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Single-cell Nanoencapsulation
Single-cell nanoencapsulation (SCNE) is an interdisciplinary research field at the intersection of chemistry, biology, nanoscience, and materials science. Single-cell nanoencapsulation involves the development and application of nanometer-scaled shells for the isolation, protection, and functionalization of individual living cells. Single-cell nanoencapsulation enables the fundamental studies of cell–material interactions at the single-cell level, and supports research and development across a range of applied fields, including cell therapy, renewable energy, regenerative medicine, probiotics, and agricultural innovation. By controlling the cellular microenvironment at the nanoscale, single-cell nanoencapsulation allows for fine-tuned investigation of individual cell responses and the design of engineered cellular systems with tailored properties. Single-cell nanoencapsulation is also a chemical strategy that creates "cell-in-shell" structures by forming artificial nanoshells (typ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cell Therapy
Cell therapy (also called cellular therapy, cell transplantation, or cytotherapy) is a therapy in which viable cells are injected, grafted or implanted into a patient in order to effectuate a medicinal effect, for example, by transplanting T-cells capable of fighting cancer cells via cell-mediated immunity in the course of immunotherapy, or grafting stem cells to regenerate diseased tissues. Cell therapy originated in the nineteenth century when scientists experimented by injecting animal material in an attempt to prevent and treat illness. Although such attempts produced no positive benefit, further research found in the mid twentieth century that human cells could be used to help prevent the human body rejecting transplanted organs, leading in time to successful bone marrow transplantation as has become common practice in treatment for patients that have compromised bone marrow after disease, infection, radiation or chemotherapy. In recent decades, however, stem cell and c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tannic Acid
Tannic acid is a specific form of tannin, a type of polyphenol. Its weak acidity (Acid dissociation constant, pKa around 6) is due to the numerous phenol groups in the structure. The chemical formula for commercial tannic acid is often given as C76H52O46, which corresponds with decagalloyl glucose, but in fact it is a mixture of polygalloyl glucoses or polygalloyl quinic acid esters with the number of gallic acid, galloyl moieties per molecule ranging from 2 up to 12 depending on the plant source used to extract the tannic acid. Commercial tannic acid is usually extracted from any of the following plant parts: Tara pods (''Caesalpinia spinosa''), gallnuts from ''Rhus semialata'' or ''Quercus infectoria'' or Sicilian sumac leaves (''Rhus coriaria''). According to the definitions provided in external references such as international pharmacopoeia, Food Chemicals Codex and FAO-WHO tannic acid monograph only tannins obtained from the above-mentioned plants can be considered as tanni ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Freeze-drying
Freeze drying, also known as lyophilization or cryodesiccation, is a low temperature Food drying, dehydration process that involves freezing the product and lowering pressure, thereby removing the ice by Sublimation (phase transition), sublimation. This is in contrast to dehydration by most conventional methods that evaporate water using heat. Because of the low temperature used in processing, the rehydrated product retains many of its original qualities. When solid objects like strawberries are freeze dried the original shape of the product is maintained. If the product to be dried is a liquid, as often seen in pharmaceutical applications, the properties of the final product are optimized by the combination of excipients (i.e., inactive ingredients). Primary applications of freeze drying include biological (e.g., bacteria and yeasts), biomedical (e.g., surgical transplants), food processing (e.g., coffee), and Food preservation, preservation. History The Inca were freeze dry ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Epigallocatechin Gallate
Epigallocatechin gallate (EGCG), also known as epigallocatechin-3-gallate, is the ester of epigallocatechin and gallic acid, and is a type of catechin. EGCG – the most abundant catechin in tea – is a polyphenol under basic research for its potential to affect human health and disease. EGCG is used in many dietary supplements. Food sources Tea It is found in high content in the dried leaves of green tea (7380 mg per 100 g), white tea (4245 mg per 100 g), and in smaller quantities, black tea (936 mg per 100 g). During black tea production, the catechins are mostly converted to theaflavins and thearubigins via polyphenol oxidases. Other Trace amounts are found in apple skin, plums, onions, hazelnuts, pecans, and carob powder (at 109 mg per 100 g). Bioavailability When taken orally, EGCG has poor absorption even at daily intake equivalent to 8 to 16 cups of green tea, an amount causing adverse effects such as nausea or heartbur ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pseudomonas Chlororaphis
''Pseudomonas chlororaphis'' is a bacterium used as a soil inoculant in agriculture and horticulture. It can act as a biocontrol agent against certain fungal plant pathogens via production of phenazine-type antibiotics. Based on 16S rRNA analysis, similar species have been placed in its group. A comparative genomic and phylogenomic study in 2020, analyzed 494 complete genomes from the entire ''Pseudomonas'' genus, with 43 of them being ''P. chlororaphis'' strains. In this study, the ''P. chlororaphis'' species was determined, based on its monophyly and criterion of Average Nucleotide Identity. This species lies within the wider ''P. fluorescens'' species complex, as determined by. The protein count and GC content of the strains of this species ranged between 5599 and 6401 (average: 6076) and between 61.9 and 64% (average: 62.8%), respectively. In addition, the 43 ''P. chlororaphis'' proteomes contained 3587 core proteins (shared among all strains of the species), with 11 core pr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antibiotic-associated Diarrhea
Antibiotic-associated diarrhea (AAD) results from an imbalance in the colonic microbiota caused by antibiotics. Microbiotal alteration changes carbohydrate metabolism with decreased short-chain fatty acid absorption and an osmotic diarrhea as a result. Another consequence of antibiotic therapy leading to diarrhea is an overgrowth of potentially pathogenic organisms such as ''Clostridioides difficile''. It is defined as frequent loose and watery stools with no other complications. __TOC__ Cause ''Clostridioides difficile'', also known more commonly as ''C. diff'', accounts for 10 to 20% of antibiotic-associated diarrhea cases, because the antibiotics administered for the treatment of certain disease processes such as inflammatory colitis also inadvertently kill a large portion of the gut flora, the normal flora that is usually present within the bowel. With this lower level of "healthy" bacteria present, the overgrowth of ''C. diff'' is then responsible "for elaborating the en ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Levofloxacin
Levofloxacin, sold under the brand name Levaquin among others, is a broad-spectrum antibiotic of the fluoroquinolone drug class. It is the left-handed isomer of the medication ofloxacin. It is used to treat a number of bacterial infections including acute bacterial sinusitis, pneumonia, '' H. pylori'' (in combination with other medications), urinary tract infections, Legionnaires' disease, chronic bacterial prostatitis, and some types of gastroenteritis. Along with other antibiotics it may be used to treat tuberculosis, meningitis, or pelvic inflammatory disease. It is available by mouth, intravenously, and in eye drop form. Common side effects include nausea, diarrhea, and trouble sleeping. A warning concerning all fluoroquinolones was issued in 2016: "An FDA safety review has shown that fluoroquinolones when used systemically (i.e. tablets, capsules, and injectable) are associated with disabling and potentially permanent serious adverse effects that can occur togeth ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Escherichia Coli Nissle 1917
''Escherichia coli'' Nissle 1917 is a strain of ''Escherichia coli'' that was isolated from the feces of a German soldier in 1917 by the German researcher Alfred Nissle. Since that time it has been widely studied as a probiotic Probiotics are live microorganisms that provide health benefits when consumed, generally by improving or restoring the microbiota in the gut. Probiotics are considered generally safe to consume, but may cause bacteria– host interactions ... and several marketed probiotics include it and naturally colonizes the human intestines and has positive probiotic properties. Only 50 to 80% of patients who take it daily have detectable amounts in their feces. The precise reason is unknown. It is known that the F1C fimbriae are important for colonization. References {{Reflist Probiotics Escherichia Infraspecific bacteria taxa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
D-galactose
Galactose (, '' galacto-'' + ''-ose'', ), sometimes abbreviated Gal, is a monosaccharide sugar that is about as sweet as glucose, and about 65% as sweet as sucrose. It is an aldohexose and a C-4 epimer of glucose. A galactose molecule linked with a glucose molecule forms a lactose molecule. Galactan is a polymeric form of galactose found in hemicellulose, and forming the core of the galactans, a class of natural polymeric carbohydrates. D-Galactose is also known as brain sugar since it is a component of glycoproteins (oligosaccharide-protein compounds) found in nerve tissue. Etymology The word ''galactose'' was coined by Charles Weissman in the mid-19th century and is derived from Greek , , and the generic chemical suffix for sugars ''-ose''. The etymology is comparable to that of the word ''lactose'' in that both contain roots meaning "milk sugar". Lactose is a disaccharide of galactose plus glucose. Structure and isomerism Galactose exists in both open-chain and cyclic form ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
D-glucose
Glucose is a sugar with the molecular formula , which is often abbreviated as Glc. It is overall the most abundant monosaccharide, a subcategory of carbohydrates. It is mainly made by plants and most algae during photosynthesis from water and carbon dioxide, using energy from sunlight. It is used by plants to make cellulose, the most abundant carbohydrate in the world, for use in cell walls, and by all living organisms to make adenosine triphosphate (ATP), which is used by the cell as energy. In energy metabolism, glucose is the most important source of energy in all organisms. Glucose for metabolism is stored as a polymer, in plants mainly as amylose and amylopectin, and in animals as glycogen. Glucose circulates in the blood of animals as blood sugar. The naturally occurring form is -glucose, while its stereoisomer L-glucose, -glucose is produced synthetically in comparatively small amounts and is less biologically active. Glucose is a monosaccharide containing six carbon ato ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
