( Daf-2) could double the lifespan of ''C. elegans''. That same year, David ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Revere, Massachusetts
Revere (, ) is a city in Suffolk County, Massachusetts. Located approximately northeast of Downtown Boston, Revere is the terminus of the Blue Line (MBTA), MBTA Blue Line, with three stations located within the city: Wonderland station, Wonderland, Revere Beach station, Revere Beach, and Beachmont station, Beachmont. The city borders Massachusetts Bay, and was the site of the Battle of Chelsea Creek. Revere Beach, a three mile (4.8 km) stretch of beach on the city's eastern coast, is the oldest public beach in the United States. Revere is one of the oldest communities in the United States. Originally known as Rumney Marsh, in reference to the 600-acre salt marsh located within the Saugus, Massachusetts, Saugus and Pines River Inlet, present-day Revere was part of Boston from 1632 until 1739, when it became part of Chelsea. Revere and neighboring, present-day Winthrop, Massachusetts, Winthrop separated from Chelsea, Massachusetts, Chelsea and were established as the town of North ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
David Andrew Sinclair
David Andrew Sinclair (born June 26, 1969) is an Australian-American biologist and academic known for his research on aging and epigenetics. Sinclair is a professor of genetics at Harvard Medical School and the founding director of the Paul F. Glenn Laboratories for the Biological Mechanisms of Aging at Harvard. He is the co-author of '' Lifespan: Why We Age – and Why We Don't Have To.'' Early life and education David Andrew Sinclair was born in Australia in 1969 and grew up in St Ives, New South Wales. His paternal grandmother had emigrated to Australia following the suppression of the Hungarian Uprising of 1956, and his father changed the family name from Szigeti to Sinclair. Sinclair studied at the University of New South Wales, Sydney, obtaining a bachelor of science in biochemistry in 1991 and a Ph.D. in molecular genetics in 1995, focusing on gene regulation in yeast. He also won the Australian Commonwealth Prize. Career Sinclair met Massachusetts Institute of Techno ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Living People
Purpose: Because living persons may suffer personal harm from inappropriate information, we should watch their articles carefully. By adding an article to this category, it marks them with a notice about sources whenever someone tries to edit them, to remind them of WP:BLP (biographies of living persons) policy that these articles must maintain a neutral point of view, maintain factual accuracy, and be properly sourced. Recent changes to these articles are listed on Special:RecentChangesLinked/Living people. Organization: This category should not be sub-categorized. Entries are generally sorted by family name In many societies, a surname, family name, or last name is the mostly hereditary portion of one's personal name that indicates one's family. It is typically combined with a given name to form the full name of a person, although several give .... Maintenance: Individuals of advanced age (over 90), for whom there has been no new documentation in the last ten ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
21st-century American Biologists
File:1st century collage.png, From top left, clockwise: Jesus is crucified by Roman authorities in Judaea (17th century painting). Four different men (Galba, Otho, Vitellius, and Vespasian) claim the title of Emperor within the span of a year; The Great Fire of Rome (18th-century painting) sees the destruction of two-thirds of the city, precipitating the empire's first persecution against Christians, who are blamed for the disaster; The Roman Colosseum is built and holds its inaugural games; Roman forces besiege Jerusalem during the First Jewish–Roman War (19th-century painting); The Trưng sisters lead a rebellion against the Chinese Han dynasty (anachronistic depiction); Boudica, queen of the British Iceni leads a rebellion against Rome (19th-century statue); Knife-shaped coin of the Xin dynasty., 335px rect 30 30 737 1077 Crucifixion of Jesus rect 767 30 1815 1077 Year of the Four Emperors rect 1846 30 3223 1077 Great Fire of Rome rect 30 1108 1106 2155 Boudican revolt ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1952 Births
Events January–February * January 26 – Cairo Fire, Black Saturday in Kingdom of Egypt, Egypt: Rioters burn Cairo's central business district, targeting British and upper-class Egyptian businesses. * February 6 ** Princess Elizabeth, Duchess of Edinburgh, becomes monarch of the United Kingdom of Great Britain and Northern Ireland and the British Dominions: Canada, Australia, New Zealand, Union of South Africa, South Africa, Dominion of Pakistan, Pakistan and Dominion of Ceylon, Ceylon. The princess, who is on a visit to Kenya when she hears of the death of her father, King George VI, aged 56, takes the regnal name Elizabeth II. ** In the United States, a Artificial heart, mechanical heart is used for the first time in a human patient. *February 7 – New York City announces its first crosswalk devices to be installed. * February 14–February 25, 25 – The 1952 Winter Olympics, Winter Olympics are held in Oslo, Norway. * February 15 – The State Funeral of King Ge ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Elysium Health
Elysium Health is an American manufacturer of dietary supplements based in New York City. History Elysium Health was founded in 2014 by Leonard Guarente, Dan Alminana, and Eric Marcotulli. In 2015, Elysium introduced its first product, Basis, which contains nicotinamide riboside and pterostilbene. In December 2016, Elysium received an investment of $20 million in Series B funding. In 2019, Elysium introduced a test called Index that uses epigenetic analysis on saliva samples to estimate biological age. In June 2020, Elysium launched a supplement called ''Matter'', which purports to maintain brain health and slow brain aging/atrophy. In October 2021, Elysium launched a supplement called Format, which is associated with anti-aging and immune system support. In 2023, Elysium launched a daily supplement called ''Mosaic'', which claims to prevent skin aging and protect collagen. In October 2024, Elysium introduced a daily supplement called ''Vision'', to maintain macular healt ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dietary Supplement
A dietary supplement is a manufactured product intended to supplement a person's diet by taking a pill (pharmacy), pill, capsule (pharmacy), capsule, tablet (pharmacy), tablet, powder, or liquid. A supplement can provide nutrients either extracted from food sources, or that are synthetic (to increase the quantity of their consumption). The classes of nutrient compounds in supplements include vitamins, Dietary mineral, minerals, Dietary fiber, fiber, fatty acids, and amino acids. Dietary supplements can also contain substances that have not been confirmed as being essential to life, and so are not ''nutrients'' per se, but are marketed as having a beneficial biological effect, such as plant pigments or polyphenols. Animals can also be a source of supplement ingredients, such as collagen from chickens or fish for example. These are also sold individually and in combination, and may be combined with nutrient ingredients. The European Commission has also established harmonize ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drosophila Melanogaster
''Drosophila melanogaster'' is a species of fly (an insect of the Order (biology), order Diptera) in the family Drosophilidae. The species is often referred to as the fruit fly or lesser fruit fly, or less commonly the "vinegar fly", "pomace fly", or "banana fly". In the wild, ''D. melanogaster'' are attracted to rotting fruit and fermenting beverages, and are often found in orchards, kitchens and pubs. Starting with Charles W. Woodworth's 1901 proposal of the use of this species as a model organism, ''D. melanogaster'' continues to be widely used for biological research in genetics, physiology, microbial pathogenesis, and Life history theory, life history evolution. ''D. melanogaster'' was the first animal to be Fruit flies in space, launched into space in 1947. As of 2017, six Nobel Prizes have been awarded to drosophilists for their work using the insect. ''Drosophila melanogaster'' is typically used in research owing to its rapid life cycle, relatively simple genetics with on ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
NAD+
Nicotinamide adenine dinucleotide (NAD) is a coenzyme central to metabolism. Found in all living cells, NAD is called a dinucleotide because it consists of two nucleotides joined through their phosphate groups. One nucleotide contains an adenine nucleobase and the other, nicotinamide. NAD exists in two forms: an oxidized and reduced form, abbreviated as NAD and NADH (H for hydrogen), respectively. In cellular metabolism, NAD is involved in redox reactions, carrying electrons from one reaction to another, so it is found in two forms: NAD is an oxidizing agent, accepting electrons from other molecules and becoming reduced; with H+, this reaction forms NADH, which can be used as a reducing agent to donate electrons. These electron transfer reactions are the main function of NAD. It is also used in other cellular processes, most notably as a substrate of enzymes in adding or removing chemical groups to or from proteins, in posttranslational modifications. Because of the importa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Venture Capitalist
Venture capital (VC) is a form of private equity financing provided by firms or funds to startup, early-stage, and emerging companies, that have been deemed to have high growth potential or that have demonstrated high growth in terms of number of employees, annual revenue, scale of operations, etc. Venture capital firms or funds invest in these early-stage companies in exchange for equity, or an ownership stake. Venture capitalists take on the risk of financing start-ups in the hopes that some of the companies they support will become successful. Because startups face high uncertainty, VC investments have high rates of failure. Start-ups are usually based on an innovative technology or business model and often come from high technology industries such as information technology (IT) or biotechnology. Pre-seed and seed rounds are the initial stages of funding for a startup company, typically occurring early in its development. During a seed round, entrepreneurs seek investment fr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sirtuin
Sirtuins are a family of signaling proteins involved in metabolic regulation. They are ancient in animal evolution and appear to possess a highly conserved structure throughout all kingdoms of life. Chemically, sirtuins are a class of proteins that possess either mono- ADP-ribosyltransferase or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. The name Sir2 comes from the yeast gene 'silent mating-type information regulation 2', the gene responsible for cellular regulation in yeast. From ''in vitro'' studies, sirtuins were thought to be implicated in influencing cellular processes like aging, transcription, apoptosis, inflammation and stress resistance, as well as energy efficiency and alertness during low-calorie situations. As of 2018, there was no clinical evidence that sirtuins affect human aging, and a 2022 review criticized researchers who propagate this claim. Yeast Sir2 and some, but not all, sirt ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sirtuins
Sirtuins are a family of signaling proteins involved in metabolic regulation. They are ancient in animal evolution and appear to possess a highly conserved structure throughout all kingdoms of life. Chemically, sirtuins are a class of proteins that possess either mono- ADP-ribosyltransferase or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. The name Sir2 comes from the yeast gene 'silent mating-type information regulation 2', the gene responsible for cellular regulation in yeast. From ''in vitro'' studies, sirtuins were thought to be implicated in influencing cellular processes like aging, transcription, apoptosis, inflammation and stress resistance, as well as energy efficiency and alertness during low-calorie situations. As of 2018, there was no clinical evidence that sirtuins affect human aging, and a 2022 review criticized researchers who propagate this claim. Yeast Sir2 and some, but not all, sirtu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
