(''R'')-''p''-Isothiocyanatobenzoylecgonine methyl ester (''p''-ISOCOC) is a
cocaine analogue and irreversible (
covalent
A covalent bond is a chemical bond that involves the sharing of electrons to form electron pairs between atoms. These electron pairs are known as shared pairs or bonding pairs. The stable balance of attractive and repulsive forces between atom ...
) binding inhibitor of the cocaine receptor, as well as irreversible blocker of dopamine uptake by DAT (the latter being unlike its C3 homologue
''m''-Isococ).
''p''-Isococ also blocks the high-affinity cocaine site in preference to the low-affinity site.
See also
*
RTI-76, covalent binding phenyltropane
*
4'-Fluorococaine
*
Fourphit
Fourphit, also known as 4-isothiocyanato-PCP, is an irreversible inhibitor, irreversible dopamine transporter (DAT) dopamine reuptake inhibitor, blocker and a reversible NMDA receptor antagonist. It blocks the binding of methylphenidate to the DAT ...
*
Metaphit
Metaphit (1- -(3-Isothiocyanato)phenylyclohexylpiperidine) is a research chemical that acts as an acylator of NMDARAn, sigma and DAT binding sites in the CNS. It is the ''m''-isothiocyanate derivative of phencyclidine (PCP) and binds irreversi ...
*
Methocinnamox
Methocinnamox (MCAM) is an opioid receptor antagonist. It is a pseudo-irreversible non-competitive antagonist of the μ-opioid receptor and a competitive antagonist of the κ- and δ-opioid receptors. The drug has a very long duration of acti ...
References
Tropanes
Dopamine reuptake inhibitors
Stimulants
Local anesthetics
Methyl esters
Isothiocyanates
Covalent inhibitors
Benzoate esters
{{nervous-system-drug-stub