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P-ISOCOC
(''R'')-''p''-Isothiocyanatobenzoylecgonine methyl ester (''p''-ISOCOC) is a List of cocaine analogues, cocaine analogue and irreversible (covalent) binding inhibitor of the cocaine receptor, as well as irreversible blocker of dopamine uptake by DAT (the latter being unlike its C3 homologue m-ISOCOC, ''m''-Isococ). Arene substitution pattern#Ortho, meta, and para substitution, ''p''-Isococ also blocks the high-affinity cocaine site in preference to the low-affinity site. See also * List of phenyltropanes#Irreversible covalent (cf. ionic) C2 ligands, RTI-76, covalent binding phenyltropane * 4'-Fluorococaine * Fourphit * Metaphit * Methocinnamox References [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fourphit
Fourphit, also known as 4-isothiocyanato-PCP, is an irreversible inhibitor, irreversible dopamine transporter (DAT) dopamine reuptake inhibitor, blocker and a reversible NMDA receptor antagonist. It blocks the binding of methylphenidate to the DAT ''in vitro'', though apparently not ''in vivo''. In any case, the drug reduces the stimulant-like effects of cocaine in animals, whilst producing mostly negligible behavioral effects itself. Fourphit is an acylation, acylating chemical derivative, derivative of phencyclidine (PCP) and a positional isomer of metaphit (3-isothiocyanato-PCP). See also * List of phenyltropanes#Irreversible covalent (cf. ionic) C2 ligands, RTI-76 * p-ISOCOC, ''p''-ISOCOC * Methocinnamox References Arylcyclohexylamines Covalent inhibitors Dopamine reuptake inhibitors Dissociative drugs Isothiocyanates NMDA receptor antagonists Piperidines {{Nervous-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |