A10A Insulins and analogues

A10AB Insulins and analogues for injection, fast-acting

:A10AB01 Insulin (human) :A10AB02 Insulin (beef) :A10AB03 Insulin (pork) :A10AB04

Insulin lispro Insulin lispro, sold under the brand name Humalog among others, is a modified type of medical insulin used to treat type 1 and type 2 diabetes. It is delivered subcutaneously either by injection or from an insulin pump. Onset of effects t ...

:A10AB05

Insulin aspart Insulin aspart, sold under the brand name Novolog, among others, is a modified type of medical insulin used to treat type 1 and type 2 diabetes. It is generally used by injection under the skin (into the abdomen, buttocks, thighs, or upper ...

:A10AB06

Insulin glulisine Insulin glulisine, sold under the brand name Apidra among others, is a rapid-acting modified form of medical insulin used for the treatment of diabetes. It differs from human insulin in that the amino acid asparagine at position B3 is replace ...

:A10AB30 Combinations

A10AC Insulins and analogues for injection, intermediate-acting

:A10AC01 Insulin (human) :A10AC02 Insulin (beef) :A10AC03 Insulin (pork) :A10AC04 Insulin lispro :A10AC30 Combinations

A10AD Insulins and analogues for injection, intermediate- or long-acting combined with fast-acting

:A10AD01 Insulin (human) :A10AD02 Insulin (beef) :A10AD03 Insulin (pork) :A10AD04

:A10AD05

:A10AD06 Insulin degludec and insulin aspart :A10AD30 Combinations

A10AE Insulins and analogues for injection, long-acting

:A10AE01 Insulin (human) :A10AE02 Insulin (beef) :A10AE03 Insulin (pork) :A10AE04

Insulin glargine Insulin glargine sold under the brand name Lantus among others is a long-acting modified form of medical insulin, used in the management of type 1 and type 2 diabetes. It is injected just under the skin. Effects generally begin an hour af ...

:A10AE05

Insulin detemir Insulin detemir, sold under the brand name Levemir among others, is a long-acting modified form of medical insulin used to treat both type 1 and type 2 diabetes. It is used by injection under the skin. It is effective for up to 24 hours. ...

:A10AE06

Insulin degludec Insulin degludec (INN/USAN) is an ultralong-acting basal insulin analogue that was developed by Novo Nordisk under the brand name Tresiba. It is administered via subcutaneous injection to help control the blood sugar level of those with diabete ...

:A10AE07

Insulin icodec Insulin icodec, sold under the brand name Awiqli, is a medication used for the treatment of diabetes to improve glycemic control. It is an ultralong-acting basal insulin analogue that is developed by Novo Nordisk. It has a plasma half-life mor ...

:A10AE30 Combinations :A10AE54 Insulin glargine and lixisenatide :A10AE56 Insulin degludec and liraglutide

A10AF Insulins and analogues for inhalation

:A10AF01 Insulin (human)

A10B Blood glucose lowering drugs, excluding insulins

A10BA Biguanides

:A10BA01

Phenformin Phenformin is an antidiabetic drug from the biguanide class. It was marketed as DBI by Ciba-Geigy, but was withdrawn from most markets in the late 1970s due to a high risk of lactic acidosis, which was fatal in 50% of cases. Phenformin was devel ...

:A10BA02

Metformin Metformin, sold under the brand name Glucophage, among others, is the main first-line medication for the treatment of type2 diabetes, particularly in people who are overweight. It is also used in the treatment of polycystic ovary syndrome, ...

:A10BA03

Buformin Buformin (1-butylbiguanide) is an oral antidiabetic drug of the biguanide class, chemically related to metformin and phenformin. Buformin was marketed by German pharmaceutical company Grünenthal as Silubin. Chemistry and animal toxicology Bufor ...

A10BB Sulfonylureas

:A10BB01

Glibenclamide Glibenclamide, also known as glyburide, is an antidiabetic medication used to treat type 2 diabetes. It is recommended that it be taken together with diet and exercise. It may be used with other antidiabetic medication. It is not recommended ...

:A10BB02

Chlorpropamide Chlorpropamide is an antidiabetic drug, belonging to the sulfonylurea class of organic compounds. It is used to treat diabetes mellitus type 2. It is a long-acting first-generation sulfonylurea. Mechanism of action Like other sulfonylureas, ch ...

:A10BB03

Tolbutamide Tolbutamide is a first-generation potassium channel blocker, sulfonylurea oral hypoglycemic medication. This drug may be used in the management of type 2 diabetes if diet alone is not effective. Tolbutamide stimulates the secretion of insulin ...

:A10BB04 Glibornuride :A10BB05

Tolazamide Tolazamide is an oral blood glucose lowering drug used for people with Type 2 diabetes. It is part of the sulfonylurea family (ATC A10BB). Synthesis ''para''-Toluenesulfonamide is converted to its carbamate with ethyl chloroformate in the pre ...

:A10BB06

Carbutamide Carbutamide (brand name Glucidoral) is an anti-diabetic drug of the sulfonylurea class, developed by Servier. It is classified as first-generation. It was patented A patent is a type of intellectual property that gives its owner the lega ...

:A10BB07

Glipizide Glipizide, sold under the brand name Glucotrol among others, is an anti-diabetic medication of the sulfonylurea class used to treat type 2 diabetes. It is used together with a diabetic diet and exercise. It is not indicated for use by itself i ...

:A10BB08 Gliquidone :A10BB09

Gliclazide Gliclazide, sold under the brand name Diamicron among others, is a sulfonylurea type of anti-diabetic medication, used to treat type 2 diabetes. It is used when dietary changes, exercise, and weight loss are not enough. It is taken by mouth. ...

:A10BB10 Metahexamide :A10BB11

Glisoxepide Glisoxepide (INN) is an orally available anti-diabetic drug from the group of sulfonylurea Sulfonylureas or sulphonylureas are a class of organic compounds used in medicine and agriculture. The functional group consists of a sulfonyl group (- ...

:A10BB12

Glimepiride Glimepiride is an antidiabetic medication within the sulfonylurea class, primarily prescribed for the management of type 2 diabetes. It is regarded as a second-line option compared to metformin, due to metformin's well-established safety and ...

:A10BB31

Acetohexamide Acetohexamide (trade name Dymelor) is a first-generation sulfonylurea medication used to treat diabetes mellitus type 2, particularly in people whose diabetes cannot be controlled by diet alone. Mechanism of action Acetohexamide binds to an A ...

A10BC Sulfonamides (heterocyclic)

:A10BC01 Glymidine

A10BD Combinations of oral blood glucose lowering drugs

:A10BD01

and

sulfonylurea Sulfonylureas or sulphonylureas are a class of organic compounds used in medicine and agriculture. The functional group consists of a sulfonyl group (-S(=O)2) with its sulphur atom bonded to a nitrogen atom of a ureylene group (N,N-dehydrourea ...

s :A10BD02

and sulfonylureas :A10BD03 Metformin and rosiglitazone :A10BD04

and

rosiglitazone Rosiglitazone (trade name Avandia) is an antidiabetic drug in the thiazolidinedione class. It works as an insulin sensitizer, by binding to the PPAR in fat cells and making the cells more responsive to insulin. It is marketed by the pharmaceut ...

:A10BD05 Metformin and pioglitazone :A10BD06 Glimepiride and pioglitazone :A10BD07 Metformin and sitagliptin :A10BD08 Metformin and vildagliptin :A10BD09 Pioglitazone and alogliptin :A10BD10 Metformin and saxagliptin :A10BD11 Metformin and linagliptin :A10BD12

Pioglitazone Pioglitazone, sold under the brand name Actos among others, is an anti-diabetic medication used to treat type 2 diabetes. It may be used with metformin, a sulfonylurea, or insulin. Use is recommended together with exercise and diet. It is not ...

and

sitagliptin Sitagliptin, sold under the brand name Januvia among others, is an anti-diabetic medication used to treat type 2 diabetes. It is in the dipeptidyl peptidase-4 (DPP-4) inhibitor class and works by increasing the production of insulin and decr ...

:A10BD13 Metformin and alogliptin :A10BD14 Metformin and

repaglinide Repaglinide is an antidiabetic drug in the class of medications known as meglitinides, and was invented in 1983. Repaglinide is a medication used in addition to diet and exercise for blood sugar control in type 2 diabetes. The mechanism of actio ...

:A10BD15 Metformin and dapagliflozin :A10BD16 Metformin and canagliflozin :A10BD17 Metformin and

acarbose Acarbose ( INN) is an anti-diabetic drug used to treat diabetes mellitus type 2 and, in some countries, prediabetes. It is a generic sold in Europe and China as Glucobay ( Bayer AG), in North America as Precose ( Bayer Pharmaceuticals), and in ...

:A10BD18 Metformin and

gemigliptin Gemigliptin ( rINN), sold under the brand name Zemiglo, is an oral anti-hyperglycemic agent (anti-diabetic drug) of the dipeptidyl peptidase-4 inhibitor (DPP-4 inhibitor) class of drugs. Glucose lowering effects of DPP-4 inhibitors are mainly m ...

:A10BD19 Linagliptin and empagliflozin :A10BD20 Metformin and empagliflozin :A10BD21 Saxagliptin and dapagliflozin :A10BD22 Metformin and evogliptin :A10BD23 Metformin and ertugliflozin :A10BD24 Sitagliptin and ertugliflozin :A10BD25 Metformin, saxagliptin and dapagliflozin :A10BD26 Metformin and

lobeglitazone Lobeglitazone (trade name Duvie, Chong Kun Dang) is an antidiabetic drug in the thiazolidinedione class of drugs. As an agonist for both PPARα and PPARγ, it works as an insulin sensitizer by binding to the PPAR receptors in fat cells and mak ...

:A10BD27 Metformin, linagliptin and empagliflozin :A10BD28 Metformin and teneligliptin :A10BD29 Sitagliptin and dapagliflozin :A10BD30 Gemigliptin and dapagliflozin

A10BF Alpha glucosidase inhibitors

:A10BF01

Acarbose Acarbose ( INN) is an anti-diabetic drug used to treat diabetes mellitus type 2 and, in some countries, prediabetes. It is a generic sold in Europe and China as Glucobay ( Bayer AG), in North America as Precose ( Bayer Pharmaceuticals), and in ...

:A10BF02

Miglitol Miglitol is an oral alpha-glucosidase inhibitor used in the treatment of type 2 diabetes. It works by reversibly inhibiting alpha-glucosidase enzymes in the small intestine, which delays the digestion of complex carbohydrates and subsequently ...

:A10BF03

Voglibose Voglibose (International Nonproprietary Name, INN and United States Adopted Name, USAN, trade name Voglib, marketed by Mascot Health Series) is an alpha-glucosidase inhibitor used for lowering postprandial blood glucose levels in people with diab ...

A10BG Thiazolidinediones

:A10BG01

Troglitazone Troglitazone is an antidiabetic and anti-inflammatory drug, and a member of the drug class of the thiazolidinediones. It was prescribed for people with diabetes mellitus type 2. It was patented in 1983 and approved for medical use in 1997. ...

:A10BG02

Rosiglitazone Rosiglitazone (trade name Avandia) is an antidiabetic drug in the thiazolidinedione class. It works as an insulin sensitizer, by binding to the PPAR in fat cells and making the cells more responsive to insulin. It is marketed by the pharmaceut ...

:A10BG03

:A10BG04

Lobeglitazone Lobeglitazone (trade name Duvie, Chong Kun Dang) is an antidiabetic drug in the thiazolidinedione class of drugs. As an agonist for both PPARα and PPARγ, it works as an insulin sensitizer by binding to the PPAR receptors in fat cells and mak ...

A10BH Dipeptidyl peptidase 4 (DPP-4) inhibitors

:A10BH01

Sitagliptin Sitagliptin, sold under the brand name Januvia among others, is an anti-diabetic medication used to treat type 2 diabetes. It is in the dipeptidyl peptidase-4 (DPP-4) inhibitor class and works by increasing the production of insulin and decr ...

:A10BH02 Vildagliptin :A10BH03

Saxagliptin Saxagliptin, sold under the brand name Onglyza, is an oral hypoglycemic (anti-diabetic drug) of the dipeptidyl peptidase-4 (DPP-4) inhibitor class. Early development was solely by Bristol-Myers Squibb; in 2007 AstraZeneca joined with Bristol-Mye ...

:A10BH04

Alogliptin Alogliptin, sold under the brand names Nesina and Vipidia, is an oral anti-diabetic drug in the DPP-4 inhibitor (gliptin) class. Like other members of the gliptin class, it causes little or no weight gain, exhibits relatively little risk of hyp ...

:A10BH05

Linagliptin Linagliptin, sold under the brand name Tradjenta among others, is a medication used to treat type 2 diabetes (but not type 1) in conjunction with exercise and diet. Linagliptin is a dipeptidyl peptidase-4 inhibitor that works by increasing the ...

:A10BH06

Gemigliptin Gemigliptin ( rINN), sold under the brand name Zemiglo, is an oral anti-hyperglycemic agent (anti-diabetic drug) of the dipeptidyl peptidase-4 inhibitor (DPP-4 inhibitor) class of drugs. Glucose lowering effects of DPP-4 inhibitors are mainly m ...

:A10BH07 Evogliptin :A10BH08

Teneligliptin Teneligliptin (INN; trade name Tenelia) is a pharmaceutical drug for the treatment of type 2 diabetes mellitus. It belongs to the class of anti-diabetic drugs known as dipeptidyl peptidase-4 inhibitors or "gliptins". Creation It was created by M ...

:A10BH51 Sitagliptin and simvastatin :A10BH52 Gemigliptin and

rosuvastatin Rosuvastatin, sold under the brand name Crestor among others, is a statin medication, used to prevent cardiovascular disease in those at high risk and treat dyslipidemia, abnormal lipids. It is recommended to be used with dietary changes, exer ...

A10BJ Glucagon-like peptide-1 (GLP-1) analogues

:A10BJ01

Exenatide Exenatide, sold under the brand name Byetta among others, is a medication used to treat type 2 diabetes. It is used together with diet, exercise, and potentially other antidiabetic medication. It is a treatment option after metformin and sulf ...

:A10BJ02

Liraglutide Liraglutide, sold under the brand name Victoza among others, is an anti-diabetic medication used to treat type2 diabetes, and chronic obesity. It is a second-line therapy for diabetes following first-line therapy with metformin. Its effects ...

:A10BJ03

Lixisenatide Lixisenatide (trade name Lyxumia in the European Union and Adlyxin in the U.S. and manufactured by Sanofi) is a once-daily injectable GLP-1 receptor agonist for the treatment of type 2 diabetes. Medical use Lixisenatide is used as adjunct to d ...

:A10BJ04 Albiglutide :A10BJ05

Dulaglutide Dulaglutide, sold under the brand name Trulicity among others, is a medication used for the treatment of type 2 diabetes in combination with diet and exercise. It is also approved in the United States for the reduction of major adverse cardio ...

:A10BJ06

Semaglutide Semaglutide is an anti-diabetic medication used for the treatment of type2 diabetes and an anti-obesity medication used for long-term weight management. It is a peptide similar to the hormone glucagon-like peptide-1 (GLP-1), modified with a ...

:A10BJ07 Beinaglutide

A10BK Sodium-glucose co-transporter 2 (SGLT2) inhibitors

:A10BK01

Dapagliflozin Dapagliflozin, sold under the brand names Farxiga (US) and Forxiga (EU) among others, is a medication used to treat type2 diabetes. It is also used to treat adults with heart failure and chronic kidney disease. It reversibly inhibits sodium- ...

:A10BK02

Canagliflozin Canagliflozin, sold under the brand name Invokana among others, is a medication used to treat type 2 diabetes. It is used together with exercise and diet. It is not recommended in type 1 diabetes. It is taken by mouth. Common side effects in ...

:A10BK03

Empagliflozin Empagliflozin, sold under the brand name Jardiance ( ), among others, is an antidiabetic medication used to improve glucose control in people with type2 diabetes and/or for patients with established heart failure with reduced ejection fract ...

:A10BK04 Ertugliflozin :A10BK05 Ipragliflozin :A10BK06 Sotagliflozin :A10BK07 Luseogliflozin :A10BK08 Bexagliflozin :A10BK09

Enavogliflozin Enavogliflozin (DWP16001/GCC5694A) is a selective SLC5A2 and SGLT2 inhibitor developed to treat diabetes and obesity. It was developed by GC Pharma and Daewoong Pharmaceutical. Enavogliflozin has been approved for clinical use in South Korea, a ...

:QA10BK90

Velagliflozin Velagliflozin, sold under the brand name Senvelgo, is an antidiabetic medication used for the treatment of cats. Velagliflozin is a SGLT2 inhibitor, sodium-glucose cotransporter 2 (SGLT2) inhibitor. It is taken by mouth. Medical uses Vela ...

A10BX Other blood glucose lowering drugs, excluding insulins

:A10BX01

Guar gum Guar gum, also called guaran, is a galactomannan polysaccharide extracted from guar beans that has thickening and stabilizing properties useful in food, feed, and industrial applications. The guar seeds are mechanically dehusked, hydrated, mi ...

:A10BX02

Repaglinide Repaglinide is an antidiabetic drug in the class of medications known as meglitinides, and was invented in 1983. Repaglinide is a medication used in addition to diet and exercise for blood sugar control in type 2 diabetes. The mechanism of actio ...

:A10BX03 Nateglinide :A10BX05

Pramlintide Pramlintide (trade name Symlin) is an injectable amylin analogue drug for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals (now a wholly owned subsidiary of AstraZeneca). Pramlintide is sold as an acetate salt. Pharmacology Pram ...

:A10BX06

Benfluorex Benfluorex, sold under the brand name Mediator, is an anorectic and hypolipidemic agent that is structurally related to fenfluramine (a substituted amphetamine). It may improve glycemic control and decrease insulin resistance in people with ...

:A10BX08 Mitiglinide :A10BX15

Imeglimin Imeglimin (EMD- 387008,PXL- 008,RVT-1501, brand name Twymeeg) is an oral anti-diabetic medication. It was approved for use in Japan in June 2021. It is an oxidative phosphorylation blocker that acts to inhibit hepatic gluconeogenesis, increase ...

:A10BX16

Tirzepatide Tirzepatide is an antidiabetic medication used to treat type2 diabetes and for weight loss. Tirzepatide is administered via subcutaneous injections (under the skin). In the United States, it is sold under the brand name Mounjaro for diabetes ...

:A10BX17

Carfloglitazar Chiglitazar (trade name Bilessglu) is a drug for the treatment of type 2 diabetes. It is a peroxisome proliferator-activated receptor (PPAR) agonist. In China, chiglitazar is approved for glycemic control Diabetes mellitus is a metabolic ...

:A10BX18 Dorzagliatin

A10X Other drugs used in diabetes

A10XA Aldose reductase inhibitors

:A10XA01

Tolrestat Tolrestat ( INN; AY-27773) is an aldose reductase inhibitor which was approved for the control of certain diabetic complications. While it was approved for marketed in several countries, it failed a Phase III trial in the U.S. due to toxicity a ...

AA10XX Other drugs used in diabetes

:A10XX01

Teplizumab Teplizumab, sold under the brand name Tzield, is a humanized anti-CD3 monoclonal antibody that is the first approved treatment indicated to delay the onset of stage 3 type1 diabetes in people with stage 2 type1 diabetes. Teplizumab's mechani ...

:A10XX02

Donislecel Donislecel, sold under the brand name Lantidra, is a cellular therapy medication used for the treatment of type 1 diabetes. Donislecel is an allogeneic (donor) pancreatic islet cellular therapy made from deceased donor pancreatic cells. Donis ...

References

{{Oral hypoglycemics and insulin analogs A10