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Isatoic Anhydride
Isatoic anhydride is an organic compound derived from anthranilic acid. A white solid, it is prepared by reaction of anthranilic acid with phosgene. Reactions Hydrolysis gives carbon dioxide and anthranilic acid. Alcoholysis proceeds similarly, affording the ester: :C6H4C2O3NH + ROH → C6H4(CO2R)(NH2) + CO2 Amines also effect ring-opening. Active methylene compounds and carbanions replace oxygen giving hydroxy4-Quinolone, quinolinone derivatives. Deprotonation followed by alkylation gives the N-substituted derivatives. Sodium azide gives the benzimidazolone via the isocyanate. Isatoic anhydride is used as a blowing agent in the polymer industry, an application that exploits its tendency to release CO2. Uses Isatoic anhydride has been used as a precursor for the synthesis of methaqualone{{cite journal , title = A survey of reported syntheses of methaqualone and some positional and structural isomers , author = Etienne F. van Zyl , journal = Forensic Sci. Int. , vol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Organic Compound
Some chemical authorities define an organic compound as a chemical compound that contains a carbon–hydrogen or carbon–carbon bond; others consider an organic compound to be any chemical compound that contains carbon. For example, carbon-containing compounds such as alkanes (e.g. methane ) and its derivatives are universally considered organic, but many others are sometimes considered inorganic, such as certain compounds of carbon with nitrogen and oxygen (e.g. cyanide ion , hydrogen cyanide , chloroformic acid , carbon dioxide , and carbonate ion ). Due to carbon's ability to catenate (form chains with other carbon atoms), millions of organic compounds are known. The study of the properties, reactions, and syntheses of organic compounds comprise the discipline known as organic chemistry. For historical reasons, a few classes of carbon-containing compounds (e.g., carbonate salts and cyanide salts), along with a few other exceptions (e.g., carbon dioxide, and even ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pelanserin
Pelanserin (TR2515) is a chemical compound that acts as an antagonist of the 5-HT2 and α1-adrenergic receptors. Synthesis Pelanserin (3) can be synthesized by a reaction between isatoic anhydride (1) and 1-(3-aminopropyl)-4-phenylpiperazine (2) in the presence of phosgene.Horacio Vidrio, (1975 to Bayer Corp). See also * Ketanserin Ketanserin, sold under the brand name Sufrexal, is an antihypertensive agent which is used to treat arterial hypertension and vasospasm, vasospastic disorders. It is also used in scientific research as an antiserotonergic medication, agent in th ... References 5-HT2 antagonists Alpha-1 blockers {{pharma-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cloperidone
Cloperidone is a quinazolinedione derivative first reported in 1965 by Miles Laboratories, notable for its sedative and antihypertensive properties. Its pharmacological activity has been demonstrated in various animal models, including behavioral studies in dogs and cats, as well as motor coordination and locomotor activity assays in mice. Cloperidone is not an approved drug and appears to remain an experimental compound with no current clinical use. References {{Hypnotics and sedatives 3-Chlorophenyl compounds Quinazolinones Antihypertensive agents Sedatives A sedative or tranquilliser is a substance that induces sedation by reducing irritability or excitement. They are central nervous system (CNS) depressants and interact with brain activity, causing its deceleration. Various kinds of sedatives ... Piperazines ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antrafenine
Antrafenine (Stakane) is a phenylpiperazine derivative drug invented in 1979. It acts as an analgesic and anti-inflammatory drug with similar efficacy to naproxen Naproxen, sold under the brand name Aleve among others, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain, menstrual cramps, and inflammatory diseases such as rheumatoid arthritis, gout and fever. It is taken orally. It ..., but is not widely used as it has largely been replaced by newer drugs. Synthesis Method E: The reaction between 2- -(trifluoromethyl)phenyl.html" ;"title="-[3-(trifluoromethyl)phenyl">-[3-(trifluoromethyl)phenyl1-piperazinylthanol [40004-29-3] (1) and Isatoic anhydride [118-48-9] (2) goes on to give 4-(3-(Trifluoromethyl)phenyl)piperazine-1-ethyl 2-aminobenzoate [51941-08-3] (3). Method G: Alkylation with 4-chloro-7-(trifluoromethyl)quinoline 46-55-4(4) completed the synthesis of antrafenine (5). See also * Phenylpiperazine * Trifluoromethylphenylpiperazine Ref ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Diproqualone
Diproqualone is a quinazolinone class GABAergic and is an analogue of methaqualone developed in the late 1950s by a team at Nogentaise de Produits Chimique. It was marketed primarily in France and some other European countries. It has sedative, anxiolytic, antihistamine and analgesic properties, resulting from its agonist activity at the β subtype of the GABAa receptor, antagonist activity at all histamine receptors, inhibition of the cyclooxygenase-1 enzyme, and possibly its agonist activity at both the sigma-1 receptor and sigma-2 receptor (the function of these receptors and their clinical relevance has not yet been determined). Diproqualone is used primarily for treating inflammatory pain associated with osteoarthritis and rheumatoid arthritis and more rarely, for treating insomnia, anxiety and neuralgia. Diproqualone is the only analogue of methaqualone that is still in widespread clinical use, due to its useful anti-inflammatory and analgesic effects in addition to the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tranilast
Tranilast (INN, brand name Rizaben) is an antiallergic drug. It was developed by Kissei Pharmaceuticals and was approved in 1982 for use in Japan and South Korea for bronchial asthma. Indications for keloid and hypertrophic scar were added in the 1980s. Medical uses It is used in Japan, South Korea, and China to treat asthma, keloid scars, and hypertrophic scars, and as an ophthalmic solution for allergic pink eye. It should not be taken by women who are or might become pregnant, and it is secreted in breast milk. Interactions People who are taking warfarin should not also take tranilast, as they interact. It appears to inhibit UGT1A1 so will interfere with metabolism of drugs that are affected by that enzyme. Adverse effects When given systemically, tranilast appears to cause liver damage; in a large well-conducted clinical trial it caused elevated transaminases three times the upper limit of normal in 11 percent of patients, as well as anemia, kidney failure, rash, and p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anthranilic Acid
Anthranilic acid is an aromatic acid with the formula C6H4(NH2)(CO2H) and has a sweetish taste. The molecule consists of a benzene ring, ''ortho''-substituted with a carboxylic acid and an amine. As a result of containing both acidic and basic functional groups, the compound is amphoteric. Anthranilic acid is a white solid when pure, although commercial samples may appear yellow. The anion 6H4(NH2)(CO2)sup>−, obtained by the deprotonation of anthranilic acid, is called anthranilate. Anthranilic acid was once thought to be a vitamin and was referred to as vitamin L1 in that context, but it is now known to be non-essential in human nutrition. Structure Although not usually referred to as such, it is an amino acid. Solid anthranilic acid typically consists of both the amino-carboxylic acid and the zwitterionic ammonium carboxylate forms, and has a monoclinic crystal structure with space group P21. It is triboluminescent. Above , it converts to an orthorhombic form with spa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Methaqualone
Methaqualone is a hypnotic sedative. It was sold under the brand names Quaalude ( ) and Sopor among others, which contained 300 mg of methaqualone, and sold as a combination drug under the brand name Mandrax, which contained 250 mg methaqualone and 25 mg diphenhydramine within the same tablet, mostly in Europe. Commercial production of methaqualone was halted in the mid-1980s due to widespread abuse and addictiveness. It is a member of the quinazolinone class. Medical use The sedative–hypnotic activity of methaqualone was recognized in 1955. Its use peaked in the early 1970s for the treatment of insomnia, and as a sedative and muscle relaxant. Methaqualone was not recommended for use while pregnant and is in pregnancy category D. Similar to other GABAergic agents, methaqualone will produce tolerance and physical dependence with extended periods of use. Overdose An overdose of methaqualone can lead to coma and death. Additional effects are delirium, con ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
