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Zbtb7
''Zbtb7'', whose protein product is also known as ''Pokemon'', is a gene that functions as a regulator of cellular growth and a proto oncogene. Zbtb7 is a member of the POK (POZ and Krüppel) family of genes, and the ZBTB protein family that contains zinc finger and BTB/POZ domain, BTB domains. It is also known as LRF10 (leukemia/lymphoma-related factor), OCZF11 (osteoclast-derived zinc finger), and FBI1 (1-3) (fourteen-three-three beta interactant). Zbtb7 is a transcription factor that regulates pathways involved in cell growth and Transcription (biology), transcription and it specifically represses many activities. When this gene binds to a consensus sequence, it prevents transcription by controlling the conformation of chromatin and bringing other transcription factors to gene regulation sites. This gene controls access to gene transcription regulation regions. Zbtb7 prevents Sp1 transcription factor, SP1, a transcription factor, from binding to DNA which will halt the process ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ZBTB7A
Zinc finger and BTB domain-containing protein 7A is a protein that in humans is encoded by the ''ZBTB7A'' gene. Interactions ZBTB7A has been shown to Protein-protein interaction, interact with BCL6. See also * ''Zbtb7'' References Further reading * * * * * * * * * * * * * External links * * Transcription factors {{gene-19-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sonic Hedgehog
Sonic hedgehog protein (SHH) is a major signaling molecule of embryonic development in humans and animals, encoded by the ''SHH'' gene. This signaling molecule is key in regulating embryonic morphogenesis in all animals. SHH controls organogenesis and the organization of the central nervous system, limbs, digits and many other parts of the body. Sonic hedgehog is a morphogen that patterns the developing embryo using a concentration gradient characterized by the French flag model. This model has a non-uniform distribution of SHH molecules which governs different cell fates according to concentration. Mutations in this gene can cause holoprosencephaly, a failure of splitting in the cerebral hemispheres, as demonstrated in an experiment using SHH knock-out mice in which the forebrain midline failed to develop and instead only a single fused telencephalic vesicle resulted. Sonic hedgehog still plays a role in differentiation, proliferation, and maintenance of adult tissues. Abno ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ZBTB7B
Zinc finger and BTB domain-containing protein 7B is a protein that in humans is encoded by the ''ZBTB7B'' gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei .... ''ZFP67'' is an early growth response gene that encodes a zinc finger-containing transcription factor that binds to the promoter regions of type I collagen genes (e.g. ''COL1A1''; ''MIM 120150'') and has a role in development. upplied by OMIMref name="entrez" /> See also * '' Zbtb7'' References Further reading * * * * * * * * External links * Transcription factors {{gene-1-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Autoregulation
Autoregulation is a process within many biological systems, resulting from an internal adaptive mechanism that works to adjust (or mitigate) that system's response to stimuli. While most systems of the body show some degree of autoregulation, it is most clearly observed in the kidney, the heart, and the brain. Perfusion of these organs is essential for life, and through autoregulation the body can divert blood (and thus, oxygen) where it is most needed. Cerebral autoregulation More so than most other organs, the brain is very sensitive to increased or decreased blood flow, and several mechanisms (metabolic, myogenic, and neurogenic) are involved in maintaining an appropriate cerebral blood pressure. Brain blood flow autoregulation is abolished in several disease states such as traumatic brain injury, stroke, brain tumors, or persistent abnormally high levels. Homeometrics and heterometric autoregulation of the heart Homeometric autoregulation, in the context of the circulator ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
GameSpot
''GameSpot'' is an American video gaming website that provides news, reviews, previews, downloads, and other information on video games. The site was launched on May 1, 1996, created by Pete Deemer, Vince Broady, and Jon Epstein. In addition to the information produced by ''GameSpot'' staff, the site also allows users to write their own reviews, blogs, and post on the site's forums. It has been owned by Fandom, Inc. since October 2022. In 2004, ''GameSpot'' won "Best Gaming Website" as chosen by the viewers in Spike TV's second ''Video Game Award Show'', and has won Webby Awards several times. The domain ''GameSpot.com'' attracted at least 60 million visitors annually by October 2008 according to a Compete.com study. History In January 1996, Pete Deemer, Vince Broady, and Jon Epstein quit their positions at IDG and founded SpotMedia Communications. SpotMedia then launched ''GameSpot'' on May 1, 1996. Originally, ''GameSpot'' focused solely on personal computer games, so ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Pokémon Company
, simply known as Pokémon is a Japanese company responsible for brand management, production, publishing, marketing, and licensing of the ''Pokémon'' franchise, which consists of video games, a trading card game, anime television series, films, manga, home entertainment products, merchandise, and other ventures. It was established through a joint investment by the three companies holding the copyright and trademark of ''Pokémon''—Nintendo, Game Freak, and Creatures—to focus in the multimedia franchise which became too big to be managed only by them. It was founded in April 1998 originally to operate the Pokémon Center stores in Japan before expanding to the entire franchise in October 2000 as it rebranded to its current name. The company is headquartered in the Roppongi Hills Mori Tower in Roppongi, Minato, Tokyo. The company has separate subsidiaries that handle operations in different parts of the world, with the Pokémon Company International supporting the terri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pokémon
is a Japanese media franchise consisting of List of Pokémon video games, video games, Pokémon (TV series), animated series and List of Pokémon films, films, Pokémon Trading Card Game, a trading card game, and other related media. The franchise takes place in a shared universe in which humans co-exist with creatures known as List of Pokémon, Pokémon, a large variety of species endowed with special powers. The franchise's primary target audience is children aged 5 to 12, but it is known to attract people of all ages. The franchise originated as Pokémon Red, Blue, and Yellow, a pair of role-playing games developed by Game Freak, from an original concept by its founder, Satoshi Tajiri. Released on the Game Boy on 27 February 1996, the games became sleeper hits and were followed by manga series, a trading card game, and anime series and films. From 1998 to 2000, ''Pokémon'' was exported to the rest of the world, creating an unprecedented global phenomenon dubbed "Pokémania ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Backronym
A backronym is an acronym formed from an already existing word by expanding its letters into the words of a phrase. Backronyms may be invented with either serious or humorous intent, or they may be a type of false etymology or folk etymology. The word is a portmanteau of ''back'' and ''acronym''. A normal acronym is a word derived from the initial letter(s) of the words of a phrase, such as ''radar'' from "radio detection and ranging". By contrast, a backronym is "an acronym deliberately formed from a phrase whose initial letters spell out a particular word or words, either to create a memorable name or as a fanciful explanation of a word's origin". Many list of fictional espionage organizations, fictional espionage organizations are backronyms, such as SPECTRE (special executive for counterintelligence, terrorism, revenge and extortion) from the ''James Bond'' franchise. For example, the Amber Alert missing-child program was named after Amber Hagerman, a nine-year-old girl w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Memorial Sloan Kettering Cancer Center
Memorial Sloan Kettering Cancer Center (MSK or MSKCC) is a cancer treatment and research institution in Manhattan in New York City. MSKCC is one of 72 National Cancer Institute– designated Comprehensive Cancer Centers. Its main campus is located at 1275 York Avenue between 67th and 68th Streets in Manhattan. It was formed in 1980 from the merger of the ''Memorial Hospital for the Treatment of Cancer and Allied Diseases'', founded in 1884, and the adjacent ''Sloan-Kettering Institute for Cancer Research'', founded in 1945. The two medical entities had formally coordinated their operations since 1960. History Early history of Memorial Hospital (1884–1934) The hospital was founded in its original building on the Upper West Side of Manhattan in 1884 as ''New York Cancer Hospital'' by a group that included John Jacob Astor III and his wife Charlotte. The hospital appointed as an attending surgeon William B. Coley, who pioneered an early form of immunotherapy to erad ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
NF-κB
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a family of transcription factor protein complexes that controls transcription (genetics), transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory. Discovery NF-κB was discovered by Ranjan Sen in the lab of Nobel laureate David Baltimore via its interaction with an 11-base pair sequence in the immunoglobulin light-chain Enhancer (genetics), enhancer in B cells. Later work ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Breast Cancer
Breast cancer is a cancer that develops from breast tissue. Signs of breast cancer may include a Breast lump, lump in the breast, a change in breast shape, dimpling of the skin, Milk-rejection sign, milk rejection, fluid coming from the nipple, a newly inverted nipple, or a red or scaly patch of skin. In those with Metastatic breast cancer, distant spread of the disease, there may be bone pain, swollen lymph nodes, shortness of breath, or yellow skin. Risk factors for developing breast cancer include obesity, a Sedentary lifestyle, lack of physical exercise, alcohol consumption, hormone replacement therapy during menopause, ionizing radiation, an early age at Menarche, first menstruation, having children late in life (or not at all), older age, having a prior history of breast cancer, and a family history of breast cancer. About five to ten percent of cases are the result of an inherited genetic predisposition, including BRCA mutation, ''BRCA'' mutations among others. Breast ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pancreatic Cancer
Pancreatic cancer arises when cell (biology), cells in the pancreas, a glandular organ behind the stomach, begin to multiply out of control and form a Neoplasm, mass. These cancerous cells have the malignant, ability to invade other parts of the body. A number of types of pancreatic cancer are known. The most common, pancreatic adenocarcinoma, accounts for about 90% of cases, and the term "pancreatic cancer" is sometimes used to refer only to that type. These adenocarcinomas start within the part of the pancreas that makes digestive enzymes. Several other types of cancer, which collectively represent the majority of the non-adenocarcinomas, can also arise from these cells. About 1–2% of cases of pancreatic cancer are neuroendocrine tumors, which arise from the hormone-producing neuroendocrine cell, cells of the pancreas. These are generally less aggressive than pancreatic adenocarcinoma. Signs and symptoms of the most-common form of pancreatic cancer may include jaundice, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
