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Seneca Valley Virus
''Senecavirus'' is a genus of viruses in the order ''Picornavirales'', in the family ''Picornaviridae''. Mammals of the order ''Artiodactyla'' (even-toed ungulates) serve as natural hosts, with senecaviruses reported in cows, pigs and dolphins. The genus contains two species. ''Senecavirus'' is a replication-competent oncolytic picornavirus. It has selective tropism for cancers with neuroendocrine features including small cell lung cancer (SCLC) and several pediatric solid tumors including retinoblastoma, neuroblastoma, and medulloblastoma. A Phase I clinical trial of ''Senecavirus'' in adults with neuroendocrine tumors showed that senecavirus is apparently safe to administer at doses up to 1E11 vp/kg. It has potential antineoplastic activity. Taxonomy The genus contains the following species, listed by scientific name and followed by the exemplar virus of the species: * ''Senecavirus cetus''; Cetacean picornavirus 1 * ''Senecavirus valles''; Senecavirus A1, also called Seneca ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Viruses
A virus is a submicroscopic infectious agent that replicates only inside the living cells of an organism. Viruses infect all life forms, from animals and plants to microorganisms, including bacteria and archaea. Viruses are found in almost every ecosystem on Earth and are the most numerous type of biological entity. Since Dmitri Ivanovsky's 1892 article describing a non-bacterial pathogen infecting tobacco plants and the discovery of the tobacco mosaic virus by Martinus Beijerinck in 1898, more than 16,000 of the millions of virus species have been described in detail. The study of viruses is known as virology, a subspeciality of microbiology. When infected, a host cell is often forced to rapidly produce thousands of copies of the original virus. When not inside an infected cell or in the process of infecting a cell, viruses exist in the form of independent viral particles, or ''virions'', consisting of (i) genetic material, i.e., long molecules of DNA or RNA that ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pestivirus
''Pestivirus'' is a genus of viruses, in the family ''Flaviviridae''. Viruses in the genus ''Pestivirus'' infect mammals, including members of the family Bovidae (which includes cattle, sheep, and goats) and the family Suidae (which includes various species of swine). There are 19 species in this genus. Diseases associated with this genus include: hemorrhagic syndromes, abortion, and fatal mucosal disease. Structure Viruses in ''Pestivirus'' are enveloped, with spherical geometries. Their diameter is around 50 nm. Genomes are linear and not segmented, around 12kb in length. Lifecycle Entry into the host cell is achieved by attachment of the viral envelope protein E2 to host receptors, which mediates clathrin-mediated endocytosis. The main viral replication process happens in host cytoplasm. Replication follows the positive strand RNA virus replication model. An IRES RNA element at the 5'-nontranslated region (NTR) of the viral genome recruits viral and cellular transl ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Virotherapy
Virotherapy is a treatment using biotechnology to convert viruses into therapeutic agents by reprogramming viruses to treat diseases. There are three main branches of virotherapy: anti-cancer oncolytic viruses, viral vectors for gene therapy and viral immunotherapy. These branches use three different types of treatment methods: gene overexpression, gene knockout, and suicide gene delivery. Gene overexpression adds genetic sequences that compensate for low to zero levels of needed gene expression. Gene knockout uses RNA methods to silence or reduce expression of disease-causing genes. Suicide gene delivery introduces genetic sequences that induce an apoptotic response in cells, usually to kill cancerous growths. In a slightly different context, virotherapy can also refer more broadly to the use of viruses to treat certain medical conditions by killing pathogens. History Chester M. Southam, a researcher at Memorial Sloan Kettering Cancer Center, pioneered the study of viruses as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is a highly aggressive form of cancer that develops from mesenchymal cells that have failed to fully differentiate into myocytes of skeletal muscle. Cells of the neoplasm, tumor are identified as rhabdomyoblasts. The four subtypes are embryonal rhabdomyosarcoma, alveolar rhabdomyosarcoma, pleomorphic rhabdomyosarcoma, and spindle-cell/sclerosing rhabdomyosarcoma. Embryonal and alveolar are the main groups, and these types are the most common soft tissue sarcomas of childhood and adolescence. The pleomorphic type is usually found in adults. It is generally considered to be a disease of childhood, as the vast majority of cases occur in those below the age of 18. It is commonly described as one of the small-blue-round-cell tumors of childhood due to its appearance on an H&E stain. Despite being relatively rare, it accounts for approximately 40% of all recorded soft-tissue sarcomas. RMS can occur in any soft-tissue site in the body, but is primarily found in t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neuroblastoma
Neuroblastoma (NB) is a type of cancer that forms in certain types of nerve tissue. It most frequently starts from one of the adrenal glands but can also develop in the head, neck, chest, abdomen, or Vertebral column, spine. Symptoms may include bone pain, a lump in the abdomen, neck, or chest, or a painless bluish lump under the skin. Typically, neuroblastoma occurs due to a genetic mutation occurring in the first trimester of pregnancy. Rarely, it may be due to a mutation heredity, inherited. Environmental factors have not been found to be involved. Diagnosis is based on a tissue biopsy. Occasionally, it may be found in a baby by ultrasound during pregnancy. At diagnosis, the cancer has usually already Metastasis, spread. The cancer is divided into low-, intermediate-, and high-risk groups based on a child's age, cancer stage, and what the cancer looks like. Treatment and outcomes depends on the risk group a person is in. Treatments may include observation, surgery, radiatio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Small Cell Lung Cancer
Small-cell carcinoma, also known as oat cell carcinoma, is a type of highly malignant cancer that most commonly arises within the lung, although it can occasionally arise in other body sites, such as the cervix, prostate, and gastrointestinal tract. Compared to non-small cell carcinoma, small cell carcinoma is more aggressive, with a shorter doubling time, higher growth fraction, and earlier development of metastases. Extensive stage small cell lung cancer (SCLC) is classified as a rare disorder. Ten-year relative survival rate (combined limited and extensive SCLC) is 3.5% (4.3% for women, 2.8% for men). Survival can be higher or lower based on a combination of factors including stage, age, sex and race. While all lung cancers are associated with tobacco smoking, SCLC is very strongly associated with tobacco smoking. Types Lung cancer Small-cell lung carcinoma (SCLC) has long been divided into two clinicopathological stages, termed limited stage (LS) and extensive stage (ES). ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hepatitis C Virus
The hepatitis C virus (HCV) is a small (55–65 nm in size), enveloped, positive-sense single-stranded RNA virus of the family ''Flaviviridae''. The hepatitis C virus is the cause of hepatitis C and some cancers such as liver cancer ( hepatocellular carcinoma, abbreviated HCC) and lymphomas in humans. Taxonomy The hepatitis C virus belongs to the genus '' Hepacivirus'', a member of the family ''Flaviviridae''. Before 2011, it was considered to be the only member of this genus. However a member of this genus has been discovered in dogs: canine hepacivirus. There is also at least one virus in this genus that infects horses. Several additional viruses in the genus have been described in bats and rodents. Structure The hepatitis C virus particle consists of a lipid membrane envelope that is 55 to 65 nm in diameter. Two viral envelope glycoproteins, E1 and E2, are embedded in the lipid envelope. They take part in viral attachment and entry into the cell. Within the e ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hepacivirus
''Hepacivirus'' is a genus of positive-strand RNA viruses in the family ''Flaviviridae''. The hepatitis C virus (HCV), in species ''Hepacivirus hominis'', infects humans and is associated with hepatitis and hepatocellular carcinoma. There are fourteen species in the genus which infect a range of other vertebrate. History Hepatitis C virus (HCV), which is the causative agent of hepatitis C in humans, and a member of the species ''Hepacivirus C'', was discovered in 1989. Eight genotypes (1–8) and eighty-six subtypes (1a, 1b etc.) of hepatitis C virus have been named. GBV-B virus (also known as GB virus B) discovered in 1995 is capable of infecting New World monkeys, in particular tamarins. Like HCV it is transmitted by the blood-borne route and similar to HCV it is associated with the viral hepatitis. However GBV-B has never been identified in wild animals and its natural host is not known. Structure Viruses in the genus ''Hepacivirus'' are enveloped and have spherical icosahe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Internal Ribosome Entry Site
An internal ribosome entry site, abbreviated IRES, is an RNA element that allows for translation initiation in a cap-independent manner, as part of the greater process of protein synthesis. Initiation of eukaryotic translation nearly always occurs at and is dependent on the 5' cap of mRNA molecules, where the translation initiation complex forms and ribosomes engage the mRNA. IRES elements, however, allow ribosomes to engage the mRNA and begin translation independently of the 5' cap. History IRES sequences were first discovered in 1988 in the poliovirus (PV) and encephalomyocarditis virus (EMCV) RNA genomes in the laboratories of Nahum Sonenberg and Eckard Wimmer, respectively. They are described as distinct regions of RNA molecules that are able to recruit the eukaryotic ribosome to the mRNA. This process is also known as cap-independent translation. It has been shown that IRES elements have a distinct secondary or even tertiary structure, but similar structural features at ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Picornavirales
''Picornavirales'' is an order of viruses with vertebrate, invertebrate, protist and plant hosts. The name has a dual etymology. First, ''picorna-'' is an acronym for poliovirus, insensitivity to ether, coxsackievirus, orphan virus, rhinovirus, and ribonucleic acid. Secondly, pico-, meaning extremely small, combines with RNA to describe these very small RNA viruses. The order comprises viruses that historically are referred to as picorna-like viruses. Characteristics The families within this order share a number of common features: * The virions are non- enveloped, icosahedral, and about 30 nanometers in diameter. * The capsid has a "pseudo T=3" structure, and is composed of 60 protomers each made of three similar-sized but nonidentical beta barrels. * The genome is made of one or a few single-stranded RNA(s) serving directly as mRNA, without overlapping open reading frames. * The genome has a small protein, VPg, covalently attached to its 5' end, and usually a poly-adeny ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cardiovirus
Cardiovirus are a group of viruses within order ''Picornavirales'', family ''Picornaviridae''. Vertebrates serve as natural hosts for these viruses. Taxonomy The genus contains the following species: * ''Cardiovirus dhusarah'' (Cardiovirus F) * ''Cardiovirus ranori'' (Cardiovirus C) * ''Cardiovirus rudhira'' (Cardiovirus E) * ''Cardiovirus rueckerti'' (Cardiovirus A), Encephalomyocarditis virus * ''Cardiovirus saffoldi'' (Cardiovirus D), Saffold virus * ''Cardiovirus theileri'' (Cardiovirus B), which contains Theiler's murine encephalomyelitis virus Structure Cardioviruses are single-stranded RNA, non-enveloped viruses with icosahedral or spherical geometries, and a T=pseudo3 icosahedral capsid protein geometry. The diameter is around 30 nm. Genomes are linear and non-segmented, around 7.8 kb in length. The T=pseudo3 icosahedral capsid of Cadiovirus is made of 60 protomers, each of which contains 4 polypeptides: VP1, VP2, VP3, and VP4. Inside the capsid of the virus th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
