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Split And Pool Synthesis
The split and pool (split-mix) synthesis is a method in combinatorial chemistry that can be used to prepare combinatorial compound libraries. It is a Stepwise reaction, stepwise, highly efficient process realized in repeated cycles. The procedure makes it possible to prepare millions or even trillions of Chemical compound, compounds as mixtures that can be used in drug research. History According to traditional methods, most organic compounds are synthesized one by one from building blocks coupling them together one after the other in a stepwise manner. Before 1982 nobody was even dreaming about making hundreds or thousands of compounds in a single process. Not speaking about millions or even trillions. So the productivity of the split and pool method invented by Prof. Á. Furka (Eötvös Loránd University Budapest Hungary), in 1982 seemed incredible at first sight. The method had been described it in a document notarized in the same year. The document is written in Hungarian and t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Combinatorial Chemistry
Combinatorial chemistry comprises chemical synthesis, chemical synthetic methods that make it possible to prepare a large number (tens to thousands or even millions) of compounds in a single process. These compound library, compound libraries can be made as mixtures, sets of individual compounds or chemical structures generated by computer software. Combinatorial chemistry can be used for the synthesis of small molecules and for peptides. Strategies that allow identification of useful components of the libraries are also part of combinatorial chemistry. The methods used in combinatorial chemistry are applied outside chemistry, too. Introduction The basic principle of combinatorial chemistry is to prepare compound library, libraries of a very large number of compounds and identify those which are useful as potential drugs or agrochemicals. This relies on high-throughput screening which is capable of assessing the output at sufficient scale. Although combinatorial chemistry has only ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Arrangement Of Tubes In Automatic Sorter
In music, an arrangement is a musical adaptation of an existing composition. Differences from the original composition may include reharmonization, melodic paraphrasing, orchestration, or formal development. Arranging differs from orchestration in that the latter process is limited to the assignment of notes to instruments for performance by an orchestra, concert band, or other musical ensemble. Arranging "involves adding compositional techniques, such as new thematic material for introductions, transitions, or modulations, and endings. Arranging is the art of giving an existing melody musical variety".(Corozine 2002, p. 3) In jazz, a memorized (unwritten) arrangement of a new or pre-existing composition is known as a ''head arrangement''. Classical music Arrangement and transcriptions of classical and serious music go back to the early history of classical music. Eighteenth century J. S. Bach frequently made arrangements of his own and other composers' pieces. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tools Used In String Synthesis
A tool is an object that can extend an individual's ability to modify features of the surrounding environment or help them accomplish a particular task. Although many animals use simple tools, only human beings, whose use of stone tools dates back hundreds of millennia, have been observed using tools to make other tools. Early human tools, made of such materials as stone, bone, and wood, were used for the preparation of food, hunting, the manufacture of weapons, and the working of materials to produce clothing and useful artifacts and crafts such as pottery, along with the construction of housing, businesses, infrastructure, and transportation. The development of metalworking made additional types of tools possible. Harnessing energy sources, such as animal power, wind, or steam, allowed increasingly complex tools to produce an even larger range of items, with the Industrial Revolution marking an inflection point in the use of tools. The introduction of widespread automation in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sorting Of Support Units In String Synthesis
Sorting refers to ordering data in an increasing or decreasing manner according to some linear relationship among the data items. # ordering: arranging items in a sequence ordered by some criterion; # categorizing: grouping items with similar properties. Ordering items is the combination of categorizing them based on equivalent order, and ordering the categories themselves. By type Information or data In , arranging in an ordered sequence is called "sorting". Sorting is a common operation in many applications, and efficient algorithms have been developed to perform it. The most common uses of sorted sequences are: * making lookup or search efficient; * making merging of sequences efficient; * enabling processing of data in a defined order. The opposite of sorting, rearranging a sequence of items in a random or meaningless order, is called shuffling. For sorting, either a weak order, "should not come after", can be specified, or a strict weak order, "should come before" (spec ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Support Units
Support may refer to: Arts, entertainment, and media * Supporting character * Support (art), a solid surface upon which a painting is executed Business and finance * Support (technical analysis) * Child support * Customer support * Income Support Construction * Support (structure), or lateral support, a type of structural support to help prevent sideways movement * Structural support, architectural components that include arches, beams, columns, balconies, and stretchers Law and politics * Advocacy, in politics, support for constituencies, issues, or legislation * Lateral and subjacent support, a legal term Mathematics Mathematics (generally) * Support (mathematics), subset of the domain of a function where it is non-zero valued * Support (measure theory), a subset of a measurable space * Supporting hyperplane, sometimes referred to as support * Support of a module, a set of prime ideals in commutative algebra Statistics * Support, the natural logarithm of the li ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Synthesis Of Single-pharmacophore Library
Synthesis or synthesize may refer to: Science Chemistry and biochemistry *Chemical synthesis, the execution of chemical reactions to form a more complex molecule from chemical precursors **Organic synthesis, the chemical synthesis of organic compounds ***Total synthesis, the complete organic synthesis of complex organic compounds, usually without the aid of biological processes ***Convergent synthesis or linear synthesis, a strategy to improve the efficiency of multi-step chemical syntheses **Dehydration synthesis, a chemical synthesis resulting in the loss of a water molecule *Biosynthesis, the creation of an organic compound in a living organism, usually aided by enzymes **Photosynthesis, a biochemical reaction using a carbon molecule to produce an organic molecule, using sunlight as a catalyst **Chemosynthesis, the synthesis of biological compounds into organic waste, using methane or an oxidized molecule as a catalyst **Amino acid synthesis, the synthesis of an amino acid ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sequence Encoded Routing
In mathematics, a sequence is an enumerated collection of objects in which repetitions are allowed and order matters. Like a set, it contains members (also called ''elements'', or ''terms''). The number of elements (possibly infinite) is called the ''length'' of the sequence. Unlike a set, the same elements can appear multiple times at different positions in a sequence, and unlike a set, the order does matter. Formally, a sequence can be defined as a function from natural numbers (the positions of elements in the sequence) to the elements at each position. The notion of a sequence can be generalized to an indexed family, defined as a function from an ''arbitrary'' index set. For example, (M, A, R, Y) is a sequence of letters with the letter "M" first and "Y" last. This sequence differs from (A, R, M, Y). Also, the sequence (1, 1, 2, 3, 5, 8), which contains the number 1 at two different positions, is a valid sequence. Sequences can be ''finite'', as in these examples, or '' infi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Self Assembling DNA Encoded Libraries
In philosophy, the self is an individual's own being, knowledge, and values, and the relationship between these attributes. The first-person perspective distinguishes selfhood from personal identity. Whereas "identity" is (literally) sameness and may involve categorization and labeling, selfhood implies a first-person perspective and suggests potential uniqueness. Conversely, "person" is used as a third-person reference. Personal identity can be impaired in late-stage Alzheimer's disease and in other neurodegenerative diseases. Finally, the self is distinguishable from "others". Including the distinction between sameness and otherness, the self versus other is a research topic in contemporary philosophy and contemporary phenomenology (see also psychological phenomenology), psychology, psychiatry, neurology, and neuroscience. Although subjective experience is central to selfhood, the privacy of this experience is only one of many problems in the philosophy of self and scie ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stepwise Reaction
A chemical reaction is a process that leads to the chemical transformation of one set of chemical substances to another. When chemical reactions occur, the atoms are rearranged and the reaction is accompanied by an energy change as new products are generated. Classically, chemical reactions encompass changes that only involve the positions of electrons in the forming and breaking of chemical bonds between atoms, with no change to the nuclei (no change to the elements present), and can often be described by a chemical equation. Nuclear chemistry is a sub-discipline of chemistry that involves the chemical reactions of unstable and radioactive elements where both electronic and nuclear changes can occur. The substance (or substances) initially involved in a chemical reaction are called reactants or reagents. Chemical reactions are usually characterized by a chemical change, and they yield one or more products, which usually have properties different from the reactants. Reactions ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scavenger Resin
Scavenger resins are polymers (resins) with bound functional groups that react with specific by-products, impurities, or excess reagents produced in a reaction. Polymer-bound functional groups permit the use of many different scavengers, as the functional groups are confined within a resin or are simply bound to the solid support of a bead. Simply, the functional groups of one scavenger will react minimally with the functional groups of another. Applications Employment of scavenger resins has become increasingly popular in solution-phase combinatorial chemistry. Used primarily in the synthesis of medicinal drugs, solution-phase combinatorial chemistry allows for the creation of large libraries of structurally related compounds. When purifying a solution, many approaches can be taken. In general chemical synthesis laboratories, a number of traditional techniques for purification are used as opposed to the employment of scavenger resins. Whether or not scavenger resins are used oft ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
