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Sphere Fluidics
Sphere Fluidics is a Cambridge(UK)-based Life Sciences R&D company that specializes in biopharmaceutical discovery and development, cell therapy engineering, bioproduction and synthetic biology, analysis and isolation. The company is reported to own 25 patented products that include instruments, biochips, and specialist chemicals. Overview Sphere Fluidics was originally established in 2010, by two chemistry professors of Cambridge University, namely, Professor Chris Abell and Professor Wilhelm Huck, Dr. Frank F. Craig, an entrepreneur, and Dr. Maher Khaled, a Cambridge University Enterprise executive, as founders. Funding November 2021: Sphere Fluidics raised $40M led by Paris-based Sofinnova Partners and San Francisco-based Redmile Group. The total funds raised by Sphere Fluidics as of 2021, is reported to be, £46.7 million through various funding rounds, loans and grants. Cyto-Mine Technology Cyto-Mine is a patented single cell analysis and characterisation ...
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Private Company
A privately held company (or simply a private company) is a company whose shares and related rights or obligations are not offered for public subscription or publicly negotiated in the respective listed markets, but rather the company's stock is offered, owned, traded, exchanged privately, or over-the-counter. In the case of a closed corporation, there are a relatively small number of shareholders or company members. Related terms are closely-held corporation, unquoted company, and unlisted company. Though less visible than their publicly traded counterparts, private companies have major importance in the world's economy. In 2008, the 441 largest private companies in the United States accounted for ($1.8 trillion) in revenues and employed 6.2 million people, according to ''Forbes''. In 2005, using a substantially smaller pool size (22.7%) for comparison, the 339 companies on '' Forbes'' survey of closely held U.S. businesses sold a trillion dollars' worth of goods and services ...
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Sofinnova
Sofinnova is the name shared by two venture capital firms, Sofinnova Partners and Sofinnova Ventures. The name Sofinnova is a contraction of the French, "Société de Financement de l’Innovation" or, Innovation Venture Capital Company. Both firms trace their roots back to Sofinnova SA, an investment institution founded in Paris in 1972. The two firms have raised ~$4B since inception and have generally shared a similar investment strategy of financing projects and ideas in the life sciences and technology sectors. The two firms distinguish themselves on the basis of their target geographies, stage of investment, and sectors. They have been independent entities since 1997. * Sofinnova Partners is based in Paris, London, and Milan and focuses primarily on European biotech, medtech, biopharma, and industrial biotech investments, with a similar allocation for the US. * Sofinnova Ventures has offices in Menlo Park, CA, and San Diego, CA, and focuses largely on US biotech investmen ...
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Queen's Awards For Enterprise
The Queen's Awards for Enterprise is an awards programme for British businesses and other organizations who excel at international trade, innovation, sustainable development or promoting opportunity (through social mobility). They are the highest official UK awards for British businesses. The scheme was established as The Queen's Award to Industry by a royal warrant of 30 November 1965, and awards are given for outstanding achievement by UK businesses in the categories of innovation, international trade, sustainable development and promoting opportunity through social mobility. Each award is valid for five years and winners are invited to a royal reception and are presented with the award at their company premises by one of the Queen's representatives, a Lord-lieutenant. Winners are also able to fly the Queen's Awards flag at their main office, and use the emblem on marketing materials such as packaging and adverts. History Every April winners of the Queen's Awards for Enterprise ...
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World Science Day For Peace And Development
The United Nations Educational, Scientific and Cultural Organization is a specialized agency of the United Nations (UN) aimed at promoting world peace and security through international cooperation in education, arts, sciences and culture. It has 193 member states and 12 associate members, as well as partners in the non-governmental, intergovernmental and private sector. Headquartered at the World Heritage Centre in Paris, France, UNESCO has 53 regional field offices and 199 national commissions that facilitate its global mandate. UNESCO was founded in 1945 as the successor to the League of Nations's International Committee on Intellectual Cooperation.English summary). Its constitution establishes the agency's goals, governing structure, and operating framework. UNESCO's founding mission, which was shaped by the Second World War, is to advance peace, sustainable development and human rights by facilitating collaboration and dialogue among nations. It pursues this objective ...
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Encapsulation (computer Programming)
In software systems, encapsulation refers to the bundling of data with the mechanisms or methods that operate on the data, or the limiting of direct access to some data, such as an object's components. Encapsulation allows developers to present a consistent and usable interface which is independent of how a system is implemented internally. As one example, encapsulation can be used to hide the values or state of a structured data object inside a class, preventing direct access to them by clients in a way that could expose hidden implementation details or violate state invariance maintained by the methods. All object-oriented programming (OOP) systems support encapsulation, but encapsulation is not unique to OOP. Implementations of abstract data types, modules, and libraries, among other systems, also offer encapsulation. The similarity has been explained by programming language theorists in terms of existential types. Meaning In object-oriented programming languages, and ...
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Hydrogel
A hydrogel is a crosslinked hydrophilic polymer that does not dissolve in water. They are highly absorbent yet maintain well defined structures. These properties underpin several applications, especially in the biomedical area. Many hydrogels are synthetic, but some are derived from nature. The term 'hydrogel' was coined in 1894. Chemistry Classification The crosslinks which bond the polymers of a hydrogel fall under two general categories: physical and chemical. Chemical hydrogels have covalent cross-linking bonds, whereas physical hydrogels have non-covalent bonds. Chemical hydrogels result in strong irreversible gels due to the covalent bonding, and they may also possess harmful properties which makes them unfavourable for medical applications. Physical hydrogels on the other hand have high biocompatibility, aren’t toxic, and are also easily reversible, by simply changing an external stimulus such as pH or temperature; thus they are favourable for use in medical applicat ...
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Microfluidics
Microfluidics refers to the behavior, precise control, and manipulation of fluids that are geometrically constrained to a small scale (typically sub-millimeter) at which surface forces dominate volumetric forces. It is a multidisciplinary field that involves engineering, physics, chemistry, biochemistry, nanotechnology, and biotechnology. It has practical applications in the design of systems that process low volumes of fluids to achieve multiplexing, automation, and high-throughput screening. Microfluidics emerged in the beginning of the 1980s and is used in the development of inkjet printheads, DNA chips, lab-on-a-chip technology, micro-propulsion, and micro-thermal technologies. Typically, micro means one of the following features: * Small volumes (μL, nL, pL, fL) * Small size * Low energy consumption * Microdomain effects Typically microfluidic systems transport, mix, separate, or otherwise process fluids. Various applications rely on passive fluid control using capillary ...
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Cyrix
Cyrix Corporation was a microprocessor developer that was founded in 1988 in Richardson, Texas, as a specialist supplier of floating point units for 286 and 386 microprocessors. The company was founded by Tom Brightman and Jerry Rogers. In 1992, Cyrix introduced its own i386 compatible processors, the 486SLC and 486DLC. These were higher performance than the Intel parts, but lower price. They were primarily marketed to users looking to upgrade existing machines. Their release sparked a lengthy series of lawsuits with Intel while their foundry partner IBM was releasing the same designs under their own branding. The combination of these events led Cyrix to begin losing money, and the company merged with National Semiconductor on 11 November 1997. National released Cyrix's latest designs under the MediaGX name and then an updated version as Geode in 1999. National sold the line to AMD in August 2003 where it was known as Geode. The line was discontinued in 2019. History At ...
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Microplate
A microplate, also known as a microtiter plate (''Microtiter'' is a registered trademark in the United States, therefore it should not be used generically without attribution), microwell plate or multiwell, is a flat plate with multiple "wells" used as small test tubes. The microplate has become a standard tool in analytical research and clinical diagnostic testing laboratories. A very common usage is in the enzyme-linked immunosorbent assay (ELISA), the basis of most modern medical diagnostic testing in humans and animals. A microplate typically has 6, 12, 24, 48, 96, 384 or 1536 sample wells arranged in a 2:3 rectangular matrix. Some microplates have been manufactured with 3456 or 9600 wells, and an "array tape" product has been developed that provides a continuous strip of microplates embossed on a flexible plastic tape. Each well of a microplate typically holds somewhere between tens of nanolitres to several millilitres of liquid. They can also be used to store dry powder ...
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Vaccine
A vaccine is a biological preparation that provides active acquired immunity to a particular infectious or malignant disease. The safety and effectiveness of vaccines has been widely studied and verified. A vaccine typically contains an agent that resembles a disease-causing microorganism and is often made from weakened or killed forms of the microbe, its toxins, or one of its surface proteins. The agent stimulates the body's to recognize the agent as a threat, destroy it, and to further recognize and destroy any of the microorganisms associated with that agent that it may encounter in the future. Vaccines can be prophylactic (to pr ...
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Inflammatory Diseases
Inflammation (from la, inflammatio) is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective response involving immune cells, blood vessels, and molecular mediators. The function of inflammation is to eliminate the initial cause of cell injury, clear out necrotic cells and tissues damaged from the original insult and the inflammatory process, and initiate tissue repair. The five cardinal signs are heat, pain, redness, swelling, and loss of function (Latin ''calor'', ''dolor'', ''rubor'', ''tumor'', and ''functio laesa''). Inflammation is a generic response, and therefore it is considered as a mechanism of innate immunity, as compared to adaptive immunity, which is specific for each pathogen. Too little inflammation could lead to progressive tissue destruction by the harmful stimulus (e.g. bacteria) and compromise the survival of the organism. In contrast, too much inflammation, in the f ...
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Cancer
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss, and a change in bowel movements. While these symptoms may indicate cancer, they can also have other causes. Over 100 types of cancers affect humans. Tobacco use is the cause of about 22% of cancer deaths. Another 10% are due to obesity, poor diet, lack of physical activity or excessive drinking of alcohol. Other factors include certain infections, exposure to ionizing radiation, and environmental pollutants. In the developing world, 15% of cancers are due to infections such as '' Helicobacter pylori'', hepatitis B, hepatitis C, human papillomavirus infection, Epstein–Barr virus and human immunodeficiency virus (HIV). These factors act, at least partly, by changing the genes o ...
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