Bacterial initiation factor 1 is a

bacterial initiation factor A bacterial initiation factor (IF) is a protein that stabilizes the initiation complex for polypeptide translation. Translation initiation is essential to protein synthesis and regulates mRNA translation fidelity and efficiency in bacteria. The 30 ...

. IF1 associates with the

30S The prokaryotic small ribosomal subunit, or 30Svedberg, S subunit, is the smaller subunit of the 70S ribosome found in prokaryotes. It is a complex of the 16S ribosomal RNA (rRNA) and 19 proteins. This complex is implicated in the binding of tr ...

ribosomal subunit in the

A site Ribosomes () are macromolecular machines, found within all cells, that perform biological protein synthesis (messenger RNA translation). Ribosomes link amino acids together in the order specified by the codons of messenger RNA molecules to for ...

and prevents an

aminoacyl-tRNA Aminoacyl-tRNA (also aa-tRNA or charged tRNA) is tRNA to which its cognate amino acid is chemically bonded (charged). The aa-tRNA, along with particular elongation factors, deliver the amino acid to the ribosome for incorporation into the polyp ...

from entering. It modulates IF2 binding to the ribosome by increasing its affinity. It may also prevent the

50S 50 S is the larger subunit of the 70S ribosome of prokaryotes, i.e. bacteria and archaea. It is the site of inhibition for antibiotics such as macrolides, chloramphenicol, clindamycin, and the pleuromutilins. It includes the 5S ribosom ...

subunit from binding, stopping the formation of the 70S subunit. It also contains a β-domain fold common for nucleic acid binding proteins. IF1– IF3 may also perform ribosome recycling.

References

{{GeneticTranslation Protein biosynthesis Gene expression