Rs4680

	Rs4680 In genetics, rs4680 (Val158Met) is a genetic variant. It is a single nucleotide polymorphism (SNP) in the ''COMT'' gene that codes catechol-''O''-Methyltransferase. The single nucleotide substitution between G--> A results in an amino acid change from valine to methionine at codon 158. The A or Met allele is associated with lower enzymatic activity (due to thermoinstability), and with exploratory behaviour. The polymorphism has been much studied in schizophrenia research but as of November 2011 meta-analysis in the '' SzGene'' database shows no or very little effect. Several personality genetics studies have examined the association of the polymorphism with personality traits including extroversion, risk aversion, and novelty seeking In Cloninger's model of psychobiology, novelty seeking (NS) is an inherited, unlearned, temperamental bias toward novel signals from the environment. It can be measured along a spectrum from low to high (as with 3 other temperamental domains) and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	COMT Catechol-''O''-methyltransferase (COMT; ) is one of several enzymes that degrade catecholamines (neurotransmitters such as dopamine, epinephrine, and norepinephrine), catecholestrogens, and various drugs and substances having a catechol structure. In humans, catechol-''O''-methyltransferase protein is encoded by the COMT gene. Two isoforms of COMT are produced: the soluble short form (S-COMT) and the membrane bound long form (MB-COMT). As the regulation of catecholamines is impaired in a number of medical conditions, several pharmaceutical drugs target COMT to alter its activity and therefore the availability of catecholamines. COMT was first discovered by the biochemist Julius Axelrod in 1957. Function Catechol-''O''-methyltransferase is involved in the inactivation of the catecholamine neurotransmitters (dopamine, epinephrine, and norepinephrine). The enzyme introduces a methyl group to the catecholamine, which is donated by S-adenosyl methionine (SAM). Any compound having a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Novelty Seeking In Cloninger's model of psychobiology, novelty seeking (NS) is an inherited, unlearned, temperamental bias toward novel signals from the environment. It can be measured along a spectrum from low to high (as with 3 other temperamental domains) and when toward the upper end of the spectrum, it is associated with higher exploratory activity, need for higher levels of baseline stimulation, impulsive decision making, extravagance in approach to reward cues, quick temperedness, low tolerance for frustration, impulsivity, and proneness to addiction. It is measured in the Tridimensional Personality Questionnaire as well as the later version Temperament and Character Inventory and is considered one of the ''temperament'' dimensions of personality. Like the other temperament dimensions, it has been found to be highly heritable. High NS has been suggested to be related to low dopaminergic activity. In the revised version of the Temperament and Character Inventory (TCI-R) novelty seeking ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Genetics Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinian friar working in the 19th century in Brno, was the first to study genetics scientifically. Mendel studied "trait inheritance", patterns in the way traits are handed down from parents to offspring over time. He observed that organisms (pea plants) inherit traits by way of discrete "units of inheritance". This term, still used today, is a somewhat ambiguous definition of what is referred to as a gene. Trait inheritance and molecular inheritance mechanisms of genes are still primary principles of genetics in the 21st century, but modern genetics has expanded to study the function and behavior of genes. Gene structure and function, variation, and distribution are studied within the context of the cell, the organism (e.g. dominance), and within the con ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Shin Young Kim Shin may refer to: Biology * The front part of the human leg below the knee * Shinbone, the tibia, the larger of the two bones in the leg below the knee in vertebrates Names * Shin (given name) (Katakana: シン, Hiragana: しん), a Japanese given name * Shin (Korean surname) (Hangul: 신, Hanja: 申, 辛, 愼), a Korean family name * Shin (Chinese: 新, which means "new"), spelled in Pinyin as Xin Fictional characters * Shin Akuma, a character in the Street Fighter series Shin Asuka (other), multiple Shin Malphur, a character in the video game '' Destiny 2: Forsaken'' * Kamen Rider Shin, a character in the Kamen Rider series Seijuro Shin (進), a character in the manga and anime series ''Eyeshield 21'' A character in the manga Dorohedoro * A character in the manga and anime ''Fist of the North Star'' Music * Shin (band) ( zh, 信樂團, links=no) * Shin (singer) (蘇見信), a Taiwanese singer and former lead singer of the band Shin * Shin, the drummer of th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Margaret Daniele Fallin Margaret is a female first name, derived via French () and Latin () from grc, μαργαρίτης () meaning "pearl". The Greek is borrowed from Persian. Margaret has been an English name since the 11th century, and remained popular throughout the Middle Ages. It became less popular between the 16th century and 18th century, but became more common again after this period, becoming the second-most popular female name in the United States in 1903. Since this time, it has become less common, but was still the ninth-most common name for women of all ages in the United States as of the 1990 census. Margaret has many diminutive forms in many different languages, including Maggie, Madge, Daisy, Margarete, Marge, Margo, Margie, Marjorie, Meg, Megan, Rita, Greta, Gretchen, and Peggy. Name variants Full name * ( Irish) * ( Irish) * (Dutch), (German), ( Swedish) * (English) Diminutives * (English) * (English) First half * ( French) * (Welsh) Second half * (Englis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Murray B Murray may refer to: Businesses * Murray (bicycle company), an American manufacturer of low-cost bicycles * Murrays, an Australian bus company * Murray International Trust, a Scottish investment trust * D. & W. Murray Limited, an Australian wholesale drapery business * John Murray (publishing house), a British publishing house Fictional characters * Murray Monster, a muppet in ''Sesame Street'' Little Murray Sparkles, a cat in ''Sesame Street'' Murray (''Monkey Island''), a character in the video game series * Murray (''Sly Cooper''), a character in the video game series * Murray Slaughter, a regular character in ''The Mary Tyler Moore Show'' Murray, the mascot of the band Dio Murray, in the 2015 Netflix series '' Richie Rich'' Murray, a ''Hotel Transylvania'' character Murray the Cop, in ''Fat Pizza'' Murray Smith, in '' Swift and Shift Couriers'' People Murray (surname) * Murray (given name) Places Australia * Division of Murray, federal electoral district in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Hiroshi Kunugi is a common masculine Japanese given name. It can also be transliterated as Hirosi. Possible writings Hiroshi can be written using different kanji characters and can mean: 浩, "meaning" 汎弘, 宏, 寛, 洋, 博, 博一, 博司, 博史, 弘詩, 大嗣, 博司, 博史, 弘詩, 大嗣, People with the name , Japanese comedian Hiroshi Abe (other), multiple people , Japanese actor , Japanese astronomer * Hiroshi Abe (war criminal) (born 1922), Japanese soldier , Japanese screenwriter and film director , Japanese baseball player , Japanese actor , Japanese handball player * Hiroshi Hara (other), multiple people Hiroshi Hashimoto (other), multiple people Hiroshi Honda (other), multiple people , Japanese ice hockey player , Japanese footballer , Japanese bobsledder , Japanese film director , Japanese footballer , Japanese diplomat , Japanese electrical engineer , Japanese lepidopterist , Japanese bryologi ... [...More Info...] [...Related Items...] OR:* [Wikipedia] [Google] [Baidu]
	Masatoshi Takeda Masatoshi (written: , , , , , , , , , , , , or ) is a masculine Japanese given name. Notable people with the name include: , Japanese politician , Japanese film director , Japanese politician , Japanese comedian , Japanese samurai , Japanese ''daimyō'' , Japanese cyclist , Japanese samurai and ''daimyō'' Masatoshi Ishida (other), multiple people , Japanese businessman , Japanese manga artist , Japanese physicist , Japanese footballer , Japanese politician , Japanese guitarist , Japanese footballer , Japanese footballer , Japanese footballer , Japanese diplomat , Japanese actor Masatoshi Nagatomi Masatoshi Nagatomi (September 1, 1926 – June 3, 2000) was Japanese professor of Buddhist studies at Harvard University. He was also known by his nickname "Mas." Nagatomi is remembered for introducing the term '' Nikaya Buddhism'' as a replacemen ... (1926–2000), Japanese professor of Buddhist studies at Harvard University , Japanese photographer , Jap ... [...More Info...] [...Related Items...] OR:* [Wikipedia] [Google] [Baidu]
	Yuka Yasuda Yuka may refer to: Yuka (music), an Afro-Cuban style of music Yuka (mammoth), mammoth specimen found in Yakutia, Russia Manshu Yuka Kogyo K.K. Ssuningkai, a Japanese-German pre-WWII industrial co-operation People Yuka (name), a Japanese personal name Yuka (singer) (born 1970), Japanese singer See also Yuca ''Manihot esculenta'', commonly called cassava (), manioc, or yuca (among numerous regional names), is a woody shrub of the spurge family, Euphorbiaceae, native to South America. Although a perennial plant, cassava is extensively cultivated ..., a plant species * Yucca (other) {{disambig ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Kazutaka Ohi Kazutaka (written: 一貴, 一宇, 一孝, 和隆 or 教隆) is a masculine Japanese given name. Notable people with the name include: Kazutaka Kogi Kazutaka Kogi (born 1933) is a Japanese academic known for his contributions to simple, low-cost interventions in small manufacturing enterprises that improve the working conditions for the employees and at the same time also improve the overall p ... (born 1933), Japanese academic , Japanese ultra-nationalist and murderer , Japanese mechanical designer , Japanese footballer , Japanese sumo wrestler , Japanese baseball player See also * 8087 Kazutaka, a main-belt asteroid {{given name Japanese masculine given names ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Hiroaki Hori Hiroaki is a masculine Japanese given name. It can be written in many ways. In the following lists, the kanji in parentheses are the individual's way of writing the name Hiroaki. Possible writings (written: , , , , , , , , , , , , , , , , , , , , , , , , , or ) People with the name , Japanese admiral , Japanese businessman , Japanese volleyball player , Japanese hammer thrower , Japanese diplomat , Japanese anime director and screenwriter , Japanese serial killer , Japanese prince , Japanese judoka , Japanese footballer , Japanese voice actor , Japanese racing driver , Japanese modern pentathlete , Japanese footballer , Japanese scientist , Japanese footballer , Japanese snowboarder , Japanese baseball player , Japanese footballer and manager , Japanese virologist , Japanese voice actor Hiroaki Morino is a Japanese ceramist. His pseudonym is . His real name is Hiroaki Morino. Overviews He is a Japanese potter from Kyoto born in 1934. His father, Mo ... [...More Info...] [...Related Items...] OR:* [Wikipedia] [Google] [Baidu]
	Hiroko Noguchi is a common feminine Japanese given name. Name meanings Hiroko can be written using different kanji characters and can mean: 裕子, "kind child" 弘子, "Beautiful child" 寛子, " small child" 浩子, "large child" 博子, "wise child" 宏子, "large child" 広子, "broad child" 紘子, "large child" The name can also be written in hiragana or katakana. People with the name * Hiroko Anzai (安西ひろこ, born 1979), Japanese model and idol * Hiroko Hatano (畑野ひろ子, born 1975), Japanese supermodel and actress , better known as Chikage Oogi, Japanese actress and politician , Japanese singer, actress and television personality , Japanese archer , Japanese fencer , Japanese slalom canoeist Hiroko Konishi (小西寛子, born 1975), Japanese voice actress , Japanese handball player , Japanese swimmer , Japanese model , Japanese writer * Hiroko Mita (三田寛子, born 1966), Japanese singer and actress * Hiroko Moriguchi (森口博子, born 1968), J ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]

	Rs4680 In genetics, rs4680 (Val158Met) is a genetic variant. It is a single nucleotide polymorphism (SNP) in the ''COMT'' gene that codes catechol-''O''-Methyltransferase. The single nucleotide substitution between G--> A results in an amino acid change from valine to methionine at codon 158. The A or Met allele is associated with lower enzymatic activity (due to thermoinstability), and with exploratory behaviour. The polymorphism has been much studied in schizophrenia research but as of November 2011 meta-analysis in the '' SzGene'' database shows no or very little effect. Several personality genetics studies have examined the association of the polymorphism with personality traits including extroversion, risk aversion, and novelty seeking In Cloninger's model of psychobiology, novelty seeking (NS) is an inherited, unlearned, temperamental bias toward novel signals from the environment. It can be measured along a spectrum from low to high (as with 3 other temperamental domains) and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	COMT Catechol-''O''-methyltransferase (COMT; ) is one of several enzymes that degrade catecholamines (neurotransmitters such as dopamine, epinephrine, and norepinephrine), catecholestrogens, and various drugs and substances having a catechol structure. In humans, catechol-''O''-methyltransferase protein is encoded by the COMT gene. Two isoforms of COMT are produced: the soluble short form (S-COMT) and the membrane bound long form (MB-COMT). As the regulation of catecholamines is impaired in a number of medical conditions, several pharmaceutical drugs target COMT to alter its activity and therefore the availability of catecholamines. COMT was first discovered by the biochemist Julius Axelrod in 1957. Function Catechol-''O''-methyltransferase is involved in the inactivation of the catecholamine neurotransmitters (dopamine, epinephrine, and norepinephrine). The enzyme introduces a methyl group to the catecholamine, which is donated by S-adenosyl methionine (SAM). Any compound having a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Novelty Seeking In Cloninger's model of psychobiology, novelty seeking (NS) is an inherited, unlearned, temperamental bias toward novel signals from the environment. It can be measured along a spectrum from low to high (as with 3 other temperamental domains) and when toward the upper end of the spectrum, it is associated with higher exploratory activity, need for higher levels of baseline stimulation, impulsive decision making, extravagance in approach to reward cues, quick temperedness, low tolerance for frustration, impulsivity, and proneness to addiction. It is measured in the Tridimensional Personality Questionnaire as well as the later version Temperament and Character Inventory and is considered one of the ''temperament'' dimensions of personality. Like the other temperament dimensions, it has been found to be highly heritable. High NS has been suggested to be related to low dopaminergic activity. In the revised version of the Temperament and Character Inventory (TCI-R) novelty seeking ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Genetics Genetics is the study of genes, genetic variation, and heredity in organisms.Hartl D, Jones E (2005) It is an important branch in biology because heredity is vital to organisms' evolution. Gregor Mendel, a Moravian Augustinian friar working in the 19th century in Brno, was the first to study genetics scientifically. Mendel studied "trait inheritance", patterns in the way traits are handed down from parents to offspring over time. He observed that organisms (pea plants) inherit traits by way of discrete "units of inheritance". This term, still used today, is a somewhat ambiguous definition of what is referred to as a gene. Trait inheritance and molecular inheritance mechanisms of genes are still primary principles of genetics in the 21st century, but modern genetics has expanded to study the function and behavior of genes. Gene structure and function, variation, and distribution are studied within the context of the cell, the organism (e.g. dominance), and within the con ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Shin Young Kim Shin may refer to: Biology * The front part of the human leg below the knee * Shinbone, the tibia, the larger of the two bones in the leg below the knee in vertebrates Names * Shin (given name) (Katakana: シン, Hiragana: しん), a Japanese given name * Shin (Korean surname) (Hangul: 신, Hanja: 申, 辛, 愼), a Korean family name * Shin (Chinese: 新, which means "new"), spelled in Pinyin as Xin Fictional characters * Shin Akuma, a character in the Street Fighter series Shin Asuka (other), multiple Shin Malphur, a character in the video game '' Destiny 2: Forsaken'' * Kamen Rider Shin, a character in the Kamen Rider series Seijuro Shin (進), a character in the manga and anime series ''Eyeshield 21'' A character in the manga Dorohedoro * A character in the manga and anime ''Fist of the North Star'' Music * Shin (band) ( zh, 信樂團, links=no) * Shin (singer) (蘇見信), a Taiwanese singer and former lead singer of the band Shin * Shin, the drummer of th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Margaret Daniele Fallin Margaret is a female first name, derived via French () and Latin () from grc, μαργαρίτης () meaning "pearl". The Greek is borrowed from Persian. Margaret has been an English name since the 11th century, and remained popular throughout the Middle Ages. It became less popular between the 16th century and 18th century, but became more common again after this period, becoming the second-most popular female name in the United States in 1903. Since this time, it has become less common, but was still the ninth-most common name for women of all ages in the United States as of the 1990 census. Margaret has many diminutive forms in many different languages, including Maggie, Madge, Daisy, Margarete, Marge, Margo, Margie, Marjorie, Meg, Megan, Rita, Greta, Gretchen, and Peggy. Name variants Full name * ( Irish) * ( Irish) * (Dutch), (German), ( Swedish) * (English) Diminutives * (English) * (English) First half * ( French) * (Welsh) Second half * (Englis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Murray B Murray may refer to: Businesses * Murray (bicycle company), an American manufacturer of low-cost bicycles * Murrays, an Australian bus company * Murray International Trust, a Scottish investment trust * D. & W. Murray Limited, an Australian wholesale drapery business * John Murray (publishing house), a British publishing house Fictional characters * Murray Monster, a muppet in ''Sesame Street'' Little Murray Sparkles, a cat in ''Sesame Street'' Murray (''Monkey Island''), a character in the video game series * Murray (''Sly Cooper''), a character in the video game series * Murray Slaughter, a regular character in ''The Mary Tyler Moore Show'' Murray, the mascot of the band Dio Murray, in the 2015 Netflix series '' Richie Rich'' Murray, a ''Hotel Transylvania'' character Murray the Cop, in ''Fat Pizza'' Murray Smith, in '' Swift and Shift Couriers'' People Murray (surname) * Murray (given name) Places Australia * Division of Murray, federal electoral district in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Hiroshi Kunugi is a common masculine Japanese given name. It can also be transliterated as Hirosi. Possible writings Hiroshi can be written using different kanji characters and can mean: 浩, "meaning" 汎弘, 宏, 寛, 洋, 博, 博一, 博司, 博史, 弘詩, 大嗣, 博司, 博史, 弘詩, 大嗣, People with the name , Japanese comedian Hiroshi Abe (other), multiple people , Japanese actor , Japanese astronomer * Hiroshi Abe (war criminal) (born 1922), Japanese soldier , Japanese screenwriter and film director , Japanese baseball player , Japanese actor , Japanese handball player * Hiroshi Hara (other), multiple people Hiroshi Hashimoto (other), multiple people Hiroshi Honda (other), multiple people , Japanese ice hockey player , Japanese footballer , Japanese bobsledder , Japanese film director , Japanese footballer , Japanese diplomat , Japanese electrical engineer , Japanese lepidopterist , Japanese bryologi ... [...More Info...] [...Related Items...] OR:* [Wikipedia] [Google] [Baidu]
	Masatoshi Takeda Masatoshi (written: , , , , , , , , , , , , or ) is a masculine Japanese given name. Notable people with the name include: , Japanese politician , Japanese film director , Japanese politician , Japanese comedian , Japanese samurai , Japanese ''daimyō'' , Japanese cyclist , Japanese samurai and ''daimyō'' Masatoshi Ishida (other), multiple people , Japanese businessman , Japanese manga artist , Japanese physicist , Japanese footballer , Japanese politician , Japanese guitarist , Japanese footballer , Japanese footballer , Japanese footballer , Japanese diplomat , Japanese actor Masatoshi Nagatomi Masatoshi Nagatomi (September 1, 1926 – June 3, 2000) was Japanese professor of Buddhist studies at Harvard University. He was also known by his nickname "Mas." Nagatomi is remembered for introducing the term '' Nikaya Buddhism'' as a replacemen ... (1926–2000), Japanese professor of Buddhist studies at Harvard University , Japanese photographer , Jap ... [...More Info...] [...Related Items...] OR:* [Wikipedia] [Google] [Baidu]
	Yuka Yasuda Yuka may refer to: Yuka (music), an Afro-Cuban style of music Yuka (mammoth), mammoth specimen found in Yakutia, Russia Manshu Yuka Kogyo K.K. Ssuningkai, a Japanese-German pre-WWII industrial co-operation People Yuka (name), a Japanese personal name Yuka (singer) (born 1970), Japanese singer See also Yuca ''Manihot esculenta'', commonly called cassava (), manioc, or yuca (among numerous regional names), is a woody shrub of the spurge family, Euphorbiaceae, native to South America. Although a perennial plant, cassava is extensively cultivated ..., a plant species * Yucca (other) {{disambig ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Kazutaka Ohi Kazutaka (written: 一貴, 一宇, 一孝, 和隆 or 教隆) is a masculine Japanese given name. Notable people with the name include: Kazutaka Kogi Kazutaka Kogi (born 1933) is a Japanese academic known for his contributions to simple, low-cost interventions in small manufacturing enterprises that improve the working conditions for the employees and at the same time also improve the overall p ... (born 1933), Japanese academic , Japanese ultra-nationalist and murderer , Japanese mechanical designer , Japanese footballer , Japanese sumo wrestler , Japanese baseball player See also * 8087 Kazutaka, a main-belt asteroid {{given name Japanese masculine given names ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Hiroaki Hori Hiroaki is a masculine Japanese given name. It can be written in many ways. In the following lists, the kanji in parentheses are the individual's way of writing the name Hiroaki. Possible writings (written: , , , , , , , , , , , , , , , , , , , , , , , , , or ) People with the name , Japanese admiral , Japanese businessman , Japanese volleyball player , Japanese hammer thrower , Japanese diplomat , Japanese anime director and screenwriter , Japanese serial killer , Japanese prince , Japanese judoka , Japanese footballer , Japanese voice actor , Japanese racing driver , Japanese modern pentathlete , Japanese footballer , Japanese scientist , Japanese footballer , Japanese snowboarder , Japanese baseball player , Japanese footballer and manager , Japanese virologist , Japanese voice actor Hiroaki Morino is a Japanese ceramist. His pseudonym is . His real name is Hiroaki Morino. Overviews He is a Japanese potter from Kyoto born in 1934. His father, Mo ... [...More Info...] [...Related Items...] OR:* [Wikipedia] [Google] [Baidu]
	Hiroko Noguchi is a common feminine Japanese given name. Name meanings Hiroko can be written using different kanji characters and can mean: 裕子, "kind child" 弘子, "Beautiful child" 寛子, " small child" 浩子, "large child" 博子, "wise child" 宏子, "large child" 広子, "broad child" 紘子, "large child" The name can also be written in hiragana or katakana. People with the name * Hiroko Anzai (安西ひろこ, born 1979), Japanese model and idol * Hiroko Hatano (畑野ひろ子, born 1975), Japanese supermodel and actress , better known as Chikage Oogi, Japanese actress and politician , Japanese singer, actress and television personality , Japanese archer , Japanese fencer , Japanese slalom canoeist Hiroko Konishi (小西寛子, born 1975), Japanese voice actress , Japanese handball player , Japanese swimmer , Japanese model , Japanese writer * Hiroko Mita (三田寛子, born 1966), Japanese singer and actress * Hiroko Moriguchi (森口博子, born 1968), J ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]