Chris Abell
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Christopher Abell (11 November 1957Abell, Prof Christopher. In ''Debrett's People of Today 2012'' (accessed 15 January 2012) ''(subscription required)'' – 26 October 2020) was a British biological chemist who was a professor of biological chemistry at the Yusuf Hamied Department of Chemistry and Todd-Hamied Fellow of
Christ's College, Cambridge Christ's College is a Colleges of the University of Cambridge, constituent college of the University of Cambridge, England. The college includes the Master, the Fellows of the College, and about 450 undergraduate and 250 graduate students. The c ...
. On his 2016 election to the
Royal Society The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, re ...
, Abell's research was described as having "changed the face of drug discovery."


Education

Abell was educated at
St John's College, Cambridge St John's College, formally the College of St John the Evangelist in the University of Cambridge, is a Colleges of the University of Cambridge, constituent college of the University of Cambridge, founded by the House of Tudor, Tudor matriarch L ...
, gaining a Bachelor of Arts degree in
Natural Sciences Natural science or empirical science is one of the branches of science concerned with the description, understanding and prediction of natural phenomena, based on empirical evidence from observation and experimentation. Mechanisms such as peer ...
in 1979 followed by PhD on the topic of
polyketide In organic chemistry, polyketides are a class of natural products derived from a Precursor (chemistry), precursor molecule consisting of a Polymer backbone, chain of alternating ketone (, or Carbonyl reduction, its reduced forms) and Methylene gro ...
biosynthesis for research supervised by James Staunton in 1982. (accessed 15 January 2013)


Career and research

Abell held a research fellowship in the laboratory of David E. Cane at
Brown University Brown University is a Private university, private Ivy League research university in Providence, Rhode Island, United States. It is the List of colonial colleges, seventh-oldest institution of higher education in the US, founded in 1764 as the ' ...
,
Providence Providence often refers to: * Providentia, the divine personification of foresight in ancient Roman religion * Divine providence, divinely ordained events and outcomes in some religions * Providence, Rhode Island, the capital of Rhode Island in the ...
, USA, studying
terpene Terpenes () are a class of natural products consisting of compounds with the formula (C5H8)n for n ≥ 2. Terpenes are major biosynthetic building blocks. Comprising more than 30,000 compounds, these unsaturated hydrocarbons are produced predomi ...
biosynthesis (1982–83). In 1984, Abell joined the department of chemistry of the University of Cambridge, successively holding the positions of demonstrator, lecturer and reader in chemical biology, and becoming professor in biological chemistry in 2002. He held visiting professorships at the
Australian National University The Australian National University (ANU) is a public university, public research university and member of the Group of Eight (Australian universities), Group of Eight, located in Canberra, the capital of Australia. Its main campus in Acton, A ...
in
Canberra Canberra ( ; ) is the capital city of Australia. Founded following the Federation of Australia, federation of the colonies of Australia as the seat of government for the new nation, it is Australia's list of cities in Australia, largest in ...
,
University of Santiago de Compostela The University of Santiago de Compostela - USC (, ) is a public university located in the city of Santiago de Compostela, Galicia, Spain. A second campus is located in Lugo, Galicia. It is one of the world's oldest universities in continuous o ...
,
University of Canterbury The University of Canterbury (UC; ; postnominal abbreviation ''Cantuar.'' or ''Cant.'' for ''Cantuariensis'', the Latin name for Canterbury) is a public research university based in Christchurch, New Zealand. It was founded in 1873 as Canterbur ...
,
Christchurch Christchurch (; ) is the largest city in the South Island and the List of cities in New Zealand, second-largest city by urban area population in New Zealand. Christchurch has an urban population of , and a metropolitan population of over hal ...
, and the
Paul Sabatier University Paul Sabatier University (''Université Paul Sabatier'' , UPS, also known as Toulouse III) was a French university, in the Academy of Toulouse. It was one of the several successor universities of the University of Toulouse, established in 1229, m ...
,
Toulouse Toulouse (, ; ; ) is a city in southern France, the Prefectures in France, prefecture of the Haute-Garonne department and of the Occitania (administrative region), Occitania region. The city is on the banks of the Garonne, River Garonne, from ...
.Astex Therapeutics: Scientific Advisors and Clinical Consultants
(accessed 5 January 2009)
He was a fellow of
Christ's College, Cambridge Christ's College is a Colleges of the University of Cambridge, constituent college of the University of Cambridge, England. The college includes the Master, the Fellows of the College, and about 450 undergraduate and 250 graduate students. The c ...
, from 1986; and was the college's Todd-Hamied Fellow.Christ's College, University of Cambridge: The Fellows of Christ's College
(accessed 7 January 2013)
In 2013 he was appointed the first director of
postdoctoral A postdoctoral fellow, postdoctoral researcher, or simply postdoc, is a person professionally conducting research after the completion of their doctoral studies (typically a PhD). Postdocs most commonly, but not always, have a temporary acade ...
affairs at the University of Cambridge, and in 2016 was appointed pro-vice-chancellor for research. Abell published over 200 papers. His research interests include
vitamin Vitamins are Organic compound, organic molecules (or a set of closely related molecules called vitamer, vitamers) that are essential to an organism in small quantities for proper metabolism, metabolic function. Nutrient#Essential nutrients, ...
and
amino acid Amino acids are organic compounds that contain both amino and carboxylic acid functional groups. Although over 500 amino acids exist in nature, by far the most important are the 22 α-amino acids incorporated into proteins. Only these 22 a ...
biosynthesis Biosynthesis, i.e., chemical synthesis occurring in biological contexts, is a term most often referring to multi-step, enzyme-Catalysis, catalyzed processes where chemical substances absorbed as nutrients (or previously converted through biosynthe ...
as targets for the
rational design In chemical biology and biomolecular engineering, rational design (RD) is an umbrella term which invites the strategy of creating new molecules with a certain functionality, based upon the ability to predict how the molecule's structure (specific ...
of
antimicrobial An antimicrobial is an agent that kills microorganisms (microbicide) or stops their growth (bacteriostatic agent). Antimicrobial medicines can be grouped according to the microorganisms they are used to treat. For example, antibiotics are used aga ...
s; fragment-based approaches to
enzyme inhibition An enzyme inhibitor is a molecule that binds to an enzyme and blocks its Enzyme activity, activity. Enzymes are proteins that speed up chemical reactions necessary for life, in which Substrate (biochemistry), substrate molecules are converted ...
; bacterial and plant
riboswitch In molecular biology, a riboswitch is a regulatory segment of a messenger RNA molecule that binds a small molecule, resulting in a change in Translation (biology), production of the proteins encoded by the mRNA. Thus, an mRNA that contains a ribo ...
es; reactions in microdroplets; and biological
nanotechnology Nanotechnology is the manipulation of matter with at least one dimension sized from 1 to 100 nanometers (nm). At this scale, commonly known as the nanoscale, surface area and quantum mechanical effects become important in describing propertie ...
. His former doctoral students include
Shankar Balasubramanian Sir Shankar Balasubramanian (born 30 September 1966) is an Indian-born British chemist and Herchel Smith Professor of Medicinal Chemistry in the Department of Chemistry at the University of Cambridge, ccessed 4 April 2013 Senior Group Leader ...
.


Commercial ventures

Abell was the co-founder of several companies. In 1999, he co-founded Astex Technology Ltd, which uses fragment-based drug discovery technology to discover cancer therapeutics. In 2001, he co-founded Akubio, which developed
biosensor A biosensor is an analytical device, used for the detection of a chemical substance, that combines a biological component with a physicochemical detector. The ''sensitive biological element'', e.g. tissue, microorganisms, organelles, cell rece ...
s for detecting bacteria and viruses; it was acquired by Inverness Medical Innovations in 2008. In 2010, he co-founded
Sphere Fluidics Sphere Bio (formerly known as Sphere Fluidics) is a Cambridge, UK, Cambridge)-based Life Sciences R&D company that specializes in biopharmaceutical discovery and development, cell therapy engineering, bioproduction and synthetic biology, chemica ...
to develop microdroplet technology. In 2012 he co-founded Aqdot, a company developing a new microencapsulation technology.


Personal life

In 1981, he married Katherine Abell, who worked with him at the department of chemistry in Cambridge; they had a son. He died suddenly on 26 October 2020.


Awards and honours

His awards include the
Imperial Chemical Industries Imperial Chemical Industries (ICI) was a British Chemical industry, chemical company. It was, for much of its history, the largest manufacturer in Britain. Its headquarters were at Millbank in London. ICI was listed on the London Stock Exchange ...
(ICI) Prize in Organic Chemistry in 1992, the Hickinbottom Award of the
Royal Society of Chemistry The Royal Society of Chemistry (RSC) is a learned society and professional association in the United Kingdom with the goal of "advancing the chemistry, chemical sciences". It was formed in 1980 from the amalgamation of the Chemical Society, the ...
, and a Yamada Science Foundation Award. In 2008 he was the MIT Novartis Lecturer, and in 2011 was a BIC International Fellow at the University of Canterbury, Christchurch, New Zealand. He was elected a
Fellow of the Academy of Medical Sciences Fellowship of the Academy of Medical Sciences (FMedSci) is an award for medical scientists who are judged by the UK Academy of Medical Sciences for the "excellence of their science, their contribution to medicine and society and the range of the ...
(FMedSci) in 2012 and a
Fellow of the Royal Society Fellowship of the Royal Society (FRS, ForMemRS and HonFRS) is an award granted by the Fellows of the Royal Society of London to individuals who have made a "substantial contribution to the improvement of natural science, natural knowledge, incl ...
(FRS) in 2016.


Selected publications

* * * ''From Microdroplets to Microfluidics: Selective Emulsion Separation in Microfluidic Devices'' * * * * * * * * *


References

{{DEFAULTSORT:Abell, Chris 1957 births 20th-century British chemists Fellows of the Academy of Medical Sciences (United Kingdom) Members of the University of Cambridge Department of Chemistry Fellows of Christ's College, Cambridge Alumni of St John's College, Cambridge Fellows of the Royal Society of Chemistry Fellows of the Royal Society 2020 deaths Brown University fellows 21st-century British chemists