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Rob Klose
Rob Klose (born December 28, 1977) is a Canadian researcher and Professor of Genetics at the Department of Biochemistry, University of Oxford. His research investigates how chromatin-based and epigenetic mechanisms contribute to the ways in which gene expression is regulated. Education Klose was an undergraduate student at the University of Waterloo in Ontario, Canada, where he graduated with Dean's Honors in Biology. He was a postgraduate student supervised by Adrian Bird at the Wellcome Centre for Cell Biology at the University of Edinburgh, Scotland, where he studied the methyl CpG binding protein MeCP2, part of the DNA methylation system, which is associated with Rett syndrome. He obtained his Doctor of Philosophy in 2005. Career and research Klose spent two years as a postdoctoral researcher in the laboratory of Yi Zhang, who was based at the University of North Carolina at Chapel Hill, identifying a novel family of histone lysine demethylase enzymes. He then moved to the Un ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CpG Island
The CpG sites or CG sites are regions of DNA where a cytosine nucleotide is followed by a guanine nucleotide in the linear sequence of bases along its 5' → 3' direction. CpG sites occur with high frequency in genomic regions called CpG islands (or CG islands). Cytosines in CpG dinucleotides can be methylated to form 5-methylcytosines. Enzymes that add a methyl group are called DNA methyltransferases. In mammals, 70% to 80% of CpG cytosines are methylated. Methylating the cytosine within a gene can change its expression, a mechanism that is part of a larger field of science studying gene regulation that is called epigenetics. Methylated cytosines often mutate to thymines. In humans, about 70% of promoters located near the transcription start site of a gene (proximal promoters) contain a CpG island. CpG characteristics Definition ''CpG'' is shorthand for ''5'—C—phosphate—G—3' '', that is, cytosine and guanine separated by only one phosphate group; phosphate ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Wellcome Trust
The Wellcome Trust is a charitable foundation focused on health research based in London, in the United Kingdom. It was established in 1936 with legacies from the pharmaceutical magnate Henry Wellcome (founder of one of the predecessors of GlaxoSmithKline) to fund research to improve human and animal health. The aim of the Trust is to "support science to solve the urgent health challenges facing everyone." It had a financial endowment of £29.1 billion in 2020, making it the fourth wealthiest charitable foundation in the world. In 2012, the Wellcome Trust was described by the ''Financial Times'' as the United Kingdom's largest provider of non-governmental funding for scientific research, and one of the largest providers in the world. According to their annual report, the Wellcome Trust spent GBP £1.1Bn on charitable activities across their 2019/2020 financial year. According to the OECD, the Wellcome Trust's financing for 2019 development increased by 22% to US$327 mill ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Living People
Related categories * :Year of birth missing (living people) / :Year of birth unknown * :Date of birth missing (living people) / :Date of birth unknown * :Place of birth missing (living people) / :Place of birth unknown * :Year of death missing / :Year of death unknown * :Date of death missing / :Date of death unknown * :Place of death missing / :Place of death unknown * :Missing middle or first names See also * :Dead people * :Template:L, which generates this category or death years, and birth year and sort keys. : {{DEFAULTSORT:Living people 21st-century people People by status ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Canadian Geneticists
Canadians (french: Canadiens) are people identified with the country of Canada. This connection may be residential, legal, historical or cultural. For most Canadians, many (or all) of these connections exist and are collectively the source of their being ''Canadian''. Canada is a multilingual and multicultural society home to people of groups of many different ethnic, religious, and national origins, with the majority of the population made up of Old World immigrants and their descendants. Following the initial period of French and then the much larger British colonization, different waves (or peaks) of immigration and settlement of non-indigenous peoples took place over the course of nearly two centuries and continue today. Elements of Indigenous, French, British, and more recent immigrant customs, languages, and religions have combined to form the culture of Canada, and thus a Canadian identity. Canada has also been strongly influenced by its linguistic, geographic, and ec ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
EMBO Member
Membership of the European Molecular Biology Organization (EMBO) is an award granted by the European Molecular Biology Organization (EMBO) in recognition of "research excellence and the outstanding achievements made by a life scientist". , 88 EMBO Members and Associate Members have been awarded Nobel Prizes in either Physiology or Medicine, Chemistry or Physics. See :Members of the European Molecular Biology Organization for examples of EMBO members. Nomination and election of new members Elections for membership are held annually with candidates for membership being nominated and elected exclusively by existing EMBO members, membership cannot be applied for directly. Three types of membership exist: # EMBO Member, for scientists living (or who have lived) in a European Molecular Biology Conference (EMBC) Member State # EMBO Associate Member, for scientists living outside of the EMBC Member States # EMBO Young Investigator See also * List of biology awards This list of bi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Royal Society
The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, recognising excellence in science, supporting outstanding science, providing scientific advice for policy, education and public engagement and fostering international and global co-operation. Founded on 28 November 1660, it was granted a royal charter by King Charles II as The Royal Society and is the oldest continuously existing scientific academy in the world. The society is governed by its Council, which is chaired by the Society's President, according to a set of statutes and standing orders. The members of Council and the President are elected from and by its Fellows, the basic members of the society, who are themselves elected by existing Fellows. , there are about 1,700 fellows, allowed to use the postnominal title FRS ( Fellow of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Francis Crick Lecture
The Francis Crick Medal and Lecture is a prize lecture of the Royal Society established in 2003 with an endowment from Sydney Brenner, the late Francis Crick's close friend and former colleague. It is delivered annually in biology, particularly the areas which Francis Crick worked (genetics, molecular biology and neurobiology), and also to theoretical work. The medal is also intended for young scientists, i.e. under 40, or at career stage corresponding to being under 40 should their career have been interrupted. List of lectures Laureates include: * 2022 Tiago Branco ''for making fundamental advances in the molecular, cellular and circuit bases of neuronal computation and for successfully linking these to animal decision behaviour'' * 2021 Serena Nik-Zainal ''for enormous contributions to understanding the aetiology of cancers by her analyses of mutation signatures in cancer genomes, which is now being applied to cancer therapy'' * 2020 Marta Zlatic ''for discovering how neural ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lister Institute Of Preventive Medicine
The Lister Institute of Preventive Medicine, informally known as the Lister Institute, was established as a research institute (the British Institute of Preventive Medicine) in 1891, with bacteriologist Marc Armand Ruffer as its first director, using a grant of £250,000 from Edward Cecil Guinness of the Guinness family. It had premises in Chelsea, London, Chelsea in London, Sudbury, Suffolk, Sudbury in Suffolk, and Elstree, Elstree in Hertfordshire, England. It was the first medical research charity in the United Kingdom. It was renamed the Jenner Institute (after Edward Jenner, the pioneer of smallpox vaccine) in 1898 and then, in 1903, as the Lister Institute in honour of the great surgeon and medical pioneer, Joseph Lister, 1st Baron Lister, Dr Joseph Lister. In 1905, the institute became a school of the University of London. History Until the 1970s the institute maintained laboratories and conducted research on infectious disease and vaccines. It was funded by manufacturing an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
European Molecular Biology Organization
The European Molecular Biology Organization (EMBO) is a professional, non-profit organization of more than 1,800 life scientists. Its goal is to promote research in life science and enable international exchange between scientists. It co-funds courses, workshops and conferences, publishes five scientific journals and supports individual scientists. The organization was founded in 1964 and is a founding member of the Initiative for Science in Europe. the Director of EMBO is Fiona Watt, a stem cell researcher, professor at King's College London and a group leader at the European Molecular Biology Laboratory. Conferences and journals EMBO funds or co-funds over 90 meetings involving more than 11,000 participants every year. EMBO publishes five peer-reviewed scientific journals: '' The EMBO Journal'', '' EMBO Reports'', ''Molecular Systems Biology'', '' EMBO Molecular Medicine'', and ''Life Science Alliance'', History The European Molecular Biology Organization (EMBO) was launc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
CpG Islands
The CpG sites or CG sites are regions of DNA where a cytosine nucleotide is followed by a guanine nucleotide in the linear sequence of bases along its 5' → 3' direction. CpG sites occur with high frequency in genomic regions called CpG islands (or CG islands). Cytosines in CpG dinucleotides can be methylated to form 5-methylcytosines. Enzymes that add a methyl group are called DNA methyltransferases. In mammals, 70% to 80% of CpG cytosines are methylated. Methylating the cytosine within a gene can change its expression, a mechanism that is part of a larger field of science studying gene regulation that is called epigenetics. Methylated cytosines often mutate to thymines. In humans, about 70% of promoters located near the transcription start site of a gene (proximal promoters) contain a CpG island. CpG characteristics Definition ''CpG'' is shorthand for ''5'—C—phosphate—G—3' '', that is, cytosine and guanine separated by only one phosphate group; ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Keble College, Oxford
Keble College () is one of the constituent colleges of the University of Oxford in England. Its main buildings are on Parks Road, opposite the University Museum and the University Parks. The college is bordered to the north by Keble Road, to the south by Museum Road, and to the west by Blackhall Road. Keble was established in 1870, having been built as a monument to John Keble, who had been a leading member of the Oxford Movement which sought to stress the Catholic nature of the Church of England. Consequently, the college's original teaching focus was primarily theological, although the college now offers a broad range of subjects, reflecting the diversity of degrees offered across the wider university. In the period after the Second World War, the trends were towards scientific courses (proximity to the university science area east of the University Museum influenced this). As originally constituted, it was for men only and the fellows were mostly bachelors resident in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Molecular Biology
Molecular biology is the branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions. The study of chemical and physical structure of biological macromolecules is known as molecular biology. Molecular biology was first described as an approach focused on the underpinnings of biological phenomena - uncovering the structures of biological molecules as well as their interactions, and how these interactions explain observations of classical biology. In 1945 the term molecular biology was used by physicist William Astbury. In 1953 Francis Crick, James Watson, Rosalind Franklin, and colleagues, working at Medical Research Council unit, Cavendish laboratory, Cambridge (now the MRC Laboratory of Molecular Biology), made a double helix model of DNA which changed the entire research scenario. They proposed the DNA structure based on previous research done by ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
