alkaloid
Alkaloids are a broad class of natural product, naturally occurring organic compounds that contain at least one nitrogen atom. Some synthetic compounds of similar structure may also be termed alkaloids.
Alkaloids are produced by a large varie ...
found in ''
Tabernanthe iboga
''Tabernanthe'' is a genus of flowering plants in the family Apocynaceae, first described as a genus in 1888. It is native to tropical central Africa
Africa is the world's second-largest and second-most populous continent after Asia. At a ...
''.
It has been used in laboratory experiments to study how addiction affects the brain.
Tabernanthine persistently reduced the self-administration of cocaine and morphine in rats.
NMDA receptor
The ''N''-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and predominantly Ca2+ ion channel found in neurons. The NMDA receptor is one of three types of ionotropic glutamate receptors, the other ...
(Ki = 10.5 μM)
antagonist
An antagonist is a character in a story who is presented as the main enemy or rival of the protagonist and is often depicted as a villain. Compared to ibogaine, it binds weakly to σ1 and σ2 receptor.
See also
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Coronaridine
Coronaridine, also known as 18-carbomethoxyibogamine, is an alkaloid found in '' Tabernanthe iboga'' and related species, including '' Tabernaemontana divaricata'' for which (under the now obsolete synonym ''Ervatamia coronaria'') it was named.
...
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Ibogamine
Ibogamine is an anti-convulsant, anti-addictive, CNS stimulant alkaloid found in '' Tabernanthe iboga'' and Crepe Jasmine ('' Tabernaemontana divaricata''). Basic research related to how addiction affects the brain has used this chemical.
Iboga ...
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Voacangine
Voacangine (12-methoxyibogamine-18-carboxylic acid methyl ester) is an alkaloid found predominantly in the root bark of the ''Voacanga africana'' tree, as well as in other plants such as '' Tabernanthe iboga'', ''Tabernaemontana africana'', '' Tra ...
Tabernanthalog
Tabernanthalog (TBG, DLX-007) is a novel water-soluble, non-toxic ibogalog or simplified analogue of the psychoactive drug tabernanthine first synthesized by David E. Olson at UC Davis.
Tabernanthalog is a non-hallucinogenic serotonin 5-HT2A ...