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Restricted Growth Association
The Restricted Growth Association (RGA) is a UK charity that supports people with dwarfism (restricted growth). The RGA was formed in 1970 by Charles Pocock, Martin Nelson and other individuals in the UK wanting to provide a support network for people with restricted growth (dwarfism). Initially known as the Association into Research of Restricted Growth, the charity aims to support all individuals and their families affected by skeletal dysplasia leading to short stature. There are many different forms of dwarfism caused by genetic conditions, but the most common form of disproportionate short stature, causing about 70% of cases, is achondroplasia Achondroplasia is a genetic disorder with an autosomal dominant pattern of inheritance whose primary feature is dwarfism. It is the most common cause of dwarfism and affects about 1 in 27,500 people. In those with the condition, the Rhizomeli .... There are over 200 known genetic conditions that can lead to short stature (dwarfis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Charitable Organization
A charitable organization or charity is an organization whose primary objectives are philanthropy and social well-being (e.g. educational, Religion, religious or other activities serving the public interest or common good). The legal definition of a charitable organization (and of charity) varies between countries and in some instances regions of the country. The Charity regulators, regulation, the tax treatment, and the way in which charity law affects charitable organizations also vary. Charitable organizations may not use any of their funds to profit individual persons or entities. However, some charitable organizations have come under scrutiny for spending a disproportionate amount of their income to pay the salaries of their leadership. Financial figures (e.g. tax refunds, revenue from fundraising, revenue from the sale of goods and services or revenue from investment, and funds held in reserve) are indicators to assess the financial sustainability of a charity, especiall ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dwarfism
Dwarfism is a condition of people and animals marked by unusually small size or short stature. In humans, it is sometimes defined as an adult height of less than , regardless of sex; the average adult height among people with dwarfism is . ''Disproportionate dwarfism'' is characterized by either Rhizomelia, short limbs or a short torso. In cases of ''proportionate dwarfism'', both the limbs and torso are unusually small. Intelligence is usually normal, and most people with it have a nearly normal life expectancy. People with dwarfism can usually bear children, although there are additional Pregnancy risks, risks to the mother and child depending upon the underlying condition. The most common and recognizable form of dwarfism in humans (comprising 70% of cases) is achondroplasia, a genetic disorder whereby the limbs are diminutive. Growth hormone deficiency is responsible for most other cases. There are many other less common causes. Treatment of the condition depends on the u ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Skeletal Dysplasia
An osteochondrodysplasia,Etymology: . or skeletal dysplasia, is a disorder of the development of bone and cartilage. Osteochondrodysplasias are rare diseases. About 1 in 5,000 babies are born with some type of skeletal dysplasia. Nonetheless, if taken collectively, genetic skeletal dysplasias or osteochondrodysplasias comprise a recognizable group of genetically determined disorders with generalized skeletal affection. These disorders lead to disproportionate short stature and bone abnormalities, particularly in the arms, legs, and spine. Skeletal dysplasia can result in marked functional limitation and even mortality. Osteochondrodysplasias or skeletal dysplasia subtypes can overlap in clinical aspects, therefore plain radiography is absolutely necessary to establish an accurate diagnosis. Magnetic resonance imaging can provide further diagnostic insights and guide treatment strategies especially in cases of spinal involvement. As some disorders that cause skeletal dysplasia have ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Achondroplasia
Achondroplasia is a genetic disorder with an autosomal dominant pattern of inheritance whose primary feature is dwarfism. It is the most common cause of dwarfism and affects about 1 in 27,500 people. In those with the condition, the Rhizomelia, arms and legs are short, while the torso is typically of normal length. Those affected have an average adult height of for males and for females. Other features can include an Macrocephaly, enlarged head with Skull bossing, prominent forehead (frontal bossing) and underdevelopment of the midface (midface hypoplasia). Complications can include sleep apnea or recurrent ear infections. Achondroplasia includes the extremely rare short-limb skeletal dysplasia with severe combined immunodeficiency. Achondroplasia is caused by a mutation in the fibroblast growth factor receptor 3 (''FGFR3'') gene that results in its protein being Gain-of-function, overactive. Achondroplasia results in impaired endochondral bone growth (bone growth within car ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BIG Lottery Fund
The National Lottery Community Fund, legally named the Big Lottery Fund, is a non-departmental public body responsible for distributing funds raised by the National Lottery for " good causes". It is the largest community funder in the UK and its purpose is to award funding that strengthens society and improves lives across the UK. Thanks to National Lottery players, it will distribute at least £4 billion by 2030, supporting activities that create resilient communities that are more inclusive and environmentally sustainable. The funder takes an equity-based approach to its work, investing most in places, people and communities experiencing poverty, disadvantage and discrimination. In June 2023 it launched its most recent strategy ‘It Starts with Community’. This sets out its focus on four key missions, which are to support communities to:National Lottery players raise over £30 million each week for good causes throughout the UK. Since The National Lottery began in 1994, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hypochondroplasia
Hypochondroplasia (HCH) is a developmental disorder caused by an autosomal dominant genetic defect in the fibroblast growth factor receptor 3 gene ('' FGFR3'') that results in a disproportionately short stature, micromeliaupdate 2013 and a head that appears large in comparison with the underdeveloped portions of the body. It is classified as short-limbed dwarfism. Signs and symptoms Individuals affected by this disorder appear normal at birth. As the infant grows, however, their arms and legs do not develop properly, and their body becomes thicker and shorter than normal. The following are characteristics consistent with this condition: * Brachydactyly * Short stature * Micromelia * Skeletal dysplasia * Abnormality of femur Cause Hypochondroplasia is inherited as an autosomal dominant trait affecting the ''FGFR3'' gene on chromosome 4p16.3. There is currently no cure for this condition. Pathophysiology This disorder results from mutations in the proximal tyrosine kinase doma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tom Shakespeare
Sir Thomas William Shakespeare, 3rd Baronet, (born 11 May 1966) is an English sociologist and bioethicist. He has achondroplasia and uses a wheelchair. Early life and education Son of Sir William Geoffrey Shakespeare, 2nd Baronet, and Susan Mary, daughter of A. Douglas Raffel, of Colombo, Sri Lanka, his grandfather, Sir Geoffrey Shakespeare, was made a baronet following long service as a member of Parliament and in various senior government roles. While still a student, Tom was featured in a television documentary by Lord Snowdon connected to his 1976 report "Integrating the Disabled" about his restricted growth, along with his father, a prominent medical practitioner, who was also born with achondroplasia. His mother was a nurse of Sri Lankan Burgher descent. Shakespeare was educated at Radley College, Oxfordshire, taking A-levels in English, History, and History of Art; and Pembroke College, Cambridge, where he matriculated in 1984 to read Anglo-Saxon, Norse a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
List Of Restricted Growth Organisations Around The World
List of dwarfism organizations around the world. Africa Uganda *Little People of Uganda Asia Hong Kong *Little People of Hong Kong 小而同罕有骨骼疾病基金會 Iran * Iranian Short Stature Association کوتاه قامتان بلند همت :انجمن کوچولوهای ایرانی Iraq * Short Stature in Iraq Australia and Oceania Australia *Short Statured People of Australia New Zealand *Little People of New Zealand Europe Austria *Union of Short-Statured People and their Families (BKMF-Osterreich) Bulgaria * Little Bulgarian People Czech Republic *Association of Little People of Czech Republic Denmark *Danish Dwarf Association (DVF) Finland Small Stature Finland(Finnish: Lyhytkasvuiset – Kortväxta ry) France * Association of Small People (APPT - L'Association des Personnes de Petite Taille) Germany * Federal Association For The Promotion of People of Short Stature () (VKM) *German Association for People of Short Stature ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Footnotes
In publishing, a note is a brief text in which the author comments on the subject and themes of the book and names supporting citations. In the editorial production of books and documents, typographically, a note is usually several lines of text at the bottom of the page, at the end of a chapter, at the end of a volume, or a house-style typographic usage throughout the text. Notes are usually identified with superscript numbers or a symbol.''The Oxford Companion to the English Language'' (1992) p. 709. Footnotes are informational notes located at the foot of the thematically relevant page, whilst endnotes are informational notes published at the end of a chapter, the end of a volume, or the conclusion of a multi-volume book. Unlike footnotes, which require manipulating the page design (text-block and page layouts) to accommodate the additional text, endnotes are advantageous to editorial production because the textual inclusion does not alter the design of the publication. H ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dwarfism
Dwarfism is a condition of people and animals marked by unusually small size or short stature. In humans, it is sometimes defined as an adult height of less than , regardless of sex; the average adult height among people with dwarfism is . ''Disproportionate dwarfism'' is characterized by either Rhizomelia, short limbs or a short torso. In cases of ''proportionate dwarfism'', both the limbs and torso are unusually small. Intelligence is usually normal, and most people with it have a nearly normal life expectancy. People with dwarfism can usually bear children, although there are additional Pregnancy risks, risks to the mother and child depending upon the underlying condition. The most common and recognizable form of dwarfism in humans (comprising 70% of cases) is achondroplasia, a genetic disorder whereby the limbs are diminutive. Growth hormone deficiency is responsible for most other cases. There are many other less common causes. Treatment of the condition depends on the u ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Health Charities In The United Kingdom
Health has a variety of definitions, which have been used for different purposes over time. In general, it refers to physical and emotional well-being, especially that associated with normal functioning of the human body, absent of disease, pain (including mental pain), or injury. Health can be promoted by encouraging healthful activities, such as regular physical exercise and adequate sleep, and by reducing or avoiding unhealthful activities or situations, such as smoking or excessive Stress (biology), stress. Some factors affecting health are due to Agency (sociology), individual choices, such as whether to engage in a high-risk behavior, while others are due to Social structure, structural causes, such as whether the society is arranged in a way that makes it easier or harder for people to get necessary healthcare services. Still, other factors are beyond both individual and group choices, such as genetic disorders. History The meaning of health has evolved over time. In k ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
1970 Establishments In The United Kingdom
Year 197 ( CXCVII) was a common year starting on Saturday of the Julian calendar. At the time, it was known as the Year of the Consulship of Magius and Rufinus (or, less frequently, year 950 ''Ab urbe condita''). The denomination 197 for this year has been used since the early medieval period, when the Anno Domini calendar era became the prevalent method in Europe for naming years. Events By place Roman Empire * February 19 – Battle of Lugdunum: Emperor Septimius Severus defeats the self-proclaimed emperor Clodius Albinus at Lugdunum (modern Lyon). Albinus commits suicide; legionaries sack the town. * Septimius Severus returns to Rome and has about 30 of Albinus's supporters in the Senate executed. After his victory he declares himself the adopted son of the late Marcus Aurelius. * Septimius Severus forms new naval units, manning all the triremes in Italy with heavily armed troops for war in the East. His soldiers embark on an artificial canal between the Tigr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
