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Roger Brent
Roger Brent (born December 28, 1955) is an American biologist known for his work on gene regulation and systems biology. He studies the quantitative behaviors of cell signaling systems and the origins and consequences of variation in them. He is Full Member in the Division of Basic Sciences at the Fred Hutchinson Cancer Research Center and an Affiliate Professor of Genome Sciences at the University of Washington. Early life Brent grew up in Hattiesburg, Mississippi and received his BA in Computer Science and Statistics from the University of Southern Mississippi, where he applied AI techniques to protein folding. He performed PhD (1982) and postdoctoral work (1985) in Biochemistry and Molecular Biology at Harvard University in the laboratory of Mark Ptashne. In work there he cloned the E. coli LexA repressor and showed how it controlled the cell's response to DNA damage, used LexA as a repressor in yeast, and created fusion proteins that used LexA to bring portions of yeast G ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Spartanburg, South Carolina
Spartanburg is a city in and the county seat of Spartanburg County, South Carolina, United States. The city had a population of 38,732 as of the 2020 United States census, 2020 census, making it the List of municipalities in South Carolina, 11th-most populous city in the state. The Office of Management and Budget (OMB) groups Spartanburg and Union County, South Carolina, Union counties together as the Spartanburg, SC Metropolitan statistical area, Metropolitan Statistical Area. Spartanburg is the second-largest city in the greater Upstate South Carolina, Greenville-Spartanburg-Anderson, SC Combined Statistical Area, which had an estimated population of 1,590,636 in 2023. It is part of a ten-county region of northwestern South Carolina known as "Upstate South Carolina, The Upstate", and is located northwest of Columbia, South Carolina, Columbia, west of Charlotte, North Carolina, and about northeast of Atlanta, Georgia. Spartanburg is the home of Wofford College, Converse Univ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aptamer
Aptamers are oligomers of artificial ssDNA, RNA, Xeno nucleic acid, XNA, or peptide that ligand, bind a specific target molecule, or family of target molecules. They exhibit a range of affinities (Dissociation constant, KD in the pM to μM range), with variable levels of Antitarget, off-target binding and are sometimes classified as antibody mimetic, chemical antibodies. Aptamers and antibodies can be used in many of the same applications, but the nucleic acid-based structure of aptamers, which are mostly oligonucleotides, is very different from the amino acid-based structure of antibodies, which are proteins. This difference can make aptamers a better choice than antibodies for some purposes (see #Antibody_replacement, antibody replacement). Aptamers are used in biological lab research and medical tests. If multiple aptamers are combined into a single assay, they can proteomics, measure large numbers of different proteins in a sample. They can be used to biomarker discovery, id ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
American Association For The Advancement Of Science
The American Association for the Advancement of Science (AAAS) is a United States–based international nonprofit with the stated mission of promoting cooperation among scientists, defending scientific freedom, encouraging scientific responsibility, and supporting science education, scientific education and science outreach for the betterment of all humanity. AAAS was the first permanent organization established to promote science and engineering nationally and to represent the interests of American researchers from across all scientific fields. It is the world's largest general scientific society, with over 120,000 members, and is the publisher of the well-known scientific journal ''Science (journal), Science''. History Creation The American Association for the Advancement of Science was created on September 20, 1848, at the Academy of Natural Sciences in Philadelphia, Pennsylvania. It was a reformation of the Association of American Geologists and Naturalists with the broaden ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ellison Medical Foundation
The Ellison Medical Foundation, a 501(c)(3) Private Nonoperating Foundation, was founded in 1997 and is located in Bethesda, Maryland. The foundation supported research in the following discipline areas: biomedical research on aging, age-related diseases and disabilities. Its major philanthropic support came from Oracle Corporation, Oracle CEO Larry Ellison. As of 2007, the foundation owned 1.3 million shares of Oracle Corporation. The foundation is classified as NTEE T99—Other Philanthropy, Voluntarism, and Grantmaking Foundations N.E.C. Since 1998 the Ellison Medical Foundation has spent hundreds of millions of dollars funding fundamental research on the biology of ageing. Forty million dollars per year was given to 25 Senior Scholars and 25 New Scholars. The Senior Scholars received $1 million each and the New Scholars received $400,000 each for four years of research. In late summer/early fall 2013 the Ellison Medical Foundation announced that it "will no lo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Pew Charitable Trusts
The Pew Charitable Trusts is an independent non-profit, non-governmental organization (NGO), founded in 1948. Pew's stated mission is to serve the public interest by "improving public policy, informing the public, and invigorating civic life". Pew operates projects and conducts research across five main areas: communities, conservation, finance and economy, governing, and health. In addition, the Pew Research Center is a nonpartisan public polling and think tank that operates as a subsidiary of The Pew Charitable Trusts. History 20th century Pew was established by the merging of several charitable trusts that had been established between 1948 and 1979. The original trusts were created by J. Howard Pew, Mary Ethel Pew, Joseph N. Pew Jr., and Mabel Pew Myrin, the adult sons and daughters of Sun Oil Company founder Joseph N. Pew and his wife, Mary Anderson Pew. Honoring their parents' religious conviction that good works should be done quietly, the original Pew Memorial Foundat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Synthetic Biology
Synthetic biology (SynBio) is a multidisciplinary field of science that focuses on living systems and organisms. It applies engineering principles to develop new biological parts, devices, and systems or to redesign existing systems found in nature. It is a branch of science that encompasses a broad range of methodologies from various disciplines, such as biochemistry, biotechnology, biomaterials, Materials science, material science/engineering, genetic engineering, molecular biology, molecular engineering, systems biology, Model lipid bilayer, membrane science, biophysics, Biological engineering, chemical and biological engineering, Electrical engineering, electrical and computer engineering, control engineering and evolutionary biology. It includes designing and constructing BioBrick, biological modules, biological systems, and biological machines, or re-designing existing biological systems for useful purposes. Additionally, it is the branch of science that focuses on the ne ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Science (journal)
''Science'' is the peer review, peer-reviewed academic journal of the American Association for the Advancement of Science (AAAS) and one of the world's top academic journals. It was first published in 1880, is currently circulated weekly and has a subscriber base of around 130,000. Because institutional subscriptions and online access serve a larger audience, its estimated readership is over 400,000 people. ''Science'' is based in Washington, D.C., United States, with a second office in Cambridge, UK. Contents The major focus of the journal is publishing important original scientific research and research reviews, but ''Science'' also publishes science-related news, opinions on science policy and other matters of interest to scientists and others who are concerned with the wide implications of science and technology. Unlike most scientific journals, which focus on a specific field, ''Science'' and its rival ''Nature (journal), Nature'' cover the full range of List of academ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wired
Wired may refer to: Arts, entertainment, and media Music * ''Wired'' (Jeff Beck album), 1976 * ''Wired'' (Hugh Cornwell album), 1993 * ''Wired'' (Mallory Knox album), 2017 * "Wired", a song by Prism from their album '' Beat Street'' * "Wired", a song by Sevendust from their '' eponymous'' debut album * "Wired", a song by Nebula from their 2006 album ''Apollo'' Television * ''Wired'' (TV series), a 2008 British television miniseries * ''Wired'', 1988 TV series produced by Tim Graham * " Wired", a 2005 two-part episode of ''Power Rangers: SPD'' * " Wired", a 2002 two-part episode of ''The Zeta Project'' animated series Other uses in arts, entertainment, and media * ''Wired'' (book), a 1984 book by Bob Woodward about the American actor and comedian John Belushi ** ''Wired'' (film), a 1989 adaptation of the book by Bob Woodward * ''Wired'' (novel), a 2005 science fiction novel by Douglas E. Richards about a brilliant genetic engineer who discovers how to temporarily achie ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Current Protocols
''Current Protocols'' is a series of laboratory manuals for life scientists. The first title, ''Current Protocols in Molecular Biology'', was established in 1987 by the founding editors Frederick M. Ausubel, Roger Brent, Robert Kingston, David Moore, Jon Seidman, Kevin Struhl, and John A. Smith of the Massachusetts General Hospital Department of Molecular Biology and the Harvard Medical School Departments of Genetics and Biological Chemistry, and Sarah Greene of Greene Publishing AssociatesAusubel, F. M., Brent, R., Kingston, R., Moore, D. D., Seiman, J., Smith, J. A., and Struhl, K. (1987-2016). ''Current Protocols in Molecular Biology''. New York, NY, John Wiley & Sons, . The Current Protocols series entered into a partnership with Wiley-Interscience, John Wiley and Sons, was acquired by Wiley in 1995, and continued to introduce additional titles. Scientists contribute methods that are peer-reviewed Peer review is the evaluation of work by one or more people with similar co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
FEBS Letters
''FEBS Letters'' is a not-for-profit peer-reviewed scientific journal published on behalf of the Federation of European Biochemical Societies (FEBS) by Wiley. It covers all aspects of molecular biosciences, including molecular biology and biochemistry. The aim of the journal is to publish primary research in the form of Research Articles, Research Letters, Communications and Hypotheses, as well as secondary research in the form of Review articles. The journal also publishes a News and Views column. The editorial office of ''FEBS Letters'' is based in Heidelberg, Germany. The journal income is reinvested in science. History The initial idea of ''FEBS Letters'' as a journal for rapid communication of short reports in biochemistry, biophysics and molecular biology was proposed by the Secretary General of FEBS, W.J. Whelan, at the 4th FEBS Meeting held in Oslo in 1967. After further discussions and preparations, the first issue of ''FEBS Letters'' appeared in July 1968 with Satya P ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fred Hutchinson Cancer Center
The Fred Hutchinson Cancer Center, formerly known as the Fred Hutchinson Cancer Research Center and also known as Fred Hutch or The Hutch, is a cancer research institute established in 1975 in Seattle, Washington. History The center grew out of the Pacific Northwest Research Foundation, founded in 1956 by William B. Hutchinson (1909–1997). The Foundation was dedicated to the study of heart surgery, cancer, and diseases of the endocrine system. Hutchinson's younger brother Fred (1919–1964) was a major league pitcher and manager who died of lung cancer at age 45. The next year, William Hutchinson established the Fred Hutchinson Cancer Research Center as a division of the Pacific Northwest Research Foundation.Louis Fiset, December 30, 2004 for HistoryLink: The Free, Online Encyclopedia of Washington State HistorHutchinson, Dr. William B. (1909–1997)/ref> In 1972, with the help of Senator Warren G. Magnuson, PNRF received federal funding under the National Cancer Act of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
