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TeMPEA-2
2,3,4,6-Tetramethoxyphenethylamine (2,3,4,6-TeMPEA), also known as TeMPEA-2, is a drug of the phenethylamine family related to the psychedelic drug mescaline (3,4,5-trimethoxyphenethylamine). It is one of the possible positional isomers of tetramethoxyphenethylamine (TeMPEA). The ''in-vitro'' metabolism and effects of TeMPEA-2 on behavior in animals have been studied. The drug showed little or no activity as a norepinephrine releasing agent ''in vitro''. It does not seem to have been tested in humans. TeMPEA-2 was first described in the scientific literature by 1955. See also * Substituted methoxyphenethylamine * Tetramethoxyphenethylamine (TeMPEA) * 2,3,4,5-Tetramethoxyphenethylamine (TeMPEA, TeMPEA-1) * 2,3,5,6-Tetramethoxyphenethylamine (TeMPEA-3) * 2,3,4,5-Tetramethoxyamphetamine (TeMA) * Pentamethoxyphenethylamine (PeMPEA) * Trimethoxyphenethylamine Trimethoxyphenethylamines (TMPEA) are a group of positional isomers of the psychedelic cactus alkaloid mescaline. Some of t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tetramethoxyphenethylamine
Tetramethoxyphenethylamines (TeMPEA) are a group of positional isomers of the psychedelic cactus alkaloid mescaline. Some of them are described in the book PiHKAL by Alexander Shulgin and Ann Shulgin. * 2,3,4,5-Tetramethoxyphenethylamine (TeMPEA-1) * TeMPEA-2 (2,3,4,6-tetramethoxyphenethylamine) * TeMPEA-3 (2,3,5,6-tetramethoxyphenethylamine) * BOM (drug) (3,4,5,β-tetramethoxyphenethylamine) See also * Substituted methoxyphenethylamine * Methoxyphenethylamine * Dimethoxyphenethylamine * Methoxyamphetamine * Dimethoxyamphetamine * Trimethoxyphenethylamine Trimethoxyphenethylamines (TMPEA) are a group of positional isomers of the psychedelic cactus alkaloid mescaline. Some of them are described in the book PiHKAL by Alexander Shulgin and Ann Shulgin. * 2,3,4-trimethoxyphenethylamine ( Isomescaline) * ... {{Phenethylamines Methoxyphenethylamines ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2,3,5,6-Tetramethoxyphenethylamine
2,3,5,6-Tetramethoxyphenethylamine (2,3,5,6-TeMPEA), also known as TeMPEA-3, is a drug of the phenethylamine family related to the psychedelic drug mescaline (3,4,5-trimethoxyphenethylamine). It is one of the possible positional isomers of tetramethoxyphenethylamine (TeMPEA). The ''in-vitro'' metabolism and effects of TeMPEA-3 on behavior in animals have been studied. Unlike mescaline, TeMPEA-3 was inactive in the conditioned avoidance response test in rats. The effects of TeMPEA-3 in humans have not been reported and are unknown. The drug was first described in the scientific literature by 1955. TeMPEA-3 was included as an entry in Alexander Shulgin's 2011 book '' The Shulgin Index, Volume One: Psychedelic Phenethylamines and Related Compounds''. See also * Substituted methoxyphenethylamine * Tetramethoxyphenethylamine (TeMPEA) * 2,3,4,5-Tetramethoxyphenethylamine (TeMPEA, TeMPEA-1) * 2,3,4,6-Tetramethoxyphenethylamine (TeMPEA-2) * 2,3,4,5-Tetramethoxyamphetamine (TeMA) * Pe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tetramethoxyphenethylamine
Tetramethoxyphenethylamines (TeMPEA) are a group of positional isomers of the psychedelic cactus alkaloid mescaline. Some of them are described in the book PiHKAL by Alexander Shulgin and Ann Shulgin. * 2,3,4,5-Tetramethoxyphenethylamine (TeMPEA-1) * TeMPEA-2 (2,3,4,6-tetramethoxyphenethylamine) * TeMPEA-3 (2,3,5,6-tetramethoxyphenethylamine) * BOM (drug) (3,4,5,β-tetramethoxyphenethylamine) See also * Substituted methoxyphenethylamine * Methoxyphenethylamine * Dimethoxyphenethylamine * Methoxyamphetamine * Dimethoxyamphetamine * Trimethoxyphenethylamine Trimethoxyphenethylamines (TMPEA) are a group of positional isomers of the psychedelic cactus alkaloid mescaline. Some of them are described in the book PiHKAL by Alexander Shulgin and Ann Shulgin. * 2,3,4-trimethoxyphenethylamine ( Isomescaline) * ... {{Phenethylamines Methoxyphenethylamines ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Substituted Methoxyphenethylamine
Methoxyphenethylamines (MPEAs), as well as methoxyamphetamines (MAs) in the case of the amphetamine (α-methylphenethylamine) homologues, are substituted phenethylamines with one or more methoxy groups. In some cases, one or more of the methoxy groups may also be extended to form other alkoxy and related groups such as ethoxy or propoxy. Methoxyphenethylamines may have additional substitutions as well. Many methoxyphenethylamines that have multiple methoxy groups in the 2- through 5-positions of the phenyl ring, for instance mescaline, 2C-B, TMA, DOM, and 25I-NBOMe, are serotonin 5-HT2A receptor agonists and serotonergic psychedelics. Other methoxyphenethylamines, particularly monomethoxyamphetamines like ''para''-methoxyamphetamine (PMA), are monoamine releasing agents of serotonin, norepinephrine, and/or dopamine, with stimulant and/or entactogen-related effects. Compounds closely related to methoxyphenethylamines include methylenedioxyphenethylamines (MDxx) like M ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drug
A drug is any chemical substance other than a nutrient or an essential dietary ingredient, which, when administered to a living organism, produces a biological effect. Consumption of drugs can be via insufflation (medicine), inhalation, drug injection, injection, smoking, ingestion, absorption (skin), absorption via a dermal patch, patch on the skin, suppository, or sublingual administration, dissolution under the tongue. In pharmacology, a drug is a chemical substance, typically of known structure, which, when administered to a living organism, produces a biological effect. A pharmaceutical drug, also called a medication or medicine, is a chemical substance used to pharmacotherapy, treat, cure, preventive healthcare, prevent, or medical diagnosis, diagnose a disease or to promote well-being. Traditionally drugs were obtained through extraction from medicinal plants, but more recently also by organic synthesis. Pharmaceutical drugs may be used for a limited duration, or on a re ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scientific Literature
Scientific literature encompasses a vast body of academic papers that spans various disciplines within the natural and social sciences. It primarily consists of academic papers that present original empirical research and theoretical contributions. These papers serve as essential sources of knowledge and are commonly referred to simply as "the literature" within specific research fields. The process of academic publishing involves disseminating research findings to a wider audience. Researchers submit their work to reputable journals or conferences, where it undergoes rigorous evaluation by experts in the field. This evaluation, known as peer review, ensures the quality, validity, and reliability of the research before it becomes part of the scientific literature. Peer-reviewed publications contribute significantly to advancing our understanding of the world and shaping future research endeavors. Original scientific research first published in scientific journals co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pentamethoxyphenethylamine
Pentamethoxyphenethylamine (PeMPEA), also known as 2,3,4,5,6-pentamethoxyphenethylamine (2,3,4,5,6-PeMPEA), is a drug of the phenethylamine family related to the psychedelic drug mescaline (3,4,5-trimethoxyphenethylamine). It has been found to produce behavioral effects in animals, with about 8-fold higher potency than mescaline in the conditioned avoidance response test. The pharmacokinetics of the drug in rodents have been studied. The effects of PeMPEA in humans have not been reported and are unknown. It was first described in the scientific literature by 1955. PeMPEA was included as an entry in Alexander Shulgin's 2011 book '' The Shulgin Index, Volume One: Psychedelic Phenethylamines and Related Compounds''. See also * Substituted methoxyphenethylamine * Pentamethoxyamphetamine (PeMA) * 2,3,4,5-Tetramethoxyphenethylamine 2,3,4,5-Tetramethoxyphenethylamine (TeMPEA) is a drug of the phenethylamine family related to mescaline (3,4,5-trimethoxyphenethylamine) and the 2C dr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2,3,4,5-Tetramethoxyamphetamine
Tetramethoxyamphetamine (TeMA), or 2,3,4,5-tetramethoxyamphetamine, is a lesser-known psychedelic drug and a substituted amphetamine. Tetramethoxyamphetamine was first synthesized by Alexander Shulgin. In his book '' PiHKAL (Phenethylamines i Have Known And Loved)'', the minimum dosage is listed as 50 mg, and the duration unknown. Tetramethoxyamphetamine produces a threshold, mydriasis, and a headache. Limited data exists about its pharmacological properties, metabolism, and toxicity. See also * Substituted methoxyphenethylamine * 2,3,4,5-Tetramethoxyphenethylamine (TeMPEA) * 2,5-Dimethoxy-3,4-methylenedioxyamphetamine 2,5-Dimethoxy-3,4-methylenedioxyamphetamine (DMMDA or DMMDA-1) is a lesser-known psychedelic drug of the substituted amphetamine, amphetamine family related to MMDA (drug), MMDA. It was first chemical synthesis, synthesized by Alexander Shulgin ... (DMMDA) References External links Tetramethoxyamphetamine entry in ''PiHKAL''Tetramethoxyamphetamine e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
2,3,4,5-Tetramethoxyphenethylamine
2,3,4,5-Tetramethoxyphenethylamine (TeMPEA) is a drug of the phenethylamine family related to mescaline (3,4,5-trimethoxyphenethylamine) and the 2C drugs (4-substituted 2,5-dimethoxyphenethylamines). It was reported to be twice as potent as mescaline in producing behavioral changes in animals. However, it does not seem to have been tested in humans. The drug was not described in Alexander Shulgin's PiHKAL, though it was included in '' The Shulgin Index, Volume One: Psychedelic Phenethylamines and Related Compounds''. A derivative is 2,3,4,5-tetramethoxyamphetamine (TeMA), which ''was'' included in PiHKAL, and was reported to be inactive in humans at the tested doses. See also * Substituted methoxyphenethylamine Methoxyphenethylamines (MPEAs), as well as methoxyamphetamines (MAs) in the case of the amphetamine (α-methylphenethylamine) homologues, are substituted phenethylamines with one or more methoxy groups. In some cases, one or more of the methoxy ... References Ext ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Norepinephrine Releasing Agent
A norepinephrine releasing agent (NRA), also known as an adrenergic releasing agent, is a catecholaminergic type of drug that induces the release of norepinephrine (noradrenaline) and epinephrine (adrenaline) from the pre-synaptic neuron into the synapse. This in turn leads to increased extracellular concentrations of norepinephrine and epinephrine therefore an increase in adrenergic neurotransmission. A closely related type of drug is a norepinephrine reuptake inhibitor (NRI), for instance reboxetine. Another class of drugs that stimulates adrenergic activity is the adrenergic receptor agonist class. Uses and examples NRAs, frequently as norepinephrine–dopamine releasing agents (NDRAs) rather than as selective NRAs, are used for a variety of clinical indications including the following: * For the treatment of attention deficit hyperactivity disorder (ADHD) — e.g., amphetamine, dextroamphetamine, levoamphetamine, lisdexamfetamine, methamphetamine * As anorectics in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Substituted Phenethylamine
Substituted phenethylamines (or simply phenethylamines) are a chemical class of organic compounds that are based upon the phenethylamine structure; the class is composed of all the derivative (chemistry), derivative compounds of phenethylamine which can be formed by replacing, or substitution reaction, substituting, one or more hydrogen atoms in the phenethylamine core structure with substituents. Phenylethylamines are also generally found to be central nervous system stimulants with many also being entactogens/empathogens, and hallucinogens. Structural classification The structural formula of any substituted phenethylamine contains a phenyl group, phenyl ring that is joined to an amino group, amino (NH) group via a two-carbon substituent, sidechain. Hence, any substituted phenethylamine can be classified according to the substitution of hydrogen atom, hydrogen (H) atoms on phenethylamine's phenyl ring, sidechain, or amino group with a moiety (chemistry), specific group of at ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Drug Metabolism
Drug metabolism is the metabolic breakdown of drugs by living organisms, usually through specialized enzymatic systems. More generally, xenobiotic metabolism (from the Greek xenos "stranger" and biotic "related to living beings") is the set of metabolic pathways that modify the chemical structure of xenobiotics, which are compounds foreign to an organism's normal biochemistry, such as any drug or poison. These pathways are a form of biotransformation present in all major groups of organisms and are considered to be of ancient origin. These reactions often act to detoxify poisonous compounds (although in some cases the intermediates in xenobiotic metabolism can themselves cause toxic effects). The study of drug metabolism is the object of pharmacokinetics. Metabolism is one of the stages (see ADME) of the drug's transit through the body that involves the breakdown of the drug so that it can be excreted by the body. The metabolism of pharmaceutical drugs is an important as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
