(''R'')-69 (3IQ) is a tetrahydropyridine derivative which acts as a 5-HT_2A receptor agonist, with 4.6-fold selectivity over 5-HT_2B and 49-fold selectivity over 5-HT_2C. It has a 5-HT_2A K_i of 680 nM and an EC₅₀ of 41 nM. (''R'')-69 is a

biased agonist Functional selectivity (or agonist trafficking, biased agonism, biased signaling, ligand bias, and differential engagement) is the ligand-dependent selectivity for certain signal transduction pathways relative to a reference ligand (often the end ...

selective for activation of the G_q coupled signalling pathway, with much weaker activation of the β-arrestin 2 coupled pathway. In animal studies it produces

antidepressant Antidepressants are a class of medications used to treat major depressive disorder, anxiety disorders, chronic pain, and addiction. Common side effects of antidepressants include Xerostomia, dry mouth, weight gain, dizziness, headaches, akathi ...

-like activity but without producing the

head-twitch response The head-twitch response (HTR), also sometimes known as wet dog shakes (WDS) in rats, is a rapid side-to-side head movement that occurs in mice and rats in association with serotonin 5-HT2A receptor activation. Serotonergic psychedelics like lys ...

associated with

psychedelic Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary mental states (known as psychedelic experiences or "trips") and a perceived "expansion of consciousness". Also referred to as classic halluci ...

effects.

References

Designer drugs Non-hallucinogenic 5-HT2A receptor agonists Pyrrolopyridines Tetrahydropyridines {{nervous-system-drug-stub

See also

References