|
Proton Computed Tomography
Proton computed tomography (pCT), or proton CT, is an imaging modality first proposed by Cormack in 1963 and initial experiment explorations identified several advantages over conventional X-ray CT (xCT). However, particle interactions such as multiple Coulomb scattering (MCS) and (in)elastic nuclear scattering events deflect the proton trajectory, resulting in nonlinear paths which can only be approximated via statistical assumptions, leading to lower spatial resolution than X-ray tomography. Further experiments were largely abandoned until the advent of proton radiation therapy in the 1990s which renewed interest in the topic due to the potential benefits of imaging and treating patients with the same particle. Description Proton computed tomography (pCT) uses measurements of a proton's position/ trajectory and energy before and after traversing an object to reconstruct an image of the object where each voxel represents the relative stopping power (RSP) of the material ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Allan McLeod Cormack
Allan MacLeod Cormack (February 23, 1924 – May 7, 1998) was a South African American physicist who won the 1979 Nobel Prize in Physiology or Medicine (along with Godfrey Hounsfield) for his work on X-ray computed tomography (CT), a significant and unusual achievement since Cormack did not hold a doctoral degree in any scientific field. Early life and education Cormack was born on February 23, 1924, in Johannesburg, South Africa. He attended Rondebosch Boys' High School in Cape Town, where he was active in the debating and tennis teams. He received his B.Sc. in physics in 1944 from the University of Cape Town and his M.Sc. in crystallography in 1945 from the same institution. He was a doctoral student at Cambridge University from 1947 to 1949, and while at Cambridge he met his future wife, Barbara Seavey, an American physics student. Career After marrying Barbara, he returned to the University of Cape Town in early 1950 to lecture. Following a sabbatical at Harvard in 1956– ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stopping Power (particle Radiation)
In nuclear and materials physics, stopping power is the retarding force acting on charged particles, typically alpha and beta particles, due to interaction with matter, resulting in loss of particle kinetic energy. Its application is important in areas such as radiation protection, ion implantation and nuclear medicine.ICRU Report 73: Stopping of Ions heavier than Helium, Journal of the ICRU, 5 No. 1 (2005), Oxford Univ. Press Definition and Bragg curve Both charged and uncharged particles lose energy while passing through matter. Positive ions are considered in most cases below. The stopping power depends on the type and energy of the radiation and on the properties of the material it passes. Since the production of an ion pair (usually a positive ion and a (negative) electron) requires a fixed amount of energy (for example, 33.97 eV in dry air), the number of ionizations per path length is proportional to the stopping power. The ''stopping power'' of the material is num ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Radiation Therapy
Radiation therapy or radiotherapy, often abbreviated RT, RTx, or XRT, is a therapy using ionizing radiation, generally provided as part of cancer treatment to control or kill malignant cells and normally delivered by a linear accelerator. Radiation therapy may be curative in a number of types of cancer if they are localized to one area of the body. It may also be used as part of adjuvant therapy, to prevent tumor recurrence after surgery to remove a primary malignant tumor (for example, early stages of breast cancer). Radiation therapy is synergistic with chemotherapy, and has been used before, during, and after chemotherapy in susceptible cancers. The subspecialty of oncology concerned with radiotherapy is called radiation oncology. A physician who practices in this subspecialty is a radiation oncologist. Radiation therapy is commonly applied to the cancerous tumor because of its ability to control cell growth. Ionizing radiation works by damaging the DNA of cancerous tis ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cancer Research UK
Cancer Research UK (CRUK) is the world's largest independent cancer research organization. It is registered as a charity in the United Kingdom and Isle of Man, and was formed on 4 February 2002 by the merger of The Cancer Research Campaign and the Imperial Cancer Research Fund. Cancer Research UK conducts research using both its own staff and grant-funded researchers. It also provides information about cancer and runs campaigns aimed at raising awareness and influencing public policy. The organisation's work is almost entirely funded by the public. It raises money through donations, legacies, community fundraising, events, retail and corporate partnerships. Over 40,000 people are regular volunteers. History The Imperial Cancer Research Fund (ICRF) was founded in 1902 as the Cancer Research Fund, changing its name to the Imperial Cancer Research Fund in 1904. It grew over the next twenty years to become one of the world's leading cancer research charities. Its flagship laborato ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MedlinePlus
MedlinePlus is an online information service produced by the United States National Library of Medicine. The service provides curated consumer health information in English and Spanish with select content in additional languages. The site brings together information from the National Library of Medicine (NLM), the National Institutes of Health (NIH), other U.S. government agencies, and health-related organizations. There is also a site optimized for display on mobile devices, in both English and Spanish. In 2015, about 400 million people from around the world used MedlinePlus. The service is funded by the NLM and is free to users. MedlinePlus provides encyclopedic information on health and drug issues, and provides a directory of medical services. MedlinePlus Connect links patients or providers in electronic health record (EHR) systems to related MedlinePlus information on conditions or medications. PubMed Health was another NLM site that offered consumer health information, in a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Line Integral
In mathematics, a line integral is an integral where the function to be integrated is evaluated along a curve. The terms ''path integral'', ''curve integral'', and ''curvilinear integral'' are also used; '' contour integral'' is used as well, although that is typically reserved for line integrals in the complex plane. The function to be integrated may be a scalar field or a vector field. The value of the line integral is the sum of values of the field at all points on the curve, weighted by some scalar function on the curve (commonly arc length or, for a vector field, the scalar product of the vector field with a differential vector in the curve). This weighting distinguishes the line integral from simpler integrals defined on intervals. Many simple formulae in physics, such as the definition of work as W=\mathbf\cdot\mathbf, have natural continuous analogues in terms of line integrals, in this case \textstyle W = \int_L \mathbf(\mathbf)\cdot d\mathbf, which computes the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Statistical Model
A statistical model is a mathematical model that embodies a set of statistical assumptions concerning the generation of sample data (and similar data from a larger population). A statistical model represents, often in considerably idealized form, the data-generating process. A statistical model is usually specified as a mathematical relationship between one or more random variables and other non-random variables. As such, a statistical model is "a formal representation of a theory" ( Herman Adèr quoting Kenneth Bollen). All statistical hypothesis tests and all statistical estimators are derived via statistical models. More generally, statistical models are part of the foundation of statistical inference. Introduction Informally, a statistical model can be thought of as a statistical assumption (or set of statistical assumptions) with a certain property: that the assumption allows us to calculate the probability of any event. As an example, consider a pair of ordinary six ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Atomic Nucleus
The atomic nucleus is the small, dense region consisting of protons and neutrons at the center of an atom, discovered in 1911 by Ernest Rutherford based on the 1909 Geiger–Marsden experiments, Geiger–Marsden gold foil experiment. After the discovery of the neutron in 1932, models for a nucleus composed of protons and neutrons were quickly developed by Dmitri Ivanenko and Werner Heisenberg. An atom is composed of a positively charged nucleus, with a cloud of negatively charged electrons surrounding it, bound together by electrostatic force. Almost all of the mass of an atom is located in the nucleus, with a very small contribution from the electron cloud. Protons and neutrons are bound together to form a nucleus by the nuclear force. The diameter of the nucleus is in the range of () for hydrogen (the diameter of a single proton) to about for uranium. These dimensions are much smaller than the diameter of the atom itself (nucleus + electron cloud), by a factor of about 2 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Electrostatic Field
An electric field (sometimes E-field) is the physical field that surrounds electrically charged particles and exerts force on all other charged particles in the field, either attracting or repelling them. It also refers to the physical field for a system of charged particles. Electric fields originate from electric charges and time-varying electric currents. Electric fields and magnetic fields are both manifestations of the electromagnetic field, one of the four fundamental interactions (also called forces) of nature. Electric fields are important in many areas of physics, and are exploited in electrical technology. In atomic physics and chemistry, for instance, the electric field is the attractive force holding the atomic nucleus and electrons together in atoms. It is also the force responsible for chemical bonding between atoms that result in molecules. The electric field is defined as a vector field that associates to each point in space the electrostatic (Coulomb) force p ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Voxel
In 3D computer graphics, a voxel represents a value on a regular grid in three-dimensional space. As with pixels in a 2D bitmap, voxels themselves do not typically have their position (i.e. coordinates) explicitly encoded with their values. Instead, rendering systems infer the position of a voxel based upon its position relative to other voxels (i.e., its position in the data structure that makes up a single volumetric image). In contrast to pixels and voxels, polygons are often explicitly represented by the coordinates of their vertices (as points). A direct consequence of this difference is that polygons can efficiently represent simple 3D structures with much empty or homogeneously filled space, while voxels excel at representing regularly sampled spaces that are non-homogeneously filled. Voxels are frequently used in the visualization and analysis of medical and scientific data (e.g. geographic information systems (GIS)). Some volumetric displays use voxels to desc ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
X-ray Computed Tomography
X-rays (or rarely, ''X-radiation'') are a form of high-energy electromagnetic radiation. In many languages, it is referred to as Röntgen radiation, after the German scientist Wilhelm Conrad Röntgen, who discovered it in 1895 and named it ''X-radiation'' to signify an unknown type of radiation.Novelline, Robert (1997). ''Squire's Fundamentals of Radiology''. Harvard University Press. 5th edition. . X-ray wavelengths are shorter than those of ultraviolet rays and longer than those of gamma rays. There is no universally accepted, strict definition of the bounds of the X-ray band. Roughly, X-rays have a wavelength ranging from 10 nanometers to 10 picometers, corresponding to frequencies in the range of 30 petahertz to 30 exahertz ( to ) and photon energies in the range of 100 eV to 100 keV, respectively. X-rays can penetrate many solid substances such as construction materials and living tissue, so X-ray radiography is widely used in medica ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Energy
In physics, energy (from Ancient Greek: ἐνέργεια, ''enérgeia'', “activity”) is the quantitative property that is transferred to a body or to a physical system, recognizable in the performance of work and in the form of heat and light. Energy is a conserved quantity—the law of conservation of energy states that energy can be converted in form, but not created or destroyed. The unit of measurement for energy in the International System of Units (SI) is the joule (J). Common forms of energy include the kinetic energy of a moving object, the potential energy stored by an object (for instance due to its position in a field), the elastic energy stored in a solid object, chemical energy associated with chemical reactions, the radiant energy carried by electromagnetic radiation, and the internal energy contained within a thermodynamic system. All living organisms constantly take in and release energy. Due to mass–energy equivalence, any object that h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
