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Apocynaceae Alkaloids
Apocynaceae alkaloids are natural products found in the plant family of the dogbane family (''Apocynaceae''). Occurrence The alkaloid tabernanthin is found in '' Tabernaemontana laurifolia''. The alkaloids voacangin and voacristin were isolated from ''Voacanga africana''. Representatives Representatives include tabernanthine, voacangine and voacristine. (-)-Voacangine Structural Formula V1.svg, (-)-Voacangine (-)-Voacristine Structural Formula V1.svg, (-)-Voacristine Tabernanthine Structural Formula V1.svg, Tabernanthine Uses Plant parts of ''Voacanga africana'' are utilized by African natives for various purposes, including as hallucinogens, in cultic ceremonies, and as aphrodisiacs. Ethnomedicinal use A decoction made from the stem or root bark is employed for the treatment of mental disorders and as an analgesic. The sap is applied to cavities in teeth. In southeastern Nigeria Nigeria, officially the Federal Republic of Nigeria, is a country in West Af ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Natural Product
A natural product is a natural compound or substance produced by a living organism—that is, found in nature. In the broadest sense, natural products include any substance produced by life. Natural products can also be prepared by chemical synthesis (both semisynthesis and total synthesis and have played a central role in the development of the field of organic chemistry by providing challenging synthetic targets). The term ''natural product'' has also been extended for commercial purposes to refer to cosmetics, dietary supplements, and foods produced from natural sources without added artificial ingredients. Within the field of organic chemistry, the definition of natural products is usually restricted to organic compounds isolated from natural sources that are produced by the pathways of primary or secondary metabolism. Within the field of medicinal chemistry, the definition is often further restricted to secondary metabolites. Secondary metabolites (or specialized meta ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Natives
There is no generally accepted definition of Indigenous peoples, although in the 21st century the focus has been on self-identification, cultural difference from other groups in a state, a special relationship with their traditional territory, and an experience of subjugation and discrimination under a dominant cultural model. Estimates of the population of Indigenous peoples range from 250 million to 600 million. There are some 5,000 distinct Indigenous peoples spread across every inhabited climate zone and inhabited continent of the world. Most Indigenous peoples are in a minority in the state or traditional territory they inhabit and have experienced domination by other groups, especially non-Indigenous peoples. Although many Indigenous peoples have experienced colonization by settlers from European nations, Indigenous identity is not determined by Western colonization. The rights of Indigenous peoples are outlined in national legislation, treaties and international law ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Teeth
A tooth (: teeth) is a hard, calcified structure found in the jaws (or mouths) of many vertebrates and used to break down food. Some animals, particularly carnivores and omnivores, also use teeth to help with capturing or wounding prey, tearing food, for defensive purposes, to intimidate other animals often including their own, or to carry prey or their young. The roots of teeth are covered by gums. Teeth are not made of bone, but rather of multiple tissues of varying density and hardness that originate from the outermost embryonic germ layer, the ectoderm. The general structure of teeth is similar across the vertebrates, although there is considerable variation in their form and position. The teeth of mammals have deep roots, and this pattern is also found in some fish, and in crocodilians. In most teleost fish, however, the teeth are attached to the outer surface of the bone, while in lizards they are attached to the inner surface of the jaw by one side. In cartilaginous ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dental Cavity
Tooth decay, also known as caries,The word 'caries' is a mass noun, and is not a plural of 'carie'.'' is the breakdown of teeth due to acids produced by bacteria. The resulting cavities may be a number of different colors, from yellow to black. Symptoms may include pain and difficulty eating. Complications may include inflammation of the tissue around the tooth, tooth loss and infection or abscess formation. Tooth regeneration is an ongoing stem cell–based field of study that aims to find methods to reverse the effects of decay; current methods are based on easing symptoms. The cause of cavities is acid from bacteria dissolving the hard tissues of the teeth ( enamel, dentin and cementum). The acid is produced by the bacteria when they break down food debris or sugar on the tooth surface. Simple sugars in food are these bacteria's primary energy source and thus a diet high in simple sugar is a risk factor. If mineral breakdown is greater than buildup from sources such as s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Analgesic
An analgesic drug, also called simply an analgesic, antalgic, pain reliever, or painkiller, is any member of the group of drugs used for pain management. Analgesics are conceptually distinct from anesthetics, which temporarily reduce, and in some instances eliminate, sensation, although analgesia and anesthesia are neurophysiologically overlapping and thus various drugs have both analgesic and anesthetic effects. Analgesic choice is also determined by the type of pain: For neuropathic pain, recent research has suggested that classes of drugs that are not normally considered analgesics, such as tricyclic antidepressants and anticonvulsants may be considered as an alternative. Various analgesics, such as many NSAIDs, are available over the counter in most countries, whereas various others are prescription drugs owing to the substantial risks and high chances of overdose, misuse, and addiction in the absence of medical supervision. Etymology The word ''analgesic'' derive ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Decoction
Decoction is a method of extraction by boiling herbal or plant material (which may include stems, roots, bark and rhizomes) to dissolve the chemicals of the material. It is the most common preparation method in various herbal medicine systems. Decoction involves first drying the plant material; then mashing, slicing, or cutting the material to allow for maximum dissolution; and finally boiling in water to extract oils, volatile organic compounds and other various chemical substances. Occasionally, aqueous ethanol or glycerol may be used instead of water. Decoction can be used to make tisanes, tinctures and similar solutions. Decoctions and infusions may produce liquids with differing chemical properties, as the temperature or preparation difference may result in more oil-soluble chemicals in decoctions versus infusions. The process can also be applied to meats and vegetables to prepare bouillon or stock, though the term is typically only used to describe boiled plant extracts, usu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aphrodisiacs
An aphrodisiac is a substance that increases libido, sexual desire, sexual attraction, sexual pleasure, or sexual behavior. These substances range from a variety of plants, spices, and foods to synthetic chemicals. Natural aphrodisiacs, such as cannabis or cocaine, are classified into plant-based and non-plant-based substances. Synthetic aphrodisiacs include MDMA and methamphetamine. Aphrodisiacs can be classified by their type of effects (psychological or physiological). Aphrodisiacs that contain hallucinogenic properties, such as bufotenin, have psychological effects that can increase sexual desire and sexual pleasure. Aphrodisiacs that have smooth muscle relaxing properties, such as yohimbine, have physiological effects that can affect hormone concentrations and increase blood flow. Substances that have the opposite effects on libido are called anaphrodisiacs. Aphrodisiac effects can also be due to the placebo effect. Both males and females can potentially benefit from t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ceremonies
A ceremony (, ) is a unified ritualistic event with a purpose, usually consisting of a number of artistic components, performed on a special occasion. The word may be of Etruscan origin, via the Latin . Religious and civil (secular) ceremonies According to Dally Messenger and Alain de Botton, in most Western countries the values and ideals articulated in both church and civil ceremonies are generally similar. The difference is in what Messenger calls the "supernatural infrastructure" or de Botton the "implausible supernatural element".Messenger, Dally; ''Murphy's Law and the Pursuit of Happiness: a History of the Civil Celebrant Movement'', Spectrum Publications, Melbourne (Australia), 2012 Most religions claim some extra advantage conferred by the deity, e.g., Roman Catholics believe that through the words of consecration in the mass ceremony, God himself becomes actually present on the altar. Both religious and civil ceremonies share the powerful psychological, social ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cult
Cults are social groups which have unusual, and often extreme, religious, spiritual, or philosophical beliefs and rituals. Extreme devotion to a particular person, object, or goal is another characteristic often ascribed to cults. The term has different, and sometimes divergent or pejorative, definitions both in popular culture and academia and has been an ongoing source of contention among scholars across several fields of study. Beginning in the 1930s, new religious movements became an object of sociological study within the context of the study of religious behavior. Since the 1940s, the Christian countercult movement has opposed some sects and new religious movements, labeling them cults because of their unorthodox beliefs. Since the 1970s, the secular anti-cult movement has opposed certain groups, which they call cults, accusing them of practicing brainwashing. Groups labelled cults are found around the world and range in size from small localized groups to some in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hallucinogens
Hallucinogens, also known as psychedelics, entheogens, or historically as psychotomimetics, are a large and diverse class of psychoactive drugs that can produce altered states of consciousness characterized by major alterations in thought, mood, and perception as well as other changes. Hallucinogens are often categorized as either being psychedelics, dissociatives, or deliriants, but not all hallucinogens fall into these three classes. Examples of hallucinogens include psychedelics or serotonin 5-HT2A receptor agonists like LSD, psilocybin, mescaline, and dimethyltryptamine, DMT; dissociatives or NMDA receptor antagonists like ketamine, phencyclidine, PCP, dextromethorphan, DXM, and nitrous oxide; deliriants or antimuscarinics like scopolamine and diphenhydramine; cannabinoids or endocannabinoid system, cannabinoid CB1 receptor, CB1 receptor agonists like tetrahydrocannabinol, THC, nabilone, and JWH-018; kappa-opioid receptor, κ-opioid receptor agonists like salvinorin A ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tabernanthine
Tabernanthine is an alkaloid found in ''Tabernanthe iboga''. It has been used in laboratory experiments to study how addiction affects the brain. Tabernanthine persistently reduced the self-administration of cocaine and morphine in rats. Pharmacology It is kappa opioid agonist (Ki = 0.15 μM) and NMDA receptor (Ki = 10.5 μM) antagonist. Compared to ibogaine, it binds weakly to σ1 and σ2 receptor. See also * Coronaridine * Ibogamine * Voacangine * Tabernaemontanine * Tabernanthalog Tabernanthalog (TBG, DLX-007) is a novel water-soluble, non-toxic ibogalog or simplified analogue of the psychoactive drug tabernanthine first synthesized by David E. Olson at UC Davis. Tabernanthalog is a non-hallucinogenic serotonin 5-HT2A ... References Alkaloids found in Iboga NMDA receptor antagonists Azepines Quinuclidine alkaloids Tryptamine alkaloids Azepinoindoles {{nervous-system-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Plant Family
Family (, : ) is one of the eight major Hierarchy, hierarchical taxonomic ranks in Linnaean taxonomy. It is classified between order (biology), order and genus. A family may be divided into subfamily, subfamilies, which are intermediate ranks between the ranks of family and genus. The official family names are Latin in origin; however, popular names are often used: for example, Juglans, walnut trees and Hickory, hickory trees belong to the family Juglandaceae, but that family is commonly referred to as the "walnut family". The delineation of what constitutes a family—or whether a described family should be acknowledged—is established and decided upon by active taxonomists. There are not strict regulations for outlining or acknowledging a family, yet in the realm of plants, these classifications often rely on both the vegetative and reproductive characteristics of plant species. Taxonomists frequently hold varying perspectives on these descriptions, leading to a lack of wide ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
