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Profen (drug Class)
The profens are a class of nonsteroidal anti-inflammatory drugs. Profens are also known as 2-arylpropionic acids to reflect their chemical structure. The most common example of a profen is ibuprofen, which has been sold under the brand name Profen among others. Other drugs in the class include: * Alminoprofen * Benoxaprofen * Carprofen * Dexibuprofen * Dexketoprofen * Fenoprofen * Flunoxaprofen * Flurbiprofen * Indoprofen * Ketoprofen * Loxoprofen * Miroprofen * Naproxen * Pelubiprofen Pelubiprofen is a nonsteroidal anti-inflammatory drug of the profen class used to treat back pain and osteoarthritis Osteoarthritis is a type of degenerative joint disease that results from breakdown of articular cartilage, joint cartilage ... * Pirprofen * Pranoprofen * Suprofen * Tarenflurbil * Tiaprofenic acid * Vedaprofen * Zaltoprofen References Nonsteroidal anti-inflammatory drugs {{analgesic-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aryl Group
In organic chemistry, an aryl is any functional group or substituent derived from an aromatic ring, usually an aromatic hydrocarbon, such as phenyl and naphthyl. "Aryl" is used for the sake of abbreviation or generalization, and "Ar" is used as a placeholder for the aryl group in chemical structure diagrams, analogous to “R” used for any organic substituent. “Ar” is not to be confused with the elemental symbol for argon. A simple aryl group is phenyl (), a group derived from benzene. Examples of other aryl groups consist of: * The tolyl group () which is derived from toluene (methylbenzene) * The xylyl group (), which is derived from xylene (dimethylbenzene) * The naphthyl group (), which is derived from naphthalene Arylation is the process in which an aryl group is attached to a substituent. It is typically achieved by cross-coupling reactions. Nomenclature The simplest aryl group is phenyl, which is made up of a benzene ring with one of its hydrogen atom repla ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Loxoprofen
Loxoprofen is a nonsteroidal anti-inflammatory drug (NSAID) in the propionic acid derivatives group, which also includes ibuprofen and naproxen among others. It is available in some countries for oral administration. A transdermal preparation was approved for sale in Japan in January 2006; medicated tape and gel formulations followed in 2008 and 2010. It was patented in 1977 and approved for medical use in 1986. Pharmacokinetics Loxoprofen is a prodrug. It is quickly converted to its active ''trans''-alcohol metabolite following oral administration, and reaches its peak plasma concentration within 30 to 50 minutes. Mechanism of action As most NSAIDs, loxoprofen is a non-selective cyclooxygenase inhibitor, and works by reducing the synthesis of prostaglandins from arachidonic acid. Interactions Loxoprofen should not be administered at the same time as second-generation quinolone antibiotics such as ciprofloxacin and norfloxacin, as it increases their inhibition of GABA and this ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vedaprofen
Vedaprofen is a nonsteroidal anti-inflammatory drug (NSAID) used in veterinary medicine for the treatment of pain and inflammation due to musculoskeletal disorders in dogs and horses and for the treatment of pain due to horse colic. It is a member of the profen (drug class), profen drug class. Medical uses Vedaprofen is indicated for the reduction of inflammation and relief of pain associated with musculo-skeletal disorders and soft tissue lesions (traumatic injuries and surgical trauma). Synthesis Vedaprofen can be synthesized beginning with 1-cyclohexylnaphthylene (left). Chloromethylation followed by functional group interconversion provides the ester (center right). Alkylation with methyl iodide then gives vedaprofen (right). Soceity and culture Legal status Vedaprofen was approved for veterinary use in the European Union in April 1997. References {{Authority control Nonsteroidal anti-inflammatory drugs Carboxylic acids Naphthalenes Cyclohexyl compound ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tiaprofenic Acid
Tiaprofenic acid is a nonsteroidal anti-inflammatory drug (NSAID) of the arylpropionic acid (profen) class, used to treat pain, especially arthritic pain. The typical adult dose is 300 mg twice daily. It is not recommended for children. Long-term use of tiaprofenic acid is associated with severe cystitis, roughly 100 times more commonly than other NSAIDs. It is contraindicated in patients with cystitis and urinary tract infections. It is sparingly metabolised in the liver to two inactive metabolites. Most of the drug is eliminated unchanged in the urine. Renal disease impairs excretion, and should be used cautiously in renal disease. It was patented in 1969 and approved for medical use in 1981. It is available in generic formulations. A sustained-release preparation is available. It is an isomer In chemistry, isomers are molecules or polyatomic ions with identical molecular formula – that is, the same number of atoms of each element (chemistry), element – but di ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tarenflurbil
Tarenflurbil, Flurizan or ''R''-flurbiprofen, is a single enantiomer of the racemate NSAID flurbiprofen. For several years, research and trials for the drug were conducted by Myriad Genetics, to investigate its potential as a treatment for Alzheimer's disease; that investigation concluded in June 2008 when the company announced it would discontinue development of the compound.Myriad Genetics Reports Results of U.S. Phase 3 Trial of Flurizan in Alzheimer's Disease from the website. Mechanism of action At proposed therapeutic concentrations, this molecule lacks ...[...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Suprofen
Suprofen is a nonsteroidal anti-inflammatory drug (NSAID) developed by Janssen Pharmaceutica that was marketed as 1% eye drops under the trade name Profenal. Uses Suprofen was originally used as tablet, but oral uses have been discontinued due to renal effects. It was subsequently used exclusively as a topical ophthalmic solution, typically to prevent miosis during and after ophthalmic surgery Surgery is a medical specialty that uses manual and instrumental techniques to diagnose or treat pathological conditions (e.g., trauma, disease, injury, malignancy), to alter bodily functions (e.g., malabsorption created by bariatric surgery s .... This application has been discontinued as well, at least in the US. References Nonsteroidal anti-inflammatory drugs Thiophenes Propionic acids Aromatic ketones Janssen Pharmaceutica {{musculoskeletal-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pranoprofen
Pranoprofen (INN) is a nonsteroidal anti-inflammatory drug (NSAID) used in ophthalmology Ophthalmology (, ) is the branch of medicine that deals with the diagnosis, treatment, and surgery of eye diseases and disorders. An ophthalmologist is a physician who undergoes subspecialty training in medical and surgical eye care. Following a .... References Nonsteroidal anti-inflammatory drugs {{Musculoskeletal-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pirprofen
Pirprofen was a nonsteroidal anti-inflammatory drug (NSAID) that was brought to market by Ciba-Geigy in 1982 as a treatment for arthritis Arthritis is a general medical term used to describe a disorder that affects joints. Symptoms generally include joint pain and stiffness. Other symptoms may include redness, warmth, Joint effusion, swelling, and decreased range of motion of ... and pain. Its label was restricted after adverse events arose, including some cases of fatal liver toxicity. Ciba-Geigy voluntarily withdrew the drug from the market worldwide in 1990.WHOConsolidated List of Products - Whose Consumption and/or Sale Have Been Banned, Withdrawn, Severely Restricted or Not Approved by Governments, Twelfth Issue - Pharmaceuticals United Nations - New York, 2005 References Propionic acids Hepatotoxins Nonsteroidal anti-inflammatory drugs Pyrrolines Chloroarenes {{musculoskeletal-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pelubiprofen
Pelubiprofen is a nonsteroidal anti-inflammatory drug of the profen class used to treat back pain and osteoarthritis Osteoarthritis is a type of degenerative joint disease that results from breakdown of articular cartilage, joint cartilage and underlying bone. A form of arthritis, it is believed to be the fourth leading cause of disability in the world, affect .... Pelubiprofen was developed in South Korea by Daewon Pharmaceuticals and it is marketed in Korea and Russia, among other countries. Research Pelubiprofen is being studied for use in combination with eperisone. Because pelubiprofen has low water solubility, development of salt formulations with better solubility are being studied. Synthesis Pelubiprofen can be prepared by the reaction of 1-(1-piperidino)cyclohexene (1) with ethyl 2-(4-formylphenyl)propanoate (2). References {{Anti-inflammatory products Nonsteroidal anti-inflammatory drugs Carboxylic acids Cyclic ketones ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Naproxen
Naproxen, sold under the brand name Aleve among others, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain, menstrual cramps, and inflammatory diseases such as rheumatoid arthritis, gout and fever. It is taken orally. It is available in immediate and delayed release formulations. Onset of effects is within an hour and lasts for up to twelve hours. Naproxen is also available in salt form, naproxen sodium, which has better solubility when taken orally. Common side effects include dizziness, headache, bruising, allergic reactions, heartburn, and stomach pain. Severe side effects include an increased risk of heart disease, stroke, gastrointestinal bleeding, and stomach ulcers. The heart disease risk may be lower than with other NSAIDs. It is not recommended in people with kidney problems. Use is not recommended in the third trimester of pregnancy. Naproxen is a nonselective COX inhibitor. As an NSAID, naproxen appears to exert its anti-inflammator ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Miroprofen
Miroprofen (INN) is an analgesic and NSAID, meaning that it has anti-inflammatory, antipyretic and antiplatelet aggregation activity. Chemically it is a carboxylic acid In organic chemistry, a carboxylic acid is an organic acid that contains a carboxyl group () attached to an Substituent, R-group. The general formula of a carboxylic acid is often written as or , sometimes as with R referring to an organyl ... belonging to the group of phenylpropanoic acids. References Nonsteroidal anti-inflammatory drugs Imidazopyridines {{musculoskeletal-drug-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ketoprofen
Ketoprofen is one of the propionic acid class of nonsteroidal anti-inflammatory drugs (NSAID) with analgesic and antipyretic effects. It acts by inhibiting the body's production of prostaglandin. It was patented in 1967 and approved for medical use in 1980. Medical uses Ketoprofen is generally prescribed for arthritis-related inflammatory pains or severe toothaches that result in the inflammation of the gums. Ketoprofen topical patches are being used for treatment of musculoskeletal pain. Ketoprofen can also be used for treatment of some pain, especially nerve pain such as sciatica, postherpetic neuralgia and referred pain for radiculopathy, in the form of a cream, ointment, liquid, spray, or gel, which may also contain ketamine and lidocaine, along with other agents which may be useful, such as cyclobenzaprine, amitriptyline, acyclovir, gabapentin, orphenadrine and other drugs used as NSAIDs or adjuvant, atypical or potentiators for pain treatment. Efficacy A 2013 syst ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
