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Split And Pool Synthesis
The split and pool (split-mix) synthesis is a method in combinatorial chemistry that can be used to prepare combinatorial compound libraries. It is a Stepwise reaction, stepwise, highly efficient process realized in repeated cycles. The procedure makes it possible to prepare millions or even trillions of Chemical compound, compounds as mixtures that can be used in drug research. History According to traditional methods, most organic compounds are synthesized one by one from building blocks coupling them together one after the other in a stepwise manner. Before 1982 nobody was even dreaming about making hundreds or thousands of compounds in a single process. Not speaking about millions or even trillions. So the productivity of the split and pool method invented by Prof. Á. Furka (Eötvös Loránd University Budapest Hungary), in 1982 seemed incredible at first sight. The method had been described it in a document notarized in the same year. The document is written in Hungarian and t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Combinatorial Chemistry
Combinatorial chemistry comprises chemical synthesis, chemical synthetic methods that make it possible to prepare a large number (tens to thousands or even millions) of compounds in a single process. These compound library, compound libraries can be made as mixtures, sets of individual compounds or chemical structures generated by computer software. Combinatorial chemistry can be used for the synthesis of small molecules and for peptides. Strategies that allow identification of useful components of the libraries are also part of combinatorial chemistry. The methods used in combinatorial chemistry are applied outside chemistry, too. Introduction The basic principle of combinatorial chemistry is to prepare compound library, libraries of a very large number of compounds and identify those which are useful as potential drugs or agrochemicals. This relies on high-throughput screening which is capable of assessing the output at sufficient scale. Although combinatorial chemistry has only ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Arrangement Of Tubes In Automatic Sorter
In music, an arrangement is a musical adaptation of an existing composition. Differences from the original composition may include reharmonization, melodic paraphrasing, orchestration, or formal development. Arranging differs from orchestration in that the latter process is limited to the assignment of notes to instruments for performance by an orchestra, concert band, or other musical ensemble. Arranging "involves adding compositional techniques, such as new thematic material for introductions, transitions, or modulations, and endings. Arranging is the art of giving an existing melody musical variety".(Corozine 2002, p. 3) In jazz, a memorized (unwritten) arrangement of a new or pre-existing composition is known as a ''head arrangement''. Classical music Arrangement and transcriptions of classical and serious music go back to the early history of classical music. Eighteenth century J. S. Bach frequently made arrangements of his own and other composers' pieces. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tools Used In String Synthesis
A tool is an object that can extend an individual's ability to modify features of the surrounding environment or help them accomplish a particular task. Although many animals use simple tools, only human beings, whose use of stone tools dates back hundreds of millennia, have been observed using tools to make other tools. Early human tools, made of such materials as stone, bone, and wood, were used for the preparation of food, hunting, the manufacture of weapons, and the working of materials to produce clothing and useful artifacts and crafts such as pottery, along with the construction of housing, businesses, infrastructure, and transportation. The development of metalworking made additional types of tools possible. Harnessing energy sources, such as animal power, wind, or steam, allowed increasingly complex tools to produce an even larger range of items, with the Industrial Revolution marking an inflection point in the use of tools. The introduction of widespread automation in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
