Robert Roskoski Jr. is the Scientific Director and President of the Blue Ridge Institute for Medical Research.

Education

Roskoski studied chemistry at

Bowling Green State University Bowling Green State University (BGSU) is a Public university, public research university in Bowling Green, Ohio, United States. The main academic and residential campus is south of Toledo, Ohio. The university has nationally recognized progr ...

, receiving a B.S. degree in 1961. He received an M.D. in 1964 and a Ph.D. in 1968 from the

University of Chicago The University of Chicago (UChicago, Chicago, or UChi) is a Private university, private research university in Chicago, Illinois, United States. Its main campus is in the Hyde Park, Chicago, Hyde Park neighborhood on Chicago's South Side, Chic ...

. His doctoral adviser was Donald F. Steiner, the discoverer of

proinsulin Proinsulin is the prohormone precursor to insulin made in the beta cells of the Pancreatic Islets, specialized regions of the pancreas. In humans, proinsulin is encoded by the ''INS'' gene. The pancreatic islets only secrete between 1% and 3% ...

. Roskoski was in the medical corps of the

United States Air Force The United States Air Force (USAF) is the Air force, air service branch of the United States Department of Defense. It is one of the six United States Armed Forces and one of the eight uniformed services of the United States. Tracing its ori ...

. Later, He became a Senior Investigator at the U.S. Air Force School of Aerospace Medicine at

Brooks Air Force Base Brooks Air Force Base was a United States Air Force facility located in San Antonio, Texas, southeast of Downtown San Antonio. In 2002, Brooks Air Force Base was renamed Brooks City-Base when the property was conveyed to the Brooks Developm ...

in San Antonio. He subsequently performed postdoctoral studies at the

Rockefeller University The Rockefeller University is a Private university, private Medical research, biomedical Research university, research and graduate-only university in New York City, New York. It focuses primarily on the biological and medical sciences and pro ...

under the tutelage of

Fritz Lipmann Fritz Albert Lipmann (; June 12, 1899 – July 24, 1986) was a German-American biochemist and a co-discoverer in 1945 of coenzyme A. For this, together with other research on coenzyme A, he was awarded the Nobel Prize in Physiology or Medicine in ...

from 1969 to 1972.

Research and career

Robert Roskoski did research on the classification of small molecule

protein kinase A protein kinase is a kinase which selectively modifies other proteins by covalently adding phosphates to them ( phosphorylation) as opposed to kinases which modify lipids, carbohydrates, or other molecules. Phosphorylation usually results in a f ...

inhibitors that are used in the treatment of several cancers and he also developed the Gold Standard procedure for the measurement of Protein Kinase Enzyme Activity. His research interests include Protein kinase structure and function,

Cancer chemotherapy Chemotherapy (often abbreviated chemo, sometimes CTX and CTx) is the type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) in a standard regimen. Chemotherapy may be given with a curat ...

, and

Signal transduction Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a biochemical cascade, series of molecular events. Proteins responsible for detecting stimuli are generally termed receptor (biology), rece ...

. He studied protein kinase structure and function and signal transduction. He also founded the Blue Ridge Institute for Medical Research in Horse Shoe, North Carolina in 2006. Research at the institute focuses on FDA-approved protein kinase inhibitors and monitoring extramural

NIH grant In the United States, the National Institutes of Health (NIH) are the primary government agency responsible for biomedical and public health research. They award NIH grants through 24 grant-awarding List of institutes and centers of the National In ...

support.

Awards and honors

Robert Roskoski received the NIH Postdoctoral membership and NIH Special postdoctoral membership. From 1991 to 2006, he was the Fred G. Brazda Professor of Biochemistry at LSU Health Sciences Center in New Orleans.

American Chemical Society The American Chemical Society (ACS) is a scientific society based in the United States that supports scientific inquiry in the field of chemistry. Founded in 1876 at New York University, the ACS currently has more than 155,000 members at all ...

honors

Publications

* Roskoski R Jr. (1983) Assays of protein kinase. Methods in Enzymology 99, 3–6. * Roskoski R Jr. (2005) Src kinase regulation by phosphorylation and dephosphorylation. Biochem Biophys. Res. Commun. 331, 1–14. * Roskoski R Jr. (2007) Vascular endothelial growth factor (VEGF) signalling in tumor progression. Crit. Rev. Oncol. Hematol. 62, 179–213. * Roskoski R Jr. (2012) ERK1/2 MAP kinases: Structure, function, and regulation. Pharmacol. Res. 66, 105–143. * Roskoski R Jr. (2014) The ErbB/HER family of protein-tyrosine kinases and cancer. Pharmacol. Res. 79, 34–74. * Roskoski R Jr. A historical overview of protein kinases and their targeted small molecule inhibitors. Pharmacol Res 2015;100:1–23. * Roskoski R Jr. (2016) Classification of small molecule inhibitors based upon the structures of their drug enzyme complexes. Pharmacol. Res. 103, 26–48.

References

External links

* {{DEFAULTSORT:Roskoski, Robert Living people American medical researchers Year of birth missing (living people)