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ZBTB7A
Zinc finger and BTB domain-containing protein 7A is a protein that in humans is encoded by the ''ZBTB7A'' gene. Interactions ZBTB7A has been shown to Protein-protein interaction, interact with BCL6. See also * ''Zbtb7'' References Further reading * * * * * * * * * * * * * External links * * Transcription factors {{gene-19-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Zbtb7
''Zbtb7'', whose protein product is also known as ''Pokemon'', is a gene that functions as a regulator of cellular growth and a proto oncogene. Zbtb7 is a member of the POK (POZ and Krüppel) family of genes, and the ZBTB protein family that contains zinc finger and BTB/POZ domain, BTB domains. It is also known as LRF10 (leukemia/lymphoma-related factor), OCZF11 (osteoclast-derived zinc finger), and FBI1 (1-3) (fourteen-three-three beta interactant). Zbtb7 is a transcription factor that regulates pathways involved in cell growth and Transcription (biology), transcription and it specifically represses many activities. When this gene binds to a consensus sequence, it prevents transcription by controlling the conformation of chromatin and bringing other transcription factors to gene regulation sites. This gene controls access to gene transcription regulation regions. Zbtb7 prevents Sp1 transcription factor, SP1, a transcription factor, from binding to DNA which will halt the process ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BCL6
Bcl-6 (B-cell lymphoma 6) is a protein that in humans is encoded by the ''BCL6'' gene. BCL6 is a master transcription factor for regulation of T follicular helper cells (TFH cells) proliferation. BCL6 has three evolutionary conserved structural domains. The interaction of these domains with corepressors allows for germinal center development and leads to B cell proliferation. The ''deletion'' of BCL6 is known to lead to failure of germinal center formation in the follicles of the lymph nodes, preventing B cells from undergoing somatic hypermutation. ''Mutations'' in BCL6 can lead to B cell lymphomas because it promotes unchecked B cell growth. Clinically, BCL6 can be used to diagnose B cell lymphomas and is shown to be upregulated in a number of cancers. Other BCL genes, including BCL2, BCL3, BCL5, BCL7A, BCL9, and BCL10, also have clinical significance in lymphoma. Normal physiological function Structure The protein encoded by the BCL6 gene is a zinc finger tran ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residue (biochemistry), residues. Proteins perform a vast array of functions within organisms, including Enzyme catalysis, catalysing metabolic reactions, DNA replication, Cell signaling, responding to stimuli, providing Cytoskeleton, structure to cells and Fibrous protein, organisms, and Intracellular transport, transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the Nucleic acid sequence, nucleotide sequence of their genes, and which usually results in protein folding into a specific Protein structure, 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called pep ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and non-coding genes. During gene expression (the synthesis of Gene product, RNA or protein from a gene), DNA is first transcription (biology), copied into RNA. RNA can be non-coding RNA, directly functional or be the intermediate protein biosynthesis, template for the synthesis of a protein. The transmission of genes to an organism's offspring, is the basis of the inheritance of phenotypic traits from one generation to the next. These genes make up different DNA sequences, together called a genotype, that is specific to every given individual, within the gene pool of the population (biology), population of a given species. The genotype, along with environmental and developmental factors, ultimately determines the phenotype ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
