Tabernanthine is an
alkaloid
Alkaloids are a class of basic
BASIC (Beginners' All-purpose Symbolic Instruction Code) is a family of general-purpose, high-level programming languages designed for ease of use. The original version was created by John G. Kemeny and Th ...
found in ''
Tabernanthe iboga
''Tabernanthe iboga'' (iboga) is an evergreen rainforest shrub native to Central Africa. A member of the Apocynaceae family indigenous to Gabon, the Democratic Republic of Congo, and the Republic of Congo, it is cultivated across Central Africa ...
''.
It has been used in laboratory experiments to study how addiction affects the brain.
Tabernanthine persistently reduced the self-administration of cocaine and morphine in rats.
Pharmacology
It is
kappa opioid agonist (K
i = 0.15 μM) and
NMDA receptor
The ''N''-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel found in neurons. The NMDA receptor is one of three types of ionotropic glutamate receptors, the other two being AMPA rece ...
(K
i = 10.5 μM)
antagonist.
Compared to ibogaine, it binds weakly to
σ1 and
σ2 receptor.
See also
*
Coronaridine
Coronaridine, also known as 18-carbomethoxyibogamine, is an alkaloid found in ''Tabernanthe iboga'' and related species, including ''Tabernaemontana divaricata'' for which (under the now obsolete synonym ''Ervatamia coronaria'') it was named.
Li ...
*
Ibogamine
*
Voacangine
Voacangine (12-methoxyibogamine-18-carboxylic acid methyl ester) is an alkaloid found predominantly in the root bark of the '' Voacanga africana'' tree, as well as in other plants such as ''Tabernanthe iboga'', '' Tabernaemontana africana'', '' Tr ...
*
Tabernaemontanine
*
Tabernanthalog
References
Alkaloids found in Iboga
NMDA receptor antagonists
Azepines
Quinuclidine alkaloids
Tryptamine alkaloids
{{nervous-system-drug-stub