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Sarah E. Reisman
Sarah Elizabeth Reisman is the Bren Professor of Chemistry and the Chair of Division of Chemistry and Chemical Engineering at California Institute of Technology. She received the (2013) Arthur C. Cope Scholar Award and the (2014) Tetrahedron Young Investigator Award for Organic Synthesis. Her research focuses on the total synthesis of complex natural products and data-driven developments of asymmetric catalysis. Early career and education Undergraduate Studies Reisman received a B.A. in chemistry from Connecticut College in 2001, conducting research in the lab of Prof. Timo V. Ovaska on the synthesis of tetracyclic terpenoid natural products, including phorbol. Graduate Studies Reisman obtained her Ph.D. from Yale University in 2006, working with John L. Wood on the total synthesis of (±)-welwitindolinone A isonitrile. Reisman's work included methodological developments towards a generalized skeleton, using a chlorine-induced semi-pinacol rearrangement and base-medi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chemistry
Chemistry is the scientific study of the properties and behavior of matter. It is a physical science within the natural sciences that studies the chemical elements that make up matter and chemical compound, compounds made of atoms, molecules and ions: their composition, structure, properties, behavior and the changes they undergo during chemical reaction, reactions with other chemical substance, substances. Chemistry also addresses the nature of chemical bonds in chemical compounds. In the scope of its subject, chemistry occupies an intermediate position between physics and biology. It is sometimes called the central science because it provides a foundation for understanding both Basic research, basic and Applied science, applied scientific disciplines at a fundamental level. For example, chemistry explains aspects of plant growth (botany), the formation of igneous rocks (geology), how atmospheric ozone is formed and how environmental pollutants are degraded (ecology), the prop ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Doctor Of Philosophy
A Doctor of Philosophy (PhD, DPhil; or ) is a terminal degree that usually denotes the highest level of academic achievement in a given discipline and is awarded following a course of Postgraduate education, graduate study and original research. The name of the degree is most often abbreviated PhD (or, at times, as Ph.D. in North American English, North America), pronounced as three separate letters ( ). The University of Oxford uses the alternative abbreviation "DPhil". PhDs are awarded for programs across the whole breadth of academic fields. Since it is an earned research degree, those studying for a PhD are required to produce original research that expands the boundaries of knowledge, normally in the form of a Thesis, dissertation, and, in some cases, defend their work before a panel of other experts in the field. In many fields, the completion of a PhD is typically required for employment as a university professor, researcher, or scientist. Definition In the context o ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Science News
''Science News'' (''SN'') is an American monthly magazine devoted to articles about new scientific and technical developments, typically gleaned from recent scientific and technical journals. The periodical has been described as having a scope across "all sciences" and as having "up to date" coverage. History ''Science News'' has been published since 1922 by the Society for Science & the Public, a non-profit organization founded by E. W. Scripps in 1920. American chemist Edwin Slosson served as the publication's first editor. From 1922 to 1966, it was called ''Science News Letter''. The title was changed to ''Science News'' with the March 12, 1966, issue (vol. 89, no. 11). Tom Siegfried was the editor from 2007 to 2012. In 2012, Siegfried stepped down, and Eva Emerson became the Editor in Chief of the magazine. In 2017, Eva Emerson stepped down to become the editor of a new digital magazine, ''Annual Reviews''. On February 1, 2018, Nancy Shute became the Editor in Chief of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lucy Weston Pickett
Lucy Weston Pickett (January 19, 1904 – November 23, 1997) was a Mary Lyon Professor and Camille and Henry Dreyfus Chair in Chemistry at Mount Holyoke College. Her research on X-ray crystallography and ultraviolet absorption spectroscopy of organic molecules received numerous honors and was supported by grants from the Office of Naval Research, the National Science Foundation and the Petroleum Research Fund of the American Chemical Society. Early life Pickett was born on January 19, 1904, in Beverly, Massachusetts, to Lucy Weston, a former school teacher and elementary school principal, and George Ernest Pickett, a former seaman. She had one brother, Thomas Austin Pickett, who also became a chemist. Both Lucy and Thomas led similar academic and professional lives, while still holding a close relationship. Education Lucy W. Pickett attended high school in Beverly and later entered Mount Holyoke College in South Hadley, Massachusetts, in 1921 and graduated in 1925. Lucy plann ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Margaret Faul
Margaret M. Faul is an Irish American chemist and executive who has won multiple awards for innovations in process chemistry. Background Faul received her undergraduate degrees from University College, Dublin before embarking on doctoral studies with Professor David A. Evans at Harvard. Her studies focused mostly on metal-catalyzed nitrene transfer reactions to produce aziridines, strained nitrogen precursors valued as pharmaceutical intermediates. Faul introduced multiple new wrinkles into this chemistry, including using chiral copper(I) catalysts to produce enantiomerically-enriched aziridines, and using a variety of different nitrene sources for the transfer. Research Faul joined the process chemistry group at Eli Lilly in 1993, and joined Amgen's process group in 2003, rising eventually to its Executive Director. According to a biosketch at ''Organic Syntheses'', Faul has expertise in Good Manufacturing Process scale-up of both chemical and biological therapeutics, and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cycloaddition
In organic chemistry, a cycloaddition is a chemical reaction in which "two or more Unsaturated hydrocarbon, unsaturated molecules (or parts of the same molecule) combine with the formation of a cyclic adduct in which there is a net reduction of the Multiplicity (chemistry)#Molecules, bond multiplicity". The resulting reaction is a cyclization reaction. Many but not all cycloadditions are Concerted reaction, concerted and thus pericyclic. Nonconcerted cycloadditions are not pericyclic. As a class of addition reaction, cycloadditions permit carbon–carbon bond formation without the use of a nucleophile or electrophile. Cycloadditions can be described using two systems of notation. An older but still common notation is based on the size of linear arrangements of atoms in the reactants. It uses parentheses: where the variables are the numbers of linear atoms in each reactant. The product is a cycle of size . In this system, the standard Diels-Alder reaction is a (4 + 2)-cyc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pleuromutilin
Pleuromutilin and its derivatives are antibacterial drugs that inhibit protein synthesis in bacteria by binding to the peptidyl transferase component of the 50S subunit of ribosomes. This class of antibiotics includes the licensed drugs lefamulin (for systemic use in humans), retapamulin (approved for topical use in humans), valnemulin and tiamulin (approved for use in animals) and the investigational drug azamulin. History Pleuromutilin was discovered as an antibiotic in 1951. It is derived from the fungi '' Omphalina mutila'' (formerly ''Pleurotus mutilus'') and '' Clitopilus passeckerianus'' (formerly ''Pleurotus passeckerianus''), and has also been found in '' Drosophila subatrata'', '' Clitopilus scyphoides'', and some other '' Clitopilus'' species. Total synthesis The total synthesis of pleuromutilin has been reported. Biosynthesis Pleuromutilin belongs to the class of secondary metabolites known as terpenes, which are produced in fungi through the mevalonate pathw ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Tokyo
The University of Tokyo (, abbreviated as in Japanese and UTokyo in English) is a public research university in Bunkyō, Tokyo, Japan. Founded in 1877 as the nation's first modern university by the merger of several pre-westernisation era institutions, its direct precursors include the '' Tenmongata'', founded in 1684, and the Shōheizaka Institute. Although established under its current name, the university was renamed in 1886 and was further retitled to distinguish it from other Imperial Universities established later. It served under this name until the official dissolution of the Empire of Japan in 1947, when it reverted to its original name. Today, the university consists of 10 faculties, 15 graduate schools, and 11 affiliated research institutes. As of 2023, it has a total of 13,974 undergraduate students and 14,258 graduate students. The majority of the university's educational and research facilities are concentrated within its three main Tokyo campuses: Hongō, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Masayuki Inoue
Masayuki (written: , ,, , , , , , , , , , , , , , or ) is a masculine Japanese given name. Notable people with the name include: *, Japanese animator and director *, Japanese actor *, Japanese baseball player and manager *, Japanese politician *, Japanese samurai *, Japanese pianist and composer *, Japanese karateka *, Japanese ''daimyō'' *, Japanese handball player *, Japanese manga artist *, Japanese astronomer *, Japanese volleyball player *, Japanese voice actor *, Japanese speed skater *, Japanese physician * Masayuki Kawamura (golfer) (born 1967), Japanese golfer *, Japanese seismologist *, Japanese swimmer *, Japanese animator and anime director *, Japanese professional wrestler and mixed martial artist *, Japanese sport wrestler *, Japanese gymnast *, Japanese volleyball player *, Japanese footballer *, Japanese anime director *, Japanese artist *, Japanese sumo wrestler *, Japanese actor *, Japanese film producer *, Japanese sculptor *, Japanese footballer *, Japanese pol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Enantioselective
In chemistry, stereoselectivity is the property of a chemical reaction in which a single reactant forms an unequal mixture of stereoisomers during a non- stereospecific creation of a new stereocenter or during a non-stereospecific transformation of a pre-existing one. The selectivity arises from differences in steric and electronic effects in the mechanistic pathways leading to the different products. Stereoselectivity can vary in degree but it can never be total since the activation energy difference between the two pathways is finite: both products are at least possible and merely differ in amount. However, in favorable cases, the minor stereoisomer may not be detectable by the analytic methods used. An enantioselective reaction is one in which one enantiomer is formed in preference to the other, in a reaction that creates an optically active product from an achiral starting material, using either a chiral catalyst, an enzyme or a chiral reagent. The degree of selectivity is m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thiourea Organocatalysis
Within the area of organocatalysis, (thio)urea organocatalysis describes the use of ureas and thioureas to accelerate and stereochemically alter organic transformations. The effects arise through hydrogen-bonding interactions between the substrate and the (thio)urea. Unlike classical catalysts, these organocatalysts interact by non-covalent interactions, especially hydrogen bonding ("partial protonation"). The scope of these small-molecule H-bond donors termed (thio)urea organocatalysis covers both non-stereoselective and stereoselective reactions. Catalyst-substrate interactions Hydrogen-bonding between thiourea derivatives and carbonyl substrates involve two hydrogen bonds provided by coplanar amino substituents in the (thio)urea. Squaramide catalysts engage in double H-bonding interactions and are often superior to thioureas. Thioureas are often found to be stronger hydrogen-bond donors (''i.e.,'' more acidic) than ureas because their amino groups are more positively charg ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Oxocarbenium
In organic chemistry, an oxocarbenium ion (alternatively spelled oxacarbenium) is a chemical species characterized by a central sp2-hybridized atom of carbon, a substituent atom of oxygen, and an overall positive charge that is delocalized between the central carbon and oxygen atoms (). An oxocarbenium ion is represented by two limiting resonance structures, one in the form of a carbenium ion with the positive charge on carbon () and the other in the form of an oxonium species with the formal charge on oxygen (). As a resonance hybrid, the true structure falls between the two. Compared to neutral carbonyl () compounds like ketones () or esters, the carbenium ion form is a larger contributor to the structure. They are common reactive intermediates in the hydrolysis of glycosidic bonds, and are a commonly used strategy for chemical glycosylation. These ions have since been proposed as reactive intermediates in a wide range of chemical transformations, and have been utilized in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
