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Stovarsol
Acetarsol (or acetarsone) is an anti- infective drug. It was first discovered in 1921 at Pasteur Institute by Ernest Fourneau, and sold under the brand name Stovarsol. It has been given in the form of suppositories. Acetarsol can be used to make arsthinol. It has been cancelled and withdrawn from the market since August 12th, 1997. Medical uses Acetarsol has been used for the treatment of diseases such as syphilis, amoebiasis, yaws, trypanosomiasisiasis and malaria. Acetarsol was used for the treatment of ''Trichomonas Vaginalis'' and ''Candida Albicans.'' In the oral form, acetarsol can be used for the treatment of intestinal amoebiasis. As a suppository, acetarsol was researched to be used for the treatment of proctitis. Mechanism of action Although the mechanism of action is not fully known, acetarsol may bind to protein-containing sulfhydryl groups located in the parasite, which then creates lethal As-S bonds, which then kills the parasite. Chemistry and pharmacok ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pasteur Institute
The Pasteur Institute (, ) is a French non-profit private foundation dedicated to the study of biology, micro-organisms, diseases, and vaccines. It is named after Louis Pasteur, who invented pasteurization and vaccines for anthrax and rabies. The institute was founded on 4 June 1887 and inaugurated on 14 November 1888. For over a century, the Institut Pasteur has researched infectious diseases. This worldwide biomedical research organization based in Paris was the first to isolate HIV, the virus that causes AIDS, in 1983. It has also been responsible for discoveries that have enabled medical science to control diseases such as diphtheria, tetanus, tuberculosis, poliomyelitis, influenza, yellow fever, and Plague (disease), plague. Since 1908, ten Institut Pasteur scientists have been awarded the Nobel Prize for medicine and physiology—the 2008 Nobel Prize in Physiology or Medicine was shared between two Pasteur scientists. History The Institut Pasteur was founded in 1887 by ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ernest Fourneau
Ernest Fourneau (4 October 1872 – 5 August 1949) was a French pharmacist who graduated in 1898 for the Paris university specialist in medicinal chemistry and pharmacology. He played a major role in the discovery of synthetic local anesthetics such as amylocaine, as well as in the synthesis of suramin. He authored more than two hundred scholarly works, and has been described as having "helped to establish the fundamental laws of chemotherapy that have saved so many human lives". Fourneau was a pupil of Friedel and Moureu, and studied in the German laboratories of Ludwig Gattermann in Heidelberg, Hermann Emil Fischer in Berlin and Richard Willstätter in Munich. He headed the research laboratory of Poulenc Frères in Ivry-sur-Seine from 1903 to 1911. One of the products was a synthetic local anesthetic that was named Stovaine ( amylocaine). This was a pun on the English translation of "fourneau" as "stove". (The same pun was used in the brand name of the drug acetarsol, S ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Infective
infection is the invasion of tissues by pathogens, their multiplication, and the reaction of host tissues to the infectious agent and the toxins they produce. An infectious disease, also known as a transmissible disease or communicable disease, is an illness resulting from an infection. Infections can be caused by a wide range of pathogens, most prominently bacteria and viruses. Hosts can fight infections using their immune systems. Mammalian hosts react to infections with an innate response, often involving inflammation, followed by an adaptive response. Treatment for infections depends on the type of pathogen involved. Common medications include: * Antibiotics for bacterial infections. * Antivirals for viral infections. * Antifungals for fungal infections. * Antiprotozoals for protozoan infections. * Antihelminthics for infections caused by parasitic worms. Infectious diseases remain a significant global health concern, causing approximately 9.2 million deaths in 20 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
