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Similarity Matrix Of Proteins
Similarity Matrix of Proteins (SIMAP) is a database of protein similarities created using volunteer computing. It is freely accessible for scientific purposes. SIMAP uses the FASTA algorithm to precalculate protein similarity, while another application uses hidden Markov models to search for protein domains. SIMAP is a joint project of the Technical University of Munich, the Helmholtz Zentrum München, and the University of Vienna. Project The project usually got new work units at the beginning of each month. More recently, (2010), inclusion of environmental sequences into the database has required longer periods of activity, several months of continuous work for example. Typically, these updates occurred twice each year. In the fourth quarter of 2010, the project relocated to the University of Vienna due to the failing electrical infrastructure at the Technical University of Munich. Part of this exercise involved the creation of a project specific URL requiring existing voluntee ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Database
In computing, a database is an organized collection of data or a type of data store based on the use of a database management system (DBMS), the software that interacts with end users, applications, and the database itself to capture and analyze the data. The DBMS additionally encompasses the core facilities provided to administer the database. The sum total of the database, the DBMS and the associated applications can be referred to as a database system. Often the term "database" is also used loosely to refer to any of the DBMS, the database system or an application associated with the database. Before digital storage and retrieval of data have become widespread, index cards were used for data storage in a wide range of applications and environments: in the home to record and store recipes, shopping lists, contact information and other organizational data; in business to record presentation notes, project research and notes, and contact information; in schools as flash c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
X86-64
x86-64 (also known as x64, x86_64, AMD64, and Intel 64) is a 64-bit extension of the x86 instruction set architecture, instruction set. It was announced in 1999 and first available in the AMD Opteron family in 2003. It introduces two new operating modes: 64-bit mode and compatibility mode, along with a new four-level paging mechanism. In 64-bit mode, x86-64 supports significantly larger amounts of virtual memory and physical memory compared to its 32-bit computing, 32-bit predecessors, allowing programs to utilize more memory for data storage. The architecture expands the number of general-purpose registers from 8 to 16, all fully general-purpose, and extends their width to 64 bits. Floating-point arithmetic is supported through mandatory SSE2 instructions in 64-bit mode. While the older x87 FPU and MMX registers are still available, they are generally superseded by a set of sixteen 128-bit Processor register, vector registers (XMM registers). Each of these vector registers ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Science In Society
Science is a systematic discipline that builds and organises knowledge in the form of testable hypotheses and predictions about the universe. Modern science is typically divided into twoor threemajor branches: the natural sciences, which study the physical world, and the social sciences, which study individuals and societies. While referred to as the formal sciences, the study of logic, mathematics, and theoretical computer science are typically regarded as separate because they rely on deductive reasoning instead of the scientific method as their main methodology. Meanwhile, applied sciences are disciplines that use scientific knowledge for practical purposes, such as engineering and medicine. The history of science spans the majority of the historical record, with the earliest identifiable predecessors to modern science dating to the Bronze Age in Egypt and Mesopotamia (). Their contributions to mathematics, astronomy, and medicine entered and shaped the Greek natural philo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Folding@home
Folding@home (FAH or F@h) is a distributed computing project aimed to help scientists develop new therapeutics for a variety of diseases by the means of simulating protein dynamics. This includes the process of protein folding and the movements of proteins, and is reliant on simulations run on volunteers' personal computers. Folding@home is currently based at the University of Pennsylvania and led by Greg Bowman, a former student of Vijay S. Pande, Vijay Pande. The project utilizes graphics processing units (GPUs), central processing units (CPUs), and ARM architecture, ARM processors like those on the Raspberry Pi for distributed computing and scientific research. The project uses statistical simulation methodology that is a paradigm shift from traditional computing methods. As part of the client–server model network architecture, the volunteered machines each receive pieces of a simulation (work units), complete them, and return them to the project's database servers, where th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Predictor@home
Predictor@home was a volunteer computing project that used BOINC software to predict protein structure from protein sequence in the context of the 6th biannual CASP, or Critical Assessment of Techniques for Protein Structure Prediction. A major goal of the project was the testing and evaluating of new algorithms to predict both known and unknown protein structures. Predictor@home was complementary to Folding@home. Whereas the latter aims to study the dynamics of protein folding, Predictor@home aimed to specify what the final tertiary structure will be. Also, the two projects differ significantly in the infrastructure they use. The project used BOINC software, whereas Folding@home maintains its own software completely outside of BOINC. However, for a time, Predictor@home competed with other BOINC protein structure prediction projects, such as Rosetta@home. Each uses different methods of rapidly and reliably predicting the final tertiary structure. Predictor@home is currently ina ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Volunteer Computing
Volunteer computing is a type of distributed computing in which people donate their computers' unused resources to a research-oriented project, and sometimes in exchange for credit points. The fundamental idea behind it is that a modern desktop computer is sufficiently powerful to perform billions of operations a second, but for most users only between 10–15% of its capacity is used. Common tasks such as word processing or web browsing leave the computer mostly idle. The practice of volunteer computing, which dates back to the mid-1990s, can potentially make substantial processing power available to researchers at minimal cost. Typically, a program running on a volunteer's computer periodically contacts a research application to request jobs and report results. A middleware system usually serves as an intermediary. History The first volunteer computing project was the Great Internet Mersenne Prime Search, which started in January 1996. It was followed in 1997 by distribu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Metagenome
Metagenomics is the study of all genetic material from all organisms in a particular environment, providing insights into their composition, diversity, and functional potential. Metagenomics has allowed researchers to profile the microbial composition of environmental and clinical samples without the need for time-consuming culture of individual species. Metagenomics has transformed microbial ecology and evolutionary biology by uncovering previously hidden biodiversity and metabolic capabilities. As the cost of DNA sequencing continues to decline, metagenomic studies now routinely profile hundreds to thousands of samples, enabling large-scale exploration of microbial communities and their roles in health and global ecosystems. Metagenomic studies most commonly employ shotgun sequencing though long-read sequencing is being increasingly utilised as technologies advance. The field is also referred to as environmental genomics, ecogenomics, community genomics, or microbiomics ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein Sequence
Protein primary structure is the linear sequence of amino acids in a peptide or protein. By convention, the primary structure of a protein is reported starting from the amino-terminal (N) end to the carboxyl-terminal (C) end. Protein biosynthesis is most commonly performed by ribosomes in cells. Peptides can also be synthesized in the laboratory. Protein primary structures can be directly sequenced, or inferred from DNA sequences. Formation Biological Amino acids are polymerised via peptide bonds to form a long backbone, with the different amino acid side chains protruding along it. In biological systems, proteins are produced during translation by a cell's ribosomes. Some organisms can also make short peptides by non-ribosomal peptide synthesis, which often use amino acids other than the encoded 22, and may be cyclised, modified and cross-linked. Chemical Peptides can be synthesised chemically via a range of laboratory methods. Chemical methods typically synt ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Android (operating System)
Android is an operating system based on a modified version of the Linux kernel and other open-source software, open-source software, designed primarily for touchscreen-based mobile devices such as smartphones and tablet computer, tablets. Android has historically been developed by a consortium of developers known as the Open Handset Alliance, but its most widely used version is primarily developed by Google. First released in 2008, Android is the world's Usage share of operating systems, most widely used operating system; the latest version, released on June 10, 2025, is Android 16. At its core, the operating system is known as the Android Open Source Project (AOSP) and is free and open-source software (FOSS) primarily licensed under the Apache License. However, most devices run the proprietary software, proprietary Android version developed by Google, which ships with additional proprietary closed-source software pre-installed, most notably Google Mobile Services (GMS), which ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mac OS
Mac operating systems were developed by Apple Inc. in a succession of two major series. In 1984, Apple debuted the operating system that is now known as the classic Mac OS with its release of the original Macintosh System Software. The system, rebranded Mac OS in 1997, was pre-installed on every Macintosh until 2002 and offered on Macintosh clones shortly in the 1990s. It was noted for its ease of use, and also criticized for its lack of modern technologies compared to its competitors. The current Mac operating system is macOS, originally named Mac OS X until 2012 and then OS X until 2016. It was developed between 1997 and 2001 after Apple's purchase of NeXT. It brought an entirely new architecture based on NeXTSTEP, a Unix system, that eliminated many of the technical challenges that the classic Mac OS faced, such as problems with memory management. The current macOS is pre-installed with every Mac and receives a major update annually. It is the basis of Apple's current syst ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Microsoft Windows
Windows is a Product lining, product line of Proprietary software, proprietary graphical user interface, graphical operating systems developed and marketed by Microsoft. It is grouped into families and subfamilies that cater to particular sectors of the computing industry – Windows (unqualified) for a consumer or corporate workstation, Windows Server for a Server (computing), server and Windows IoT for an embedded system. Windows is sold as either a consumer retail product or licensed to Original equipment manufacturer, third-party hardware manufacturers who sell products Software bundles, bundled with Windows. The first version of Windows, Windows 1.0, was released on November 20, 1985, as a graphical operating system shell for MS-DOS in response to the growing interest in graphical user interfaces (GUIs). The name "Windows" is a reference to the windowing system in GUIs. The 1990 release of Windows 3.0 catapulted its market success and led to various other product families ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
