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Robert Roskoski
Robert Roskoski Jr. is the Scientific Director and President of the Blue Ridge Institute for Medical Research. Education Roskoski studied chemistry at Bowling Green State University, receiving a B.S. degree in 1961. He received an M.D. in 1964 and a Ph.D. in 1968 from the University of Chicago. His doctoral adviser was Donald F. Steiner, the discoverer of proinsulin. Roskoski was in the medical corps of the United States Air Force. Later, He became a Senior Investigator at the U.S. Air Force School of Aerospace Medicine at Brooks Air Force Base in San Antonio. He subsequently performed postdoctoral studies at the Rockefeller University under the tutelage of Fritz Lipmann from 1969 to 1972. Research and career Robert Roskoski did research on the classification of small molecule protein kinase inhibitors that are used in the treatment of several cancers and he also developed the Gold Standard procedure for the measurement of Protein Kinase Enzyme Activity. His research interes ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Blue Ridge Institute For Medical Research
The Blue Ridge Institute for Medical Research (BRIMR) is an independent, non-profit, scientific research institute located in Horse Shoe, North Carolina. The Institute was founded by Robert Roskoski Jr., who serves as President and Scientific Director. Mission The general goals of the Institute are to explore the interrelationships of fundamental biological science, clinical science, and clinical care. Research Research at BRIMR focuses on the structure and regulation of protein kinases, their downstream signaling pathways, and therapeutic drugs that inhibit these enzymes. Protein kinases regulate the activity of their substrate targets by adding phosphate groups in a reaction known as protein phosphorylation. The United States Food and Drug Administration has approved the use of about 50 protein kinase inhibitors for the treatment of several cancers including those of breast, kidney, and lung and inflammatory diseases such as rheumatoid arthritis and ulcerative colitis. An av ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bowling Green State University
Bowling Green State University (BGSU) is a Public university, public research university in Bowling Green, Ohio, United States. The main academic and residential campus is south of Toledo, Ohio. The university has nationally recognized programs and research facilities in the natural and social sciences, education, arts, business, health and wellness, humanities and applied technologies. The institution was granted a charter in 1910 as a normal school, specializing in teacher training and education. The university has developed from a small rural normal school into a comprehensive public research university. It is a part of the University System of Ohio and is currently Carnegie Classification of Institutions of Higher Education, classified as R2: Doctoral Universities with list of research universities in the United States, high research activity. In 2019, Bowling Green offered over 200 undergraduate programs, as well as master's and doctoral degrees through eight academic co ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
University Of Chicago
The University of Chicago (UChicago, Chicago, or UChi) is a Private university, private research university in Chicago, Illinois, United States. Its main campus is in the Hyde Park, Chicago, Hyde Park neighborhood on Chicago's South Side, Chicago, South Side, near the shore of Lake Michigan about from Chicago Loop, the Loop. The university is composed of an College of the University of Chicago, undergraduate college and four graduate divisions: Biological Science, Arts & Humanities, Physical Science, and Social Science, which include various organized departments and institutes. In addition, the university operates eight professional schools in the fields of University of Chicago Booth School of Business, business, Crown Family School of Social Work, Policy, and Practice, social work, University of Chicago Divinity School, divinity, Graham School of Continuing Liberal and Professional Studies, continuing studies, Harris School of Public Policy, public policy, University of Chi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rockefeller University
The Rockefeller University is a Private university, private Medical research, biomedical Research university, research and graduate-only university in New York City, New York. It focuses primarily on the biological and medical sciences and provides doctoral and postdoctoral education. It is Carnegie Classification of Institutions of Higher Education, classified as a "Special Focus – Research Institution". Rockefeller is the oldest biomedical research institute in the United States. The university is located on the Upper East Side of Manhattan, between 63rd and 68th streets on York Avenue / Sutton Place, York Avenue. Richard P. Lifton became the university's eleventh president on September 1, 2016. The Rockefeller University Press publishes the ''Journal of Experimental Medicine'', the ''Journal of Cell Biology'', and ''The Journal of General Physiology''. In 2018, the faculty included 82 tenured and tenure-track members, including 37 members of the National Academy of Scienc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Donald F
Donald is a Scottish masculine given name. It is derived from the Gaelic name ''Dòmhnall''.. This comes from the Proto-Celtic *''Dumno-ualos'' ("world-ruler" or "world-wielder"). The final -''d'' in ''Donald'' is partly derived from a misinterpretation of the Gaelic pronunciation by English speakers. A short form of Donald is Don, and pet forms of Donald include Donnie and Donny. The feminine given name Donella is derived from Donald. ''Donald'' has cognates in other Celtic languages: Modern Irish ''Dónal'' (anglicised as ''Donal'' and ''Donall'');. Scottish Gaelic ''Dòmhnall'', ''Domhnull'' and ''Dòmhnull''; Welsh '' Dyfnwal'' and Cumbric ''Dumnagual''. Although the feminine given name '' Donna'' is sometimes used as a feminine form of ''Donald'', the names are not etymologically related. Variations Kings and noblemen Domnall or Domhnall is the name of many ancient and medieval Gaelic kings and noblemen: * Dyfnwal Moelmud (Dunvallo Molmutius), legendary kin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Proinsulin
Proinsulin is the prohormone precursor to insulin made in the beta cells of the Pancreatic Islets, specialized regions of the pancreas. In humans, proinsulin is encoded by the ''INS'' gene. The pancreatic islets only secrete between 1% and 3% of proinsulin intact. However, because proinsulin has a longer half life than insulin, it can account for anywhere from 5–30% of the insulin-like structures circulating in the blood. There are higher concentrations of proinsulin after meals and lower levels when a person is fasting. Additionally, while proinsulin and insulin have structural differences, proinsulin does demonstrate some affinity for the insulin receptor. Due to the relative similarities in structure, proinsulin can produce between 5% and 10% of the metabolic activity similarly induced by insulin. Proinsulin is the final single chain protein structure secreted by cells before cleavage into mature insulin. Proinsulin was discovered by Professor Donald F. Steiner of the Un ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
United States Air Force
The United States Air Force (USAF) is the Air force, air service branch of the United States Department of Defense. It is one of the six United States Armed Forces and one of the eight uniformed services of the United States. Tracing its origins to 1 August 1907, as a part of the United States Army Signal Corps, the USAF was established by transfer of personnel from the Army Air Forces with the enactment of the National Security Act of 1947. It is the second youngest branch of the United States Armed Forces and the fourth in United States order of precedence, order of precedence. The United States Air Force articulates its core missions as air supremacy, intelligence, surveillance, target acquisition, and reconnaissance, global integrated intelligence, surveillance and reconnaissance, airlift, rapid global mobility, Strategic bombing, global strike, and command and control. The United States Department of the Air Force, Department of the Air Force, which serves as the USAF's ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brooks Air Force Base
Brooks Air Force Base was a United States Air Force facility located in San Antonio, Texas, southeast of Downtown San Antonio. In 2002, Brooks Air Force Base was renamed Brooks City-Base when the property was conveyed to the Brooks Development Authority as part of a project between local, state, and federal government. The Brooks Development Authority is now the owner and operator of the property, and is redeveloping it as a science, business, and technology center; the U.S. Air Force was the largest tenant at Brooks City-Base before the departure of its operations in 2011. Units Major units * 311th Air Base Group * 311th Human Systems Wing Tenant units * Air Force Audit Agency * Air Force Research Laboratory History On February 16, 1918, Kelly Field No. 5 became a separate post and named Brooks Field by the Aviation Section, U.S. Signal Corps to honor San Antonio aviator Sidney Johnson Brooks, Jr. The first commander of Brooks Field was Lt. Col. H. Conger Pratt, w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fritz Lipmann
Fritz Albert Lipmann (; June 12, 1899 – July 24, 1986) was a German-American biochemist and a co-discoverer in 1945 of coenzyme A. For this, together with other research on coenzyme A, he was awarded the Nobel Prize in Physiology or Medicine in 1953 (shared with Hans Adolf Krebs). Early life and education Lipmann was born in Königsberg, Germany, to a Jewish family. His parents were Gertrud (Lachmanski) and Leopold Lipmann, an attorney. Lipmann studied medicine at the University of Königsberg, Berlin, and Munich, graduating in Berlin in 1924. He returned to Königsberg to study chemistry under Professor Hans Meerwein. In 1926 he joined Otto Meyerhof at the Kaiser Wilhelm Institute for Biology, Dahlem, Berlin, for his doctoral thesis. After that he followed Meyerhof to Heidelberg to the Kaiser Wilhelm Institute for Medical Research. Career From 1939 on, Lipmann lived and worked in the United States. He was a Research Associate in the Department of Biochemistry, Cornell Univ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein Kinase
A protein kinase is a kinase which selectively modifies other proteins by covalently adding phosphates to them ( phosphorylation) as opposed to kinases which modify lipids, carbohydrates, or other molecules. Phosphorylation usually results in a functional change of the target protein ( substrate) by changing enzyme activity, cellular location, or association with other proteins. The human genome contains about 500 protein kinase genes and they constitute about 2% of all human genes. There are two main types of protein kinase. The great majority are serine/threonine kinases, which phosphorylate the hydroxyl groups of serines and threonines in their targets. Most of the others are tyrosine kinases, although additional types exist. Protein kinases are also found in bacteria and plants. Up to 30% of all human proteins may be modified by kinase activity, and kinases are known to regulate the majority of cellular pathways, especially those involved in signal transduction. Chemical ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cancer Chemotherapy
Chemotherapy (often abbreviated chemo, sometimes CTX and CTx) is the type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) in a standard regimen. Chemotherapy may be given with a curative intent (which almost always involves combinations of drugs), or it may aim only to prolong life or to reduce symptoms (palliative chemotherapy). Chemotherapy is one of the major categories of the medical discipline specifically devoted to pharmacotherapy for cancer, which is called '' medical oncology''. The term ''chemotherapy'' now means the non-specific use of intracellular poisons to inhibit mitosis (cell division) or to induce DNA damage (so that DNA repair can augment chemotherapy). This meaning excludes the more-selective agents that block extracellular signals (signal transduction). Therapies with specific molecular or genetic targets, which inhibit growth-promoting signals from classic endocrine hormones (primarily estrogens ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Signal Transduction
Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a biochemical cascade, series of molecular events. Proteins responsible for detecting stimuli are generally termed receptor (biology), receptors, although in some cases the term sensor is used. The changes elicited by ligand (biochemistry), ligand binding (or signal sensing) in a receptor give rise to a biochemical cascade, which is a chain of biochemical events known as a Cell signaling#Signaling pathways, signaling pathway. When signaling pathways interact with one another they form networks, which allow cellular responses to be coordinated, often by combinatorial signaling events. At the molecular level, such responses include changes in the transcription (biology), transcription or translation (biology), translation of genes, and post-translational modification, post-translational and conformational changes in proteins, as well as changes in their location. These molecula ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
