Tiaprofenic acid is a

nonsteroidal anti-inflammatory drug Non-steroidal anti-inflammatory drugs (NSAID) are members of a Indication (medicine), therapeutic drug class which Analgesic, reduces pain, Anti-inflammatory, decreases inflammation, Antipyretic, decreases fever, and Antithrombotic, prevents bl ...

(NSAID) of the arylpropionic acid (profen) class, used to treat pain, especially

arthritic Arthritis is a general medical term used to describe a disorder that affects joints. Symptoms generally include joint pain and stiffness. Other symptoms may include redness, warmth, swelling, and decreased range of motion of the affected jo ...

pain. The typical adult dose is 300 mg twice daily. It is not recommended for children. Long-term use of tiaprofenic acid is associated with severe

cystitis A urinary tract infection (UTI) is an infection that affects a part of the urinary tract. Lower urinary tract infections may involve the bladder (cystitis) or urethra ( urethritis) while upper urinary tract infections affect the kidney (py ...

, roughly 100 times more commonly than other NSAIDs. It is contraindicated in patients with cystitis and urinary tract infections. It is sparingly metabolised in the

liver The liver is a major metabolic organ (anatomy), organ exclusively found in vertebrates, which performs many essential biological Function (biology), functions such as detoxification of the organism, and the Protein biosynthesis, synthesis of var ...

to two inactive metabolites. Most of the drug is eliminated unchanged in the

urine Urine is a liquid by-product of metabolism in humans and many other animals. In placental mammals, urine flows from the Kidney (vertebrates), kidneys through the ureters to the urinary bladder and exits the urethra through the penile meatus (mal ...

. Renal disease impairs excretion, and should be used cautiously in renal disease. It was patented in 1969 and approved for medical use in 1981. It is available in generic formulations. A sustained-release preparation is available. It is an

isomer In chemistry, isomers are molecules or polyatomic ions with identical molecular formula – that is, the same number of atoms of each element (chemistry), element – but distinct arrangements of atoms in space. ''Isomerism'' refers to the exi ...

of Suprofen.

References

External links

* Manufacturer Data Shee

Nonsteroidal anti-inflammatory drugs Diarylketones Thiophenes {{musculoskeletal-drug-stub